| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.243545 |
| VGF | VGF nerve growth factor inducible | 0.174991 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.166054 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.121674 |
| MCL1 | myeloid cell leukemia 1 | 0.0914151 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0802482 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.070507 |
| CPE | carboxypeptidase E | 0.0637344 |
| INHBA | inhibin, beta A | 0.0591679 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0565413 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0504378 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0475952 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0472073 |
| CENPF | centromere protein F, 350/400kDa | 0.0426294 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0424694 |
| FAT1 | FAT atypical cadherin 1 | 0.0417537 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0384115 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0381602 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0364782 |
| SIK2 | salt-inducible kinase 2 | 0.0364112 |
| UBE2QL1 | ubiquitin-conjugating enzyme E2Q family-like 1 | 0.0336152 |
| TOP1 | topoisomerase (DNA) I | 0.0335902 |
| EGR1 | early growth response 1 | 0.0334629 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334382 |
| RPL3 | ribosomal protein L3 | 0.0326294 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0318061 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.0292414 |
| TPM4 | tropomyosin 4 | 0.0286662 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0282434 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0279135 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0277158 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0274912 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.027133 |
| MATR3 | matrin 3 | 0.0266618 |
| GRAMD4 | GRAM domain containing 4 | 0.0266048 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0265963 |
| DACH1 | dachshund family transcription factor 1 | 0.0263964 |
| AHR | aryl hydrocarbon receptor | 0.0256414 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0252143 |
| SURF4 | surfeit 4 | 0.0251774 |
| POTEF | POTE ankyrin domain family, member F | 0.0247343 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0242255 |
| IRS2 | insulin receptor substrate 2 | 0.02418 |
| TPM3 | tropomyosin 3 | 0.0241352 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.024129 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0241215 |
| MSN | moesin | 0.023706 |
| STK24 | serine/threonine kinase 24 | 0.0232447 |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.0225749 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0221936 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0214609 |
| MEF2D | myocyte enhancer factor 2D | 0.0211087 |
| TXNRD1 | thioredoxin reductase 1 | 0.0210221 |
| PALLD | palladin, cytoskeletal associated protein | 0.020983 |
| DUSP4 | dual specificity phosphatase 4 | 0.020937 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0209142 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0208641 |
| HMGB3 | high mobility group box 3 | 0.0205738 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0205387 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0205221 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0203147 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0198175 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0196091 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.0194098 |
| TMEM255B | transmembrane protein 255B | 0.0191646 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0190171 |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | 0.0189395 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0188492 |
| AGO2 | argonaute RISC catalytic component 2 | 0.018841 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0187682 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0184464 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0184148 |
| SGMS2 | sphingomyelin synthase 2 | 0.0184095 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0183368 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0183143 |
| ZNF146 | zinc finger protein 146 | 0.0180636 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0180185 |
| TUBB | tubulin, beta class I | 0.0179819 |
| GPRIN3 | GPRIN family member 3 | 0.0179049 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0177686 |
| SYT13 | synaptotagmin XIII | 0.0176147 |
| SFMBT2 | Scm-like with four mbt domains 2 | 0.0175715 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0175657 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0175556 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0173789 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0172831 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0172411 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.0171594 |
| EGFR | epidermal growth factor receptor | 0.0168439 |
| FAM120A | family with sequence similarity 120A | 0.0164625 |
| FBXO41 | F-box protein 41 | 0.0162725 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0161762 |
| SMAD4 | SMAD family member 4 | 0.0161397 |
| AOPEP | aminopeptidase O (putative) | 0.0161371 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0160906 |
| BRD4 | bromodomain containing 4 | 0.0160348 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.0156845 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0156725 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0156237 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0154984 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.227714 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.14134 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.139998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.119906 |
| ESRRG | estrogen-related receptor gamma | -0.115841 |
| GPC6 | glypican 6 | -0.0985581 |
| TENM1 | teneurin transmembrane protein 1 | -0.0936057 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0708653 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0701678 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0678911 |
| RORA | RAR-related orphan receptor A | -0.0638666 |
| SNTG1 | syntrophin, gamma 1 | -0.0635728 |
| ACTG1 | actin gamma 1 | -0.0578987 |
| PTMA | prothymosin, alpha | -0.0574311 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0559931 |
| SCG2 | secretogranin II | -0.0553775 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0545249 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0526258 |
| NDRG1 | N-myc downstream regulated 1 | -0.0517526 |
| GPC5 | glypican 5 | -0.0502593 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0484263 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0477423 |
| NCKAP5 | NCK-associated protein 5 | -0.0461988 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0451086 |
| CANX | calnexin | -0.0450014 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0440476 |
| NELL1 | NEL-like 1 (chicken) | -0.0440219 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.043554 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0433767 |
| PGK1 | phosphoglycerate kinase 1 | -0.0430064 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0423922 |
| ENO1 | enolase 1, (alpha) | -0.0420761 |
| SMYD3 | SET and MYND domain containing 3 | -0.0417427 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0409 |
| LSAMP | limbic system-associated membrane protein | -0.0396827 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0396694 |
| TMSB4X | thymosin beta 4, X-linked | -0.0391666 |
| PEG10 | paternally expressed 10 | -0.0382985 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0373493 |
| DTNA | dystrobrevin, alpha | -0.0367531 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0364587 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0363093 |
| NLGN1 | neuroligin 1 | -0.0356397 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0343062 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0337094 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0336449 |
| MYT1L | myelin transcription factor 1-like | -0.0332348 |
| AGBL4 | ATP/GTP binding protein-like 4 | -0.0331499 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0331095 |
| PTCHD4 | patched domain containing 4 | -0.0315845 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0314927 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0295813 |
| RAD51B | RAD51 paralog B | -0.0292615 |
| SYT1 | synaptotagmin I | -0.0284818 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0281385 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0274604 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271437 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0269443 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0268597 |
| MT2A | metallothionein 2A | -0.0268003 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.0267765 |
| H1-0 | H1.0 linker histone | -0.026745 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0265763 |
| STC1 | stanniocalcin 1 | -0.0259264 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0256339 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.0256063 |
| GPATCH8 | G patch domain containing 8 | -0.0254897 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0251489 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0250702 |
| NAV1 | neuron navigator 1 | -0.0249434 |
| PCDH9 | protocadherin 9 | -0.0247808 |
| S100A9 | S100 calcium binding protein A9 | -0.0244789 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0243052 |
| GOLGB1 | golgin B1 | -0.0240756 |
| EXOC4 | exocyst complex component 4 | -0.0238485 |
| ZNF804A | zinc finger protein 804A | -0.0236643 |
| FTL | ferritin, light polypeptide | -0.0235611 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0234261 |
| SRP72 | signal recognition particle 72kDa | -0.023408 |
| JAM3 | junctional adhesion molecule 3 | -0.0232989 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0231938 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0226853 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0224619 |
| AUTS2 | autism susceptibility candidate 2 | -0.022431 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0223409 |
| SQSTM1 | sequestosome 1 | -0.0218174 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0217977 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0215857 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0214643 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.021402 |
| CADM1 | cell adhesion molecule 1 | -0.0213508 |
| FBXO34 | F-box protein 34 | -0.021341 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.021294 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0211491 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.021146 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0211298 |
| BPTF | bromodomain PHD finger transcription factor | -0.0209644 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0209168 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0208963 |
| MTDH | metadherin | -0.0206763 |
