NVP-BHG712_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.168277
MYH9 myosin, heavy chain 9, non-muscle 0.136808
AKAP12 A kinase (PRKA) anchor protein 12 0.122194
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.105236
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.102887
LOC112694756 uncharaterized LOC112694756 0.0957491
VIM vimentin 0.0947224
COL6A3 collagen, type VI, alpha 3 0.0877742
CD44 CD44 molecule (Indian blood group) 0.087175
LDHA lactate dehydrogenase A 0.0811445
GLIS3 GLIS family zinc finger 3 0.070513
ZMIZ1 zinc finger, MIZ-type containing 1 0.0693901
AHNAK AHNAK nucleoprotein 0.0641033
HLA-A major histocompatibility complex, class I, A 0.0634242
CDH13 cadherin 13 0.0632307
COL5A1 collagen, type V, alpha 1 0.063198
SFTPA2 surfactant protein A2 0.0620384
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0580182
NDRG1 N-myc downstream regulated 1 0.057156
IGFBP3 insulin-like growth factor binding protein 3 0.055914
HLA-C major histocompatibility complex, class I, C 0.0547167
ENO1 enolase 1, (alpha) 0.0533473
VEGFA vascular endothelial growth factor A 0.0533259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0533171
BACE2 beta-site APP-cleaving enzyme 2 0.0531361
HMGA2 high mobility group AT-hook 2 0.0530364
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0527019
MACF1 microtubule-actin crosslinking factor 1 0.0518713
FLNA filamin A, alpha 0.0514108
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0501498
SMAD3 SMAD family member 3 0.0499094
TRIO trio Rho guanine nucleotide exchange factor 0.0466409
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0457464
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0448211
SQSTM1 sequestosome 1 0.044615
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0446091
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0443878
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0426212
MLPH melanophilin 0.0415276
HLA-E major histocompatibility complex, class I, E 0.0411086
CALR calreticulin 0.0409794
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.040166
RND3 Rho family GTPase 3 0.0400316
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.040008
HDAC9 histone deacetylase 9 0.0386609
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0368971
FTH1 ferritin, heavy polypeptide 1 0.0367913
ANXA2 annexin A2 0.0365065
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0364323
ZSWIM6 zinc finger, SWIM-type containing 6 0.036371
RPL37A ribosomal protein L37a 0.0362461
RPLP1 ribosomal protein, large, P1 0.0361422
CANX calnexin 0.0360642
RPS4X ribosomal protein S4, X-linked 0.0358075
COL4A2 collagen, type IV, alpha 2 0.0351825
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0348062
EIF4H eukaryotic translation initiation factor 4H 0.0347694
PLEC plectin 0.0346003
RPS3 ribosomal protein S3 0.0345681
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0345036
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0343723
RPL11 ribosomal protein L11 0.0337938
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.033282
APP amyloid beta (A4) precursor protein 0.0327547
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0323807
PPARD peroxisome proliferator-activated receptor delta 0.0314965
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.031484
RACK1 receptor for activated C kinase 1 0.0312826
DUSP10 dual specificity phosphatase 10 0.0312121
FRMPD4 FERM and PDZ domain containing 4 0.0310737
SYNJ2 synaptojanin 2 0.0307847
B2M beta-2-microglobulin 0.0305177
RPS12 ribosomal protein S12 0.0304197
APLP2 amyloid beta (A4) precursor-like protein 2 0.0304132
DST dystonin 0.0303607
INTS6 integrator complex subunit 6 0.0301548
CEP250 centrosomal protein 250kDa 0.0300405
ABTB3 ankyrin repeat and BTB domain containing 3 0.0299046
RPS8 ribosomal protein S8 0.0298889
CTSB cathepsin B 0.0297149
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0295004
HDLBP high density lipoprotein binding protein 0.0287883
RPL3 ribosomal protein L3 0.0287534
ACTN1 actinin, alpha 1 0.0286695
EGFR epidermal growth factor receptor 0.0285857
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0282027
AFF3 AF4/FMR2 family, member 3 0.0281571
TLN1 talin 1 0.0279972
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0279725
TMEM132D transmembrane protein 132D 0.0276622
LOXL2 lysyl oxidase-like 2 0.0274207
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026881
TMSB4X thymosin beta 4, X-linked 0.0266616
ARHGAP22 Rho GTPase activating protein 22 0.0265235
FAM20C family with sequence similarity 20, member C 0.0262028
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0258093
RPS2 ribosomal protein S2 0.0256429
COL6A2 collagen, type VI, alpha 2 0.025271
THBS2 thrombospondin 2 0.025151
FN1 fibronectin 1 0.0250557

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.106581
FRMD4A FERM domain containing 4A -0.105033
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.07685
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0663889
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0658324
BICC1 BicC family RNA binding protein 1 -0.0645015
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0636903
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0624575
CCNL1 cyclin L1 -0.0579574
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0565348
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0511079
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0490118
FNDC3B fibronectin type III domain containing 3B -0.0479652
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0476423
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0474817
RTN4 reticulon 4 -0.045201
VCL vinculin -0.0445729
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0429157
ZNFX1 zinc finger, NFX1-type containing 1 -0.0414338
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0408802
MX1 MX dynamin-like GTPase 1 -0.0397162
ZMYND8 zinc finger, MYND-type containing 8 -0.0394709
UGCG UDP-glucose ceramide glucosyltransferase -0.0388154
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0371118
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0366175
JMJD1C jumonji domain containing 1C -0.0365962
ELL2 elongation factor, RNA polymerase II, 2 -0.0351908
CENPF centromere protein F, 350/400kDa -0.0334382
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0331675
PTMA prothymosin, alpha -0.0325758
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0323042
ANKRD12 ankyrin repeat domain 12 -0.0320581
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0318176
DLG1 discs, large homolog 1 (Drosophila) -0.031715
ATP13A3 ATPase type 13A3 -0.031576
SBF2 SET binding factor 2 -0.0314688
EGR1 early growth response 1 -0.0314257
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0306893
SETD5 SET domain containing 5 -0.0304808
COL1A1 collagen, type I, alpha 1 -0.0294839
CLIC4 chloride intracellular channel 4 -0.0293469
COL8A1 collagen, type VIII, alpha 1 -0.0289297
CALD1 caldesmon 1 -0.0288814
THBS1 thrombospondin 1 -0.02851
EXT1 exostosin glycosyltransferase 1 -0.0284466
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0282929
VMP1 vacuole membrane protein 1 -0.0282035
IFI16 interferon, gamma-inducible protein 16 -0.0273488
TMEM41B transmembrane protein 41B -0.0269191
RIGI RNA sensor RIG-I -0.0268272
ARF4 ADP-ribosylation factor 4 -0.0263871
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0259082
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0250667
BIRC6 baculoviral IAP repeat containing 6 -0.0249401
PTBP3 polypyrimidine tract binding protein 3 -0.0243031
GBP1 guanylate binding protein 1, interferon-inducible -0.024177
ZNF292 zinc finger protein 292 -0.0240613
IFI6 interferon, alpha-inducible protein 6 -0.024016
DIAPH3 diaphanous-related formin 3 -0.0239273
YBX3 Y box binding protein 3 -0.0236809
PRKD3 protein kinase D3 -0.0230542
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0230028
TM9SF3 transmembrane 9 superfamily member 3 -0.0229932
TXNRD1 thioredoxin reductase 1 -0.0229532
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0227774
FTL ferritin, light polypeptide -0.0226355
SAMHD1 SAM domain and HD domain 1 -0.0223458
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0223217
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0221363
SCFD1 sec1 family domain containing 1 -0.0217706
IFIH1 interferon induced with helicase C domain 1 -0.0214386
PFN1 profilin 1 -0.0210591
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0205719
LRRC7 leucine rich repeat containing 7 -0.0205395
RBM39 RNA binding motif protein 39 -0.020411
SOD2 superoxide dismutase 2, mitochondrial -0.0203952
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0203669
PLPP6 phospholipid phosphatase 6 -0.0202126
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0202029
TPM4 tropomyosin 4 -0.0200183
NF1 neurofibromin 1 -0.0198592
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.019843
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0196995
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0194299
UBE2K ubiquitin-conjugating enzyme E2K -0.0193866
RAI1 retinoic acid induced 1 -0.0193794
TRIP12 thyroid hormone receptor interactor 12 -0.0189321
CD2AP CD2-associated protein -0.0188255
CKAP5 cytoskeleton associated protein 5 -0.0186815
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0185142
PMP22 peripheral myelin protein 22 -0.0184914
PTBP2 polypyrimidine tract binding protein 2 -0.0183822
STAU1 staufen double-stranded RNA binding protein 1 -0.0183641
FAM13A family with sequence similarity 13, member A -0.0181816
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0181755
BRWD1 bromodomain and WD repeat domain containing 1 -0.0180475
RSRC2 arginine/serine-rich coiled-coil 2 -0.0179582
IL6ST interleukin 6 signal transducer -0.0179467
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.017793
FRMD5 FERM domain containing 5 -0.0177809