| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nafamostat (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.141964 |
| GRAMD1B | GRAM domain containing 1B | 0.0858143 |
| PM20D1 | peptidase M20 domain containing 1 | 0.084495 |
| RPL4 | ribosomal protein L4 | 0.0808641 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0727649 |
| WDR43 | WD repeat domain 43 | 0.0720483 |
| RBM39 | RNA binding motif protein 39 | 0.0647977 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0557443 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0552198 |
| USP3 | ubiquitin specific peptidase 3 | 0.0529362 |
| RTN4 | reticulon 4 | 0.0517006 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0499406 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0483848 |
| NUP58 | nucleoporin 58 | 0.0412829 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0410391 |
| FGB | fibrinogen beta chain | 0.0400713 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.03993 |
| FAM168A | family with sequence similarity 168, member A | 0.0397382 |
| ZNF292 | zinc finger protein 292 | 0.0395044 |
| RBM25 | RNA binding motif protein 25 | 0.0393871 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0391849 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0390187 |
| DENND4A | DENN/MADD domain containing 4A | 0.0384375 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0374233 |
| RPS12 | ribosomal protein S12 | 0.0371738 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0364412 |
| CCNL1 | cyclin L1 | 0.0352628 |
| NNMT | nicotinamide N-methyltransferase | 0.0351722 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0350465 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0320722 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0316436 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0311158 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0307982 |
| RHEB | Ras homolog enriched in brain | 0.0294227 |
| MKI67 | marker of proliferation Ki-67 | 0.0293986 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0290179 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0290168 |
| YBX3 | Y box binding protein 3 | 0.0285982 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0281765 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0279799 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.02793 |
| TPD52 | tumor protein D52 | 0.0273326 |
| JAK1 | Janus kinase 1 | 0.0265885 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0262749 |
| CRY1 | cryptochrome circadian clock 1 | 0.0260964 |
| FGA | fibrinogen alpha chain | 0.0259217 |
| ENAH | enabled homolog (Drosophila) | 0.0258748 |
| NOL10 | nucleolar protein 10 | 0.0257163 |
| NTN4 | netrin 4 | 0.0257151 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0256415 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.025512 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.02507 |
| WWOX | WW domain containing oxidoreductase | 0.0245809 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0237129 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0234709 |
| CENPF | centromere protein F, 350/400kDa | 0.0232158 |
| WTAP | Wilms tumor 1 associated protein | 0.0231781 |
| MATR3 | matrin 3 | 0.0229167 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0229111 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0226027 |
| WBP11 | WW domain binding protein 11 | 0.0225383 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0224452 |
| OLA1 | Obg-like ATPase 1 | 0.0222767 |
| KLF6 | Kruppel-like factor 6 | 0.0222663 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0217445 |
| TMEM123 | transmembrane protein 123 | 0.0216565 |
| TNPO1 | transportin 1 | 0.0215369 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0215309 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0214343 |
| RBM33 | RNA binding motif protein 33 | 0.020628 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.020606 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0204192 |
| KNL1 | kinetochore scaffold 1 | 0.0203583 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0202428 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0201602 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0200871 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0200292 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0199501 |
| MTMR3 | myotubularin related protein 3 | 0.0198954 |
| ZNF207 | zinc finger protein 207 | 0.0198345 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0195944 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0195768 |
| FAM168B | family with sequence similarity 168, member B | 0.0194025 |
| CHN1 | chimerin 1 | 0.0192432 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.019221 |
| FGG | fibrinogen gamma chain | 0.0191938 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0191583 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0190229 |
| TFG | TRK-fused gene | 0.0189975 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0189758 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0189427 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0188797 |
| PFDN2 | prefoldin subunit 2 | 0.0188406 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0188221 |
| SPAG9 | sperm associated antigen 9 | 0.0185051 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0184912 |
| TUBB | tubulin, beta class I | 0.0183183 |
| XPO1 | exportin 1 | 0.0182878 |
| PRPF39 | pre-mRNA processing factor 39 | 0.0179362 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0177675 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.216976 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154352 |
| DOCK4 | dedicator of cytokinesis 4 | -0.149623 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.148895 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.146712 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.145293 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.139556 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.102883 |
| CMIP | c-Maf inducing protein | -0.0980645 |
| TMSB10 | thymosin beta 10 | -0.089047 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0870422 |
| FLNB | filamin B, beta | -0.0835312 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0811214 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0786211 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0735376 |
| FMNL2 | formin-like 2 | -0.0725971 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0708856 |
| EGFR | epidermal growth factor receptor | -0.0693804 |
| FTL | ferritin, light polypeptide | -0.0678839 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0673211 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0663709 |
| SVIL | supervillin | -0.0657286 |
| ACTG1 | actin gamma 1 | -0.0650261 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0619029 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0613579 |
| LDHA | lactate dehydrogenase A | -0.0606509 |
| PYGL | phosphorylase, glycogen, liver | -0.0602087 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0596356 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0587333 |
| GLIS3 | GLIS family zinc finger 3 | -0.0576302 |
| STC1 | stanniocalcin 1 | -0.0575663 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0562691 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0547648 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0542403 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0540078 |
| PKM | pyruvate kinase, muscle | -0.0522748 |
| NEGR1 | neuronal growth regulator 1 | -0.0519335 |
| ATXN1 | ataxin 1 | -0.0507165 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0494624 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0493778 |
| NDRG1 | N-myc downstream regulated 1 | -0.0485012 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0477168 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0476585 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0475322 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0467582 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0465224 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0459441 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0456563 |
| AHNAK | AHNAK nucleoprotein | -0.0450719 |
| DST | dystonin | -0.0448937 |
| TPM1 | tropomyosin 1 (alpha) | -0.0445478 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0441072 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0437657 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0432195 |
| EHBP1 | EH domain binding protein 1 | -0.0427694 |
| UTRN | utrophin | -0.042275 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0414228 |
| IGF2 | insulin-like growth factor 2 | -0.0403842 |
| MYO1E | myosin IE | -0.0403602 |
| ACTN1 | actinin, alpha 1 | -0.0403398 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0401267 |
| ASPH | aspartate beta-hydroxylase | -0.039338 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0385441 |
| POTEF | POTE ankyrin domain family, member F | -0.0384428 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0382124 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0380342 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0379395 |
| IER3 | immediate early response 3 | -0.0372993 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0367262 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0361161 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0352941 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0350816 |
| MORF4L2 | mortality factor 4 like 2 | -0.0346723 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0346583 |
| NEBL | nebulette | -0.0346521 |
| MCL1 | myeloid cell leukemia 1 | -0.0342636 |
| PARD3 | par-3 family cell polarity regulator | -0.0342384 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0340153 |
| S100A6 | S100 calcium binding protein A6 | -0.033759 |
| CTBP2 | C-terminal binding protein 2 | -0.0334946 |
| CUX1 | cut-like homeobox 1 | -0.0331096 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0327771 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0327065 |
| NUMB | numb homolog (Drosophila) | -0.0326008 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.032385 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0314093 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0304193 |
| MAP7 | microtubule-associated protein 7 | -0.0303781 |
| ANXA2 | annexin A2 | -0.0296543 |
| ATG7 | autophagy related 7 | -0.0296031 |
| VIM | vimentin | -0.0294363 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0291901 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.029167 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0290431 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0290297 |
| CFDP1 | craniofacial development protein 1 | -0.0287943 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0284475 |
| APP | amyloid beta (A4) precursor protein | -0.0283507 |
| PRKCA | protein kinase C, alpha | -0.0281219 |
| CDCP1 | CUB domain containing protein 1 | -0.0278366 |
