Nafamostat (mesylate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0548106
DSPP dentin sialophosphoprotein 0.0531928
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0511891
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0484078
DSCAM Down syndrome cell adhesion molecule 0.043019
RPL4 ribosomal protein L4 0.0374665
EZR ezrin 0.0355936
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0339202
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0306847
PDIA4 protein disulfide isomerase family A, member 4 0.0305101
OGA O-GlcNAcase 0.0301123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0294123
RBM39 RNA binding motif protein 39 0.0293717
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0286106
RNF43 ring finger protein 43 0.0283501
ITGA6 integrin, alpha 6 0.0282722
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0278406
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0258324
FTH1 ferritin, heavy polypeptide 1 0.0255808
TNS4 tensin 4 0.0245718
ZNF292 zinc finger protein 292 0.0239709
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0213659
RPS2 ribosomal protein S2 0.0209564
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0205589
CANX calnexin 0.0202902
LMO7 LIM domain 7 0.0197793
EREG epiregulin 0.0197017
EHF ets homologous factor 0.0195426
NEBL nebulette 0.0195133
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0193102
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.019233
PRRC2C proline-rich coiled-coil 2C 0.0192096
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0189959
FAT1 FAT atypical cadherin 1 0.0187848
KDM3A lysine (K)-specific demethylase 3A 0.0183152
CLCN3 chloride channel, voltage-sensitive 3 0.0183122
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0182979
SOX9 SRY (sex determining region Y)-box 9 0.0178071
PRELID2 PRELI domain containing 2 0.017524
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0173708
H1-0 H1.0 linker histone 0.0172034
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0170794
CEMIP2 cell migration inducing hyaluronidase 2 0.0170209
HDLBP high density lipoprotein binding protein 0.0170116
KIF5B kinesin family member 5B 0.0169306
ATXN1 ataxin 1 0.0168829
TRIM2 tripartite motif containing 2 0.0165923
DERA deoxyribose-phosphate aldolase (putative) 0.0165041
USP6NL USP6 N-terminal like 0.0163877
GOLGA4 golgin A4 0.0162276
EEF2 eukaryotic translation elongation factor 2 0.0161021
RBM25 RNA binding motif protein 25 0.0160589
NEK7 NIMA-related kinase 7 0.0159419
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.015322
EIF4B eukaryotic translation initiation factor 4B 0.0151398
SET SET nuclear proto-oncogene 0.0149506
SHROOM3 shroom family member 3 0.0147406
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0147217
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0146549
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0145529
ARHGAP32 Rho GTPase activating protein 32 0.0145509
TPM3 tropomyosin 3 0.0145389
TBC1D5 TBC1 domain family, member 5 0.0143782
SPRED1 sprouty-related, EVH1 domain containing 1 0.0143675
RPS18 ribosomal protein S18 0.0142568
PTPRR protein tyrosine phosphatase, receptor type, R 0.0141669
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0140736
PDZD8 PDZ domain containing 8 0.0139609
TM9SF3 transmembrane 9 superfamily member 3 0.0138292
PCDHB16 protocadherin beta 16 0.0137002
CADPS Ca++-dependent secretion activator 0.0134462
NIPBL Nipped-B homolog (Drosophila) 0.0134442
MED13L mediator complex subunit 13-like 0.0133918
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0132603
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0132415
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0131782
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0130238
EPCAM epithelial cell adhesion molecule 0.0128796
MON2 MON2 homolog (S. cerevisiae) 0.0128545
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0128136
SRRM1 serine/arginine repetitive matrix 1 0.0128108
GAK cyclin G associated kinase 0.0127847
PTEN phosphatase and tensin homolog 0.012675
EXOC1 exocyst complex component 1 0.0125796
SHB Src homology 2 domain containing adaptor protein B 0.0123964
CUL3 cullin 3 0.0122878
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.012194
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0121826
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0121536
PTBP3 polypyrimidine tract binding protein 3 0.0121356
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0121092
PCM1 pericentriolar material 1 0.0120983
CSNK1A1 casein kinase 1, alpha 1 0.0118925
RPL18 ribosomal protein L18 0.0117585
GIGYF2 GRB10 interacting GYF protein 2 0.0117421
ETNK1 ethanolamine kinase 1 0.0117384
ARB2A ARB2 cotranscriptional regulator A 0.0116702
ARL15 ADP-ribosylation factor-like 15 0.0116182
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0115846
RRBP1 ribosome binding protein 1 0.011582

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147143
TMSB10 thymosin beta 10 -0.130241
TPT1 tumor protein, translationally-controlled 1 -0.125954
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0771322
RPS6 ribosomal protein S6 -0.0758016
PTMA prothymosin, alpha -0.0745209
ACTG1 actin gamma 1 -0.0718016
RPL35A ribosomal protein L35a -0.0713436
RPS8 ribosomal protein S8 -0.061442
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0606228
FTL ferritin, light polypeptide -0.0586756
NPSR1 neuropeptide S receptor 1 -0.0568299
RPS23 ribosomal protein S23 -0.0498591
TPM4 tropomyosin 4 -0.0461392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0449171
RPS29 ribosomal protein S29 -0.0427858
RPL31 ribosomal protein L31 -0.0423126
RPL9 ribosomal protein L9 -0.0405961
GMDS GDP-mannose 4,6-dehydratase -0.0405757
RPS25 ribosomal protein S25 -0.0404409
RPS13 ribosomal protein S13 -0.0402531
RPLP2 ribosomal protein, large, P2 -0.0394195
POTEF POTE ankyrin domain family, member F -0.0392094
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0389462
RPS19 ribosomal protein S19 -0.0349827
TFF1 trefoil factor 1 -0.0346292
RPL37A ribosomal protein L37a -0.0333959
NDRG1 N-myc downstream regulated 1 -0.0330606
RPS24 ribosomal protein S24 -0.0326853
VCL vinculin -0.0313644
RPLP1 ribosomal protein, large, P1 -0.0309232
RPL19 ribosomal protein L19 -0.0305816
MT2A metallothionein 2A -0.0302553
RPL7A ribosomal protein L7a -0.029837
RPS11 ribosomal protein S11 -0.0293308
S100A10 S100 calcium binding protein A10 -0.0293246
ATP5F1B ATP synthase F1 subunit beta -0.029311
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0286812
RPL34 ribosomal protein L34 -0.0282648
RPS21 ribosomal protein S21 -0.0282109
RPS10 ribosomal protein S10 -0.0276244
RPL11 ribosomal protein L11 -0.0263713
HMGA1 high mobility group AT-hook 1 -0.026059
RPLP0 ribosomal protein, large, P0 -0.025856
GREB1L growth regulation by estrogen in breast cancer-like -0.0256179
RPL8 ribosomal protein L8 -0.0247655
RPS15 ribosomal protein S15 -0.0240394
MYO1E myosin IE -0.024029
IER3 immediate early response 3 -0.0239379
RPL36A ribosomal protein L36a -0.0237788
PDIA3 protein disulfide isomerase family A, member 3 -0.0231804
S100A9 S100 calcium binding protein A9 -0.0231616
TUBB4B tubulin, beta 4B class IVb -0.0231569
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230501
RPS14 ribosomal protein S14 -0.0230464
PKM pyruvate kinase, muscle -0.0230458
RPL23 ribosomal protein L23 -0.0228749
S100P S100 calcium binding protein P -0.0227856
EGFR epidermal growth factor receptor -0.022582
DSTN destrin (actin depolymerizing factor) -0.0224075
RPL38 ribosomal protein L38 -0.0223691
TFF3 trefoil factor 3 (intestinal) -0.0222822
RPL15 ribosomal protein L15 -0.0222758
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0220421
MUC17 mucin 17, cell surface associated -0.0218872
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0217357
PSD3 pleckstrin and Sec7 domain containing 3 -0.0215738
EXT1 exostosin glycosyltransferase 1 -0.0214952
RPL28 ribosomal protein L28 -0.0214748
ALCAM activated leukocyte cell adhesion molecule -0.0213687
S100A6 S100 calcium binding protein A6 -0.0207981
RPS17 ribosomal protein S17 -0.0206083
RPS27 ribosomal protein S27 -0.020212
LDHA lactate dehydrogenase A -0.0199831
PARD3 par-3 family cell polarity regulator -0.0199699
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0199696
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0196044
PDLIM5 PDZ and LIM domain 5 -0.0194701
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0193904
KRT18 keratin 18, type I -0.0192771
MBNL1 muscleblind-like splicing regulator 1 -0.019235
AGR2 anterior gradient 2 -0.0190252
RPS12 ribosomal protein S12 -0.0189941
DEK DEK proto-oncogene -0.0186054
RPL7 ribosomal protein L7 -0.018206
ENO2 enolase 2 (gamma, neuronal) -0.018044
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.017838
FBXO11 F-box protein 11 -0.0177588
VDAC1 voltage-dependent anion channel 1 -0.0176004
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0174272
RPS16 ribosomal protein S16 -0.0173979
F3 coagulation factor III (thromboplastin, tissue factor) -0.0168904
SLC35F3 solute carrier family 35, member F3 -0.0167225
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0165871
SVIL supervillin -0.0165605
TUBA1B tubulin, alpha 1b -0.016376
KLK10 kallikrein-related peptidase 10 -0.0163593
RPS5 ribosomal protein S5 -0.016116
RPL37 ribosomal protein L37 -0.0160602
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0160131