NVP-BHG712_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.123241
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0763453
EEF2 eukaryotic translation elongation factor 2 0.0720281
EGR1 early growth response 1 0.0537758
ACTG1 actin gamma 1 0.0528871
EGFR epidermal growth factor receptor 0.0521496
HSPA8 heat shock 70kDa protein 8 0.0519717
SNX9 sorting nexin 9 0.0486519
HMGA2 high mobility group AT-hook 2 0.0484479
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0464234
FHL2 four and a half LIM domains 2 0.045332
RPL3 ribosomal protein L3 0.0443978
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0443374
RPS19 ribosomal protein S19 0.0428471
MYH9 myosin, heavy chain 9, non-muscle 0.0407949
AREG amphiregulin 0.0391196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0384024
ATXN1 ataxin 1 0.0375905
RPL37A ribosomal protein L37a 0.0374569
RPLP2 ribosomal protein, large, P2 0.0372849
RCOR1 REST corepressor 1 0.0369262
ZSWIM6 zinc finger, SWIM-type containing 6 0.0344522
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0334387
FLNA filamin A, alpha 0.0332598
HILPDA hypoxia inducible lipid droplet-associated 0.0330931
RPLP1 ribosomal protein, large, P1 0.0325437
MCL1 myeloid cell leukemia 1 0.0309519
EZR ezrin 0.030292
SYNE2 spectrin repeat containing, nuclear envelope 2 0.028659
RPS8 ribosomal protein S8 0.0283843
RPS17 ribosomal protein S17 0.0277077
POTEF POTE ankyrin domain family, member F 0.0276297
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272532
FHIT fragile histidine triad 0.0268206
ITGA6 integrin, alpha 6 0.0265015
TSC22D2 TSC22 domain family, member 2 0.0264139
MT2A metallothionein 2A 0.0261369
RPS12 ribosomal protein S12 0.0261086
FLNB filamin B, beta 0.0256487
PLEC plectin 0.0254478
PCBP2 poly(rC) binding protein 2 0.0252072
RPS23 ribosomal protein S23 0.0249282
NDRG1 N-myc downstream regulated 1 0.0248724
TUBB4B tubulin, beta 4B class IVb 0.0248135
BRD2 bromodomain containing 2 0.024776
EEF1G eukaryotic translation elongation factor 1 gamma 0.0247319
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0246806
EPHA2 EPH receptor A2 0.0245605
CENPF centromere protein F, 350/400kDa 0.0242316
PRELID2 PRELI domain containing 2 0.0239534
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0236071
NAV2 neuron navigator 2 0.023405
GPC5 glypican 5 0.0232312
APLP2 amyloid beta (A4) precursor-like protein 2 0.0228057
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0226226
FLOT1 flotillin 1 0.0221346
GCLC glutamate-cysteine ligase, catalytic subunit 0.0220097
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0219349
RPS29 ribosomal protein S29 0.0214084
HOMER1 homer scaffolding protein 1 0.0210771
B2M beta-2-microglobulin 0.0208291
HDAC4 histone deacetylase 4 0.0207161
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0206216
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0206124
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0204039
MPRIP myosin phosphatase Rho interacting protein 0.0203622
FAM168A family with sequence similarity 168, member A 0.0202734
SAMD4A sterile alpha motif domain containing 4A 0.0199662
RPL37 ribosomal protein L37 0.0198004
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0197571
RACK1 receptor for activated C kinase 1 0.0197518
EFNB2 ephrin-B2 0.019343
KLF12 Kruppel-like factor 12 0.0190721
HDGF hepatoma-derived growth factor 0.0187893
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0186495
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0185288
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0184243
ZFAND3 zinc finger, AN1-type domain 3 0.0182016
KTN1 kinectin 1 (kinesin receptor) 0.0181324
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0180339
IER2 immediate early response 2 0.0179523
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0179231
ENO2 enolase 2 (gamma, neuronal) 0.0176169
INTS6 integrator complex subunit 6 0.0176011
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0174721
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0174341
DDIT4 DNA-damage-inducible transcript 4 0.0173934
PGM3 phosphoglucomutase 3 0.0173614
ANXA2 annexin A2 0.0173593
IL18 interleukin 18 0.0172963
NT5E 5'-nucleotidase, ecto (CD73) 0.0172694
PDE10A phosphodiesterase 10A 0.01711
H1-10 H1.10 linker histone 0.017057
PTPRG protein tyrosine phosphatase, receptor type, G 0.0170229
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0170028
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0169475
TUBA1B tubulin, alpha 1b 0.0169301
ATP5F1B ATP synthase F1 subunit beta 0.0168976
SMAD3 SMAD family member 3 0.0167892
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0167706

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.259406
LMO7 LIM domain 7 -0.134663
CD36 CD36 molecule (thrombospondin receptor) -0.0913479
PTMA prothymosin, alpha -0.0717345
HDAC2 histone deacetylase 2 -0.0698239
SERINC5 serine incorporator 5 -0.0623511
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0584057
OXR1 oxidation resistance 1 -0.0576
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0516221
TOP1 topoisomerase (DNA) I -0.0472564
RAB10 RAB10, member RAS oncogene family -0.0448288
RBM25 RNA binding motif protein 25 -0.043531
MTAP methylthioadenosine phosphorylase -0.0431589
ITPRID2 ITPR interacting domain containing 2 -0.0430847
NCEH1 neutral cholesterol ester hydrolase 1 -0.043022
RUNX2 runt-related transcription factor 2 -0.0419405
NEMF nuclear export mediator factor -0.0394288
TXNRD1 thioredoxin reductase 1 -0.0385851
ANXA1 annexin A1 -0.0382309
RPS24 ribosomal protein S24 -0.0372756
PERP PERP, TP53 apoptosis effector -0.0365451
OSBPL3 oxysterol binding protein-like 3 -0.0353669
ARHGAP32 Rho GTPase activating protein 32 -0.0318529
NCOR1 nuclear receptor corepressor 1 -0.0318279
DSPP dentin sialophosphoprotein -0.0315596
PDLIM5 PDZ and LIM domain 5 -0.0311605
FERMT1 fermitin family member 1 -0.0307808
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0305895
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0303609
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0303383
FOXO1 forkhead box O1 -0.0301449
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.029665
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.029128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0291136
PUM2 pumilio RNA-binding family member 2 -0.028447
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0279847
TCF12 transcription factor 12 -0.0279523
KLF3 Kruppel-like factor 3 (basic) -0.0278151
EVA1C eva-1 homolog C (C. elegans) -0.027775
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0272698
RSL1D1 ribosomal L1 domain containing 1 -0.0272381
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.0268886
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0267196
TNPO1 transportin 1 -0.0261046
ZMYM2 zinc finger, MYM-type 2 -0.0258694
GOLGA4 golgin A4 -0.0258236
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0258179
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0256173
FMN1 formin 1 -0.0254611
NEK7 NIMA-related kinase 7 -0.0250541
THOC2 THO complex 2 -0.0247076
TCERG1 transcription elongation regulator 1 -0.0243923
NF1 neurofibromin 1 -0.0239879
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0239316
SOS1 son of sevenless homolog 1 (Drosophila) -0.0238879
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0238241
NPEPPS aminopeptidase puromycin sensitive -0.0235904
CSDE1 cold shock domain containing E1, RNA-binding -0.0234822
ANKRD28 ankyrin repeat domain 28 -0.023453
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0232203
TMEM123 transmembrane protein 123 -0.0231973
LMAN1 lectin, mannose-binding, 1 -0.0229253
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0228448
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0226968
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0226748
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0226459
EREG epiregulin -0.0226087
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.022427
R3HDM1 R3H domain containing 1 -0.0223143
OGA O-GlcNAcase -0.0222808
PHF14 PHD finger protein 14 -0.0220839
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0219379
STRN3 striatin, calmodulin binding protein 3 -0.0219192
TM9SF3 transmembrane 9 superfamily member 3 -0.0218027
URI1 URI1, prefoldin-like chaperone -0.0217969
GPHN gephyrin -0.0217569
APP amyloid beta (A4) precursor protein -0.0216951
IARS1 isoleucyl-tRNA synthetase 1 -0.0216524
PRRC2C proline-rich coiled-coil 2C -0.0216116
SRSF11 serine/arginine-rich splicing factor 11 -0.0213954
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0213015
PHIP pleckstrin homology domain interacting protein -0.0212049
AOPEP aminopeptidase O (putative) -0.0208803
IER3 immediate early response 3 -0.0206071
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0205494
KITLG KIT ligand -0.0205308
DIAPH2 diaphanous-related formin 2 -0.0204654
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0203733
GIGYF2 GRB10 interacting GYF protein 2 -0.0203564
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0203335
GSK3B glycogen synthase kinase 3 beta -0.0203237
FAM3C family with sequence similarity 3, member C -0.0203144
WDR43 WD repeat domain 43 -0.0203076
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0202894
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0201845
CD2AP CD2-associated protein -0.0198366
MARCHF6 membrane associated ring-CH-type finger 6 -0.0197633
IGFBP3 insulin-like growth factor binding protein 3 -0.019606
FAR1 fatty acyl CoA reductase 1 -0.019592
VWA8 von Willebrand factor A domain containing 8 -0.0195511