NVP-BHG712_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.20953
FRMD6 FERM domain containing 6 0.184111
MCL1 myeloid cell leukemia 1 0.112629
RPL3 ribosomal protein L3 0.105631
EXT1 exostosin glycosyltransferase 1 0.0907215
LOC112694756 uncharaterized LOC112694756 0.0731415
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0668751
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0662913
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0661651
NAV2 neuron navigator 2 0.0610659
SAMD4A sterile alpha motif domain containing 4A 0.0592224
MYH9 myosin, heavy chain 9, non-muscle 0.059058
RPS12 ribosomal protein S12 0.0577668
NDRG1 N-myc downstream regulated 1 0.057094
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.056637
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0565794
RPS3 ribosomal protein S3 0.0542886
SRRM2 serine/arginine repetitive matrix 2 0.0515185
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.049867
MCTP1 multiple C2 domains, transmembrane 1 0.0482938
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0480532
FLNA filamin A, alpha 0.0474212
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.046911
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0467586
AGO2 argonaute RISC catalytic component 2 0.0465619
ARHGAP22 Rho GTPase activating protein 22 0.0429028
APLP2 amyloid beta (A4) precursor-like protein 2 0.0426273
RPS4X ribosomal protein S4, X-linked 0.0424668
RPS2 ribosomal protein S2 0.0422597
ENO1 enolase 1, (alpha) 0.0409234
HSPA8 heat shock 70kDa protein 8 0.0393413
RPS17 ribosomal protein S17 0.0381734
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0362291
SMTN smoothelin 0.0353383
RACK1 receptor for activated C kinase 1 0.0353203
CD68 CD68 molecule 0.0352597
CREB5 cAMP responsive element binding protein 5 0.0350795
RAD51B RAD51 paralog B 0.0346834
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341464
SET SET nuclear proto-oncogene 0.034144
RCOR1 REST corepressor 1 0.0339392
HDAC9 histone deacetylase 9 0.0338535
FLNB filamin B, beta 0.0336693
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0335591
EEF1G eukaryotic translation elongation factor 1 gamma 0.0335375
SGMS2 sphingomyelin synthase 2 0.0334042
PCBP2 poly(rC) binding protein 2 0.0321426
EIF4H eukaryotic translation initiation factor 4H 0.0318122
PRRC2A proline-rich coiled-coil 2A 0.0312912
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0303232
INTS6 integrator complex subunit 6 0.0294308
ZSWIM6 zinc finger, SWIM-type containing 6 0.0287678
RPL37 ribosomal protein L37 0.0286231
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0285234
GLRX glutaredoxin (thioltransferase) 0.0284619
TPM3 tropomyosin 3 0.0283458
RPL27 ribosomal protein L27 0.0281586
ADTRP androgen-dependent TFPI-regulating protein 0.0281274
SURF4 surfeit 4 0.0277855
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0269696
ANK2 ankyrin 2, neuronal 0.0264622
SESN2 sestrin 2 0.026345
RPL23 ribosomal protein L23 0.0262528
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0262518
PICALM phosphatidylinositol binding clathrin assembly protein 0.0260835
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0256666
CEP250 centrosomal protein 250kDa 0.0254741
PKM pyruvate kinase, muscle 0.0253074
SND1 staphylococcal nuclease and tudor domain containing 1 0.0252897
KTN1 kinectin 1 (kinesin receptor) 0.0251026
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0249628
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0246105
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0244437
PLEC plectin 0.0242808
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0239353
DGKI diacylglycerol kinase, iota 0.0237623
UPP1 uridine phosphorylase 1 0.0236099
AKAP12 A kinase (PRKA) anchor protein 12 0.0236074
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0235657
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0233323
RUNX1 runt-related transcription factor 1 0.0232343
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0231739
PRELID2 PRELI domain containing 2 0.0231442
RPL37A ribosomal protein L37a 0.0228875
RPS26 ribosomal protein S26 0.0224773
ENO2 enolase 2 (gamma, neuronal) 0.0224735
NOCT nocturnin 0.0221126
KDM6A lysine (K)-specific demethylase 6A 0.0220416
TM4SF19 transmembrane 4 L six family member 19 0.0220198
GSE1 Gse1 coiled-coil protein 0.0219812
CAPRIN2 caprin family member 2 0.0217987
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0217798
TSC22D2 TSC22 domain family, member 2 0.0215287
RPS20 ribosomal protein S20 0.02132
CORO1C coronin, actin binding protein, 1C 0.0212344
COL27A1 collagen, type XXVII, alpha 1 0.0206615
RPL7 ribosomal protein L7 0.0205116
RTN4 reticulon 4 0.0204717
RPS18 ribosomal protein S18 0.020303
EIF4B eukaryotic translation initiation factor 4B 0.0201232

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.227692
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.11092
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0928219
IFI16 interferon, gamma-inducible protein 16 -0.0798084
TTR transthyretin -0.074641
ANTXR2 anthrax toxin receptor 2 -0.0618441
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0580647
STC1 stanniocalcin 1 -0.0536761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0529624
TXNRD1 thioredoxin reductase 1 -0.0523635
ELL2 elongation factor, RNA polymerase II, 2 -0.0510138
RBM25 RNA binding motif protein 25 -0.0499524
RAD21 RAD21 homolog (S. pombe) -0.0493845
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0467018
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0462163
NAV3 neuron navigator 3 -0.0448435
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0446879
SLC38A2 solute carrier family 38, member 2 -0.0443473
PTK2 protein tyrosine kinase 2 -0.0435371
PCNX4 pecanex 4 -0.0403829
CALD1 caldesmon 1 -0.0382186
MTAP methylthioadenosine phosphorylase -0.0376452
NAP1L1 nucleosome assembly protein 1-like 1 -0.0375925
PTMA prothymosin, alpha -0.035554
RPS24 ribosomal protein S24 -0.0350384
DIAPH3 diaphanous-related formin 3 -0.0349178
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0334854
TCF12 transcription factor 12 -0.0333142
TEX10 testis expressed 10 -0.0327441
TPT1 tumor protein, translationally-controlled 1 -0.0326595
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0314411
ZC3H12B zinc finger CCCH-type containing 12B -0.0314047
MTDH metadherin -0.0311071
C2CD2 C2 calcium-dependent domain containing 2 -0.0310679
SBF2 SET binding factor 2 -0.0310619
EIF5B eukaryotic translation initiation factor 5B -0.0309934
STAU1 staufen double-stranded RNA binding protein 1 -0.0306091
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0304917
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0303821
PGK1 phosphoglycerate kinase 1 -0.0301341
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293989
FUS FUS RNA binding protein -0.0290086
TM9SF3 transmembrane 9 superfamily member 3 -0.0287886
RPL32 ribosomal protein L32 -0.0284962
SETX senataxin -0.0283004
BZW1 basic leucine zipper and W2 domains 1 -0.0278605
THOC2 THO complex 2 -0.0274983
CD2AP CD2-associated protein -0.0274747
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0270453
SRPK1 SRSF protein kinase 1 -0.0270387
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0270386
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0265232
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0263658
NEMF nuclear export mediator factor -0.0262545
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0261669
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0259614
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0259173
TOP1 topoisomerase (DNA) I -0.0257186
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0256061
GNAS GNAS complex locus -0.0254459
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0253069
NF1 neurofibromin 1 -0.0251702
SQLE squalene epoxidase -0.0249863
LPP LIM domain containing preferred translocation partner in lipoma -0.024897
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0248123
BMAL2 basic helix-loop-helix ARNT like 2 -0.0247819
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0247644
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0247519
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0246819
RRBP1 ribosome binding protein 1 -0.0244969
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0240372
MKI67 marker of proliferation Ki-67 -0.0240061
TASOR2 transcription activation suppressor family member 2 -0.023932
MIS18BP1 MIS18 binding protein 1 -0.0238849
RPL6 ribosomal protein L6 -0.0237224
NSD3 nuclear receptor binding SET domain protein 3 -0.0235924
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0235274
WSB1 WD repeat and SOCS box containing 1 -0.0233682
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0233632
PFN1 profilin 1 -0.0233019
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0232906
MAP4 microtubule-associated protein 4 -0.0232474
RBBP6 retinoblastoma binding protein 6 -0.0232174
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0229077
SENP5 SUMO1/sentrin specific peptidase 5 -0.0227934
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0227404
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.022696
RPL19 ribosomal protein L19 -0.0226395
TAS2R14 taste receptor, type 2, member 14 -0.0225722
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0224792
MON2 MON2 homolog (S. cerevisiae) -0.0221271
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0221069
CHD9 chromodomain helicase DNA binding protein 9 -0.0221014
SCLT1 sodium channel and clathrin linker 1 -0.0220565
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0218262
TMSB10 thymosin beta 10 -0.0218131
RPS6 ribosomal protein S6 -0.0218029
DNAH14 dynein, axonemal, heavy chain 14 -0.0217884
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0217849
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0217313