Nafamostat (mesylate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Nafamostat (mesylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.258047
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114335
DSCAM Down syndrome cell adhesion molecule 0.0978164
RPL4 ribosomal protein L4 0.0854289
PRRC2C proline-rich coiled-coil 2C 0.0848898
PRELID2 PRELI domain containing 2 0.0841586
EZR ezrin 0.0825376
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0799583
RBM39 RNA binding motif protein 39 0.0779631
AKAP9 A kinase (PRKA) anchor protein 9 0.0742624
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0732715
RAD51B RAD51 paralog B 0.0719424
NQO1 NAD(P)H dehydrogenase, quinone 1 0.071358
TXNRD1 thioredoxin reductase 1 0.0690441
ZNF292 zinc finger protein 292 0.0650677
EIF1 eukaryotic translation initiation factor 1 0.0637009
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0588374
MBD5 methyl-CpG binding domain protein 5 0.0585433
RPS6 ribosomal protein S6 0.0575794
OGA O-GlcNAcase 0.0573203
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0569927
ENO1 enolase 1, (alpha) 0.0563188
FAT1 FAT atypical cadherin 1 0.0559106
CANX calnexin 0.0537178
CTNND1 catenin (cadherin-associated protein), delta 1 0.0531541
MKI67 marker of proliferation Ki-67 0.0518172
NF1 neurofibromin 1 0.0516807
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0515637
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0514751
PCM1 pericentriolar material 1 0.0511857
KDM4C lysine (K)-specific demethylase 4C 0.0511513
DSPP dentin sialophosphoprotein 0.0505261
RPS2 ribosomal protein S2 0.0505063
TENM3 teneurin transmembrane protein 3 0.0504577
GOLGB1 golgin B1 0.0496383
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0495845
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.04881
ANKRD11 ankyrin repeat domain 11 0.0483661
JMJD1C jumonji domain containing 1C 0.0482739
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0480844
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0477002
RAD21 RAD21 homolog (S. pombe) 0.047551
KTN1 kinectin 1 (kinesin receptor) 0.0471121
RPS3 ribosomal protein S3 0.0461394
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0453356
MED13L mediator complex subunit 13-like 0.0449991
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0446441
RSRC2 arginine/serine-rich coiled-coil 2 0.0437028
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0436371
TBC1D22A TBC1 domain family, member 22A 0.0435624
WWC2 WW and C2 domain containing 2 0.0428273
SMYD3 SET and MYND domain containing 3 0.0419651
SRSF11 serine/arginine-rich splicing factor 11 0.0418396
HDLBP high density lipoprotein binding protein 0.0415944
RRBP1 ribosome binding protein 1 0.0415727
FHIT fragile histidine triad 0.0414048
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0414031
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0413958
RBM25 RNA binding motif protein 25 0.0413088
ZBTB20 zinc finger and BTB domain containing 20 0.0409584
EXOC4 exocyst complex component 4 0.0406885
N4BP2L2 NEDD4 binding protein 2-like 2 0.040656
CSNK1A1 casein kinase 1, alpha 1 0.0405777
SON SON DNA binding protein 0.040454
TM9SF3 transmembrane 9 superfamily member 3 0.0400563
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0400024
ZFAND3 zinc finger, AN1-type domain 3 0.0397605
HMGB2 high mobility group box 2 0.039428
DST dystonin 0.0392461
EEF2 eukaryotic translation elongation factor 2 0.039136
SLC38A2 solute carrier family 38, member 2 0.0389467
APLP2 amyloid beta (A4) precursor-like protein 2 0.038455
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0382867
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0382476
FAF1 Fas (TNFRSF6) associated factor 1 0.0382007
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0374768
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0374084
SPIDR scaffolding protein involved in DNA repair 0.0372013
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0371721
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370757
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0370192
CALR calreticulin 0.0369858
GOLM2 golgi membrane protein 2 0.0366269
MYO9A myosin IXA 0.036523
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0363383
GPHN gephyrin 0.0362506
KMT2C lysine (K)-specific methyltransferase 2C 0.0362192
SET SET nuclear proto-oncogene 0.0360499
TMF1 TATA element modulatory factor 1 0.0360328
MATR3 matrin 3 0.0359879
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0357627
ZC3H12B zinc finger CCCH-type containing 12B 0.0356611
RPS12 ribosomal protein S12 0.0355942
VCL vinculin 0.035122
CENPF centromere protein F, 350/400kDa 0.035092
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0350378
EXOC6B exocyst complex component 6B 0.0345691
KMT2E lysine (K)-specific methyltransferase 2E 0.0344645
WSB1 WD repeat and SOCS box containing 1 0.0341775
ASPH aspartate beta-hydroxylase 0.03413

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.155657
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0710843
TPT1 tumor protein, translationally-controlled 1 -0.0406394
VEGFA vascular endothelial growth factor A -0.0322488
PTMA prothymosin, alpha -0.0307728
WASF2 WAS protein family, member 2 -0.0252715
POTEF POTE ankyrin domain family, member F -0.0233608
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0233451
TMSB10 thymosin beta 10 -0.0221265
UBC ubiquitin C -0.0215174
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0209603
RPS25 ribosomal protein S25 -0.020425
RPS15 ribosomal protein S15 -0.018277
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0180763
ESYT2 extended synaptotagmin-like protein 2 -0.0176839
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0169701
HMGA1 high mobility group AT-hook 1 -0.0166826
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0166604
RPS23 ribosomal protein S23 -0.0164911
RPS29 ribosomal protein S29 -0.0148162
MRPS6 mitochondrial ribosomal protein S6 -0.0144939
CDCP1 CUB domain containing protein 1 -0.014385
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.014283
RPL8 ribosomal protein L8 -0.0141959
HLA-B major histocompatibility complex, class I, B -0.0141887
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0140957
PAQR5 progestin and adipoQ receptor family member V -0.0138641
PPARD peroxisome proliferator-activated receptor delta -0.0135141
GPC5 glypican 5 -0.0134307
S100A10 S100 calcium binding protein A10 -0.0133142
DOCK6 dedicator of cytokinesis 6 -0.0133027
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0126496
MCL1 myeloid cell leukemia 1 -0.0126166
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0123225
KCMF1 potassium channel modulatory factor 1 -0.0121372
RPL7A ribosomal protein L7a -0.0121022
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0119703
IGFBP4 insulin-like growth factor binding protein 4 -0.0117694
RPS13 ribosomal protein S13 -0.0117643
H2AZ1 H2A.Z variant histone 1 -0.0117411
HMGA2 high mobility group AT-hook 2 -0.0117232
TUBA1B tubulin, alpha 1b -0.0115272
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0114688
RPS11 ribosomal protein S11 -0.0114274
NRF1 nuclear respiratory factor 1 -0.0113327
RCC1 regulator of chromosome condensation 1 -0.0111876
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0111602
F3 coagulation factor III (thromboplastin, tissue factor) -0.0110864
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0110101
INTS6 integrator complex subunit 6 -0.0110071
EFHD2 EF-hand domain family, member D2 -0.0108849
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0108177
RAD23A RAD23 homolog A (S. cerevisiae) -0.0108093
WDR45B WD repeat domain 45B -0.0107653
KDM7A lysine (K)-specific demethylase 7A -0.0107253
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0106664
MNT MAX network transcriptional repressor -0.0106171
RPS21 ribosomal protein S21 -0.0104981
PSEN1 presenilin 1 -0.0104872
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0102576
VAT1 vesicle amine transport 1 -0.0102357
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0102321
BACE2 beta-site APP-cleaving enzyme 2 -0.0101861
ONECUT3 one cut homeobox 3 -0.0101097
VDAC1 voltage-dependent anion channel 1 -0.0100629
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0100552
PFKP phosphofructokinase, platelet -0.0100118
SH3BP4 SH3-domain binding protein 4 -0.0100071
UHMK1 U2AF homology motif (UHM) kinase 1 -0.00989762
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.00984298
FN1 fibronectin 1 -0.00973911
IGF2 insulin-like growth factor 2 -0.0095219
PFN1 profilin 1 -0.00951872
UFM1 ubiquitin-fold modifier 1 -0.00940418
NXN nucleoredoxin -0.00934265
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.00931291
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.00931134
AHNAK AHNAK nucleoprotein -0.00924309
FOXO3 forkhead box O3 -0.00923779
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.00919216
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.00912272
TPM2 tropomyosin 2 (beta) -0.0090562
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.00894095
ATP5F1B ATP synthase F1 subunit beta -0.00891988
CADPS Ca++-dependent secretion activator -0.00888938
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.00888444
GRID1 glutamate receptor, ionotropic, delta 1 -0.00879373
RLIM ring finger protein, LIM domain interacting -0.00877053
PRKG1 protein kinase, cGMP-dependent, type I -0.00874114
RPL38 ribosomal protein L38 -0.0087403
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -0.0087374
HOOK2 hook microtubule-tethering protein 2 -0.00869892
LRRC8A leucine rich repeat containing 8 family, member A -0.00867316
LYPD5 LY6/PLAUR domain containing 5 -0.00863211
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00861571
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0085217
SHISA5 shisa family member 5 -0.0084124
IST1 increased sodium tolerance 1 homolog (yeast) -0.00839924
GARRE1 granule associated Rac and RHOG effector 1 -0.00838656
MCM4 minichromosome maintenance complex component 4 -0.0083791