NVP-BHG712_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.0829392
NKD1 naked cuticle homolog 1 (Drosophila) 0.0661441
CCND1 cyclin D1 0.0649429
INTS6 integrator complex subunit 6 0.0631787
SAMD4A sterile alpha motif domain containing 4A 0.0574847
BACE2 beta-site APP-cleaving enzyme 2 0.0538503
CDH13 cadherin 13 0.0530763
WWOX WW domain containing oxidoreductase 0.0529131
RPL35A ribosomal protein L35a 0.0524074
ASPH aspartate beta-hydroxylase 0.0507484
VCL vinculin 0.0497115
HSPA8 heat shock 70kDa protein 8 0.0484974
RAD51B RAD51 paralog B 0.0448003
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0413439
RPL37A ribosomal protein L37a 0.0412737
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0389732
NAV2 neuron navigator 2 0.0388121
ACTN1 actinin, alpha 1 0.0376588
HDAC4 histone deacetylase 4 0.0375206
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0374533
SDK1 sidekick cell adhesion molecule 1 0.0367024
TNS3 tensin 3 0.0361608
ANO1 anoctamin 1, calcium activated chloride channel 0.0354149
PCDH9 protocadherin 9 0.035082
NTSR1 neurotensin receptor 1 (high affinity) 0.0348682
EGFR epidermal growth factor receptor 0.0347916
RPS12 ribosomal protein S12 0.0343792
TIMP2 TIMP metallopeptidase inhibitor 2 0.0342962
CDHR3 cadherin-related family member 3 0.0335199
LPP LIM domain containing preferred translocation partner in lipoma 0.033229
SMAD3 SMAD family member 3 0.0327214
CD44 CD44 molecule (Indian blood group) 0.0318636
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0309247
EIF4H eukaryotic translation initiation factor 4H 0.0305064
FLNB filamin B, beta 0.030204
ANXA2 annexin A2 0.0301052
MPRIP myosin phosphatase Rho interacting protein 0.0301024
COBL cordon-bleu WH2 repeat protein 0.0300604
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0294385
RPS17 ribosomal protein S17 0.0287824
NPAS2 neuronal PAS domain protein 2 0.0282
IGF2 insulin-like growth factor 2 0.0273931
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.027101
DOCK9 dedicator of cytokinesis 9 0.0270777
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.026717
FRMD5 FERM domain containing 5 0.0265969
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0265968
BCAR3 breast cancer anti-estrogen resistance 3 0.0264795
LRMDA leucine rich melanocyte differentiation associated 0.0264694
RPL3 ribosomal protein L3 0.0263673
MYH9 myosin, heavy chain 9, non-muscle 0.0261939
EXOC4 exocyst complex component 4 0.0259543
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0251899
CUL4A cullin 4A 0.0248809
FAT1 FAT atypical cadherin 1 0.0245946
FLNA filamin A, alpha 0.0244626
AHNAK2 AHNAK nucleoprotein 2 0.0241125
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0238282
CLSTN2 calsyntenin 2 0.0232826
EPHB2 EPH receptor B2 0.0232469
RBP1 retinol binding protein 1, cellular 0.0229239
CMIP c-Maf inducing protein 0.0228835
SQSTM1 sequestosome 1 0.0227691
TBC1D4 TBC1 domain family, member 4 0.0225615
UBAP2 ubiquitin associated protein 2 0.0224736
IGF1R insulin-like growth factor 1 receptor 0.0223046
ATXN7L1 ataxin 7-like 1 0.0222921
EXT1 exostosin glycosyltransferase 1 0.0222028
DOCK5 dedicator of cytokinesis 5 0.0219512
ANXA3 annexin A3 0.0218401
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0213189
NCOR2 nuclear receptor corepressor 2 0.0212065
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.020739
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0206561
FHIT fragile histidine triad 0.0201652
RPH3AL rabphilin 3A-like (without C2 domains) 0.020117
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0198549
UBASH3B ubiquitin associated and SH3 domain containing B 0.0197125
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0195137
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0194558
GLI3 GLI family zinc finger 3 0.0193318
SET SET nuclear proto-oncogene 0.0192602
DST dystonin 0.0191228
ABR active BCR-related 0.0189839
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.018957
CNKSR3 CNKSR family member 3 0.0187904
CAVIN1 caveolae associated protein 1 0.0187439
RNF213 ring finger protein 213 0.0186435
TPT1 tumor protein, translationally-controlled 1 0.018526
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184061
TRAPPC9 trafficking protein particle complex 9 0.0183316
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0182411
PDLIM5 PDZ and LIM domain 5 0.0182029
SEPTIN9 septin 9 0.0181586
RPS3 ribosomal protein S3 0.0181153
ARHGAP23 Rho GTPase activating protein 23 0.0180826
PPL periplakin 0.0180281
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0180117
ZNF704 zinc finger protein 704 0.0179621
SHB Src homology 2 domain containing adaptor protein B 0.0179472

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.339439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.119176
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.074896
PGK1 phosphoglycerate kinase 1 -0.0746483
TMSB10 thymosin beta 10 -0.070833
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0693932
ETNK1 ethanolamine kinase 1 -0.0683015
RBM39 RNA binding motif protein 39 -0.0681767
KRT8 keratin 8, type II -0.0671788
PTMA prothymosin, alpha -0.0661214
ANLN anillin, actin binding protein -0.0658967
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0636534
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0636362
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0634824
ESYT2 extended synaptotagmin-like protein 2 -0.0605572
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0594457
PDGFA platelet-derived growth factor alpha polypeptide -0.0589084
JMJD1C jumonji domain containing 1C -0.05505
MORF4L2 mortality factor 4 like 2 -0.0546037
SMC4 structural maintenance of chromosomes 4 -0.0540816
ZNF292 zinc finger protein 292 -0.0538429
SETD5 SET domain containing 5 -0.0538398
KMT2E lysine (K)-specific methyltransferase 2E -0.0525579
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0524211
RPS6 ribosomal protein S6 -0.0522219
OXR1 oxidation resistance 1 -0.0516566
DIAPH3 diaphanous-related formin 3 -0.0505076
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0500645
TMEM123 transmembrane protein 123 -0.0491249
GOLGA4 golgin A4 -0.0467709
PCBP2 poly(rC) binding protein 2 -0.0464531
BIRC6 baculoviral IAP repeat containing 6 -0.0460973
PFN1 profilin 1 -0.0458855
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0454364
SNX9 sorting nexin 9 -0.0450843
PERP PERP, TP53 apoptosis effector -0.0446052
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0441146
ABHD2 abhydrolase domain containing 2 -0.0437667
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0437405
VMP1 vacuole membrane protein 1 -0.0432529
WDFY2 WD repeat and FYVE domain containing 2 -0.0419996
GARS1 glycyl-tRNA synthetase 1 -0.041682
KMT2C lysine (K)-specific methyltransferase 2C -0.0412044
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0411794
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0411379
BRWD3 bromodomain and WD repeat domain containing 3 -0.0409551
EGR1 early growth response 1 -0.0409279
ARF4 ADP-ribosylation factor 4 -0.0408749
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0408241
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0401954
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0401449
SBF2 SET binding factor 2 -0.0393266
RPS24 ribosomal protein S24 -0.0391959
PROX1 prospero homeobox 1 -0.0391286
USP34 ubiquitin specific peptidase 34 -0.0390876
ZMYM2 zinc finger, MYM-type 2 -0.0388199
RPL32 ribosomal protein L32 -0.0385154
DLG1 discs, large homolog 1 (Drosophila) -0.0372343
TUBA1B tubulin, alpha 1b -0.0368954
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0366684
TXNIP thioredoxin interacting protein -0.0365523
H1-0 H1.0 linker histone -0.0361379
RLF rearranged L-myc fusion -0.0360528
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.036003
HMGA1 high mobility group AT-hook 1 -0.035767
THOC2 THO complex 2 -0.0356491
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0354892
CD46 CD46 molecule, complement regulatory protein -0.0354425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0353785
TMEM41B transmembrane protein 41B -0.035375
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0352702
WASF2 WAS protein family, member 2 -0.0351896
PIBF1 progesterone immunomodulatory binding factor 1 -0.0347136
NUP58 nucleoporin 58 -0.0344993
EIF1 eukaryotic translation initiation factor 1 -0.0344775
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0344003
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0342904
DDIT4 DNA-damage-inducible transcript 4 -0.0336676
NF1 neurofibromin 1 -0.0336282
RPLP0 ribosomal protein, large, P0 -0.0335726
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0333931
MIS18BP1 MIS18 binding protein 1 -0.0332915
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0332698
NIPBL Nipped-B homolog (Drosophila) -0.0330253
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0328265
TM9SF3 transmembrane 9 superfamily member 3 -0.0323887
CEMIP2 cell migration inducing hyaluronidase 2 -0.0322006
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.032063
OGA O-GlcNAcase -0.0320455
KRT18 keratin 18, type I -0.0315323
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.031157
ITGA6 integrin, alpha 6 -0.0309327
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0307872
HELZ helicase with zinc finger -0.0306986
GLG1 golgi glycoprotein 1 -0.0306363
CCNL1 cyclin L1 -0.0305205
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0304067
PDE8A phosphodiesterase 8A -0.0301948
LOC102724023 ES1 protein homolog, mitochondrial -0.030131
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0299146