NVP-BSK805 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/46398810
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Genes

199 proteins with high or low expression in NVP-BSK805 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PAH phenylalanine hydroxylase 5.25
APOB apolipoprotein B 4.17
APOE apolipoprotein E 3.75
LAPTM4A lysosomal protein transmembrane 4 alpha 3.7
TMEM59 transmembrane protein 59 3.64
ITM2B integral membrane protein 2B 3.51
NDFIP1 Nedd4 family interacting protein 1 3.44
AREG amphiregulin 3.17
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.13
FGFBP1 fibroblast growth factor binding protein 1 3.11
ITM2C integral membrane protein 2C 3.1
APLP2 amyloid beta (A4) precursor-like protein 2 3.05
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.76
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.75
NCOA4 nuclear receptor coactivator 4 2.58
TMEM248 transmembrane protein 248 2.55
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.54
SLC16A6 solute carrier family 16, member 6 2.52
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.51
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.48
APP amyloid beta (A4) precursor protein 2.48
LRP10 low density lipoprotein receptor-related protein 10 2.45
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.42
NPDC1 neural proliferation, differentiation and control, 1 2.37
NDFIP2 Nedd4 family interacting protein 2 2.37
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.36
NBR1 neighbor of BRCA1 gene 1 2.36
GINM1 glycoprotein integral membrane 1 2.31
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.25
CLK1 CDC-like kinase 1 2.19
IFNGR1 interferon gamma receptor 1 2.14
LDLR low density lipoprotein receptor 2.12
EREG epiregulin 2.11
SQSTM1 sequestosome 1 2.1
PSAP prosaposin 2.05
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.04
CTSL cathepsin L 2.02
IL13RA1 interleukin 13 receptor, alpha 1 1.97
RNF149 ring finger protein 149 1.97
SERINC3 serine incorporator 3 1.97
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.94
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.94
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.93
RNF130 ring finger protein 130 1.91
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 1.9
ELOVL6 ELOVL fatty acid elongase 6 1.89
SDC4 syndecan 4 1.87
TMEM185B transmembrane protein 185B 1.84
IL6ST interleukin 6 signal transducer 1.84
PCSK9 proprotein convertase subtilisin/kexin type 9 1.73
SQLE squalene epoxidase 1.7
OSMR oncostatin M receptor 1.7
TMUB1 transmembrane and ubiquitin-like domain containing 1 1.69
ZNF624 zinc finger protein 624 1.66
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.66
F5 coagulation factor V (proaccelerin, labile factor) 1.64
HGFAC HGF activator 1.64
GDF15 growth differentiation factor 15 1.6
CLDND1 claudin domain containing 1 1.59
FGFR4 fibroblast growth factor receptor 4 1.56
LPIN1 lipin 1 1.55
SLC38A2 solute carrier family 38, member 2 1.54
ADGRG1 adhesion G protein-coupled receptor G1 1.53
CALCOCO2 calcium binding and coiled-coil domain 2 1.49
HMOX1 heme oxygenase 1 1.48
CCPG1 cell cycle progression 1 1.48
SERINC1 serine incorporator 1 1.48
MSMO1 methylsterol monooxygenase 1 1.46
BMERB1 bMERB domain containing 1 1.46
LRP11 low density lipoprotein receptor-related protein 11 1.46
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.46
KMT2C lysine (K)-specific methyltransferase 2C 1.43
IL10RB interleukin 10 receptor, beta 1.41
IGSF8 immunoglobulin superfamily, member 8 1.41
GRN granulin 1.39
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.39
FN1 fibronectin 1 1.38
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.38
TMEM200A transmembrane protein 200A 1.37
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1.34
BMPR1A bone morphogenetic protein receptor, type IA 1.32
ACSS2 acyl-CoA synthetase short-chain family member 2 1.31
F13A1 coagulation factor XIII, A1 polypeptide 1.31
ACVR1B activin A receptor, type IB 1.31
PLD3 phospholipase D family, member 3 1.3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1.29
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.29
UGCG UDP-glucose ceramide glucosyltransferase 1.28
PTPRS protein tyrosine phosphatase, receptor type, S 1.26
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.26
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 1.25
FAT1 FAT atypical cadherin 1 1.25
IDI1 isopentenyl-diphosphate delta isomerase 1 1.25
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.25
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.23
HRH1 histamine receptor H1 1.23
KMT2B lysine (K)-specific methyltransferase 2B 1.23
PTPRF protein tyrosine phosphatase, receptor type, F 1.22
ATF3 activating transcription factor 3 1.21

low expression

Symbol Name Standardized Value
CCNA1 cyclin A1 -1.95
PTTG1 pituitary tumor-transforming 1 -1.73
RRM2 ribonucleotide reductase M2 -1.69
CDC20 cell division cycle 20 -1.68
POLQ polymerase (DNA directed), theta -1.66
PCLAF PCNA clamp associated factor -1.57
TK1 thymidine kinase 1, soluble -1.56
MPHOSPH9 M-phase phosphoprotein 9 -1.54
GMNN geminin, DNA replication inhibitor -1.54
ZMYND19 zinc finger, MYND-type containing 19 -1.53
ANLN anillin, actin binding protein -1.45
CCNA2 cyclin A2 -1.43
CLSPN claspin -1.42
C9ORF40 chromosome 9 open reading frame 40 -1.42
CDC6 cell division cycle 6 -1.41
CCNB1 cyclin B1 -1.4
UBE2C ubiquitin-conjugating enzyme E2C -1.4
CCNE2 cyclin E2 -1.38
TPM2 tropomyosin 2 (beta) -1.37
RAD51AP1 RAD51 associated protein 1 -1.36
CCNF cyclin F -1.35
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.34
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -1.34
WSB2 WD repeat and SOCS box containing 2 -1.33
FBXO5 F-box protein 5 -1.32
TYMS thymidylate synthetase -1.31
PRR11 proline rich 11 -1.31
DONSON downstream neighbor of SON -1.3
CDC25B cell division cycle 25B -1.29
EXO1 exonuclease 1 -1.29
PLK1 polo-like kinase 1 -1.27
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.27
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.26
E2F7 E2F transcription factor 7 -1.26
RFLNB refilin B -1.23
TRIB1 tribbles pseudokinase 1 -1.23
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.23
TPX2 TPX2, microtubule-associated -1.22
HPCAL4 hippocalcin like 4 -1.22
KIF22 kinesin family member 22 -1.2
SCARA3 scavenger receptor class A, member 3 -1.2
KIF18A kinesin family member 18A -1.2
WDR76 WD repeat domain 76 -1.2
RAD54B RAD54 homolog B (S. cerevisiae) -1.18
TTK TTK protein kinase -1.18
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -1.17
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -1.16
NDRG2 NDRG family member 2 -1.16
CDC7 cell division cycle 7 -1.15
MCM8 minichromosome maintenance complex component 8 -1.13
SLBP stem-loop binding protein -1.12
GLA galactosidase, alpha -1.12
AEN apoptosis enhancing nuclease -1.12
CENPF centromere protein F, 350/400kDa -1.12
CTSZ cathepsin Z -1.12
UHRF1 ubiquitin-like with PHD and ring finger domains 1 -1.11
AURKA aurora kinase A -1.11
TCTEX1D2 Tctex1 domain containing 2 -1.1
TACC3 transforming, acidic coiled-coil containing protein 3 -1.09
TOP2A topoisomerase (DNA) II alpha 170kDa -1.09
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -1.08
SPDL1 spindle apparatus coiled-coil protein 1 -1.07
CCDC138 coiled-coil domain containing 138 -1.06
OBI1 ORC ubiquitin ligase 1 -1.06
MCM10 minichromosome maintenance complex component 10 -1.05
CDCA7 cell division cycle associated 7 -1.05
SMTN smoothelin -1.05
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.05
WEE1 WEE1 G2 checkpoint kinase -1.04
RHOBTB3 Rho-related BTB domain containing 3 -1.04
CDCA5 cell division cycle associated 5 -1.04
ECT2 epithelial cell transforming 2 -1.04
ENC1 ectodermal-neural cortex 1 (with BTB domain) -1.04
CENPM centromere protein M -1.04
PSRC1 proline/serine-rich coiled-coil 1 -1.04
SAPCD2 suppressor APC domain containing 2 -1.03
KIF11 kinesin family member 11 -1.03
USP37 ubiquitin specific peptidase 37 -1.03
UBE2T ubiquitin-conjugating enzyme E2T -1.02
ZNF296 zinc finger protein 296 -1.02
PTMA prothymosin, alpha -1.02
CIT citron rho-interacting serine/threonine kinase -1.02
PBK PDZ binding kinase -1.01
PARPBP PARP1 binding protein -1.01
REEP1 receptor accessory protein 1 -1.01
TCF3 transcription factor 3 -1.0
NES nestin -1.0
ATAD5 ATPase family, AAA domain containing 5 -1.0
GTSE1 G-2 and S-phase expressed 1 -1.0
HELLS helicase, lymphoid-specific -1.0
MTFR2 mitochondrial fission regulator 2 -0.99
SGO1 shugoshin 1 -0.98
CSRP2 cysteine and glycine-rich protein 2 -0.98
CCDC170 coiled-coil domain containing 170 -0.98
GSE1 Gse1 coiled-coil protein -0.98
FAM111B family with sequence similarity 111, member B -0.98
UCK1 uridine-cytidine kinase 1 -0.98
CCNB2 cyclin B2 -0.98
SACK1D scaffolding CK1 anchoring protein D -0.98