| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the NVP-BHG712_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0988288 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0625878 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0588642 |
| RPS3 | ribosomal protein S3 | 0.0584689 |
| VCL | vinculin | 0.057843 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0521637 |
| RPS12 | ribosomal protein S12 | 0.0521047 |
| INTS6 | integrator complex subunit 6 | 0.0515485 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0505428 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0486853 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0464094 |
| RPL37A | ribosomal protein L37a | 0.043266 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0404261 |
| MYO1E | myosin IE | 0.039079 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0375371 |
| SMAD3 | SMAD family member 3 | 0.0373931 |
| FLNA | filamin A, alpha | 0.0372483 |
| FTL | ferritin, light polypeptide | 0.0345136 |
| RPS19 | ribosomal protein S19 | 0.0343922 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0327197 |
| PLEC | plectin | 0.0327022 |
| RPS17 | ribosomal protein S17 | 0.031497 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.030813 |
| RPL36 | ribosomal protein L36 | 0.030681 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0305541 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0299373 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.029738 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0296156 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0293665 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0289491 |
| RUNX1 | runt-related transcription factor 1 | 0.0282289 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0273796 |
| RPL18 | ribosomal protein L18 | 0.0271877 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0271031 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0268016 |
| RPS4X | ribosomal protein S4, X-linked | 0.0267755 |
| GOLGB1 | golgin B1 | 0.026672 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0265842 |
| EGFR | epidermal growth factor receptor | 0.0264976 |
| BRD2 | bromodomain containing 2 | 0.0262246 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0262 |
| SIK3 | SIK family kinase 3 | 0.0261532 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0260432 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0260357 |
| RACK1 | receptor for activated C kinase 1 | 0.0256552 |
| RPL3 | ribosomal protein L3 | 0.0254561 |
| RPL35A | ribosomal protein L35a | 0.0253027 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.025285 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0246133 |
| UBAP2 | ubiquitin associated protein 2 | 0.0242579 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0241368 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0240102 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0238067 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0231945 |
| RPL9 | ribosomal protein L9 | 0.0231207 |
| HM13 | histocompatibility (minor) 13 | 0.0230191 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0228097 |
| FHL2 | four and a half LIM domains 2 | 0.0227731 |
| RCOR1 | REST corepressor 1 | 0.0227303 |
| FAT1 | FAT atypical cadherin 1 | 0.0221836 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0221058 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0220728 |
| RPL37 | ribosomal protein L37 | 0.0220197 |
| RPL31 | ribosomal protein L31 | 0.0214756 |
| FAM107B | family with sequence similarity 107, member B | 0.0209304 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0206948 |
| HYOU1 | hypoxia up-regulated 1 | 0.0201159 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0201007 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0200693 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | 0.0200256 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0198739 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.019631 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0195596 |
| SET | SET nuclear proto-oncogene | 0.0195021 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0194842 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0194578 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0194348 |
| NDRG1 | N-myc downstream regulated 1 | 0.0193711 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0189471 |
| RPL13A | ribosomal protein L13a | 0.0188866 |
| AMOTL2 | angiomotin like 2 | 0.0185837 |
| MT2A | metallothionein 2A | 0.0184671 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0184411 |
| ACTN1 | actinin, alpha 1 | 0.0182956 |
| ACTG1 | actin gamma 1 | 0.0182645 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0180069 |
| SON | SON DNA binding protein | 0.0179574 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0177973 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0177622 |
| SMAD2 | SMAD family member 2 | 0.0176074 |
| TUFT1 | tuftelin 1 | 0.0175881 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.017576 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0175006 |
| VMP1 | vacuole membrane protein 1 | 0.0174892 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0174197 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.017255 |
| RPL19 | ribosomal protein L19 | 0.0172489 |
| STC2 | stanniocalcin 2 | 0.017196 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0171543 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0170809 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.161594 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154877 |
| H1-0 | H1.0 linker histone | -0.0923752 |
| KRT8 | keratin 8, type II | -0.0767076 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0754411 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0725693 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.06926 |
| AHNAK | AHNAK nucleoprotein | -0.066574 |
| EZR | ezrin | -0.0582004 |
| RAD21 | RAD21 homolog (S. pombe) | -0.056196 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0559608 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0545166 |
| CCND1 | cyclin D1 | -0.0538892 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0537233 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.052335 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0520003 |
| EHBP1 | EH domain binding protein 1 | -0.0511406 |
| ZNRF3 | zinc and ring finger 3 | -0.0494469 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0490508 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0487988 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0479438 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0478852 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0478275 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0477323 |
| TMEM123 | transmembrane protein 123 | -0.0467244 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0454565 |
| CD2AP | CD2-associated protein | -0.0453323 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0452792 |
| IER3 | immediate early response 3 | -0.0422553 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.041275 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0411583 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0410339 |
| S100A10 | S100 calcium binding protein A10 | -0.0398198 |
| SERINC5 | serine incorporator 5 | -0.0385614 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0384773 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0379204 |
| PGK1 | phosphoglycerate kinase 1 | -0.0376621 |
| UBC | ubiquitin C | -0.0372942 |
| EPCAM | epithelial cell adhesion molecule | -0.0372064 |
| ZNF292 | zinc finger protein 292 | -0.036132 |
| SBF2 | SET binding factor 2 | -0.0352651 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0350586 |
| PRELID2 | PRELI domain containing 2 | -0.0345698 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0343209 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.033769 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0335624 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0331949 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0326802 |
| MAP4 | microtubule-associated protein 4 | -0.0325646 |
| RHEB | Ras homolog enriched in brain | -0.0323892 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0320021 |
| USP3 | ubiquitin specific peptidase 3 | -0.031295 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0309172 |
| PTK2 | protein tyrosine kinase 2 | -0.0308738 |
| TMSB4X | thymosin beta 4, X-linked | -0.0308374 |
| XPO1 | exportin 1 | -0.0306682 |
| S100A6 | S100 calcium binding protein A6 | -0.0306088 |
| RPL8 | ribosomal protein L8 | -0.0303582 |
| PERP | PERP, TP53 apoptosis effector | -0.0303283 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0303001 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0302499 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0301289 |
| NF1 | neurofibromin 1 | -0.0300687 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0298168 |
| RBM39 | RNA binding motif protein 39 | -0.0290833 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0289636 |
| RPS24 | ribosomal protein S24 | -0.0286167 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0284893 |
| NFIA | nuclear factor I/A | -0.0284175 |
| FRMD5 | FERM domain containing 5 | -0.0282534 |
| MKI67 | marker of proliferation Ki-67 | -0.0281993 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0281819 |
| SRPK2 | SRSF protein kinase 2 | -0.0281374 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0280344 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0279733 |
| TPX2 | TPX2, microtubule-associated | -0.0278819 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0277551 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0276386 |
| KRT18 | keratin 18, type I | -0.0275242 |
| CANX | calnexin | -0.0270611 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0269305 |
| RPL28 | ribosomal protein L28 | -0.0268373 |
| KIF5B | kinesin family member 5B | -0.026509 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0262726 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0258932 |
| SDC4 | syndecan 4 | -0.0255939 |
| THOC2 | THO complex 2 | -0.0255518 |
| EHF | ets homologous factor | -0.0253986 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0252524 |
| RPL36A | ribosomal protein L36a | -0.0252505 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0251625 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0250971 |
| MATR3 | matrin 3 | -0.0250951 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0250249 |
| HMGB1 | high mobility group box 1 | -0.0249473 |
| HMGB2 | high mobility group box 2 | -0.0249144 |
| FMN1 | formin 1 | -0.0248307 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.024223 |
| RNF149 | ring finger protein 149 | -0.0240891 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0240192 |
