Nafamostat (mesylate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.318554
ZMYND8 zinc finger, MYND-type containing 8 0.209346
RPL19 ribosomal protein L19 0.200169
FTH1 ferritin, heavy polypeptide 1 0.114461
PTMA prothymosin, alpha 0.0956321
RPS3 ribosomal protein S3 0.0920998
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0909971
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0794736
ASPH aspartate beta-hydroxylase 0.0765366
ENO1 enolase 1, (alpha) 0.0673288
TMSB10 thymosin beta 10 0.0636036
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0576601
RPL12 ribosomal protein L12 0.0570865
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0546496
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0546124
SET SET nuclear proto-oncogene 0.0542196
PRRC2C proline-rich coiled-coil 2C 0.0526661
ANKRD12 ankyrin repeat domain 12 0.0511215
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0510602
EIF1 eukaryotic translation initiation factor 1 0.0500743
RPS19 ribosomal protein S19 0.0499161
ACSS2 acyl-CoA synthetase short-chain family member 2 0.048716
ZFP36L1 ZFP36 ring finger protein-like 1 0.0480922
RPL35A ribosomal protein L35a 0.0462078
RPS6 ribosomal protein S6 0.0450933
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0442693
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0439601
RPL37A ribosomal protein L37a 0.04392
NDRG1 N-myc downstream regulated 1 0.0434782
SRRM2 serine/arginine repetitive matrix 2 0.042404
SLC38A1 solute carrier family 38, member 1 0.0415654
RPS8 ribosomal protein S8 0.0402219
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0401276
RPL37 ribosomal protein L37 0.038087
B2M beta-2-microglobulin 0.037427
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0370501
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0360714
RPS12 ribosomal protein S12 0.035065
RPL31 ribosomal protein L31 0.0347584
LASP1 LIM and SH3 protein 1 0.0335314
RAB6A RAB6A, member RAS oncogene family 0.0330897
TMEM165 transmembrane protein 165 0.0327068
FTL ferritin, light polypeptide 0.0323284
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0316321
RPL35 ribosomal protein L35 0.0315481
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0315277
RPS2 ribosomal protein S2 0.0314743
WSB1 WD repeat and SOCS box containing 1 0.0308596
LMNA lamin A/C 0.0308023
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0302676
KRT19 keratin 19, type I 0.0301097
RPL18 ribosomal protein L18 0.0295997
RPS17 ribosomal protein S17 0.0295225
RPL4 ribosomal protein L4 0.0293446
EZR ezrin 0.0288332
FBXL20 F-box and leucine-rich repeat protein 20 0.0288123
AKAP9 A kinase (PRKA) anchor protein 9 0.0286066
FAM13A family with sequence similarity 13, member A 0.0285372
MT2A metallothionein 2A 0.0282219
RPL5 ribosomal protein L5 0.0281829
RPS14 ribosomal protein S14 0.0281528
MMP24OS MMP24 opposite strand 0.027942
ACTG1 actin gamma 1 0.0276933
EGFR epidermal growth factor receptor 0.0275752
RPL26 ribosomal protein L26 0.0273581
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.027309
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0272186
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.027094
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0270628
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0270216
GOLGA4 golgin A4 0.0266067
RACK1 receptor for activated C kinase 1 0.0265489
CBX3 chromobox homolog 3 0.0252406
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0249951
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0249926
LOC112694756 uncharaterized LOC112694756 0.0249622
PGK1 phosphoglycerate kinase 1 0.0248442
RPL30 ribosomal protein L30 0.0246996
KIF5B kinesin family member 5B 0.0244945
BBX bobby sox homolog (Drosophila) 0.0244505
TMEM123 transmembrane protein 123 0.0242531
RPL34 ribosomal protein L34 0.0240526
EEF2 eukaryotic translation elongation factor 2 0.0240424
BRD4 bromodomain containing 4 0.0240278
FBXO32 F-box protein 32 0.0237915
PNISR PNN-interacting serine/arginine-rich protein 0.023567
CALR calreticulin 0.0233083
ANLN anillin, actin binding protein 0.0231421
LDHA lactate dehydrogenase A 0.0231189
RPS27 ribosomal protein S27 0.0230362
RPLP1 ribosomal protein, large, P1 0.022839
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0228254
MBNL2 muscleblind-like splicing regulator 2 0.0227587
BIRC3 baculoviral IAP repeat containing 3 0.0222287
KMT2E lysine (K)-specific methyltransferase 2E 0.0221303
DSPP dentin sialophosphoprotein 0.0220217
OGA O-GlcNAcase 0.0218295
IFI6 interferon, alpha-inducible protein 6 0.021807
SOX4 SRY (sex determining region Y)-box 4 0.0216917
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0215549

decreased expression

Symbol Name Standardized Value
CDK12 cyclin-dependent kinase 12 -0.0623479
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0609434
ACACA acetyl-CoA carboxylase alpha -0.059518
CATSPERB catsper channel auxiliary subunit beta -0.0528588
TRPS1 trichorhinophalangeal syndrome I -0.0445636
VMP1 vacuole membrane protein 1 -0.0440743
ITCH itchy E3 ubiquitin protein ligase -0.0436659
THSD4 thrombospondin, type I, domain containing 4 -0.0408411
EXT1 exostosin glycosyltransferase 1 -0.0341844
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0328386
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.03212
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0308335
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0305859
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0295978
CLTC clathrin, heavy chain (Hc) -0.0291264
TC2N tandem C2 domains, nuclear -0.0283665
ZFAND3 zinc finger, AN1-type domain 3 -0.0259879
PBX1 pre-B-cell leukemia homeobox 1 -0.0258971
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.025048
NTN4 netrin 4 -0.0246628
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0243517
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0238897
KAZN kazrin, periplakin interacting protein -0.023631
DNAH14 dynein, axonemal, heavy chain 14 -0.0235634
AGFG1 ArfGAP with FG repeats 1 -0.0224937
ACTN4 actinin, alpha 4 -0.0220016
PTPRK protein tyrosine phosphatase, receptor type, K -0.0219494
STRN3 striatin, calmodulin binding protein 3 -0.0218901
NAMPT nicotinamide phosphoribosyltransferase -0.0214143
PTK2 protein tyrosine kinase 2 -0.0213882
YAP1 Yes-associated protein 1 -0.0208705
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0204996
BCAS1 breast carcinoma amplified sequence 1 -0.0204931
GLCCI1 glucocorticoid induced 1 -0.0204088
MSI2 musashi RNA-binding protein 2 -0.0200823
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0197621
TENM2 teneurin transmembrane protein 2 -0.0196566
NFIA nuclear factor I/A -0.0195949
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0194219
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0190095
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.018954
COBL cordon-bleu WH2 repeat protein -0.018851
ARHGAP32 Rho GTPase activating protein 32 -0.0186967
MARCHF7 membrane associated ring-CH-type finger 7 -0.0183855
CEMIP cell migration inducing protein, hyaluronan binding -0.018376
STXBP4 syntaxin binding protein 4 -0.0180855
FNDC3B fibronectin type III domain containing 3B -0.0177582
MAPK8 mitogen-activated protein kinase 8 -0.0175453
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0173724
DOCK5 dedicator of cytokinesis 5 -0.0172539
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0170022
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0166548
LARP4B La ribonucleoprotein domain family, member 4B -0.0164531
NRP1 neuropilin 1 -0.0163573
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0162425
TRIO trio Rho guanine nucleotide exchange factor -0.0161914
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0161096
ELOVL5 ELOVL fatty acid elongase 5 -0.0158435
LPP LIM domain containing preferred translocation partner in lipoma -0.0157694
AHNAK AHNAK nucleoprotein -0.0156848
OLA1 Obg-like ATPase 1 -0.0154878
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0154225
WWC1 WW and C2 domain containing 1 -0.0153638
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0152758
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0151817
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0149263
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0147423
MYO5B myosin VB -0.0146947
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0146658
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0144419
CCNL1 cyclin L1 -0.0143738
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0143022
SEPTIN11 septin 11 -0.0140094
MYO1D myosin ID -0.0140053
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0139679
APP amyloid beta (A4) precursor protein -0.0139349
GMDS GDP-mannose 4,6-dehydratase -0.0138773
PGR progesterone receptor -0.013863
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0138226
GSE1 Gse1 coiled-coil protein -0.0137701
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0137206
AZIN1 antizyme inhibitor 1 -0.0135812
UBE2H ubiquitin-conjugating enzyme E2H -0.0135308
MED13L mediator complex subunit 13-like -0.0134741
TFRC transferrin receptor -0.0134738
WDFY3 WD repeat and FYVE domain containing 3 -0.0134672
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0134198
PRKCA protein kinase C, alpha -0.0133759
EFNA5 ephrin-A5 -0.0133501
ZFAND6 zinc finger, AN1-type domain 6 -0.0132838
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0132239
NF1 neurofibromin 1 -0.0132189
ALCAM activated leukocyte cell adhesion molecule -0.0131782
SGMS1 sphingomyelin synthase 1 -0.0131246
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0131033
MPRIP myosin phosphatase Rho interacting protein -0.013072
CD164 CD164 molecule, sialomucin -0.0129964
CUX1 cut-like homeobox 1 -0.0129814
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0129362
USP3 ubiquitin specific peptidase 3 -0.0129293