Nafamostat (mesylate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EIF1 eukaryotic translation initiation factor 1 0.114687
RPL4 ribosomal protein L4 0.10379
RPS2 ribosomal protein S2 0.0971623
CCL2 chemokine (C-C motif) ligand 2 0.0967271
PRRC2C proline-rich coiled-coil 2C 0.0814473
PTMA prothymosin, alpha 0.0783972
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0774162
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0768267
NAMPT nicotinamide phosphoribosyltransferase 0.0758285
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0754463
SPTBN1 spectrin, beta, non-erythrocytic 1 0.068534
HLA-A major histocompatibility complex, class I, A 0.0653428
RPL26 ribosomal protein L26 0.0598746
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0592483
PBX1 pre-B-cell leukemia homeobox 1 0.0590611
EIF4H eukaryotic translation initiation factor 4H 0.0520495
RRBP1 ribosome binding protein 1 0.0508903
BIRC3 baculoviral IAP repeat containing 3 0.0505914
RPS6 ribosomal protein S6 0.0498092
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0495578
SAA2 serum amyloid A2 0.0494425
HLA-B major histocompatibility complex, class I, B 0.0483117
RPL12 ribosomal protein L12 0.0481672
CALR calreticulin 0.0475936
AKAP9 A kinase (PRKA) anchor protein 9 0.0467984
RBM39 RNA binding motif protein 39 0.0467507
B2M beta-2-microglobulin 0.0462387
SAA2-SAA4 SAA2-SAA4 readthrough 0.0454192
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0453439
TXNRD1 thioredoxin reductase 1 0.0452171
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431482
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0423464
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.042295
CP ceruloplasmin (ferroxidase) 0.0420371
FUS FUS RNA binding protein 0.0407932
GOLGA4 golgin A4 0.040513
SET SET nuclear proto-oncogene 0.0403947
RPS8 ribosomal protein S8 0.0396824
TLN1 talin 1 0.0390131
HIPK2 homeodomain interacting protein kinase 2 0.0388577
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0386219
RPL23 ribosomal protein L23 0.0379926
NAP1L1 nucleosome assembly protein 1-like 1 0.037845
SRRM2 serine/arginine repetitive matrix 2 0.0374709
TPM3 tropomyosin 3 0.0374195
MYH9 myosin, heavy chain 9, non-muscle 0.0369651
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0367038
RPS12 ribosomal protein S12 0.0365308
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.034984
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0345076
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342942
RPL37A ribosomal protein L37a 0.0341735
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.033593
HMGB2 high mobility group box 2 0.0324582
GIGYF2 GRB10 interacting GYF protein 2 0.0314787
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0314706
SPIDR scaffolding protein involved in DNA repair 0.0312749
OGA O-GlcNAcase 0.0310265
ENO1 enolase 1, (alpha) 0.030645
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0303892
RPS3 ribosomal protein S3 0.0302744
SRSF11 serine/arginine-rich splicing factor 11 0.0300849
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0299797
PER1 period circadian clock 1 0.0291048
KPNB1 karyopherin (importin) beta 1 0.0289382
IRS2 insulin receptor substrate 2 0.028868
NFE2L1 nuclear factor, erythroid 2-like 1 0.0283774
EEF2 eukaryotic translation elongation factor 2 0.0283263
VCAN versican 0.0278418
RPL18 ribosomal protein L18 0.0275008
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0273873
EIF5B eukaryotic translation initiation factor 5B 0.0265952
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0265899
FTL ferritin, light polypeptide 0.0265091
ATF4 activating transcription factor 4 0.0264832
GCC2 GRIP and coiled-coil domain containing 2 0.0259763
RPL5 ribosomal protein L5 0.0257523
FKBP5 FK506 binding protein 5 0.0256692
RPL34 ribosomal protein L34 0.0256126
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0252284
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.025098
RB1CC1 RB1-inducible coiled-coil 1 0.0250478
RACK1 receptor for activated C kinase 1 0.0249816
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0247305
ZBTB41 zinc finger and BTB domain containing 41 0.0244701
RPL37 ribosomal protein L37 0.0244645
HDLBP high density lipoprotein binding protein 0.0240511
ANKRD11 ankyrin repeat domain 11 0.0239856
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.0239763
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0239581
BUD31 BUD31 homolog (S. cerevisiae) 0.0239414
RPS17 ribosomal protein S17 0.0238307
TPR translocated promoter region, nuclear basket protein 0.0237822
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0236431
RPL35A ribosomal protein L35a 0.023536
SSH2 slingshot protein phosphatase 2 0.0234268
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0234128
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.023254
MT2A metallothionein 2A 0.0230623
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0230514

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.270665
CXCL8 chemokine (C-X-C motif) ligand 8 -0.201099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181856
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.128061
CD44 CD44 molecule (Indian blood group) -0.117833
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0824773
NDRG1 N-myc downstream regulated 1 -0.081539
FRMD4A FERM domain containing 4A -0.0777734
POTEF POTE ankyrin domain family, member F -0.0748681
MAP1B microtubule-associated protein 1B -0.0735713
FAT1 FAT atypical cadherin 1 -0.0703618
FNDC3B fibronectin type III domain containing 3B -0.0690322
CADM1 cell adhesion molecule 1 -0.0647357
RAI14 retinoic acid induced 14 -0.0620143
SOD2 superoxide dismutase 2, mitochondrial -0.0605207
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0591968
ATP13A3 ATPase type 13A3 -0.0554644
MSN moesin -0.0538421
UBC ubiquitin C -0.0526806
TRIO trio Rho guanine nucleotide exchange factor -0.0507238
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0494183
RTN4 reticulon 4 -0.0488564
UBA6 ubiquitin-like modifier activating enzyme 6 -0.048267
RHEB Ras homolog enriched in brain -0.0481818
RND3 Rho family GTPase 3 -0.0475657
CDCP1 CUB domain containing protein 1 -0.0473928
PDIA3 protein disulfide isomerase family A, member 3 -0.045026
HSPB1 heat shock 27kDa protein 1 -0.0443989
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0443661
PALLD palladin, cytoskeletal associated protein -0.0442989
CTSD cathepsin D -0.0421887
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0409459
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0408241
FAM107B family with sequence similarity 107, member B -0.0397133
RAB1A RAB1A, member RAS oncogene family -0.0395074
CREB5 cAMP responsive element binding protein 5 -0.0394941
PFN1 profilin 1 -0.0389303
UBE2H ubiquitin-conjugating enzyme E2H -0.0387241
TMSB10 thymosin beta 10 -0.0385974
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0376364
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0374283
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0358277
LOXL2 lysyl oxidase-like 2 -0.0343082
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0339727
PLK2 polo-like kinase 2 -0.0337531
SMAD3 SMAD family member 3 -0.0336654
PKM pyruvate kinase, muscle -0.0333338
MRPS6 mitochondrial ribosomal protein S6 -0.0330991
VEGFA vascular endothelial growth factor A -0.0328057
GLIS3 GLIS family zinc finger 3 -0.032282
TSC22D2 TSC22 domain family, member 2 -0.0317979
EFHD2 EF-hand domain family, member D2 -0.0316086
CALU calumenin -0.0314096
S100A10 S100 calcium binding protein A10 -0.0312794
TMEM165 transmembrane protein 165 -0.0311577
KCMF1 potassium channel modulatory factor 1 -0.0303798
NCEH1 neutral cholesterol ester hydrolase 1 -0.0302149
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0299988
UGCG UDP-glucose ceramide glucosyltransferase -0.0297574
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0294943
TSPAN13 tetraspanin 13 -0.0290421
EGFR epidermal growth factor receptor -0.0289826
MYADM myeloid-associated differentiation marker -0.0287888
BICD1 bicaudal D homolog 1 (Drosophila) -0.0283084
ATP5F1B ATP synthase F1 subunit beta -0.0280743
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0280409
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0277515
DPYSL3 dihydropyrimidinase-like 3 -0.0276921
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0273665
NRP2 neuropilin 2 -0.0273649
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0261478
HMGA1 high mobility group AT-hook 1 -0.0260264
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0259898
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0259645
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0257536
NAV2 neuron navigator 2 -0.0257404
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0253672
PTBP3 polypyrimidine tract binding protein 3 -0.025357
RAB18 RAB18, member RAS oncogene family -0.0251236
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0250781
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0249893
ANKRD10 ankyrin repeat domain 10 -0.0247213
ANKRD17 ankyrin repeat domain 17 -0.0243841
ADAM9 ADAM metallopeptidase domain 9 -0.0242063
CD109 CD109 molecule -0.023984
CYB5R3 cytochrome b5 reductase 3 -0.0238553
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0237447
P3H2 prolyl 3-hydroxylase 2 -0.0237195
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0235997
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0233096
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0232081
ALCAM activated leukocyte cell adhesion molecule -0.023167
COPA coatomer protein complex, subunit alpha -0.0231638
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0231207
NUP98 nucleoporin 98kDa -0.0231177
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0229586
USP3 ubiquitin specific peptidase 3 -0.022732
NAP1L4 nucleosome assembly protein 1-like 4 -0.0224806
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.022351
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0221699