Nafamostat (mesylate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.135391
RPS3 ribosomal protein S3 0.124918
EGFR epidermal growth factor receptor 0.115491
ASPH aspartate beta-hydroxylase 0.115231
PTMA prothymosin, alpha 0.113996
MT2A metallothionein 2A 0.101962
ENO1 enolase 1, (alpha) 0.0940636
PDE4D phosphodiesterase 4D, cAMP-specific 0.0893733
RPL4 ribosomal protein L4 0.0853508
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0850773
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0802746
FTL ferritin, light polypeptide 0.0741355
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0710234
RPL37A ribosomal protein L37a 0.0705908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0699055
RPS8 ribosomal protein S8 0.0662325
RPS12 ribosomal protein S12 0.065855
PRRC2C proline-rich coiled-coil 2C 0.0653338
RPL35A ribosomal protein L35a 0.059974
EIF1 eukaryotic translation initiation factor 1 0.0590519
RPS27A ribosomal protein S27a 0.0575951
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0552505
RPS6 ribosomal protein S6 0.0503356
CAV1 caveolin 1, caveolae protein, 22kDa 0.0486158
MKI67 marker of proliferation Ki-67 0.0475585
LRP1B low density lipoprotein receptor-related protein 1B 0.0461118
RPL5 ribosomal protein L5 0.0448078
RPL12 ribosomal protein L12 0.0443568
B2M beta-2-microglobulin 0.0426281
TXNRD1 thioredoxin reductase 1 0.0424495
SEC61G Sec61 gamma subunit 0.0403765
SRRM2 serine/arginine repetitive matrix 2 0.0402167
RPLP1 ribosomal protein, large, P1 0.0400878
ANKRD12 ankyrin repeat domain 12 0.0399645
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0395576
AKAP9 A kinase (PRKA) anchor protein 9 0.0393619
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0383794
DSPP dentin sialophosphoprotein 0.0380804
RPL31 ribosomal protein L31 0.0379416
RPL26 ribosomal protein L26 0.037691
GRAMD1B GRAM domain containing 1B 0.037623
RBM25 RNA binding motif protein 25 0.0373087
IGFBP3 insulin-like growth factor binding protein 3 0.0365857
ATF4 activating transcription factor 4 0.036477
SLC38A1 solute carrier family 38, member 1 0.0363323
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0360086
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0357543
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0357053
PKM pyruvate kinase, muscle 0.0354475
RACK1 receptor for activated C kinase 1 0.0350675
RBM39 RNA binding motif protein 39 0.0347852
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0347166
EFNA5 ephrin-A5 0.0344044
AKAP12 A kinase (PRKA) anchor protein 12 0.0343839
RPS17 ribosomal protein S17 0.034129
HDLBP high density lipoprotein binding protein 0.0340512
RPS2 ribosomal protein S2 0.0337414
EGR1 early growth response 1 0.0333021
RPL37 ribosomal protein L37 0.0331384
TES testin LIM domain protein 0.0328594
GOLGA4 golgin A4 0.0324744
RPS27 ribosomal protein S27 0.0322967
LAMA4 laminin, alpha 4 0.0320836
RPL30 ribosomal protein L30 0.0318297
S100P S100 calcium binding protein P 0.0314986
LAMB3 laminin, beta 3 0.0311391
ZBTB20 zinc finger and BTB domain containing 20 0.0306543
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0302927
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0302136
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.030046
THSD4 thrombospondin, type I, domain containing 4 0.0294571
NAP1L1 nucleosome assembly protein 1-like 1 0.0289854
CXCL8 chemokine (C-X-C motif) ligand 8 0.0289788
RPL34 ribosomal protein L34 0.0288547
IGFBP5 insulin-like growth factor binding protein 5 0.0283608
GCLC glutamate-cysteine ligase, catalytic subunit 0.028201
RPL36 ribosomal protein L36 0.0281699
RPS19 ribosomal protein S19 0.0280576
ZMYND8 zinc finger, MYND-type containing 8 0.0280011
RPS14 ribosomal protein S14 0.0279828
TPT1 tumor protein, translationally-controlled 1 0.0279237
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0278563
RPL23 ribosomal protein L23 0.0276247
UBC ubiquitin C 0.0276136
S100A11 S100 calcium binding protein A11 0.0275882
TBC1D22A TBC1 domain family, member 22A 0.0271245
EZR ezrin 0.026834
PTPRM protein tyrosine phosphatase, receptor type, M 0.0264592
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0264378
RPL13A ribosomal protein L13a 0.0263578
SERF2 small EDRK-rich factor 2 0.0261085
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.025886
TNRC6B trinucleotide repeat containing 6B 0.0258122
RPL11 ribosomal protein L11 0.0256369
RPS4X ribosomal protein S4, X-linked 0.0254271
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.025363
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0253384
SQSTM1 sequestosome 1 0.0252053
GNAS GNAS complex locus 0.0251768
CST3 cystatin C 0.0251434

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.343744
NDRG1 N-myc downstream regulated 1 -0.116332
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0905716
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0447488
ARRDC3 arrestin domain containing 3 -0.0446019
GSK3B glycogen synthase kinase 3 beta -0.0339643
WASF2 WAS protein family, member 2 -0.0337164
PDIA3 protein disulfide isomerase family A, member 3 -0.031532
KMT2E lysine (K)-specific methyltransferase 2E -0.0313501
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0310708
AGO2 argonaute RISC catalytic component 2 -0.0296718
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.029356
SPAG9 sperm associated antigen 9 -0.0292746
TMEM165 transmembrane protein 165 -0.0284204
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0275594
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0266842
ATP13A3 ATPase type 13A3 -0.0261407
UVRAG UV radiation resistance associated -0.0255867
LAMC2 laminin, gamma 2 -0.0253314
ADAM17 ADAM metallopeptidase domain 17 -0.0252204
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0246739
TSC22D2 TSC22 domain family, member 2 -0.0244648
PDE8A phosphodiesterase 8A -0.0241203
CDCP1 CUB domain containing protein 1 -0.023894
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.023894
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0238014
MXD1 MAX dimerization protein 1 -0.0237143
KCMF1 potassium channel modulatory factor 1 -0.0231441
NABP1 nucleic acid binding protein 1 -0.0227729
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.022327
ANKRD37 ankyrin repeat domain 37 -0.0222722
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0222059
SOD2 superoxide dismutase 2, mitochondrial -0.0220988
DTNA dystrobrevin, alpha -0.021914
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0218153
HILPDA hypoxia inducible lipid droplet-associated -0.021646
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0215346
GLS2 glutaminase 2 (liver, mitochondrial) -0.0211526
BTG1 B-cell translocation gene 1, anti-proliferative -0.02111
RAP1B RAP1B, member of RAS oncogene family -0.0203677
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019944
ADNP activity-dependent neuroprotector homeobox -0.0198549
KDM6A lysine (K)-specific demethylase 6A -0.0198369
ELL2 elongation factor, RNA polymerase II, 2 -0.0194253
USP3 ubiquitin specific peptidase 3 -0.0183607
MYO1B myosin IB -0.0177356
ANKRD17 ankyrin repeat domain 17 -0.0173532
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0173373
TPD52 tumor protein D52 -0.0172092
MCL1 myeloid cell leukemia 1 -0.0172042
RASA2 RAS p21 protein activator 2 -0.0171339
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0167681
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.0166935
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0166264
ZFAND6 zinc finger, AN1-type domain 6 -0.0164767
WDFY3 WD repeat and FYVE domain containing 3 -0.0161274
WDR45B WD repeat domain 45B -0.0157232
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0156477
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0156188
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0155608
SLMAP sarcolemma associated protein -0.0152722
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0151809
FAM13A family with sequence similarity 13, member A -0.015055
CCNL1 cyclin L1 -0.0149776
LRRC8C leucine rich repeat containing 8 family, member C -0.0148918
TAOK1 TAO kinase 1 -0.0147621
CYLD cylindromatosis (turban tumor syndrome) -0.014685
MON2 MON2 homolog (S. cerevisiae) -0.014679
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0146597
ABLIM1 actin binding LIM protein 1 -0.0145776
RAB1A RAB1A, member RAS oncogene family -0.0145765
ADAM9 ADAM metallopeptidase domain 9 -0.014474
PUM2 pumilio RNA-binding family member 2 -0.0144143
CSNK1E casein kinase 1, epsilon -0.0142846
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142373
ARL5B ADP-ribosylation factor-like 5B -0.0141809
NDFIP1 Nedd4 family interacting protein 1 -0.0140281
GPC6 glypican 6 -0.0139717
WAC WW domain containing adaptor with coiled-coil -0.0138201
SEC31A SEC31 homolog A (S. cerevisiae) -0.013765
HOOK2 hook microtubule-tethering protein 2 -0.0137467
GK glycerol kinase -0.0132023
BRWD3 bromodomain and WD repeat domain containing 3 -0.0130065
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0128221
MIMS1 mitochondrial inner membrane scaffold 1 -0.012726
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0126087
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0125233
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0124501
AFF4 AF4/FMR2 family, member 4 -0.0123603
KDM7A lysine (K)-specific demethylase 7A -0.0122669
PNPLA8 patatin-like phospholipase domain containing 8 -0.0122034
ELOVL7 ELOVL fatty acid elongase 7 -0.0120972
NCKAP1 NCK-associated protein 1 -0.0120028
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0119492
CCNK cyclin K -0.0119361
PTEN phosphatase and tensin homolog -0.0118671
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0118556
ANXA5 annexin A5 -0.0118057
SETD5 SET domain containing 5 -0.0117972
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.0116187