Nafamostat (mesylate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.277989
RPS2 ribosomal protein S2 0.0733124
VCL vinculin 0.067862
RPL4 ribosomal protein L4 0.0661487
EIF1 eukaryotic translation initiation factor 1 0.065499
ERRFI1 ERBB receptor feedback inhibitor 1 0.0617666
VCAN versican 0.0606651
EZR ezrin 0.0563163
MYOF myoferlin 0.0525863
DOCK5 dedicator of cytokinesis 5 0.0518259
RPS12 ribosomal protein S12 0.0516015
SQSTM1 sequestosome 1 0.0502749
RBM39 RNA binding motif protein 39 0.0482329
RPL12 ribosomal protein L12 0.0480765
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0469938
RPS6 ribosomal protein S6 0.0467389
EFNA5 ephrin-A5 0.0464545
RPL37A ribosomal protein L37a 0.0458406
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0452214
RPS3 ribosomal protein S3 0.0447551
RPS8 ribosomal protein S8 0.044374
PRRC2C proline-rich coiled-coil 2C 0.0440253
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0435133
BCL2L1 BCL2-like 1 0.0424769
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0421313
PLEC plectin 0.0420865
RPL23 ribosomal protein L23 0.0408819
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0408248
RPL26 ribosomal protein L26 0.0403098
SRRM2 serine/arginine repetitive matrix 2 0.0402569
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0396899
RPLP1 ribosomal protein, large, P1 0.0394758
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0393246
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0376329
OGA O-GlcNAcase 0.0374985
PLAUR plasminogen activator, urokinase receptor 0.0374173
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0370431
RPL35A ribosomal protein L35a 0.0363147
CAB39 calcium binding protein 39 0.0362086
LMTK2 lemur tyrosine kinase 2 0.0355624
WWC1 WW and C2 domain containing 1 0.0354868
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0353537
FOXO1 forkhead box O1 0.0351417
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0348968
ANXA11 annexin A11 0.034886
RPL37 ribosomal protein L37 0.0345429
B2M beta-2-microglobulin 0.0343697
TJP1 tight junction protein 1 0.0338865
RBM25 RNA binding motif protein 25 0.03387
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0337211
RACK1 receptor for activated C kinase 1 0.0328174
RPL34 ribosomal protein L34 0.0324242
KTN1 kinectin 1 (kinesin receptor) 0.0312106
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0308504
DUSP4 dual specificity phosphatase 4 0.0307664
PTMA prothymosin, alpha 0.0307628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0305728
RPS27 ribosomal protein S27 0.0298223
TXNRD1 thioredoxin reductase 1 0.0297923
FTL ferritin, light polypeptide 0.029582
RPL5 ribosomal protein L5 0.0293351
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0291022
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0290141
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028873
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0287584
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0286524
EIF5B eukaryotic translation initiation factor 5B 0.0285912
TUFT1 tuftelin 1 0.0277585
SLC38A2 solute carrier family 38, member 2 0.0276974
RPS19 ribosomal protein S19 0.0276079
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273595
SMAD3 SMAD family member 3 0.0270669
TMSB10 thymosin beta 10 0.0270013
RPL9 ribosomal protein L9 0.0268697
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0268427
RPLP2 ribosomal protein, large, P2 0.0268314
RPL31 ribosomal protein L31 0.0266831
RPL30 ribosomal protein L30 0.0265507
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0262091
NCOA3 nuclear receptor coactivator 3 0.0255541
TRIO trio Rho guanine nucleotide exchange factor 0.0252344
RTN4 reticulon 4 0.0250944
NAP1L1 nucleosome assembly protein 1-like 1 0.0250722
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.02503
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0249552
ZNFX1 zinc finger, NFX1-type containing 1 0.0248264
H1-0 H1.0 linker histone 0.0246504
DSPP dentin sialophosphoprotein 0.0243112
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0241831
KLF6 Kruppel-like factor 6 0.0238163
MYO6 myosin VI 0.023571
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.023507
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0234944
RPL36 ribosomal protein L36 0.0234504
TOP1 topoisomerase (DNA) I 0.0232033
SEPTIN9 septin 9 0.0231878
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0230727
IFI6 interferon, alpha-inducible protein 6 0.0227341
RPS14 ribosomal protein S14 0.0224634
MTUS1 microtubule associated tumor suppressor 1 0.0224326

decreased expression

Symbol Name Standardized Value
MUC17 mucin 17, cell surface associated -0.166275
NDRG1 N-myc downstream regulated 1 -0.103105
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0974422
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.093345
F3 coagulation factor III (thromboplastin, tissue factor) -0.0929109
POTEF POTE ankyrin domain family, member F -0.0837365
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.083097
HMGA1 high mobility group AT-hook 1 -0.0755917
MXD1 MAX dimerization protein 1 -0.074418
FLNB filamin B, beta -0.0732004
TRRAP transformation/transcription domain-associated protein -0.0672897
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0649198
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0648483
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0610522
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0580616
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0550136
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.054363
KLK10 kallikrein-related peptidase 10 -0.0521842
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0515855
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0504982
SLC35F3 solute carrier family 35, member F3 -0.0504292
UBE2H ubiquitin-conjugating enzyme E2H -0.0504107
UBC ubiquitin C -0.0459386
LDHA lactate dehydrogenase A -0.0458928
PGK1 phosphoglycerate kinase 1 -0.0446369
PERP PERP, TP53 apoptosis effector -0.0436794
RAB1A RAB1A, member RAS oncogene family -0.0435327
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0433876
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0423848
COPB1 coatomer protein complex, subunit beta 1 -0.0414058
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0412326
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0406199
TXNIP thioredoxin interacting protein -0.0400987
NPSR1 neuropeptide S receptor 1 -0.0395728
DSG2 desmoglein 2 -0.0393219
BIRC6 baculoviral IAP repeat containing 6 -0.0388646
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0386433
SKAP2 src kinase associated phosphoprotein 2 -0.0375586
ITPRID2 ITPR interacting domain containing 2 -0.0372021
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0359828
TAOK3 TAO kinase 3 -0.0352662
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0350565
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0339051
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0336033
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0329272
KCMF1 potassium channel modulatory factor 1 -0.0322033
COPA coatomer protein complex, subunit alpha -0.0320948
SPDYA speedy/RINGO cell cycle regulator family member A -0.031559
CD59 CD59 molecule, complement regulatory protein -0.0312973
ANTXR2 anthrax toxin receptor 2 -0.0312612
GREB1L growth regulation by estrogen in breast cancer-like -0.031015
DIAPH2 diaphanous-related formin 2 -0.0304449
WASF2 WAS protein family, member 2 -0.0302529
SEC31A SEC31 homolog A (S. cerevisiae) -0.0297909
SMNDC1 survival motor neuron domain containing 1 -0.0297569
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0295695
CALU calumenin -0.029149
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0291448
LY6E lymphocyte antigen 6 complex, locus E -0.0289998
ARF4 ADP-ribosylation factor 4 -0.0288721
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0287629
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0285927
MSN moesin -0.028083
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0274931
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.0263936
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0262747
NBEAL1 neurobeachin-like 1 -0.0260602
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0257177
FAM107B family with sequence similarity 107, member B -0.0251786
ANXA2 annexin A2 -0.0249808
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0247392
ITCH itchy E3 ubiquitin protein ligase -0.0247323
LAMC2 laminin, gamma 2 -0.0246633
CLMP CXADR-like membrane protein -0.0246152
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0245756
MORF4L2 mortality factor 4 like 2 -0.0243862
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0240007
KRT8 keratin 8, type II -0.0237503
PARD3 par-3 family cell polarity regulator -0.0235587
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0233807
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0232064
TMEM263 transmembrane protein 263 -0.0231484
LAMA4 laminin, alpha 4 -0.0228233
PDLIM5 PDZ and LIM domain 5 -0.0227937
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0227245
MBNL1 muscleblind-like splicing regulator 1 -0.0227035
KCTD9 potassium channel tetramerization domain containing 9 -0.0225408
FERMT1 fermitin family member 1 -0.0224148
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -0.0223584
PRRC1 proline-rich coiled-coil 1 -0.0222528
RHOA ras homolog family member A -0.0221192
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0220215
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0219688
SULF2 sulfatase 2 -0.0219176
MCL1 myeloid cell leukemia 1 -0.0219107
CDK13 cyclin-dependent kinase 13 -0.0217999
EGFR epidermal growth factor receptor -0.0217813
CCNK cyclin K -0.0216933
PDE4D phosphodiesterase 4D, cAMP-specific -0.0216677
RIOK3 RIO kinase 3 -0.0216156