Nafamostat (mesylate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL4 ribosomal protein L4 0.263665
DSPP dentin sialophosphoprotein 0.123649
EZR ezrin 0.120447
RPS6 ribosomal protein S6 0.117008
LMO7 LIM domain 7 0.11347
RPS12 ribosomal protein S12 0.109408
THSD4 thrombospondin, type I, domain containing 4 0.103456
RPS2 ribosomal protein S2 0.0956337
MYO1E myosin IE 0.0835487
RPS3 ribosomal protein S3 0.075809
AKAP13 A kinase (PRKA) anchor protein 13 0.0746919
LAMA4 laminin, alpha 4 0.0684165
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0675662
FLNB filamin B, beta 0.0615794
EIF1 eukaryotic translation initiation factor 1 0.0602459
RPL26 ribosomal protein L26 0.0575311
MPRIP myosin phosphatase Rho interacting protein 0.0566583
PELI1 pellino E3 ubiquitin protein ligase 1 0.0563999
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0537776
P3H2 prolyl 3-hydroxylase 2 0.0527133
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0510647
SRRM2 serine/arginine repetitive matrix 2 0.0508355
PDE4D phosphodiesterase 4D, cAMP-specific 0.0507867
PKP2 plakophilin 2 0.0498355
PRSS3 protease, serine, 3 0.049274
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0482374
CALB1 calbindin 1, 28kDa 0.0474851
TC2N tandem C2 domains, nuclear 0.047479
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0468701
RBM25 RNA binding motif protein 25 0.0468576
RPLP1 ribosomal protein, large, P1 0.0452506
IFI6 interferon, alpha-inducible protein 6 0.0451581
RIMKLB ribosomal modification protein rimK-like family member B 0.04471
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.044117
RAD51B RAD51 paralog B 0.0440514
RPS18 ribosomal protein S18 0.0439513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0437285
RPL37A ribosomal protein L37a 0.0436854
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0433351
RPL5 ribosomal protein L5 0.0431747
RPS14 ribosomal protein S14 0.043094
MUC13 mucin 13, cell surface associated 0.0423154
MYOF myoferlin 0.0420889
VCL vinculin 0.0417213
SP100 SP100 nuclear antigen 0.041699
KRT18 keratin 18, type I 0.0416204
RBM39 RNA binding motif protein 39 0.0414509
KTN1 kinectin 1 (kinesin receptor) 0.0410518
EGR1 early growth response 1 0.0409575
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0400197
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0398935
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.039885
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0394663
RPL12 ribosomal protein L12 0.03901
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0387693
LAMB3 laminin, beta 3 0.0380505
RPS8 ribosomal protein S8 0.037817
HLA-A major histocompatibility complex, class I, A 0.037603
ITGB4 integrin, beta 4 0.03747
PRRC2C proline-rich coiled-coil 2C 0.0370981
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0370524
DST dystonin 0.03691
JUN jun proto-oncogene 0.0366499
PTMA prothymosin, alpha 0.0355407
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0351803
MACF1 microtubule-actin crosslinking factor 1 0.0348953
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0348565
DOCK5 dedicator of cytokinesis 5 0.0342217
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0338175
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0337592
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.033687
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0336263
RPL18 ribosomal protein L18 0.0334826
CUX1 cut-like homeobox 1 0.0333613
ENO1 enolase 1, (alpha) 0.0331676
EMP1 epithelial membrane protein 1 0.033087
RPS19 ribosomal protein S19 0.032845
SLC38A2 solute carrier family 38, member 2 0.0326244
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0326017
CEMIP cell migration inducing protein, hyaluronan binding 0.0321851
FOXP1 forkhead box P1 0.0320834
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0319181
HLA-B major histocompatibility complex, class I, B 0.0316709
TPM3 tropomyosin 3 0.0313927
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0312157
SET SET nuclear proto-oncogene 0.0312021
LOC102724023 ES1 protein homolog, mitochondrial 0.0308761
MX1 MX dynamin-like GTPase 1 0.0307616
ANXA2 annexin A2 0.0306872
OXSR1 oxidative stress responsive 1 0.0306826
SEPTIN9 septin 9 0.0305302
CAPRIN2 caprin family member 2 0.0303388
RPL23 ribosomal protein L23 0.0301121
SEPTIN10 septin 10 0.0300714
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0300591
ITGA6 integrin, alpha 6 0.030045
EPHA2 EPH receptor A2 0.0295773
RPL36 ribosomal protein L36 0.0291813
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0289681
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0289275

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175912
EPS8 epidermal growth factor receptor pathway substrate 8 -0.170128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115911
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0769595
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.069926
PDIA3 protein disulfide isomerase family A, member 3 -0.0635249
COG5 component of oligomeric golgi complex 5 -0.0497984
TRIM2 tripartite motif containing 2 -0.0463792
MON2 MON2 homolog (S. cerevisiae) -0.0462931
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0457404
USP3 ubiquitin specific peptidase 3 -0.0446595
CXADR coxsackie virus and adenovirus receptor -0.0425428
CALU calumenin -0.0392368
GARS1 glycyl-tRNA synthetase 1 -0.0388847
GOLGA4 golgin A4 -0.0388364
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0388261
SEC31A SEC31 homolog A (S. cerevisiae) -0.0369931
CANX calnexin -0.0361384
TMSB10 thymosin beta 10 -0.0357378
RAB1A RAB1A, member RAS oncogene family -0.0354233
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.03511
CCNI cyclin I -0.0339899
ATP5F1B ATP synthase F1 subunit beta -0.0315464
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0310144
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0308752
POU2F1 POU class 2 homeobox 1 -0.0308471
GLG1 golgi glycoprotein 1 -0.0307681
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.030088
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0300372
PTPRR protein tyrosine phosphatase, receptor type, R -0.0293396
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0293063
HMGA1 high mobility group AT-hook 1 -0.0287225
NDRG1 N-myc downstream regulated 1 -0.028486
CCND2 cyclin D2 -0.0279556
SEC24A SEC24 family member A -0.0267179
TMEM263 transmembrane protein 263 -0.026569
ETNK1 ethanolamine kinase 1 -0.026449
RARS1 arginyl-tRNA synthetase 1 -0.0264205
IARS1 isoleucyl-tRNA synthetase 1 -0.0263375
RNF145 ring finger protein 145 -0.0261638
RLF rearranged L-myc fusion -0.0259939
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.02518
PRRC1 proline-rich coiled-coil 1 -0.0248529
CLINT1 clathrin interactor 1 -0.0247687
NKTR natural killer cell triggering receptor -0.0246015
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241672
TMEM165 transmembrane protein 165 -0.0241117
UBE2H ubiquitin-conjugating enzyme E2H -0.0240783
RPS23 ribosomal protein S23 -0.023593
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0233524
RPS15 ribosomal protein S15 -0.0231333
COPB1 coatomer protein complex, subunit beta 1 -0.0224295
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0224223
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0222469
SETD5 SET domain containing 5 -0.0221349
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0219753
KCMF1 potassium channel modulatory factor 1 -0.0217786
SRP54 signal recognition particle 54kDa -0.0216192
TTC3 tetratricopeptide repeat domain 3 -0.0215648
ZFR zinc finger RNA binding protein -0.0210526
APAF1 apoptotic peptidase activating factor 1 -0.020978
BTBD9 BTB (POZ) domain containing 9 -0.020861
RPS21 ribosomal protein S21 -0.0207205
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.020634
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0204987
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0204508
PHIP pleckstrin homology domain interacting protein -0.0202926
SHROOM3 shroom family member 3 -0.0201839
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0199624
GAN gigaxonin -0.0199242
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0198635
ZNF638 zinc finger protein 638 -0.0197894
RHOA ras homolog family member A -0.01977
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0195898
AVL9 AVL9 homolog (S. cerevisiase) -0.0195882
NFIA nuclear factor I/A -0.0193484
TMED2 transmembrane emp24 domain trafficking protein 2 -0.0193024
AGR2 anterior gradient 2 -0.018972
POTEF POTE ankyrin domain family, member F -0.0189368
CARS1 cysteinyl-tRNA synthetase 1 -0.0188873
GDF15 growth differentiation factor 15 -0.0188757
CLTC clathrin, heavy chain (Hc) -0.0188494
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0186715
RAP1B RAP1B, member of RAS oncogene family -0.0184303
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0183121
RAD21 RAD21 homolog (S. pombe) -0.0182759
PDE8A phosphodiesterase 8A -0.0182412
GOSR1 golgi SNAP receptor complex member 1 -0.0182282
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0181641
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0181598
ARFGEF3 ARFGEF family member 3 -0.0181544
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0180462
SUCO SUN domain containing ossification factor -0.0179026
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0178692
SEC24D SEC24 family member D -0.0178664
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0176978
NF1 neurofibromin 1 -0.0175745
NBAS neuroblastoma amplified sequence -0.0175352
RPL8 ribosomal protein L8 -0.0173335
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0173213