NVP-BHG712_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0321858
EEF2 eukaryotic translation elongation factor 2 0.0310961
PLEC plectin 0.0306079
MSN moesin 0.0272361
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0261377
TPM3 tropomyosin 3 0.0255411
POTEF POTE ankyrin domain family, member F 0.0235366
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0227605
LOC112694756 uncharaterized LOC112694756 0.0218847
FLNA filamin A, alpha 0.0205418
NOTCH2 notch 2 0.0198083
WWTR1 WW domain containing transcription regulator 1 0.0190379
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0182888
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0181339
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0179407
MYH9 myosin, heavy chain 9, non-muscle 0.0173514
EXT1 exostosin glycosyltransferase 1 0.017281
RPL3 ribosomal protein L3 0.0170066
ACTG1 actin gamma 1 0.0168889
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0164044
RTN4 reticulon 4 0.0162862
GOLGA4 golgin A4 0.0161181
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0160059
NAV2 neuron navigator 2 0.0156969
ANXA5 annexin A5 0.0155294
CD44 CD44 molecule (Indian blood group) 0.0152991
RHOA ras homolog family member A 0.0147252
PKM pyruvate kinase, muscle 0.0141007
SRRM2 serine/arginine repetitive matrix 2 0.013848
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0138177
MCL1 myeloid cell leukemia 1 0.013794
SAMD4A sterile alpha motif domain containing 4A 0.013696
FRMD5 FERM domain containing 5 0.0135769
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.013557
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0134631
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0134331
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.013226
EZR ezrin 0.0131115
ACTN4 actinin, alpha 4 0.0130072
SFTPA2 surfactant protein A2 0.0129714
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0119775
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0118802
TRIM33 tripartite motif containing 33 0.0118706
AKAP13 A kinase (PRKA) anchor protein 13 0.0118482
SREBF2 sterol regulatory element binding transcription factor 2 0.011643
CORO1C coronin, actin binding protein, 1C 0.0114744
UBC ubiquitin C 0.0113186
TXNRD1 thioredoxin reductase 1 0.0112661
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0110694
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.011031
TIMP2 TIMP metallopeptidase inhibitor 2 0.0108935
USP53 ubiquitin specific peptidase 53 0.0108275
TPD52 tumor protein D52 0.0107781
PCBP2 poly(rC) binding protein 2 0.0107619
VMP1 vacuole membrane protein 1 0.010718
MACF1 microtubule-actin crosslinking factor 1 0.0106962
TPM4 tropomyosin 4 0.0106788
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0105303
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0104521
TLN1 talin 1 0.0103867
ZNF148 zinc finger protein 148 0.0102677
NIBAN2 niban apoptosis regulator 2 0.0102379
DIAPH1 diaphanous-related formin 1 0.0101837
SPAG9 sperm associated antigen 9 0.0101835
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0101827
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0101272
ERBIN erbb2 interacting protein 0.0101192
CCND1 cyclin D1 0.0101142
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0099614
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00995394
ENO1 enolase 1, (alpha) 0.00995291
NPC1 Niemann-Pick disease, type C1 0.00992762
EIF4H eukaryotic translation initiation factor 4H 0.00985966
LEF1 lymphoid enhancer-binding factor 1 0.00983341
CLIC4 chloride intracellular channel 4 0.00979659
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00978523
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00973395
ZMIZ1 zinc finger, MIZ-type containing 1 0.00973201
APLP2 amyloid beta (A4) precursor-like protein 2 0.00967406
WAC WW domain containing adaptor with coiled-coil 0.0096677
ACTN1 actinin, alpha 1 0.00965505
ANKRD28 ankyrin repeat domain 28 0.009638
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0096332
GLG1 golgi glycoprotein 1 0.00959852
CALR calreticulin 0.0095887
MOSMO modulator of smoothened 0.00939847
SKIL SKI-like proto-oncogene 0.00933506
FBXL17 F-box and leucine-rich repeat protein 17 0.00930016
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00929943
CEP250 centrosomal protein 250kDa 0.00925974
EP300 E1A binding protein p300 0.00924067
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.00918106
FXR1 fragile X mental retardation, autosomal homolog 1 0.00908157
FNBP1L formin binding protein 1-like 0.00907125
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00906767
ZC3H7B zinc finger CCCH-type containing 7B 0.00902971
NFE2L1 nuclear factor, erythroid 2-like 1 0.00901658
TENM1 teneurin transmembrane protein 1 0.00901297
IL1RAP interleukin 1 receptor accessory protein 0.00891743
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00886427

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.0861926
NLGN1 neuroligin 1 -0.0821233
NRG3 neuregulin 3 -0.0684813
FRMD4A FERM domain containing 4A -0.0554064
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0517312
AKAP12 A kinase (PRKA) anchor protein 12 -0.0403773
FMN1 formin 1 -0.0391556
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0329005
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.032338
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0254612
CXCL8 chemokine (C-X-C motif) ligand 8 -0.025168
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0240959
TNNC1 troponin C type 1 (slow) -0.0228738
TMSB10 thymosin beta 10 -0.022301
EHBP1 EH domain binding protein 1 -0.0188797
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0188011
IFI16 interferon, gamma-inducible protein 16 -0.0185077
IFI44L interferon-induced protein 44-like -0.0183515
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0181912
PTMA prothymosin, alpha -0.0178096
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0168114
MSI2 musashi RNA-binding protein 2 -0.0164095
CADM1 cell adhesion molecule 1 -0.0154219
IGFBP3 insulin-like growth factor binding protein 3 -0.0150215
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.014956
IFI6 interferon, alpha-inducible protein 6 -0.0148681
SP100 SP100 nuclear antigen -0.0148037
SLC39A11 solute carrier family 39, member 11 -0.0139037
HLA-B major histocompatibility complex, class I, B -0.0136941
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0134084
DIAPH2 diaphanous-related formin 2 -0.0130145
VIM vimentin -0.0121853
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0113069
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0112865
TNIK TRAF2 and NCK interacting kinase -0.0109782
RPLP2 ribosomal protein, large, P2 -0.0108911
TMEM45A transmembrane protein 45A -0.0108284
RAD51B RAD51 paralog B -0.0104603
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0103736
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0101957
PRAME preferentially expressed antigen in melanoma -0.0101891
GPHN gephyrin -0.00986459
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.00965421
FOXP1 forkhead box P1 -0.00954376
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.00953233
BCAS3 breast carcinoma amplified sequence 3 -0.00910712
RPS3 ribosomal protein S3 -0.0089816
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.00897728
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00897168
TAS2R14 taste receptor, type 2, member 14 -0.00896424
SOX5 SRY (sex determining region Y)-box 5 -0.00864602
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.00863742
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00863353
CFAP20DC CFAP20 domain containing -0.00857939
COMMD10 COMM domain containing 10 -0.0085473
KAZN kazrin, periplakin interacting protein -0.00848902
RPL34 ribosomal protein L34 -0.00845263
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.00842311
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.00819305
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.00814484
ARHGAP5 Rho GTPase activating protein 5 -0.00812002
MAML3 mastermind-like 3 (Drosophila) -0.00800668
HSPH1 heat shock 105kDa/110kDa protein 1 -0.00792589
MT2A metallothionein 2A -0.00783515
IFIH1 interferon induced with helicase C domain 1 -0.00778367
IGF2 insulin-like growth factor 2 -0.00764712
TENM3 teneurin transmembrane protein 3 -0.00758015
NHSL1 NHS-like 1 -0.00751546
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00750349
FGF13 fibroblast growth factor 13 -0.00749735
NAMPT nicotinamide phosphoribosyltransferase -0.0074824
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.00746441
RALY RALY heterogeneous nuclear ribonucleoprotein -0.00744569
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00729767
WNT2B wingless-type MMTV integration site family, member 2B -0.00729244
TCF12 transcription factor 12 -0.00725786
AFF3 AF4/FMR2 family, member 3 -0.00723687
PMP22 peripheral myelin protein 22 -0.00723682
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.00718299
NPR2 natriuretic peptide receptor 2 -0.00715611
RPS27A ribosomal protein S27a -0.00712543
SOX6 SRY (sex determining region Y)-box 6 -0.00703117
BBX bobby sox homolog (Drosophila) -0.00702504
TFPI2 tissue factor pathway inhibitor 2 -0.00701826
RPL38 ribosomal protein L38 -0.00692807
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0069106
XAF1 XIAP associated factor 1 -0.00690993
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00675957
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00673806
CUL1 cullin 1 -0.00673079
EIF5B eukaryotic translation initiation factor 5B -0.00667884
RIGI RNA sensor RIG-I -0.00664232
TBCA tubulin folding cofactor A -0.00662967
ANGPTL4 angiopoietin-like 4 -0.00659791
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.00657402
CBX3 chromobox homolog 3 -0.00655815
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.00650112
IER3 immediate early response 3 -0.00644144
WWC1 WW and C2 domain containing 1 -0.00643789
TRIM56 tripartite motif containing 56 -0.00632535