Nafamostat (mesylate)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0905635
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.064936
POTEF POTE ankyrin domain family, member F 0.0616918
BCL2L1 BCL2-like 1 0.0519829
CLDN4 claudin 4 0.0480838
FLNB filamin B, beta 0.0466011
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0459218
C6ORF132 chromosome 6 open reading frame 132 0.0449058
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0417897
TJP1 tight junction protein 1 0.04117
JUP junction plakoglobin 0.0381552
LOC102724023 ES1 protein homolog, mitochondrial 0.0353462
EGR1 early growth response 1 0.0344712
ANXA11 annexin A11 0.0312159
MYOF myoferlin 0.0310714
STK24 serine/threonine kinase 24 0.0296144
SH3RF1 SH3 domain containing ring finger 1 0.0292512
WWC1 WW and C2 domain containing 1 0.0262669
AREG amphiregulin 0.0261771
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0259788
CCNL1 cyclin L1 0.0258879
PCBP2 poly(rC) binding protein 2 0.0247905
LIPH lipase, member H 0.0247404
IFI27 interferon, alpha-inducible protein 27 0.0245192
ASPH aspartate beta-hydroxylase 0.0242385
RBM47 RNA binding motif protein 47 0.0236728
RPL4 ribosomal protein L4 0.0236359
SRRM2 serine/arginine repetitive matrix 2 0.0230174
MUC1 mucin 1, cell surface associated 0.0230012
LAMA4 laminin, alpha 4 0.0226931
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0226048
VMP1 vacuole membrane protein 1 0.0221613
PRSS3 protease, serine, 3 0.0215209
MACC1 metastasis associated in colon cancer 1 0.0209966
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0208178
UGCG UDP-glucose ceramide glucosyltransferase 0.0204678
MYO1E myosin IE 0.0202264
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0200505
PLSCR1 phospholipid scramblase 1 0.019956
FOSL1 FOS-like antigen 1 0.0197483
HYOU1 hypoxia up-regulated 1 0.0193153
SEPTIN9 septin 9 0.0191621
APLP2 amyloid beta (A4) precursor-like protein 2 0.0184169
TNRC18 trinucleotide repeat containing 18 0.0180541
LIMA1 LIM domain and actin binding 1 0.0179974
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0178642
ADGRF1 adhesion G protein-coupled receptor F1 0.0175404
PCDH1 protocadherin 1 0.0171443
ZFP36L2 ZFP36 ring finger protein-like 2 0.0171059
ATF4 activating transcription factor 4 0.0168503
NECTIN2 nectin cell adhesion molecule 2 0.0166631
CAPN8 calpain 8 0.0165509
MPRIP myosin phosphatase Rho interacting protein 0.0164556
PLEC plectin 0.0164081
ARHGAP26 Rho GTPase activating protein 26 0.0162494
EZR ezrin 0.0162478
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0158981
DIAPH1 diaphanous-related formin 1 0.0158778
SLC38A2 solute carrier family 38, member 2 0.0156099
EDN1 endothelin 1 0.01545
BCL9L B-cell CLL/lymphoma 9-like 0.015445
ITPKC inositol-trisphosphate 3-kinase C 0.0152987
AKAP13 A kinase (PRKA) anchor protein 13 0.0152401
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0151524
VEGFA vascular endothelial growth factor A 0.0150956
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0150832
SMAD3 SMAD family member 3 0.0149487
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0149009
CLDN7 claudin 7 0.0148952
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.014764
PFN1 profilin 1 0.0147408
LYZ lysozyme 0.0146047
LMO7 LIM domain 7 0.0144108
NCEH1 neutral cholesterol ester hydrolase 1 0.0141603
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0140861
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.0140265
MCU mitochondrial calcium uniporter 0.0139093
ARHGAP42 Rho GTPase activating protein 42 0.0137772
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0136783
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0136776
PTBP3 polypyrimidine tract binding protein 3 0.0136611
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0136235
MCL1 myeloid cell leukemia 1 0.013601
ITGA6 integrin, alpha 6 0.0135838
CAPN5 calpain 5 0.0135433
TNS4 tensin 4 0.0134238
NFE2L1 nuclear factor, erythroid 2-like 1 0.0133773
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0130484
TRIM31 tripartite motif containing 31 0.0130006
DSPP dentin sialophosphoprotein 0.0127033
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0126888
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0126677
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0125513
HDAC9 histone deacetylase 9 0.0125184
TTYH3 tweety family member 3 0.0125075
TGFA transforming growth factor, alpha 0.0124898
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 0.012467
RPS18 ribosomal protein S18 0.0123513
EPHA2 EPH receptor A2 0.0122185
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0121206

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.42436
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.212529
TPT1 tumor protein, translationally-controlled 1 -0.120284
AGR2 anterior gradient 2 -0.0881083
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0813514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.068667
PGK1 phosphoglycerate kinase 1 -0.0677247
PTMA prothymosin, alpha -0.0591503
NPSR1 neuropeptide S receptor 1 -0.0579377
AHNAK AHNAK nucleoprotein -0.0573861
KDM3A lysine (K)-specific demethylase 3A -0.0546046
CANX calnexin -0.0530743
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.05197
CEMIP cell migration inducing protein, hyaluronan binding -0.0515494
WDR45B WD repeat domain 45B -0.0494327
ANXA2 annexin A2 -0.049198
EPCAM epithelial cell adhesion molecule -0.0478517
FTL ferritin, light polypeptide -0.0471671
CDK6 cyclin-dependent kinase 6 -0.0458512
RPL35A ribosomal protein L35a -0.0446583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0439227
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.04155
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0407591
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0405603
IARS1 isoleucyl-tRNA synthetase 1 -0.0400924
RAB1A RAB1A, member RAS oncogene family -0.0394487
TMEM123 transmembrane protein 123 -0.039357
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0389687
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0388531
MBNL2 muscleblind-like splicing regulator 2 -0.0387082
HLA-C major histocompatibility complex, class I, C -0.0372202
TFRC transferrin receptor -0.0362195
SLC38A1 solute carrier family 38, member 1 -0.0357698
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0341165
KRT18 keratin 18, type I -0.0336554
RSL1D1 ribosomal L1 domain containing 1 -0.0330928
RPS25 ribosomal protein S25 -0.0329089
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0327448
RPL38 ribosomal protein L38 -0.0314468
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0313405
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0307817
RPLP1 ribosomal protein, large, P1 -0.0306805
MAML2 mastermind-like 2 (Drosophila) -0.0304117
HLA-E major histocompatibility complex, class I, E -0.0294387
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0293598
TMSB4X thymosin beta 4, X-linked -0.0286887
RPL34 ribosomal protein L34 -0.0286673
NDRG1 N-myc downstream regulated 1 -0.028308
TRPS1 trichorhinophalangeal syndrome I -0.0281714
DSG2 desmoglein 2 -0.028151
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0281445
ATF5 activating transcription factor 5 -0.0279632
EMP1 epithelial membrane protein 1 -0.0276518
AGR3 anterior gradient 3 -0.0275749
KLF5 Kruppel-like factor 5 (intestinal) -0.027444
RPS8 ribosomal protein S8 -0.0273025
RPL19 ribosomal protein L19 -0.0271678
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0270768
ACACA acetyl-CoA carboxylase alpha -0.0267401
PDIA3 protein disulfide isomerase family A, member 3 -0.0267368
KPNB1 karyopherin (importin) beta 1 -0.0265767
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0264548
CCDC47 coiled-coil domain containing 47 -0.0264327
GOLGA4 golgin A4 -0.0262934
EHBP1 EH domain binding protein 1 -0.0260979
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0260482
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0258856
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0257999
MORF4L2 mortality factor 4 like 2 -0.0255893
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025339
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0252688
UBB ubiquitin B -0.0247597
RAB2A RAB2A, member RAS oncogene family -0.0245912
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0243558
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0242315
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.023963
NFIA nuclear factor I/A -0.0239192
RTN3 reticulon 3 -0.0237693
FRMD5 FERM domain containing 5 -0.0232848
SUN1 Sad1 and UNC84 domain containing 1 -0.0232779
AOPEP aminopeptidase O (putative) -0.023056
ADD3 adducin 3 (gamma) -0.022998
RPS24 ribosomal protein S24 -0.0229796
KLHL29 kelch-like family member 29 -0.0229476
H1-0 H1.0 linker histone -0.0227602
BACE2 beta-site APP-cleaving enzyme 2 -0.022624
RPS27A ribosomal protein S27a -0.0223679
ZMYND8 zinc finger, MYND-type containing 8 -0.0221236
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0220714
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0215314
GMDS GDP-mannose 4,6-dehydratase -0.0212786
TTC3 tetratricopeptide repeat domain 3 -0.0211343
STAU1 staufen double-stranded RNA binding protein 1 -0.0208753
CCND1 cyclin D1 -0.0208488
LOC112694756 uncharaterized LOC112694756 -0.0204415
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0204265
RNF43 ring finger protein 43 -0.0202623
HDLBP high density lipoprotein binding protein -0.0201722
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0201279
RPL36A ribosomal protein L36a -0.0200749