Nafamostat (mesylate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0905343
RPL4 ribosomal protein L4 0.0696105
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0549845
CADM2 cell adhesion molecule 2 0.0530597
NPAS3 neuronal PAS domain protein 3 0.0525326
SLIT2 slit homolog 2 (Drosophila) 0.0492548
RPS2 ribosomal protein S2 0.0465702
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0435762
GRID2 glutamate receptor, ionotropic, delta 2 0.0399761
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373056
PDE4D phosphodiesterase 4D, cAMP-specific 0.0366022
SOX5 SRY (sex determining region Y)-box 5 0.034599
ZFP36L1 ZFP36 ring finger protein-like 1 0.0338899
AKAP12 A kinase (PRKA) anchor protein 12 0.0332975
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0316938
BCLAF1 BCL2-associated transcription factor 1 0.030577
AKAP9 A kinase (PRKA) anchor protein 9 0.0291701
DST dystonin 0.0286318
EGR1 early growth response 1 0.0286057
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.02835
EFNA5 ephrin-A5 0.028289
CENPF centromere protein F, 350/400kDa 0.0281605
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0276462
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0253871
RPS18 ribosomal protein S18 0.025345
ATG10 autophagy related 10 0.0247764
PRRC2C proline-rich coiled-coil 2C 0.0245487
PDE10A phosphodiesterase 10A 0.0238646
GOLGA4 golgin A4 0.0236788
PNN pinin, desmosome associated protein 0.0236034
CDH18 cadherin 18, type 2 0.0235423
ASPH aspartate beta-hydroxylase 0.022929
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0227287
TBC1D5 TBC1 domain family, member 5 0.0224442
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0224379
SRRM2 serine/arginine repetitive matrix 2 0.021068
SET SET nuclear proto-oncogene 0.0209235
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0206358
IFI6 interferon, alpha-inducible protein 6 0.0199266
EIF1 eukaryotic translation initiation factor 1 0.0192645
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0191972
NEBL nebulette 0.0190008
PRPF4B pre-mRNA processing factor 4B 0.0187534
PSD3 pleckstrin and Sec7 domain containing 3 0.0185714
GCC2 GRIP and coiled-coil domain containing 2 0.0182082
FTH1 ferritin, heavy polypeptide 1 0.0181882
TMSB4X thymosin beta 4, X-linked 0.0179534
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0176535
TPM3 tropomyosin 3 0.0174982
CCSER1 coiled-coil serine-rich protein 1 0.0174979
PRRC2A proline-rich coiled-coil 2A 0.0172161
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0171214
SDK1 sidekick cell adhesion molecule 1 0.01654
OSMR oncostatin M receptor 0.0165372
ITSN1 intersectin 1 (SH3 domain protein) 0.0163935
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0163438
HMGN2 high mobility group nucleosomal binding domain 2 0.0162693
N4BP2L2 NEDD4 binding protein 2-like 2 0.016134
CALD1 caldesmon 1 0.0160216
ALMS1 Alstrom syndrome protein 1 0.0159783
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0159489
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0159
FHIT fragile histidine triad 0.0158616
HHIP hedgehog interacting protein 0.0157866
ZNF146 zinc finger protein 146 0.015773
RBM39 RNA binding motif protein 39 0.0155795
PHF14 PHD finger protein 14 0.0152314
EXOC4 exocyst complex component 4 0.015042
RBM25 RNA binding motif protein 25 0.0150081
IWS1 IWS1 homolog (S. cerevisiae) 0.0148943
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.014724
MBD5 methyl-CpG binding domain protein 5 0.0146632
MCTP1 multiple C2 domains, transmembrane 1 0.0146403
MAML2 mastermind-like 2 (Drosophila) 0.0146039
SLF1 SMC5-SMC6 complex localization factor 1 0.0144785
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.014314
KDM6B lysine (K)-specific demethylase 6B 0.014278
SMC1A structural maintenance of chromosomes 1A 0.0141856
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0141219
MON2 MON2 homolog (S. cerevisiae) 0.014065
SRSF11 serine/arginine-rich splicing factor 11 0.0138717
ARGLU1 arginine and glutamate rich 1 0.0138411
ZSCAN5A zinc finger and SCAN domain containing 5A 0.0136943
RB1CC1 RB1-inducible coiled-coil 1 0.0136223
WDR43 WD repeat domain 43 0.013562
ANKRD36 ankyrin repeat domain 36 0.0135164
YARS1 tyrosyl-tRNA synthetase 1 0.0134847
ICE1 interactor of little elongation complex ELL subunit 1 0.0134786
PRELID2 PRELI domain containing 2 0.0133894
PRRC2B proline-rich coiled-coil 2B 0.0133456
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0133327
ANKRD26 ankyrin repeat domain 26 0.0133259
PUDP pseudouridine 5'-phosphatase 0.0132697
ATP5ME ATP synthase membrane subunit e 0.0131099
EIF5B eukaryotic translation initiation factor 5B 0.013074
LMO7 LIM domain 7 0.0130501
ANK2 ankyrin 2, neuronal 0.0130077
SP100 SP100 nuclear antigen 0.0129977
TBC1D32 TBC1 domain family, member 32 0.0129859
HLA-A major histocompatibility complex, class I, A 0.0129396

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.362876
ACTG1 actin gamma 1 -0.100472
LDHA lactate dehydrogenase A -0.0977541
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0891753
UBC ubiquitin C -0.0868095
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0735059
RPL11 ribosomal protein L11 -0.0723813
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0710398
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0700524
KDM3A lysine (K)-specific demethylase 3A -0.0593638
WDR45B WD repeat domain 45B -0.0563757
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0561793
RPS11 ribosomal protein S11 -0.0552909
DEK DEK proto-oncogene -0.0548486
RPLP0 ribosomal protein, large, P0 -0.0502886
RPS21 ribosomal protein S21 -0.049994
FAM162A family with sequence similarity 162, member A -0.0492638
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0488756
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0484833
RPL28 ribosomal protein L28 -0.0481529
PGK1 phosphoglycerate kinase 1 -0.0476183
NFIA nuclear factor I/A -0.0474647
GNAS GNAS complex locus -0.046879
TAOK1 TAO kinase 1 -0.0464736
RPS24 ribosomal protein S24 -0.0461633
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0455977
EEF2 eukaryotic translation elongation factor 2 -0.0445219
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0442641
TMSB10 thymosin beta 10 -0.0431452
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0430129
RLF rearranged L-myc fusion -0.0424916
VDAC1 voltage-dependent anion channel 1 -0.0421603
RPL7A ribosomal protein L7a -0.0417187
ENAH enabled homolog (Drosophila) -0.0413595
SOX4 SRY (sex determining region Y)-box 4 -0.0411347
TPD52 tumor protein D52 -0.0409854
RPL8 ribosomal protein L8 -0.0401089
RHOA ras homolog family member A -0.0400813
ACACA acetyl-CoA carboxylase alpha -0.0392734
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390839
SETD5 SET domain containing 5 -0.0389248
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0388298
PTMA prothymosin, alpha -0.0383788
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0381997
JMJD1C jumonji domain containing 1C -0.0379394
LOC112694756 uncharaterized LOC112694756 -0.0376912
ANKRD17 ankyrin repeat domain 17 -0.0371653
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0371399
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0364514
CCNI cyclin I -0.0356464
RPS29 ribosomal protein S29 -0.0354675
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0352152
RPS15 ribosomal protein S15 -0.035165
BMPR1A bone morphogenetic protein receptor, type IA -0.0350649
CCDC47 coiled-coil domain containing 47 -0.0350213
ARFGEF3 ARFGEF family member 3 -0.0344174
RPS8 ribosomal protein S8 -0.0342076
PARD3 par-3 family cell polarity regulator -0.0340752
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0339766
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0339494
PKM pyruvate kinase, muscle -0.0338543
RPS27A ribosomal protein S27a -0.0333752
RAP1B RAP1B, member of RAS oncogene family -0.033299
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0331219
BRWD1 bromodomain and WD repeat domain containing 1 -0.032824
SRPK2 SRSF protein kinase 2 -0.0319864
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0319744
RPL19 ribosomal protein L19 -0.0319532
NCOR1 nuclear receptor corepressor 1 -0.0318369
APP amyloid beta (A4) precursor protein -0.0317246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0316453
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0311534
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0306476
FNBP1L formin binding protein 1-like -0.0303012
PEG10 paternally expressed 10 -0.0299084
TTC3 tetratricopeptide repeat domain 3 -0.0296188
ADNP activity-dependent neuroprotector homeobox -0.0295139
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0293842
RPL38 ribosomal protein L38 -0.029362
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0292497
SPDYA speedy/RINGO cell cycle regulator family member A -0.0292207
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0290974
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.02897
RPL36A ribosomal protein L36a -0.0289028
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0288487
USP9X ubiquitin specific peptidase 9, X-linked -0.0287213
GLG1 golgi glycoprotein 1 -0.0281765
RPS19 ribosomal protein S19 -0.027882
TENM3 teneurin transmembrane protein 3 -0.0278042
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0276501
CELF2 CUGBP, Elav-like family member 2 -0.027604
S100A9 S100 calcium binding protein A9 -0.0274747
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0273589
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0273466
CALU calumenin -0.0273172
UBE2K ubiquitin-conjugating enzyme E2K -0.0273152
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0273001
ENO1 enolase 1, (alpha) -0.0272933
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0272471
AUTS2 autism susceptibility candidate 2 -0.0271833