Nafamostat (mesylate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.165137
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0922415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0755676
PTMA prothymosin, alpha 0.0742235
ENO1 enolase 1, (alpha) 0.0727307
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0726154
EIF1 eukaryotic translation initiation factor 1 0.0684466
RPS8 ribosomal protein S8 0.0675755
RPS6 ribosomal protein S6 0.0622997
TMSB10 thymosin beta 10 0.0589005
RPS2 ribosomal protein S2 0.0547478
B2M beta-2-microglobulin 0.0545487
FTL ferritin, light polypeptide 0.0544916
FTH1 ferritin, heavy polypeptide 1 0.0523941
RPL12 ribosomal protein L12 0.0508863
RPL26 ribosomal protein L26 0.050067
RPL35A ribosomal protein L35a 0.0491775
RPL23 ribosomal protein L23 0.0475642
CALR calreticulin 0.0442097
RPS3 ribosomal protein S3 0.0436751
RPS12 ribosomal protein S12 0.0428381
HLA-A major histocompatibility complex, class I, A 0.0421555
RACK1 receptor for activated C kinase 1 0.042023
RPL4 ribosomal protein L4 0.0415591
IFI6 interferon, alpha-inducible protein 6 0.0396066
RPL37A ribosomal protein L37a 0.0388042
RPS19 ribosomal protein S19 0.0385867
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0367865
RPL18 ribosomal protein L18 0.0359948
VIM vimentin 0.0358868
RPL5 ribosomal protein L5 0.0356846
LGALS1 lectin, galactoside-binding, soluble, 1 0.0354748
RPL36 ribosomal protein L36 0.0352881
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0337687
RPLP1 ribosomal protein, large, P1 0.0330092
HLA-B major histocompatibility complex, class I, B 0.0322676
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0317095
IGFBP7 insulin-like growth factor binding protein 7 0.0316403
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313517
RPL11 ribosomal protein L11 0.0311053
RPL19 ribosomal protein L19 0.0303502
CSF1 colony stimulating factor 1 (macrophage) 0.0300791
S100A9 S100 calcium binding protein A9 0.0299689
RPL30 ribosomal protein L30 0.0283932
NAP1L1 nucleosome assembly protein 1-like 1 0.0281861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0277945
RPL13A ribosomal protein L13a 0.0263619
RPLP2 ribosomal protein, large, P2 0.0262798
RPS20 ribosomal protein S20 0.0260725
RPS27A ribosomal protein S27a 0.0245897
HIPK2 homeodomain interacting protein kinase 2 0.0245518
NFE2L1 nuclear factor, erythroid 2-like 1 0.0241207
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023908
YBX1 Y box binding protein 1 0.0236508
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0232694
RPS14 ribosomal protein S14 0.0231777
IER3 immediate early response 3 0.0231069
WWTR1 WW domain containing transcription regulator 1 0.0229071
RPL34 ribosomal protein L34 0.0221634
RPL35 ribosomal protein L35 0.0218665
SP100 SP100 nuclear antigen 0.0217276
RPL31 ribosomal protein L31 0.0213991
LOC112694756 uncharaterized LOC112694756 0.0212881
RPL7 ribosomal protein L7 0.0209349
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0208774
TMSB4X thymosin beta 4, X-linked 0.0206111
RPL37 ribosomal protein L37 0.0205474
PRRC2C proline-rich coiled-coil 2C 0.0205358
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0203722
RPL9 ribosomal protein L9 0.0203512
RPS17 ribosomal protein S17 0.0203512
ALCAM activated leukocyte cell adhesion molecule 0.0201303
VCL vinculin 0.0201102
RPS5 ribosomal protein S5 0.0200633
RRBP1 ribosome binding protein 1 0.0200257
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0199751
EGR1 early growth response 1 0.0199624
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0196842
NAMPT nicotinamide phosphoribosyltransferase 0.01952
IFITM3 interferon induced transmembrane protein 3 0.0194186
SQSTM1 sequestosome 1 0.0193297
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192464
ATF4 activating transcription factor 4 0.0187149
SKP1 S-phase kinase-associated protein 1 0.0186398
NACA nascent polypeptide-associated complex alpha subunit 0.0182191
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0180777
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0178117
HMGB2 high mobility group box 2 0.0176852
RPS27 ribosomal protein S27 0.0174932
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0173296
ACTG1 actin gamma 1 0.0170578
ANGPTL4 angiopoietin-like 4 0.0170474
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0166782
RPL32 ribosomal protein L32 0.0163633
HMGN2 high mobility group nucleosomal binding domain 2 0.0163117
TPT1 tumor protein, translationally-controlled 1 0.0162483
OAZ1 ornithine decarboxylase antizyme 1 0.015932
SET SET nuclear proto-oncogene 0.0156613
PNRC1 proline-rich nuclear receptor coactivator 1 0.0154562
RPS18 ribosomal protein S18 0.0154112

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.532453
IGFBP3 insulin-like growth factor binding protein 3 -0.271089
NDRG1 N-myc downstream regulated 1 -0.264545
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.148436
COL6A3 collagen, type VI, alpha 3 -0.132722
COL1A2 collagen, type I, alpha 2 -0.119593
FBN1 fibrillin 1 -0.083073
ATP13A3 ATPase type 13A3 -0.0781897
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0740711
VEGFA vascular endothelial growth factor A -0.0595432
PDE10A phosphodiesterase 10A -0.0559821
LOXL2 lysyl oxidase-like 2 -0.0544241
LOX lysyl oxidase -0.0539731
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0529034
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0508314
TRIO trio Rho guanine nucleotide exchange factor -0.0483361
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0481557
EXT1 exostosin glycosyltransferase 1 -0.0471359
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0466375
COL6A1 collagen, type VI, alpha 1 -0.0459699
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0435229
CADM1 cell adhesion molecule 1 -0.0399511
POSTN periostin, osteoblast specific factor -0.0376886
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.036699
MRPS6 mitochondrial ribosomal protein S6 -0.0365998
FNDC3B fibronectin type III domain containing 3B -0.0362653
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.034726
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0324409
F3 coagulation factor III (thromboplastin, tissue factor) -0.0313811
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0310537
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0303393
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0297934
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0296099
TRAM1 translocation associated membrane protein 1 -0.0287993
TMEM165 transmembrane protein 165 -0.0274999
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0272093
EHD2 EH-domain containing 2 -0.0266754
CDH13 cadherin 13 -0.0266693
COL1A1 collagen, type I, alpha 1 -0.0266456
CLMP CXADR-like membrane protein -0.0262879
WASF2 WAS protein family, member 2 -0.025921
CD109 CD109 molecule -0.0258614
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0257793
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0256686
PDIA3 protein disulfide isomerase family A, member 3 -0.0256569
MAP1B microtubule-associated protein 1B -0.0255978
DPYD dihydropyrimidine dehydrogenase -0.0253421
PTK2 protein tyrosine kinase 2 -0.0252158
LMAN1 lectin, mannose-binding, 1 -0.0240641
DPYSL2 dihydropyrimidinase-like 2 -0.0237536
SETD5 SET domain containing 5 -0.0234563
UBC ubiquitin C -0.023126
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.022829
RAB1A RAB1A, member RAS oncogene family -0.0222232
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0221637
KCTD9 potassium channel tetramerization domain containing 9 -0.0218951
ANTXR2 anthrax toxin receptor 2 -0.0217343
ELL2 elongation factor, RNA polymerase II, 2 -0.021584
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0215235
TTC3 tetratricopeptide repeat domain 3 -0.0214673
ADAM9 ADAM metallopeptidase domain 9 -0.0213995
MRTFA myocardin related transcription factor A -0.0212369
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0211378
PRRC1 proline-rich coiled-coil 1 -0.0210618
TGFBI transforming growth factor, beta-induced, 68kDa -0.0210442
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0208506
ITCH itchy E3 ubiquitin protein ligase -0.0208133
DLG1 discs, large homolog 1 (Drosophila) -0.0206228
CMIP c-Maf inducing protein -0.0205638
TBC1D23 TBC1 domain family, member 23 -0.0205224
KDM7A lysine (K)-specific demethylase 7A -0.0204328
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0204119
TM4SF1 transmembrane 4 L six family member 1 -0.0202271
GOLGA4 golgin A4 -0.020172
TAOK1 TAO kinase 1 -0.0199944
HMCN1 hemicentin 1 -0.0199126
CYB5R3 cytochrome b5 reductase 3 -0.0198308
COG5 component of oligomeric golgi complex 5 -0.019824
STC1 stanniocalcin 1 -0.0197255
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0195143
PSD3 pleckstrin and Sec7 domain containing 3 -0.0194202
SBF2 SET binding factor 2 -0.0194196
ADAM17 ADAM metallopeptidase domain 17 -0.0193433
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0190553
KMT2C lysine (K)-specific methyltransferase 2C -0.0186079
EVI5 ecotropic viral integration site 5 -0.0185869
BIRC6 baculoviral IAP repeat containing 6 -0.0183449
BBX bobby sox homolog (Drosophila) -0.0182707
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0182286
PDE8A phosphodiesterase 8A -0.0182125
KIF13A kinesin family member 13A -0.0181965
DPYSL3 dihydropyrimidinase-like 3 -0.0178903
JARID2 jumonji, AT rich interactive domain 2 -0.017879
COPA coatomer protein complex, subunit alpha -0.017852
SKIC3 SKI3 subunit of superkiller complex -0.0177566
SEC31A SEC31 homolog A (S. cerevisiae) -0.0177326
GLG1 golgi glycoprotein 1 -0.0175561
COL5A1 collagen, type V, alpha 1 -0.0175396
DST dystonin -0.0174465
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0173679