NVP-BHG712_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.0644297
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0618964
RPS3 ribosomal protein S3 0.0599129
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.054778
LAMB3 laminin, beta 3 0.0530926
RNF213 ring finger protein 213 0.0511155
RPL35A ribosomal protein L35a 0.0495502
RPS12 ribosomal protein S12 0.0456617
INTS6 integrator complex subunit 6 0.0447683
EEF2 eukaryotic translation elongation factor 2 0.0430636
PLEC plectin 0.042837
SMAD3 SMAD family member 3 0.0419148
RPL37A ribosomal protein L37a 0.0413798
NDRG1 N-myc downstream regulated 1 0.0411167
RACK1 receptor for activated C kinase 1 0.0398098
ANXA2 annexin A2 0.0374764
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0369057
SVIL supervillin 0.0361714
MYH9 myosin, heavy chain 9, non-muscle 0.0353885
HLA-B major histocompatibility complex, class I, B 0.0350198
LOC112694756 uncharaterized LOC112694756 0.0342852
KRT7 keratin 7, type II 0.0342299
DSPP dentin sialophosphoprotein 0.0334519
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0332048
RPS17 ribosomal protein S17 0.032897
RPS8 ribosomal protein S8 0.0320085
RPL23 ribosomal protein L23 0.0316584
LPP LIM domain containing preferred translocation partner in lipoma 0.0307522
AFDN afadin, adherens junction formation factor 0.0306297
ZSWIM6 zinc finger, SWIM-type containing 6 0.0297547
RPL37 ribosomal protein L37 0.0290049
KTN1 kinectin 1 (kinesin receptor) 0.0285627
B2M beta-2-microglobulin 0.0281268
RPS13 ribosomal protein S13 0.0280046
VEGFA vascular endothelial growth factor A 0.0272944
MUC16 mucin 16, cell surface associated 0.0269906
BACE2 beta-site APP-cleaving enzyme 2 0.026741
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0265064
SQSTM1 sequestosome 1 0.0264713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262475
RPS19 ribosomal protein S19 0.0257207
RPL31 ribosomal protein L31 0.0253681
KRT19 keratin 19, type I 0.0251861
FN1 fibronectin 1 0.0251362
CD44 CD44 molecule (Indian blood group) 0.0250818
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0250066
MACF1 microtubule-actin crosslinking factor 1 0.0248803
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0244863
FLNA filamin A, alpha 0.0240204
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0237845
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0236665
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0236033
RPS6 ribosomal protein S6 0.0236004
RPL36 ribosomal protein L36 0.0232347
TPI1 triosephosphate isomerase 1 0.0232027
MYO5B myosin VB 0.0231091
HSPA8 heat shock 70kDa protein 8 0.0229693
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0217037
MCL1 myeloid cell leukemia 1 0.0216208
IFI27 interferon, alpha-inducible protein 27 0.0215635
POTEF POTE ankyrin domain family, member F 0.0214321
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0213744
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0213114
SEPTIN9 septin 9 0.0210562
RPS27A ribosomal protein S27a 0.0210165
FTL ferritin, light polypeptide 0.0208283
HDAC9 histone deacetylase 9 0.0207534
LDHA lactate dehydrogenase A 0.0206762
TPT1 tumor protein, translationally-controlled 1 0.0205308
RPL12 ribosomal protein L12 0.0204116
APLP2 amyloid beta (A4) precursor-like protein 2 0.0203662
MX1 MX dynamin-like GTPase 1 0.0198951
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0198783
MAML2 mastermind-like 2 (Drosophila) 0.019819
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019761
NAV2 neuron navigator 2 0.0196603
SRRM2 serine/arginine repetitive matrix 2 0.0195672
RPL13A ribosomal protein L13a 0.019546
SH3KBP1 SH3-domain kinase binding protein 1 0.0193454
RPL34 ribosomal protein L34 0.0193048
TRIO trio Rho guanine nucleotide exchange factor 0.0189271
EGFR epidermal growth factor receptor 0.018668
RPL27 ribosomal protein L27 0.0186556
AKAP13 A kinase (PRKA) anchor protein 13 0.0184747
DST dystonin 0.0182855
TPM3 tropomyosin 3 0.0182782
RAD51B RAD51 paralog B 0.0182585
SAMD4A sterile alpha motif domain containing 4A 0.0182369
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0182332
IGFBP3 insulin-like growth factor binding protein 3 0.0181604
EIF4H eukaryotic translation initiation factor 4H 0.0181065
NACA nascent polypeptide-associated complex alpha subunit 0.0179816
RPS4X ribosomal protein S4, X-linked 0.0179592
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0177376
FLNB filamin B, beta 0.0176984
SET SET nuclear proto-oncogene 0.0176432
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0175081
PCBP2 poly(rC) binding protein 2 0.0174829
MPRIP myosin phosphatase Rho interacting protein 0.0172001
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0171583

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165045
LAMA4 laminin, alpha 4 -0.0385081
PTMA prothymosin, alpha -0.0382528
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0328161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300233
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0291692
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026785
TM4SF1 transmembrane 4 L six family member 1 -0.0242054
SMC4 structural maintenance of chromosomes 4 -0.0240812
FAM3C family with sequence similarity 3, member C -0.0238987
ECT2 epithelial cell transforming 2 -0.0231329
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0227718
KDM3A lysine (K)-specific demethylase 3A -0.0227369
CD2AP CD2-associated protein -0.0226319
ANLN anillin, actin binding protein -0.0224714
LY6E lymphocyte antigen 6 complex, locus E -0.0218753
NPEPPS aminopeptidase puromycin sensitive -0.021747
DIAPH3 diaphanous-related formin 3 -0.0212317
OSBPL3 oxysterol binding protein-like 3 -0.0203811
TMEM123 transmembrane protein 123 -0.0196135
RBM39 RNA binding motif protein 39 -0.0187794
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0180399
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0170186
RPS15 ribosomal protein S15 -0.0165078
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0164435
RAD21 RAD21 homolog (S. pombe) -0.0162733
DLG1 discs, large homolog 1 (Drosophila) -0.0157912
PLAT plasminogen activator, tissue -0.015505
NAMPT nicotinamide phosphoribosyltransferase -0.0151349
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0151265
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0151109
MIS18BP1 MIS18 binding protein 1 -0.0150187
S100A10 S100 calcium binding protein A10 -0.0149122
MKI67 marker of proliferation Ki-67 -0.0147196
H1-0 H1.0 linker histone -0.0146281
UGCG UDP-glucose ceramide glucosyltransferase -0.0143009
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0139915
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0139486
ITCH itchy E3 ubiquitin protein ligase -0.013682
ZFAND3 zinc finger, AN1-type domain 3 -0.0135368
CANX calnexin -0.0135333
KRT17 keratin 17, type I -0.013459
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0133132
CCNL1 cyclin L1 -0.0133123
MYO6 myosin VI -0.0131913
SENP5 SUMO1/sentrin specific peptidase 5 -0.0131858
NEK7 NIMA-related kinase 7 -0.0128891
RLF rearranged L-myc fusion -0.0128663
GOLGA4 golgin A4 -0.0127867
RPS24 ribosomal protein S24 -0.0126812
NCEH1 neutral cholesterol ester hydrolase 1 -0.0126499
EMP1 epithelial membrane protein 1 -0.0125696
ARHGAP29 Rho GTPase activating protein 29 -0.0122879
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.01205
TOP1 topoisomerase (DNA) I -0.0119966
OSMR oncostatin M receptor -0.0116792
COPB1 coatomer protein complex, subunit beta 1 -0.0116778
RIOK3 RIO kinase 3 -0.0116557
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0116009
TM9SF3 transmembrane 9 superfamily member 3 -0.0114151
DLC1 DLC1 Rho GTPase activating protein -0.0113267
SPAG9 sperm associated antigen 9 -0.011277
TXNRD1 thioredoxin reductase 1 -0.0110211
KRT8 keratin 8, type II -0.0109549
NF1 neurofibromin 1 -0.0109049
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0107775
HMGB2 high mobility group box 2 -0.010481
PARD6B par-6 family cell polarity regulator beta -0.010324
ETNK1 ethanolamine kinase 1 -0.010223
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0101092
UBE2H ubiquitin-conjugating enzyme E2H -0.0100233
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.010007
ANKRD28 ankyrin repeat domain 28 -0.00969528
PTBP3 polypyrimidine tract binding protein 3 -0.00967295
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.00961073
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.00956761
CENPE centromere protein E, 312kDa -0.00950697
ATP13A3 ATPase type 13A3 -0.00945994
LCORL ligand dependent nuclear receptor corepressor-like -0.0093609
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.00933196
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00927036
EHF ets homologous factor -0.00926582
MARCHF6 membrane associated ring-CH-type finger 6 -0.00926435
SENP6 SUMO1/sentrin specific peptidase 6 -0.00924603
ADGRF1 adhesion G protein-coupled receptor F1 -0.0092043
JMJD1C jumonji domain containing 1C -0.00920178
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.00917166
LMAN1 lectin, mannose-binding, 1 -0.00907743
BZW1 basic leucine zipper and W2 domains 1 -0.00898557
TSC22D2 TSC22 domain family, member 2 -0.00882705
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00882249
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00871764
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.00854725
EREG epiregulin -0.00851353
TFG TRK-fused gene -0.00849185
NDFIP1 Nedd4 family interacting protein 1 -0.00847746
GOLT1B golgi transport 1B -0.00845021
RHEB Ras homolog enriched in brain -0.00839612
ELL2 elongation factor, RNA polymerase II, 2 -0.00835854
WWC1 WW and C2 domain containing 1 -0.00833756