Nafamostat (mesylate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0931929
RPS3 ribosomal protein S3 0.0908234
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0823932
PRRC2C proline-rich coiled-coil 2C 0.081113
PTMA prothymosin, alpha 0.0753141
AKAP12 A kinase (PRKA) anchor protein 12 0.0698977
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0698974
ASPH aspartate beta-hydroxylase 0.0672635
RACK1 receptor for activated C kinase 1 0.065912
HMGA2 high mobility group AT-hook 2 0.0639067
MYOF myoferlin 0.0638331
EGFR epidermal growth factor receptor 0.0631849
KMT2E lysine (K)-specific methyltransferase 2E 0.0596703
PSD3 pleckstrin and Sec7 domain containing 3 0.0593729
SEC31A SEC31 homolog A (S. cerevisiae) 0.0579697
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0576193
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0575206
RPL4 ribosomal protein L4 0.0567425
RPL12 ribosomal protein L12 0.0566764
PRKCA protein kinase C, alpha 0.0565289
EIF1 eukaryotic translation initiation factor 1 0.0559121
PHF21A PHD finger protein 21A 0.0554972
FLNB filamin B, beta 0.0552922
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0548208
RAB7A RAB7A, member RAS oncogene family 0.0544824
HDAC9 histone deacetylase 9 0.0541914
CDH13 cadherin 13 0.0537317
TRIO trio Rho guanine nucleotide exchange factor 0.0534648
NAV2 neuron navigator 2 0.0534082
ACTG1 actin gamma 1 0.05315
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0530392
FAM13A family with sequence similarity 13, member A 0.0520196
TTC28 tetratricopeptide repeat domain 28 0.0503223
TPD52 tumor protein D52 0.0502102
SIK3 SIK family kinase 3 0.0500866
MT2A metallothionein 2A 0.049748
NPAS2 neuronal PAS domain protein 2 0.0491995
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.049059
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0488025
RPS14 ribosomal protein S14 0.0482481
ENO1 enolase 1, (alpha) 0.0479991
UBE3A ubiquitin protein ligase E3A 0.0478378
NALF1 NALCN channel auxiliary factor 1 0.0477636
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0477368
RPS25 ribosomal protein S25 0.0472296
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0470171
SENP5 SUMO1/sentrin specific peptidase 5 0.0470085
NBEAL1 neurobeachin-like 1 0.0469895
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0468899
ZCCHC7 zinc finger, CCHC domain containing 7 0.0467333
SCFD2 sec1 family domain containing 2 0.0465257
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0462228
FTL ferritin, light polypeptide 0.0462141
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0461915
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0460261
ANO6 anoctamin 6 0.0457842
RPL5 ribosomal protein L5 0.0454688
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0452787
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0448041
EZR ezrin 0.0446727
CD109 CD109 molecule 0.0445353
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0443479
USP34 ubiquitin specific peptidase 34 0.0442466
STC1 stanniocalcin 1 0.0441727
CALU calumenin 0.0439758
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0438951
DLG1 discs, large homolog 1 (Drosophila) 0.043674
DPYSL2 dihydropyrimidinase-like 2 0.0433537
TTC3 tetratricopeptide repeat domain 3 0.0431372
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431119
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0429326
RPL23 ribosomal protein L23 0.0426356
ATXN1 ataxin 1 0.0424615
RPL35A ribosomal protein L35a 0.0416367
SMYD3 SET and MYND domain containing 3 0.0412707
KDM5B lysine (K)-specific demethylase 5B 0.0402167
TPT1 tumor protein, translationally-controlled 1 0.0401192
UBE3C ubiquitin protein ligase E3C 0.0398911
GOLGA4 golgin A4 0.0397225
RPL32 ribosomal protein L32 0.0396923
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.039288
CDC27 cell division cycle 27 0.0392653
RPL37 ribosomal protein L37 0.0392548
SUCO SUN domain containing ossification factor 0.0391017
ELL2 elongation factor, RNA polymerase II, 2 0.0385937
COG5 component of oligomeric golgi complex 5 0.0383987
CCNY cyclin Y 0.038225
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0381898
FAF1 Fas (TNFRSF6) associated factor 1 0.038084
KPNB1 karyopherin (importin) beta 1 0.0379954
ZMYND8 zinc finger, MYND-type containing 8 0.0379383
ARB2A ARB2 cotranscriptional regulator A 0.0378975
TKT transketolase 0.0376242
MSRB3 methionine sulfoxide reductase B3 0.0375658
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0370312
LOC112694756 uncharaterized LOC112694756 0.0368193
TOP1 topoisomerase (DNA) I 0.0367813
APLP2 amyloid beta (A4) precursor-like protein 2 0.0367059
VMP1 vacuole membrane protein 1 0.0366745
PGM3 phosphoglucomutase 3 0.0362455

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.111487
MCTP1 multiple C2 domains, transmembrane 1 -0.0934154
NKD1 naked cuticle homolog 1 (Drosophila) -0.0924343
PDE10A phosphodiesterase 10A -0.0818825
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0816054
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0808708
MUC16 mucin 16, cell surface associated -0.07872
RTN4 reticulon 4 -0.0756808
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0749136
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0744276
ZNF638 zinc finger protein 638 -0.0736407
BACE2 beta-site APP-cleaving enzyme 2 -0.0722103
KIF5B kinesin family member 5B -0.0706565
EXT1 exostosin glycosyltransferase 1 -0.0690815
KYNU kynureninase -0.0688612
NAMPT nicotinamide phosphoribosyltransferase -0.065479
PDE4D phosphodiesterase 4D, cAMP-specific -0.0638665
ATOSA atos homolog A -0.0614755
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0609351
DDIT4 DNA-damage-inducible transcript 4 -0.0605842
KDM6A lysine (K)-specific demethylase 6A -0.060027
GRB10 growth factor receptor-bound protein 10 -0.059112
CARD16 caspase recruitment domain family, member 16 -0.0587388
LMAN1 lectin, mannose-binding, 1 -0.0585393
DENND1A DENN/MADD domain containing 1A -0.0552062
COPB1 coatomer protein complex, subunit beta 1 -0.0541329
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0538811
LAMB3 laminin, beta 3 -0.0536085
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0535235
CEMIP2 cell migration inducing hyaluronidase 2 -0.0532632
PLK2 polo-like kinase 2 -0.0527962
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0521945
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0509355
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0497709
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0493749
TUSC3 tumor suppressor candidate 3 -0.0480959
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0478889
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0469054
SPAG9 sperm associated antigen 9 -0.046251
ZNF207 zinc finger protein 207 -0.0459876
SAMD4A sterile alpha motif domain containing 4A -0.0445911
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0442273
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0441161
CDK19 cyclin-dependent kinase 19 -0.0437489
SEPTIN7 septin 7 -0.0434505
CEMIP cell migration inducing protein, hyaluronan binding -0.0434499
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0431681
USP33 ubiquitin specific peptidase 33 -0.0429743
GCC2 GRIP and coiled-coil domain containing 2 -0.0427597
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0425054
RLF rearranged L-myc fusion -0.0423917
RYBP RING1 and YY1 binding protein -0.0417017
AKAP13 A kinase (PRKA) anchor protein 13 -0.0412995
BRWD1 bromodomain and WD repeat domain containing 1 -0.0409964
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0403327
PLSCR1 phospholipid scramblase 1 -0.040285
LAMC2 laminin, gamma 2 -0.0401295
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0401269
ZNF292 zinc finger protein 292 -0.0399437
ANTXR2 anthrax toxin receptor 2 -0.039877
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0396148
NHSL1 NHS-like 1 -0.039414
HELZ helicase with zinc finger -0.0389818
WAPL WAPL cohesin release factor -0.0385749
MCL1 myeloid cell leukemia 1 -0.0380924
KLF6 Kruppel-like factor 6 -0.0371652
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0371248
AGO3 argonaute RISC catalytic component 3 -0.0371005
SRPK2 SRSF protein kinase 2 -0.037054
MTUS1 microtubule associated tumor suppressor 1 -0.0369129
CAPN2 calpain 2, (m/II) large subunit -0.0366792
PDIA6 protein disulfide isomerase family A, member 6 -0.0361646
KIF13B kinesin family member 13B -0.0361121
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0358606
PTK2 protein tyrosine kinase 2 -0.0358597
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0358412
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.035507
RANBP2 RAN binding protein 2 -0.0353255
RB1CC1 RB1-inducible coiled-coil 1 -0.035192
AK1 adenylate kinase 1 -0.0350343
NUP98 nucleoporin 98kDa -0.0349628
SP100 SP100 nuclear antigen -0.0348825
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0346172
CALR calreticulin -0.0344197
SCAF4 SR-related CTD-associated factor 4 -0.0343284
KDM1A lysine (K)-specific demethylase 1A -0.0339802
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0338026
CNKSR3 CNKSR family member 3 -0.0336961
SMG6 SMG6 nonsense mediated mRNA decay factor -0.033513
UBE2H ubiquitin-conjugating enzyme E2H -0.0333343
INTS6 integrator complex subunit 6 -0.032982
JMJD1C jumonji domain containing 1C -0.0327105
SAMD12 sterile alpha motif domain containing 12 -0.0326715
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0325471
PICALM phosphatidylinositol binding clathrin assembly protein -0.0323674
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0322696
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0322653
WDR1 WD repeat domain 1 -0.0322233
CAMTA1 calmodulin binding transcription activator 1 -0.0322078
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0320139