Nafamostat (mesylate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I 0.126368
PTMA prothymosin, alpha 0.0879587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0862263
ENO1 enolase 1, (alpha) 0.0785704
RPS2 ribosomal protein S2 0.0675831
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0653789
TMSB10 thymosin beta 10 0.0628807
EZR ezrin 0.0615424
LMNA lamin A/C 0.0529675
RPS3 ribosomal protein S3 0.0497587
EIF1 eukaryotic translation initiation factor 1 0.0490576
RPS6 ribosomal protein S6 0.048224
EGR1 early growth response 1 0.04672
RPL4 ribosomal protein L4 0.0466909
B2M beta-2-microglobulin 0.0463106
KRT14 keratin 14, type I 0.0461177
FTH1 ferritin, heavy polypeptide 1 0.0432426
EEF2 eukaryotic translation elongation factor 2 0.0423969
RPS12 ribosomal protein S12 0.0423594
LOC112694756 uncharaterized LOC112694756 0.0422211
SQSTM1 sequestosome 1 0.0412609
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0400729
PRRC2C proline-rich coiled-coil 2C 0.0400316
RACK1 receptor for activated C kinase 1 0.0397146
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0390798
ANXA1 annexin A1 0.0388612
SET SET nuclear proto-oncogene 0.0385521
HLA-A major histocompatibility complex, class I, A 0.0366341
KTN1 kinectin 1 (kinesin receptor) 0.0363395
RPL37 ribosomal protein L37 0.0362857
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0361526
RPL37A ribosomal protein L37a 0.0353842
RBM39 RNA binding motif protein 39 0.0340397
APLP2 amyloid beta (A4) precursor-like protein 2 0.0340307
MT2A metallothionein 2A 0.033104
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0326376
GOLGA4 golgin A4 0.032236
SRRM2 serine/arginine repetitive matrix 2 0.0303478
TPM3 tropomyosin 3 0.0287238
RPL5 ribosomal protein L5 0.0283043
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0282783
RPL12 ribosomal protein L12 0.0282735
BHLHE40 basic helix-loop-helix family, member e40 0.0279524
CALR calreticulin 0.026487
LIMA1 LIM domain and actin binding 1 0.0263405
RPL18 ribosomal protein L18 0.0257449
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0257185
TLN1 talin 1 0.0256074
IFITM1 interferon induced transmembrane protein 1 0.0252726
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0251761
RPS8 ribosomal protein S8 0.0251337
GUK1 guanylate kinase 1 0.0249746
ATF4 activating transcription factor 4 0.0249421
RPS27 ribosomal protein S27 0.0247482
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0243286
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0242393
ITGB4 integrin, beta 4 0.0237928
CNRIP1 cannabinoid receptor interacting protein 1 0.0235876
S100A11 S100 calcium binding protein A11 0.0235745
RPL13A ribosomal protein L13a 0.0234756
FTL ferritin, light polypeptide 0.0231993
HSPG2 heparan sulfate proteoglycan 2 0.0230716
SRRM1 serine/arginine repetitive matrix 1 0.0229747
RSRC2 arginine/serine-rich coiled-coil 2 0.0228898
ENO2 enolase 2 (gamma, neuronal) 0.0228405
TMSB4X thymosin beta 4, X-linked 0.0227342
DHFR dihydrofolate reductase 0.0226378
RPS17 ribosomal protein S17 0.0225528
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0223351
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0223318
ANGPTL4 angiopoietin-like 4 0.022243
RPL36 ribosomal protein L36 0.0221464
KPNB1 karyopherin (importin) beta 1 0.0220667
RPL30 ribosomal protein L30 0.021822
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0217962
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0214192
BRD2 bromodomain containing 2 0.0210017
NUCB2 nucleobindin 2 0.0208239
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207724
VIM vimentin 0.0206527
BCL9L B-cell CLL/lymphoma 9-like 0.0205747
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0203003
FLNA filamin A, alpha 0.0199302
IFITM3 interferon induced transmembrane protein 3 0.0199276
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0196422
KRT5 keratin 5, type II 0.0195573
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0195375
TPR translocated promoter region, nuclear basket protein 0.019406
PFN1 profilin 1 0.019359
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0193505
TMF1 TATA element modulatory factor 1 0.0192712
HMGN2 high mobility group nucleosomal binding domain 2 0.0189571
S100A2 S100 calcium binding protein A2 0.0189062
RPS14 ribosomal protein S14 0.018599
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0184915
RPL26 ribosomal protein L26 0.0183424
RPS18 ribosomal protein S18 0.0183295
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0183179
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0183109
RPS15A ribosomal protein S15a 0.0182383

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.228255
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168109
AHNAK AHNAK nucleoprotein -0.146622
TPT1 tumor protein, translationally-controlled 1 -0.0883906
DPYD dihydropyrimidine dehydrogenase -0.0732133
MYOF myoferlin -0.0682644
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0652951
MTSS1 metastasis suppressor 1 -0.0632566
STC1 stanniocalcin 1 -0.063209
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0630977
PTK2 protein tyrosine kinase 2 -0.0628168
NAMPT nicotinamide phosphoribosyltransferase -0.0563412
CUL4B cullin 4B -0.0543271
GRB10 growth factor receptor-bound protein 10 -0.0487722
FOXP1 forkhead box P1 -0.048459
RPS21 ribosomal protein S21 -0.0484052
RAI14 retinoic acid induced 14 -0.0467065
NDRG1 N-myc downstream regulated 1 -0.0457154
SULF1 sulfatase 1 -0.0453612
MEF2A myocyte enhancer factor 2A -0.0438595
PDE4D phosphodiesterase 4D, cAMP-specific -0.0432174
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0422573
BCAR3 breast cancer anti-estrogen resistance 3 -0.0409386
NEK7 NIMA-related kinase 7 -0.039539
EXT1 exostosin glycosyltransferase 1 -0.0394553
FNDC3B fibronectin type III domain containing 3B -0.0389694
CAV1 caveolin 1, caveolae protein, 22kDa -0.03849
RABGAP1L RAB GTPase activating protein 1-like -0.0376515
PRELID2 PRELI domain containing 2 -0.0372952
UBE2H ubiquitin-conjugating enzyme E2H -0.037201
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0368569
OSMR oncostatin M receptor -0.0360767
SLC45A4 solute carrier family 45, member 4 -0.0357601
KIAA1217 KIAA1217 -0.0356644
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0344911
AKAP13 A kinase (PRKA) anchor protein 13 -0.0341698
NRIP1 nuclear receptor interacting protein 1 -0.0341107
FNDC3A fibronectin type III domain containing 3A -0.0337544
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0336834
STAU1 staufen double-stranded RNA binding protein 1 -0.0335455
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0333622
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0328884
FNIP1 folliculin interacting protein 1 -0.0326185
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0323403
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0320688
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.03174
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0316679
PSD3 pleckstrin and Sec7 domain containing 3 -0.0316037
SAMD9 sterile alpha motif domain containing 9 -0.0313965
FLNB filamin B, beta -0.0312706
FOXO1 forkhead box O1 -0.0311178
RPS24 ribosomal protein S24 -0.0310714
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0307748
MAML2 mastermind-like 2 (Drosophila) -0.030735
SLC35F3 solute carrier family 35, member F3 -0.030438
S100A10 S100 calcium binding protein A10 -0.0301255
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0300232
RAD51B RAD51 paralog B -0.0296971
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0295983
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0292367
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0292365
EXOC4 exocyst complex component 4 -0.0288871
DENND4C DENN/MADD domain containing 4C -0.0286243
ITGA6 integrin, alpha 6 -0.0285518
VDAC1 voltage-dependent anion channel 1 -0.0283463
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0282332
CEMIP cell migration inducing protein, hyaluronan binding -0.028187
INTS6 integrator complex subunit 6 -0.028157
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0281541
RPS25 ribosomal protein S25 -0.028045
CLU clusterin -0.0277113
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0276774
UBC ubiquitin C -0.0273979
MYO10 myosin X -0.0273921
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.027219
SLC38A2 solute carrier family 38, member 2 -0.0271918
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0267429
RPLP0 ribosomal protein, large, P0 -0.0266686
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0265248
LMO7 LIM domain 7 -0.026497
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0258027
BMAL2 basic helix-loop-helix ARNT like 2 -0.0257796
DGKH diacylglycerol kinase, eta -0.0257391
RAB1A RAB1A, member RAS oncogene family -0.0256453
DOCK4 dedicator of cytokinesis 4 -0.0256034
DLG1 discs, large homolog 1 (Drosophila) -0.02542
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.025404
POTEF POTE ankyrin domain family, member F -0.0253999
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0251131
ADAM10 ADAM metallopeptidase domain 10 -0.0250006
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0249832
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0247846
EFNA5 ephrin-A5 -0.0247661
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0247082
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0247047
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0246339
RPS23 ribosomal protein S23 -0.0245831
MACF1 microtubule-actin crosslinking factor 1 -0.0245322
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0244219
RPL8 ribosomal protein L8 -0.0242239