Nafamostat (mesylate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.115358
VIM vimentin 0.105193
EIF1 eukaryotic translation initiation factor 1 0.098711
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0902508
FTL ferritin, light polypeptide 0.0849276
RPL4 ribosomal protein L4 0.08357
GARS1 glycyl-tRNA synthetase 1 0.0628156
RPL35A ribosomal protein L35a 0.0609984
EGR1 early growth response 1 0.0570398
AKAP12 A kinase (PRKA) anchor protein 12 0.0568442
CALR calreticulin 0.0565411
SBF2 SET binding factor 2 0.0561076
PTMA prothymosin, alpha 0.0560559
VCL vinculin 0.0557164
AKAP9 A kinase (PRKA) anchor protein 9 0.0556143
PRRC2C proline-rich coiled-coil 2C 0.054575
PABPC1 poly(A) binding protein, cytoplasmic 1 0.053491
RPLP2 ribosomal protein, large, P2 0.045497
RPL37A ribosomal protein L37a 0.0418023
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0404395
RPL9 ribosomal protein L9 0.0402977
MAP1B microtubule-associated protein 1B 0.0397626
TUBB tubulin, beta class I 0.0391661
RPS19 ribosomal protein S19 0.0387991
ENO1 enolase 1, (alpha) 0.0387328
TPI1 triosephosphate isomerase 1 0.0378441
EEF2 eukaryotic translation elongation factor 2 0.0371715
RPL23 ribosomal protein L23 0.0364161
VMP1 vacuole membrane protein 1 0.0363393
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0361745
NFE2L2 nuclear factor, erythroid 2-like 2 0.0361109
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0359061
RPS8 ribosomal protein S8 0.0344113
RPL5 ribosomal protein L5 0.0343829
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0342754
RPS12 ribosomal protein S12 0.0342468
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0342258
OGA O-GlcNAcase 0.0341971
RBM39 RNA binding motif protein 39 0.0341291
ACTN1 actinin, alpha 1 0.0339566
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0336358
RBM25 RNA binding motif protein 25 0.033017
SCFD1 sec1 family domain containing 1 0.0329039
RPS6 ribosomal protein S6 0.0328876
FNIP1 folliculin interacting protein 1 0.0324897
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0324298
ANKRD11 ankyrin repeat domain 11 0.0322493
SRRM2 serine/arginine repetitive matrix 2 0.03208
MBD5 methyl-CpG binding domain protein 5 0.0319937
SRSF11 serine/arginine-rich splicing factor 11 0.0319597
N4BP2L2 NEDD4 binding protein 2-like 2 0.0318982
RPL12 ribosomal protein L12 0.031608
RACK1 receptor for activated C kinase 1 0.0313454
RPL26 ribosomal protein L26 0.0313447
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0308679
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0305138
MAGED1 melanoma antigen family D1 0.0301311
TTC17 tetratricopeptide repeat domain 17 0.0297596
DGKD diacylglycerol kinase, delta 130kDa 0.0292901
TM9SF3 transmembrane 9 superfamily member 3 0.0291967
ACBD3 acyl-CoA binding domain containing 3 0.0289167
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0288368
ZFC3H1 zinc finger, C3H1-type containing 0.0285379
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0284926
RPL18 ribosomal protein L18 0.0284252
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0283895
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0283012
ENO2 enolase 2 (gamma, neuronal) 0.028164
DIAPH3 diaphanous-related formin 3 0.0281594
KDM5A lysine (K)-specific demethylase 5A 0.0273806
USP9X ubiquitin specific peptidase 9, X-linked 0.0272628
RPLP1 ribosomal protein, large, P1 0.0268431
RPL7A ribosomal protein L7a 0.0267884
EEF1G eukaryotic translation elongation factor 1 gamma 0.026572
PDLIM5 PDZ and LIM domain 5 0.0260817
PRRC2B proline-rich coiled-coil 2B 0.0259396
TNRC18 trinucleotide repeat containing 18 0.0257486
TMSB4X thymosin beta 4, X-linked 0.0256722
HDLBP high density lipoprotein binding protein 0.0256243
SEM1 SEM1 26S proteasome subunit 0.0255326
FTH1 ferritin, heavy polypeptide 1 0.025401
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252962
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0252454
S100A6 S100 calcium binding protein A6 0.0252012
BBS9 Bardet-Biedl syndrome 9 0.0251065
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0249994
LMNA lamin A/C 0.024997
LOC112694756 uncharaterized LOC112694756 0.0248739
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0248611
SMC5 structural maintenance of chromosomes 5 0.0248075
RPS2 ribosomal protein S2 0.0247744
INHBA inhibin, beta A 0.0246749
ALCAM activated leukocyte cell adhesion molecule 0.0246465
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0245712
ANKRD17 ankyrin repeat domain 17 0.02398
GOLGB1 golgin B1 0.0239405
NFE2L1 nuclear factor, erythroid 2-like 1 0.0237984
SON SON DNA binding protein 0.0237156
EFNA5 ephrin-A5 0.0236273
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235699

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.160956
COL6A3 collagen, type VI, alpha 3 -0.153097
FN1 fibronectin 1 -0.152375
NALF1 NALCN channel auxiliary factor 1 -0.150388
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.143348
GRB10 growth factor receptor-bound protein 10 -0.108576
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0962854
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0932265
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.092667
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0919261
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.086099
TRIO trio Rho guanine nucleotide exchange factor -0.0822303
DTNA dystrobrevin, alpha -0.0788797
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0705333
PDIA3 protein disulfide isomerase family A, member 3 -0.0553998
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0533259
HLA-B major histocompatibility complex, class I, B -0.0530099
NAV3 neuron navigator 3 -0.052345
ASPH aspartate beta-hydroxylase -0.0514378
APP amyloid beta (A4) precursor protein -0.0510302
CALU calumenin -0.0505617
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.050367
EXT1 exostosin glycosyltransferase 1 -0.0500867
NDRG1 N-myc downstream regulated 1 -0.0500597
ANTXR2 anthrax toxin receptor 2 -0.0500248
BACE2 beta-site APP-cleaving enzyme 2 -0.0477114
CLMP CXADR-like membrane protein -0.0476559
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0474763
STC1 stanniocalcin 1 -0.0472757
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0452383
TENM3 teneurin transmembrane protein 3 -0.045159
TNS3 tensin 3 -0.0440455
NAMPT nicotinamide phosphoribosyltransferase -0.0440435
CANX calnexin -0.0437678
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0437085
NRXN3 neurexin 3 -0.0411817
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0405801
KYNU kynureninase -0.040117
RIGI RNA sensor RIG-I -0.0384133
NAV1 neuron navigator 1 -0.0383284
COL5A1 collagen, type V, alpha 1 -0.0373992
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.037123
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0367316
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0364769
MYLK myosin light chain kinase -0.035783
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0355129
DMD dystrophin -0.035256
SMAD3 SMAD family member 3 -0.0348991
TMEM165 transmembrane protein 165 -0.0347191
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0344581
EGFR epidermal growth factor receptor -0.0344242
AHNAK AHNAK nucleoprotein -0.0343047
LOXL2 lysyl oxidase-like 2 -0.0342485
PTK2 protein tyrosine kinase 2 -0.0341073
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0337714
NPAS2 neuronal PAS domain protein 2 -0.0333756
RUNX1 runt-related transcription factor 1 -0.0329162
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0325256
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0321366
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0319462
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.031864
IGF2 insulin-like growth factor 2 -0.0318539
MAP4 microtubule-associated protein 4 -0.0308137
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0298544
COL5A2 collagen, type V, alpha 2 -0.0296804
VEGFA vascular endothelial growth factor A -0.0296267
IGFBP5 insulin-like growth factor binding protein 5 -0.0295952
KDM3A lysine (K)-specific demethylase 3A -0.0287618
AFAP1 actin filament associated protein 1 -0.0285508
PXDN peroxidasin -0.0284583
PGK1 phosphoglycerate kinase 1 -0.0284222
LMAN1 lectin, mannose-binding, 1 -0.0279837
ZBTB1 zinc finger and BTB domain containing 1 -0.0279458
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0277078
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0273132
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0266928
UBE2H ubiquitin-conjugating enzyme E2H -0.0265966
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0265323
TGFBI transforming growth factor, beta-induced, 68kDa -0.0263733
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0262406
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0260365
PLEC plectin -0.0258093
PRKCE protein kinase C, epsilon -0.0257638
MYO10 myosin X -0.0254974
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0250335
KIF13A kinesin family member 13A -0.0246411
ARRDC3 arrestin domain containing 3 -0.0246152
MT2A metallothionein 2A -0.0245004
SDK1 sidekick cell adhesion molecule 1 -0.0243703
VEGFC vascular endothelial growth factor C -0.0242982
FSTL1 follistatin-like 1 -0.0242806
COL8A1 collagen, type VIII, alpha 1 -0.02408
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0239538
CAPN2 calpain 2, (m/II) large subunit -0.023775
AUTS2 autism susceptibility candidate 2 -0.0234596
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0232769
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0232755
UBE2K ubiquitin-conjugating enzyme E2K -0.0231639
SAMD4A sterile alpha motif domain containing 4A -0.0231625
SOX5 SRY (sex determining region Y)-box 5 -0.0229163