| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.0815402 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.062534 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0613634 |
| HLA-B | major histocompatibility complex, class I, B | 0.0608783 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0607956 |
| CDH13 | cadherin 13 | 0.05404 |
| ASPH | aspartate beta-hydroxylase | 0.0501808 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0489868 |
| ANXA2 | annexin A2 | 0.0472882 |
| TMEM178B | transmembrane protein 178B | 0.0459519 |
| HLA-A | major histocompatibility complex, class I, A | 0.0453176 |
| NRP1 | neuropilin 1 | 0.0433204 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0425183 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | 0.0410867 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0402286 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0393929 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0386877 |
| COL1A2 | collagen, type I, alpha 2 | 0.0379665 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0379035 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0372439 |
| HDAC9 | histone deacetylase 9 | 0.036494 |
| LOXL2 | lysyl oxidase-like 2 | 0.0362289 |
| NAV1 | neuron navigator 1 | 0.0361914 |
| SP100 | SP100 nuclear antigen | 0.034767 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0341694 |
| DST | dystonin | 0.0334427 |
| COL5A1 | collagen, type V, alpha 1 | 0.0325505 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0321974 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0316697 |
| FHIT | fragile histidine triad | 0.0312998 |
| ECE1 | endothelin converting enzyme 1 | 0.0303553 |
| ANGPTL4 | angiopoietin-like 4 | 0.0301154 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0294133 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0292782 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0290776 |
| TPM1 | tropomyosin 1 (alpha) | 0.028904 |
| CTSB | cathepsin B | 0.0288622 |
| SMYD3 | SET and MYND domain containing 3 | 0.0283895 |
| FRMD4A | FERM domain containing 4A | 0.0282679 |
| PLEC | plectin | 0.0281799 |
| MTSS1 | metastasis suppressor 1 | 0.027893 |
| VEGFA | vascular endothelial growth factor A | 0.0278557 |
| HMGA2 | high mobility group AT-hook 2 | 0.0275961 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0272973 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0270782 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0267686 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0265447 |
| RPL35A | ribosomal protein L35a | 0.0264206 |
| GLIS3 | GLIS family zinc finger 3 | 0.0263766 |
| HLA-C | major histocompatibility complex, class I, C | 0.0250463 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0248543 |
| COL5A3 | collagen, type V, alpha 3 | 0.0248433 |
| SVIL | supervillin | 0.0247551 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0245492 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0243735 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0241794 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0238463 |
| HPCAL1 | hippocalcin-like 1 | 0.0231497 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0231453 |
| ACTG1 | actin gamma 1 | 0.0230227 |
| RNF213 | ring finger protein 213 | 0.0230007 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0229154 |
| ITGA1 | integrin, alpha 1 | 0.0227998 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0227733 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0226985 |
| SLFN5 | schlafen family member 5 | 0.0226187 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0224538 |
| SMAD3 | SMAD family member 3 | 0.0220141 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0217685 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0212577 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0205524 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0202385 |
| PLAT | plasminogen activator, tissue | 0.0202303 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0196773 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0196103 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0195349 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0194803 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.019366 |
| C1S | complement component 1, s subcomponent | 0.0185387 |
| FBN1 | fibrillin 1 | 0.018418 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0182326 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0181902 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0181307 |
| EGFR | epidermal growth factor receptor | 0.0181029 |
| INTS6 | integrator complex subunit 6 | 0.0180493 |
| RPL37A | ribosomal protein L37a | 0.0177084 |
| EGR1 | early growth response 1 | 0.0171094 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0170469 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0169199 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0168909 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0167861 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0167803 |
| UTRN | utrophin | 0.0166642 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0166125 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0163844 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0163742 |
| HLA-E | major histocompatibility complex, class I, E | 0.0162587 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0162455 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0162442 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.016233 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.149393 |
| VIM | vimentin | -0.142539 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.114557 |
| ZNF292 | zinc finger protein 292 | -0.0673643 |
| MT2A | metallothionein 2A | -0.0658167 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0647175 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0617504 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0615099 |
| PGK1 | phosphoglycerate kinase 1 | -0.0604514 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.059058 |
| GOLGA4 | golgin A4 | -0.0583683 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0562287 |
| RBM39 | RNA binding motif protein 39 | -0.0554869 |
| CENPF | centromere protein F, 350/400kDa | -0.0541644 |
| UBC | ubiquitin C | -0.0487395 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0482658 |
| STC1 | stanniocalcin 1 | -0.0479718 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0465436 |
| PTMA | prothymosin, alpha | -0.0447372 |
| FN1 | fibronectin 1 | -0.0395327 |
| TPX2 | TPX2, microtubule-associated | -0.0376404 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0365154 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0361496 |
| H1-0 | H1.0 linker histone | -0.0361022 |
| SETD5 | SET domain containing 5 | -0.0347855 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.034574 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0330145 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0323011 |
| ANLN | anillin, actin binding protein | -0.0319458 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0314332 |
| POTEF | POTE ankyrin domain family, member F | -0.0308956 |
| PKM | pyruvate kinase, muscle | -0.0307525 |
| THBS1 | thrombospondin 1 | -0.030396 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0302335 |
| XPO1 | exportin 1 | -0.0299789 |
| MKI67 | marker of proliferation Ki-67 | -0.0299748 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.029755 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0294915 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293395 |
| CALU | calumenin | -0.0292961 |
| HMGB2 | high mobility group box 2 | -0.0292718 |
| TFG | TRK-fused gene | -0.0291205 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0285546 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0269022 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0265061 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0264456 |
| SEPTIN7 | septin 7 | -0.0262826 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0261213 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0260997 |
| RAB1A | RAB1A, member RAS oncogene family | -0.026046 |
| COPA | coatomer protein complex, subunit alpha | -0.0257397 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0256392 |
| NDRG1 | N-myc downstream regulated 1 | -0.0250913 |
| DIAPH3 | diaphanous-related formin 3 | -0.0250837 |
| RTN4 | reticulon 4 | -0.0247236 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0246319 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.024557 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0243212 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0239049 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0229756 |
| SRP54 | signal recognition particle 54kDa | -0.0228961 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.022688 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0226615 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0224875 |
| OGA | O-GlcNAcase | -0.0224065 |
| QKI | QKI, KH domain containing, RNA binding | -0.0220986 |
| CCNL1 | cyclin L1 | -0.0218205 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0218072 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0215236 |
| SPAG9 | sperm associated antigen 9 | -0.0214775 |
| RNF24 | ring finger protein 24 | -0.0214092 |
| CANX | calnexin | -0.0212166 |
| SUCO | SUN domain containing ossification factor | -0.021097 |
| SEPTIN2 | septin 2 | -0.021092 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0210127 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0209032 |
| CENPE | centromere protein E, 312kDa | -0.0208477 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0208326 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0206933 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0206244 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0204739 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0204228 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0203285 |
| SEC24D | SEC24 family member D | -0.0203123 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0202071 |
| MORF4L1 | mortality factor 4 like 1 | -0.0201582 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0201337 |
| IER3 | immediate early response 3 | -0.0200345 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.019895 |
| HELZ | helicase with zinc finger | -0.0197435 |
| ATP13A3 | ATPase type 13A3 | -0.0195131 |
| SBF2 | SET binding factor 2 | -0.0194792 |
| RLF | rearranged L-myc fusion | -0.0193578 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0193383 |
| PHIP | pleckstrin homology domain interacting protein | -0.0193336 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0193294 |
| ECT2 | epithelial cell transforming 2 | -0.0191727 |
| ZNF654 | zinc finger protein 654 | -0.0190665 |
| KIF4A | kinesin family member 4A | -0.0189171 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0187118 |
