| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nafamostat (mesylate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nafamostat (mesylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.153569 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0869652 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.083597 |
| RPS2 | ribosomal protein S2 | 0.0775781 |
| PRRC2C | proline-rich coiled-coil 2C | 0.050806 |
| RPS3 | ribosomal protein S3 | 0.0496611 |
| RPL26 | ribosomal protein L26 | 0.0428565 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0426145 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0420259 |
| RPL18 | ribosomal protein L18 | 0.0388392 |
| PTMA | prothymosin, alpha | 0.0384113 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0377384 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0374858 |
| SET | SET nuclear proto-oncogene | 0.0340852 |
| RBM39 | RNA binding motif protein 39 | 0.0327353 |
| EGR1 | early growth response 1 | 0.0310087 |
| RPS12 | ribosomal protein S12 | 0.0299431 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0298818 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0287708 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0284197 |
| RPS15A | ribosomal protein S15a | 0.0283074 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0281733 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0273075 |
| RBM25 | RNA binding motif protein 25 | 0.0269874 |
| RPS6 | ribosomal protein S6 | 0.0265509 |
| ANGPTL4 | angiopoietin-like 4 | 0.0261976 |
| RPS18 | ribosomal protein S18 | 0.0259566 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0257502 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0256134 |
| RPS17 | ribosomal protein S17 | 0.0252782 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0242723 |
| OGA | O-GlcNAcase | 0.0239996 |
| RPL37A | ribosomal protein L37a | 0.0236991 |
| RPL14 | ribosomal protein L14 | 0.0236972 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0233689 |
| GOLGA4 | golgin A4 | 0.0227309 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0223404 |
| DHFR | dihydrofolate reductase | 0.0222953 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0219879 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0216258 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0213906 |
| ENO1 | enolase 1, (alpha) | 0.0212958 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0210019 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0193266 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0193169 |
| JUN | jun proto-oncogene | 0.0187372 |
| RRBP1 | ribosome binding protein 1 | 0.0183775 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0183563 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0182439 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0179215 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0177559 |
| ATF4 | activating transcription factor 4 | 0.0176742 |
| WDR43 | WD repeat domain 43 | 0.0176347 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0175725 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0175546 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0174235 |
| TPM3 | tropomyosin 3 | 0.0172894 |
| RPL5 | ribosomal protein L5 | 0.016933 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0165753 |
| RPL13A | ribosomal protein L13a | 0.0163781 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0161157 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0160557 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0159287 |
| RPS27 | ribosomal protein S27 | 0.0155784 |
| RACK1 | receptor for activated C kinase 1 | 0.0153725 |
| PNN | pinin, desmosome associated protein | 0.0150966 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0150193 |
| YBX3 | Y box binding protein 3 | 0.0148584 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0145107 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0144993 |
| NOP58 | NOP58 ribonucleoprotein | 0.0141168 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0141147 |
| SLK | STE20-like kinase | 0.0140433 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0138519 |
| TMF1 | TATA element modulatory factor 1 | 0.0138304 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0138115 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0135843 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0135528 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0135505 |
| RPL12 | ribosomal protein L12 | 0.0134071 |
| KIF5B | kinesin family member 5B | 0.0130862 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0129954 |
| TNS1 | tensin 1 | 0.0128736 |
| MATR3 | matrin 3 | 0.0128654 |
| CAPRIN2 | caprin family member 2 | 0.0127878 |
| HLA-A | major histocompatibility complex, class I, A | 0.0127752 |
| MINK1 | misshapen-like kinase 1 | 0.0127563 |
| RPL23 | ribosomal protein L23 | 0.0127557 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0126948 |
| MPHOSPH10 | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) | 0.0124983 |
| SMYD3 | SET and MYND domain containing 3 | 0.0124857 |
| TLN1 | talin 1 | 0.0123811 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0122989 |
| ANLN | anillin, actin binding protein | 0.0121574 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.012152 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0120656 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0119858 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0118935 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0118006 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0117498 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.490711 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.164466 |
| NDRG1 | N-myc downstream regulated 1 | -0.135608 |
| ACTG1 | actin gamma 1 | -0.130473 |
| ANXA2 | annexin A2 | -0.123143 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0958397 |
| PDE10A | phosphodiesterase 10A | -0.0950912 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0933786 |
| UBC | ubiquitin C | -0.0900483 |
| LDHA | lactate dehydrogenase A | -0.0814535 |
| KRT81 | keratin 81, type II | -0.0795723 |
| KYNU | kynureninase | -0.0777589 |
| STC1 | stanniocalcin 1 | -0.0743813 |
| USP3 | ubiquitin specific peptidase 3 | -0.0707167 |
| VIM | vimentin | -0.0697995 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0693876 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0655283 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0641401 |
| SMAD3 | SMAD family member 3 | -0.061366 |
| AHNAK | AHNAK nucleoprotein | -0.0606388 |
| FTL | ferritin, light polypeptide | -0.0597779 |
| MT1X | metallothionein 1X | -0.0584699 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0581043 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.057798 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0575585 |
| S100A10 | S100 calcium binding protein A10 | -0.0547624 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0545826 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0539264 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0533623 |
| RPS24 | ribosomal protein S24 | -0.0484563 |
| PARD3 | par-3 family cell polarity regulator | -0.0484487 |
| PKM | pyruvate kinase, muscle | -0.0477687 |
| PGK1 | phosphoglycerate kinase 1 | -0.0473349 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0467107 |
| CD44 | CD44 molecule (Indian blood group) | -0.0460621 |
| RPLP0 | ribosomal protein, large, P0 | -0.0452799 |
| PDE8A | phosphodiesterase 8A | -0.044973 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0448801 |
| SPAG9 | sperm associated antigen 9 | -0.0448269 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0447176 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.044413 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0440854 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0434767 |
| HMGA1 | high mobility group AT-hook 1 | -0.0433 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0430259 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0430121 |
| ECT2 | epithelial cell transforming 2 | -0.0428262 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0427795 |
| ASPH | aspartate beta-hydroxylase | -0.0427333 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.042523 |
| TXNRD1 | thioredoxin reductase 1 | -0.0423729 |
| CA12 | carbonic anhydrase XII | -0.0421421 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0419825 |
| RPL8 | ribosomal protein L8 | -0.0417573 |
| PTK2 | protein tyrosine kinase 2 | -0.041571 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0415101 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0408845 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0399884 |
| RASA2 | RAS p21 protein activator 2 | -0.0399225 |
| AUTS2 | autism susceptibility candidate 2 | -0.0392118 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0391826 |
| CMIP | c-Maf inducing protein | -0.0389115 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.038907 |
| TMSB10 | thymosin beta 10 | -0.0385117 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.038431 |
| POTEF | POTE ankyrin domain family, member F | -0.0372257 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0371323 |
| RPS23 | ribosomal protein S23 | -0.0367666 |
| RNF213 | ring finger protein 213 | -0.0361214 |
| KRT7 | keratin 7, type II | -0.0359236 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.035765 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0353579 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0351689 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0351632 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0347122 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0346531 |
| TAOK1 | TAO kinase 1 | -0.034386 |
| RPS16 | ribosomal protein S16 | -0.0343196 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0342208 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0337654 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0331196 |
| USP34 | ubiquitin specific peptidase 34 | -0.032868 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.032683 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0323889 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0322556 |
| TNS3 | tensin 3 | -0.0315786 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0305741 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0303696 |
| ETNK1 | ethanolamine kinase 1 | -0.0302584 |
| DENND4C | DENN/MADD domain containing 4C | -0.0295547 |
| MCL1 | myeloid cell leukemia 1 | -0.0292591 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0290892 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0285466 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0284322 |
| RPS11 | ribosomal protein S11 | -0.0282026 |
| TKT | transketolase | -0.0281708 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0280856 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.027923 |
| IER3 | immediate early response 3 | -0.0278646 |
| MAP1B | microtubule-associated protein 1B | -0.0276007 |
