Nafamostat (mesylate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Nafamostat (mesylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.163011
RPL4 ribosomal protein L4 0.0882109
B2M beta-2-microglobulin 0.0842222
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0729682
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0671389
MKI67 marker of proliferation Ki-67 0.0664658
RPS12 ribosomal protein S12 0.053829
RPL26 ribosomal protein L26 0.0522653
RPS2 ribosomal protein S2 0.0508374
RPS3 ribosomal protein S3 0.0496631
RPL18 ribosomal protein L18 0.0486826
RPL12 ribosomal protein L12 0.0483066
MACROD2 MACRO domain containing 2 0.0482511
PRRC2C proline-rich coiled-coil 2C 0.0478817
SET SET nuclear proto-oncogene 0.0472062
VCL vinculin 0.0454278
RBM25 RNA binding motif protein 25 0.0444334
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0440719
RPL23 ribosomal protein L23 0.0425652
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0423684
RPS19 ribosomal protein S19 0.042353
RPL35 ribosomal protein L35 0.0422951
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0402856
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0401554
CENPF centromere protein F, 350/400kDa 0.0392866
ENO1 enolase 1, (alpha) 0.0387299
ANLN anillin, actin binding protein 0.0380759
EGR1 early growth response 1 0.0376939
HMGB2 high mobility group box 2 0.0374676
TPI1 triosephosphate isomerase 1 0.0362206
FTL ferritin, light polypeptide 0.0356938
CBX3 chromobox homolog 3 0.0356013
RBM39 RNA binding motif protein 39 0.0346188
RHEX regulator of hemoglobinization and erythroid cell expansion 0.0342686
RPL13A ribosomal protein L13a 0.033371
SON SON DNA binding protein 0.0333683
PTMA prothymosin, alpha 0.0332524
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0331014
PNN pinin, desmosome associated protein 0.0327363
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0315187
ARHGAP29 Rho GTPase activating protein 29 0.0313136
RPS8 ribosomal protein S8 0.0311194
SENP5 SUMO1/sentrin specific peptidase 5 0.0310064
NAP1L1 nucleosome assembly protein 1-like 1 0.030945
EIF4H eukaryotic translation initiation factor 4H 0.0307237
RPL36 ribosomal protein L36 0.0304602
ZNF292 zinc finger protein 292 0.0302842
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0302578
IPO7 importin 7 0.0301938
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.029114
NRIP1 nuclear receptor interacting protein 1 0.0289114
BICC1 BicC family RNA binding protein 1 0.0282854
RACK1 receptor for activated C kinase 1 0.0281533
RPL5 ribosomal protein L5 0.0281198
EIF5B eukaryotic translation initiation factor 5B 0.0278351
RPS15A ribosomal protein S15a 0.027583
RPS14 ribosomal protein S14 0.0275335
OGA O-GlcNAcase 0.0270327
IWS1 IWS1 homolog (S. cerevisiae) 0.0269767
GPX4 glutathione peroxidase 4 0.0269004
SRRM2 serine/arginine repetitive matrix 2 0.0268613
KDM5C lysine (K)-specific demethylase 5C 0.026567
MBD5 methyl-CpG binding domain protein 5 0.026231
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0261951
KAZN kazrin, periplakin interacting protein 0.0260509
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02586
FTH1 ferritin, heavy polypeptide 1 0.0257792
EIF1 eukaryotic translation initiation factor 1 0.0257744
SRRM1 serine/arginine repetitive matrix 1 0.0257588
RPS4X ribosomal protein S4, X-linked 0.0257287
KIF5B kinesin family member 5B 0.0254985
RPS5 ribosomal protein S5 0.0251414
RPL14 ribosomal protein L14 0.0251279
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0250686
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0243949
MATR3 matrin 3 0.0243144
TMSB4X thymosin beta 4, X-linked 0.0242319
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0241919
ITGB8 integrin, beta 8 0.0241523
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0240211
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0239793
EZR ezrin 0.0235051
RAD21 RAD21 homolog (S. pombe) 0.0232418
UBE3A ubiquitin protein ligase E3A 0.0229377
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0229248
UTRN utrophin 0.0226894
OXR1 oxidation resistance 1 0.0222819
BICD1 bicaudal D homolog 1 (Drosophila) 0.0222474
RSRC2 arginine/serine-rich coiled-coil 2 0.0217144
HP1BP3 heterochromatin protein 1, binding protein 3 0.0216968
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0215147
SKP1 S-phase kinase-associated protein 1 0.0214475
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0214103
SPIDR scaffolding protein involved in DNA repair 0.0213664
H1-0 H1.0 linker histone 0.021116
ASPH aspartate beta-hydroxylase 0.0210809
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0206965
PLS3 plastin 3 0.0205874
TXNRD1 thioredoxin reductase 1 0.020542
DHFR dihydrofolate reductase 0.0203419

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.290741
NDRG1 N-myc downstream regulated 1 -0.203893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.13967
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0932374
FNDC3B fibronectin type III domain containing 3B -0.0918497
POTEF POTE ankyrin domain family, member F -0.0876581
FLNB filamin B, beta -0.0797295
LAMB3 laminin, beta 3 -0.0775646
TPM4 tropomyosin 4 -0.0732339
ANXA2 annexin A2 -0.0677491
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0656691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0645459
ACTG1 actin gamma 1 -0.0609772
IARS1 isoleucyl-tRNA synthetase 1 -0.0596945
HMGA1 high mobility group AT-hook 1 -0.0591873
AHNAK AHNAK nucleoprotein -0.0551471
CD44 CD44 molecule (Indian blood group) -0.0548483
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0546188
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0539993
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0524009
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0518117
LAMA4 laminin, alpha 4 -0.0514446
PDIA3 protein disulfide isomerase family A, member 3 -0.0510772
MT2A metallothionein 2A -0.0507748
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0487116
LAMC2 laminin, gamma 2 -0.0475355
S100A10 S100 calcium binding protein A10 -0.0435046
IGFBP3 insulin-like growth factor binding protein 3 -0.0431493
TPT1 tumor protein, translationally-controlled 1 -0.0423708
CDCP1 CUB domain containing protein 1 -0.041112
ITGA6 integrin, alpha 6 -0.0409959
TAOK1 TAO kinase 1 -0.0407829
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0407022
KRT7 keratin 7, type II -0.0405374
EGFR epidermal growth factor receptor -0.0404403
BPTF bromodomain PHD finger transcription factor -0.0377268
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0371048
PATJ PATJ crumbs cell polarity complex component -0.0369646
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0364163
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0363398
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0360275
PKM pyruvate kinase, muscle -0.0355603
DSG2 desmoglein 2 -0.035281
HMGA2 high mobility group AT-hook 2 -0.0351965
VDAC1 voltage-dependent anion channel 1 -0.0345917
CANX calnexin -0.0344115
ZNF609 zinc finger protein 609 -0.0342657
LDHA lactate dehydrogenase A -0.0334914
TMSB10 thymosin beta 10 -0.0329047
EMP1 epithelial membrane protein 1 -0.0327911
ANKRD11 ankyrin repeat domain 11 -0.0324721
SETD5 SET domain containing 5 -0.0323851
CAPN2 calpain 2, (m/II) large subunit -0.0321953
UPP1 uridine phosphorylase 1 -0.0320589
DLC1 DLC1 Rho GTPase activating protein -0.0319206
HSPG2 heparan sulfate proteoglycan 2 -0.0316162
PAX8 paired box 8 -0.0314966
AKAP12 A kinase (PRKA) anchor protein 12 -0.0313773
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.03093
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.030815
F3 coagulation factor III (thromboplastin, tissue factor) -0.0301247
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0301197
MAP4 microtubule-associated protein 4 -0.0299486
TTC3 tetratricopeptide repeat domain 3 -0.0298368
TPD52 tumor protein D52 -0.0297031
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0296121
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.029267
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0289444
AFF1 AF4/FMR2 family, member 1 -0.0286969
FNIP1 folliculin interacting protein 1 -0.0281767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0281397
SH3KBP1 SH3-domain kinase binding protein 1 -0.0277879
TIMP2 TIMP metallopeptidase inhibitor 2 -0.02761
TRIO trio Rho guanine nucleotide exchange factor -0.0268206
RAP1B RAP1B, member of RAS oncogene family -0.0266889
KRT19 keratin 19, type I -0.0266746
RPS15 ribosomal protein S15 -0.0266521
WASF2 WAS protein family, member 2 -0.0263934
FBXL2 F-box and leucine-rich repeat protein 2 -0.0263853
MBNL2 muscleblind-like splicing regulator 2 -0.0259704
GARS1 glycyl-tRNA synthetase 1 -0.0256515
SEC31A SEC31 homolog A (S. cerevisiae) -0.0253643
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0253102
RHOA ras homolog family member A -0.0251664
SMAD3 SMAD family member 3 -0.0247078
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0246435
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0246055
ANK2 ankyrin 2, neuronal -0.0244362
UBE2H ubiquitin-conjugating enzyme E2H -0.0244271
RPL7A ribosomal protein L7a -0.0243298
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -0.0243095
THSD4 thrombospondin, type I, domain containing 4 -0.0240785
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0240538
ANXA1 annexin A1 -0.0239214
ARFGEF3 ARFGEF family member 3 -0.0238342
MAML2 mastermind-like 2 (Drosophila) -0.0237326
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0235864
FNBP1L formin binding protein 1-like -0.0231257
CARD11 caspase recruitment domain family, member 11 -0.0230906
ESYT2 extended synaptotagmin-like protein 2 -0.0226937