NVP-BHG712_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0414556
LOC112694756 uncharaterized LOC112694756 0.0269838
HSPA8 heat shock 70kDa protein 8 0.0259373
EGFR epidermal growth factor receptor 0.0254318
MYO5C myosin VC 0.0234171
ZEB1 zinc finger E-box binding homeobox 1 0.0233529
ZNF608 zinc finger protein 608 0.0205732
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0193738
AHNAK AHNAK nucleoprotein 0.0178808
EIF4H eukaryotic translation initiation factor 4H 0.0168905
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0165642
KMT2E lysine (K)-specific methyltransferase 2E 0.0162219
NCEH1 neutral cholesterol ester hydrolase 1 0.0159956
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0148555
EEF2 eukaryotic translation elongation factor 2 0.0146543
RPL3 ribosomal protein L3 0.0140475
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0137387
PRRC2A proline-rich coiled-coil 2A 0.0137142
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0136827
HELZ helicase with zinc finger 0.0136091
ANXA1 annexin A1 0.0132478
QKI QKI, KH domain containing, RNA binding 0.0125681
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0123964
SPAG9 sperm associated antigen 9 0.0123494
NCOR1 nuclear receptor corepressor 1 0.0122635
RLF rearranged L-myc fusion 0.0121941
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0121272
KMT2C lysine (K)-specific methyltransferase 2C 0.0121228
WNK1 WNK lysine deficient protein kinase 1 0.0120941
SPATS2L spermatogenesis associated, serine-rich 2-like 0.011701
ECT2 epithelial cell transforming 2 0.0116786
GLI2 GLI family zinc finger 2 0.0115818
LMCD1 LIM and cysteine-rich domains 1 0.0114147
SGMS2 sphingomyelin synthase 2 0.0113048
GATA6 GATA binding protein 6 0.0112527
NCOA3 nuclear receptor coactivator 3 0.0110114
CTBP2 C-terminal binding protein 2 0.0109764
SLMAP sarcolemma associated protein 0.0109245
KDM4C lysine (K)-specific demethylase 4C 0.0108092
DSCAM Down syndrome cell adhesion molecule 0.0106949
SPPL3 signal peptide peptidase like 3 0.0106159
HLA-C major histocompatibility complex, class I, C 0.010605
CORO1C coronin, actin binding protein, 1C 0.0103963
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0102618
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0102384
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0101844
EZR ezrin 0.0101517
KDM3A lysine (K)-specific demethylase 3A 0.01014
HDLBP high density lipoprotein binding protein 0.0101117
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0100152
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00999536
PDGFC platelet derived growth factor C 0.00992196
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00989257
ASCC3 activating signal cointegrator 1 complex subunit 3 0.00988731
SERGEF secretion regulating guanine nucleotide exchange factor 0.00966127
ZFAND3 zinc finger, AN1-type domain 3 0.00962833
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.00942761
DENND5A DENN/MADD domain containing 5A 0.00939259
YTHDC1 YTH domain containing 1 0.0092616
ZNF800 zinc finger protein 800 0.00916809
PLPP3 phospholipid phosphatase 3 0.00916532
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00915555
NAMPT nicotinamide phosphoribosyltransferase 0.00914373
INTS6 integrator complex subunit 6 0.00910719
SMAP1 small ArfGAP 1 0.00899172
CABIN1 calcineurin binding protein 1 0.00896397
TOP2B topoisomerase (DNA) II beta 180kDa 0.0089625
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.00894122
PLXNA1 plexin A1 0.00892729
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.00890125
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00883729
DCAF6 DDB1 and CUL4 associated factor 6 0.00882947
CDC73 cell division cycle 73 0.00865284
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.00847965
ZNF217 zinc finger protein 217 0.00847132
PRPF4B pre-mRNA processing factor 4B 0.00830525
NBAS neuroblastoma amplified sequence 0.00830127
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00829825
RPS18 ribosomal protein S18 0.00825988
MACF1 microtubule-actin crosslinking factor 1 0.00824059
SKIC3 SKI3 subunit of superkiller complex 0.00819797
CASC3 cancer susceptibility candidate 3 0.00815732
ATP11A ATPase, class VI, type 11A 0.00814976
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00809014
KDM4B lysine (K)-specific demethylase 4B 0.0080116
TRA2A transformer 2 alpha homolog (Drosophila) 0.00799328
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.00798464
AFF4 AF4/FMR2 family, member 4 0.00792091
ARRDC3 arrestin domain containing 3 0.00786623
WDFY3 WD repeat and FYVE domain containing 3 0.00785483
PRPF39 pre-mRNA processing factor 39 0.00778091
FIP1L1 factor interacting with PAPOLA and CPSF1 0.00773362
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00772521
EHBP1L1 EH domain binding protein 1-like 1 0.00768863
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.00762141
RPL29 ribosomal protein L29 0.00753144
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.00752557
NIPBL Nipped-B homolog (Drosophila) 0.00750107
ELP2 elongator acetyltransferase complex subunit 2 0.00747914
ARID1A AT rich interactive domain 1A (SWI-like) 0.00745085

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.354431
PTMA prothymosin, alpha -0.297361
RPS6 ribosomal protein S6 -0.104628
TPT1 tumor protein, translationally-controlled 1 -0.100153
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0866192
RPS8 ribosomal protein S8 -0.0826344
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0652103
RPL35A ribosomal protein L35a -0.0627204
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0607184
PKM pyruvate kinase, muscle -0.0567519
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0553693
HSPB1 heat shock 27kDa protein 1 -0.055136
ARL4C ADP-ribosylation factor-like 4C -0.0519335
RPS23 ribosomal protein S23 -0.0501905
RPLP2 ribosomal protein, large, P2 -0.0482315
S100A4 S100 calcium binding protein A4 -0.0472572
POTEF POTE ankyrin domain family, member F -0.0465932
BMP10 bone morphogenetic protein 10 -0.0462589
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0456425
S100A6 S100 calcium binding protein A6 -0.0447194
ACTG1 actin gamma 1 -0.0432734
CCND1 cyclin D1 -0.0423435
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0416819
RPL19 ribosomal protein L19 -0.040608
DLG1 discs, large homolog 1 (Drosophila) -0.0401153
RPLP0 ribosomal protein, large, P0 -0.039885
RPL7A ribosomal protein L7a -0.0398817
RPS13 ribosomal protein S13 -0.0390316
RPL9 ribosomal protein L9 -0.0390132
RPL37A ribosomal protein L37a -0.0388463
PFN1 profilin 1 -0.0381609
RPS25 ribosomal protein S25 -0.0379197
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0377937
TPM4 tropomyosin 4 -0.0375482
PDE4B phosphodiesterase 4B, cAMP-specific -0.0369336
RPLP1 ribosomal protein, large, P1 -0.0369302
TXNRD1 thioredoxin reductase 1 -0.036881
MYL12B myosin, light chain 12B, regulatory -0.0359659
RPL34 ribosomal protein L34 -0.0353551
IGF2 insulin-like growth factor 2 -0.035132
RPS24 ribosomal protein S24 -0.0348693
S100A10 S100 calcium binding protein A10 -0.0340398
RPL11 ribosomal protein L11 -0.0334742
RPL8 ribosomal protein L8 -0.0332962
RPL36A ribosomal protein L36a -0.0332644
FOXP1 forkhead box P1 -0.0329243
SMC3 structural maintenance of chromosomes 3 -0.0324264
KPNB1 karyopherin (importin) beta 1 -0.0324196
S100A9 S100 calcium binding protein A9 -0.0316893
RPL28 ribosomal protein L28 -0.0310172
RPL26 ribosomal protein L26 -0.0309505
GNAS GNAS complex locus -0.0304998
RPS14 ribosomal protein S14 -0.0304818
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0304453
RPL32 ribosomal protein L32 -0.0302301
RPL27A ribosomal protein L27a -0.0301442
RPL23 ribosomal protein L23 -0.0296792
RPS11 ribosomal protein S11 -0.029194
RPL31 ribosomal protein L31 -0.0287525
MT2A metallothionein 2A -0.0285102
VCL vinculin -0.0281336
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0280122
RPS21 ribosomal protein S21 -0.0279254
DIAPH3 diaphanous-related formin 3 -0.0278342
SMC4 structural maintenance of chromosomes 4 -0.0276769
GCLM glutamate-cysteine ligase, modifier subunit -0.0275633
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0275389
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0273956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0273875
RPS19 ribosomal protein S19 -0.0271955
ENO1 enolase 1, (alpha) -0.0271554
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0269881
GOLGA4 golgin A4 -0.026257
EBNA1BP2 EBNA1 binding protein 2 -0.0261771
RPL12 ribosomal protein L12 -0.0261081
PTMS parathymosin -0.0259775
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0254652
MKI67 marker of proliferation Ki-67 -0.0254437
CENPF centromere protein F, 350/400kDa -0.0252131
CCNI cyclin I -0.0251443
HEG1 heart development protein with EGF-like domains 1 -0.0248232
TMSB10 thymosin beta 10 -0.0243809
ENO2 enolase 2 (gamma, neuronal) -0.0241149
TUBA1B tubulin, alpha 1b -0.0239964
RPS16 ribosomal protein S16 -0.023857
NBEA neurobeachin -0.0238071
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.023788
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0235645
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0234035
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0233904
WSB1 WD repeat and SOCS box containing 1 -0.0230762
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0229147
TAS2R14 taste receptor, type 2, member 14 -0.0224772
RPS15 ribosomal protein S15 -0.0220642
HMGA1 high mobility group AT-hook 1 -0.0220253
HMGB1 high mobility group box 1 -0.0217111
RPS29 ribosomal protein S29 -0.021591
SBF2 SET binding factor 2 -0.0214631
RPS27 ribosomal protein S27 -0.0214286
PRDX2 peroxiredoxin 2 -0.0212754