Nafamostat (mesylate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0991885
RPL4 ribosomal protein L4 0.0820417
EGR1 early growth response 1 0.0620832
TPM3 tropomyosin 3 0.0586992
EIF1 eukaryotic translation initiation factor 1 0.0488248
RPS3 ribosomal protein S3 0.0482065
RPS2 ribosomal protein S2 0.0475774
RPS12 ribosomal protein S12 0.0460198
SET SET nuclear proto-oncogene 0.0430735
RPS18 ribosomal protein S18 0.041977
EEF2 eukaryotic translation elongation factor 2 0.0392448
AKAP9 A kinase (PRKA) anchor protein 9 0.0386646
RPS6 ribosomal protein S6 0.0384004
RBM25 RNA binding motif protein 25 0.0374041
KTN1 kinectin 1 (kinesin receptor) 0.0362482
TLN1 talin 1 0.0361806
HLA-A major histocompatibility complex, class I, A 0.0345191
AKAP12 A kinase (PRKA) anchor protein 12 0.0326388
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0323853
PTMA prothymosin, alpha 0.0314373
EIF5B eukaryotic translation initiation factor 5B 0.0312182
PRRC2C proline-rich coiled-coil 2C 0.0304563
BRD2 bromodomain containing 2 0.0302394
RPL26 ribosomal protein L26 0.0299243
RPL18 ribosomal protein L18 0.0295609
SRRM2 serine/arginine repetitive matrix 2 0.0294633
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291103
RPL12 ribosomal protein L12 0.0288777
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0284165
RPL5 ribosomal protein L5 0.0280238
PRRC2A proline-rich coiled-coil 2A 0.0277917
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0275479
ENO1 enolase 1, (alpha) 0.0274141
RPL37A ribosomal protein L37a 0.0271146
RBM39 RNA binding motif protein 39 0.0261662
RPS14 ribosomal protein S14 0.0261235
PNN pinin, desmosome associated protein 0.0259728
FTL ferritin, light polypeptide 0.0250344
SRRM1 serine/arginine repetitive matrix 1 0.0241666
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0238578
SRSF11 serine/arginine-rich splicing factor 11 0.0236201
RPS27 ribosomal protein S27 0.0228283
OGA O-GlcNAcase 0.0226445
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0226289
LOC102724023 ES1 protein homolog, mitochondrial 0.022552
PFDN2 prefoldin subunit 2 0.02163
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0211639
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0210181
CBX3 chromobox homolog 3 0.0205699
ATF4 activating transcription factor 4 0.0202626
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0202568
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0196322
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0195223
RPS17 ribosomal protein S17 0.0193065
TBC1D15 TBC1 domain family, member 15 0.0191836
RPL36 ribosomal protein L36 0.0189149
PER1 period circadian clock 1 0.0187583
RPL37 ribosomal protein L37 0.0187452
TCIM transcriptional and immune response regulator 0.0185696
DOCK5 dedicator of cytokinesis 5 0.0183828
MT2A metallothionein 2A 0.0178615
RPS19 ribosomal protein S19 0.0177298
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0175933
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0170193
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.016826
KMT2D lysine (K)-specific methyltransferase 2D 0.0164095
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.016404
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0160541
PELP1 proline, glutamate and leucine rich protein 1 0.0159803
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0158849
PFN1 profilin 1 0.0155421
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0154823
RPS8 ribosomal protein S8 0.0153335
MKI67 marker of proliferation Ki-67 0.0151758
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.0151025
PTMS parathymosin 0.0150533
DSPP dentin sialophosphoprotein 0.0150039
PARP4 poly (ADP-ribose) polymerase family, member 4 0.014989
CHIC2 cysteine-rich hydrophobic domain 2 0.014972
EZR ezrin 0.0149608
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0146102
ERRFI1 ERBB receptor feedback inhibitor 1 0.0145063
RPS15A ribosomal protein S15a 0.0143298
EIF4H eukaryotic translation initiation factor 4H 0.01425
GYS1 glycogen synthase 1 (muscle) 0.0142143
DHFR dihydrofolate reductase 0.0141996
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.014151
MYO6 myosin VI 0.0139786
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0138785
SLK STE20-like kinase 0.0138169
HDGF hepatoma-derived growth factor 0.0137945
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0137725
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.0137278
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0136076
HMGN2 high mobility group nucleosomal binding domain 2 0.0135284
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0134967
GOLGA4 golgin A4 0.013493
PDCD5 programmed cell death 5 0.0133119
NUP58 nucleoporin 58 0.013161
BCLAF1 BCL2-associated transcription factor 1 0.0129996

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.4207
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0999368
TFPI2 tissue factor pathway inhibitor 2 -0.0861985
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0739057
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0661261
IGF1R insulin-like growth factor 1 receptor -0.0627352
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0590802
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0573683
AHNAK AHNAK nucleoprotein -0.0568857
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0562897
TRIO trio Rho guanine nucleotide exchange factor -0.0549166
EML4 echinoderm microtubule associated protein like 4 -0.0547344
CCND2 cyclin D2 -0.0527556
CSDE1 cold shock domain containing E1, RNA-binding -0.0482799
TAS2R14 taste receptor, type 2, member 14 -0.0461833
THSD4 thrombospondin, type I, domain containing 4 -0.0460395
PGK1 phosphoglycerate kinase 1 -0.0448788
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0436112
NCOA7 nuclear receptor coactivator 7 -0.043503
SMAD3 SMAD family member 3 -0.0428729
TAOK1 TAO kinase 1 -0.0420353
NF1 neurofibromin 1 -0.041791
GRAMD1B GRAM domain containing 1B -0.0414385
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0412942
KDM3A lysine (K)-specific demethylase 3A -0.0407905
ZFR zinc finger RNA binding protein -0.0406043
ACTG1 actin gamma 1 -0.0394503
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.038311
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0378999
PHIP pleckstrin homology domain interacting protein -0.0377058
PDE4D phosphodiesterase 4D, cAMP-specific -0.0376726
VDAC1 voltage-dependent anion channel 1 -0.0376712
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.037178
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0368868
FBXO11 F-box protein 11 -0.0364392
CAVIN1 caveolae associated protein 1 -0.0359904
KCMF1 potassium channel modulatory factor 1 -0.0359016
RPS21 ribosomal protein S21 -0.0356734
OSMR oncostatin M receptor -0.0347537
ZFAND3 zinc finger, AN1-type domain 3 -0.0341038
UBE2H ubiquitin-conjugating enzyme E2H -0.0338056
TMSB10 thymosin beta 10 -0.0335075
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0334694
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0332115
UBC ubiquitin C -0.0331844
NIPBL Nipped-B homolog (Drosophila) -0.0329549
PTK2 protein tyrosine kinase 2 -0.0328137
ATF6 activating transcription factor 6 -0.0326909
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0326147
ADGRG6 adhesion G protein-coupled receptor G6 -0.0322967
BZW1 basic leucine zipper and W2 domains 1 -0.0319548
CDK17 cyclin-dependent kinase 17 -0.0319203
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0317749
YBX3 Y box binding protein 3 -0.031656
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0313325
BBX bobby sox homolog (Drosophila) -0.0311003
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.030519
ZNF217 zinc finger protein 217 -0.0302696
CAMKMT calmodulin-lysine N-methyltransferase -0.0302113
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0299901
PUM2 pumilio RNA-binding family member 2 -0.0297851
LDHA lactate dehydrogenase A -0.0297338
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0296386
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0295295
TXNRD1 thioredoxin reductase 1 -0.029418
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0293453
PCNX1 pecanex 1 -0.0291751
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0289135
ATP5F1B ATP synthase F1 subunit beta -0.0288961
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0288232
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0285535
CANX calnexin -0.0285027
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0284301
RAB1A RAB1A, member RAS oncogene family -0.0283607
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.028307
POTEF POTE ankyrin domain family, member F -0.0280001
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0279837
EXOC4 exocyst complex component 4 -0.0279619
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0274097
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0273747
CAMTA1 calmodulin binding transcription activator 1 -0.027127
PCNP PEST proteolytic signal containing nuclear protein -0.027095
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0270586
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0270491
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0267312
PFKP phosphofructokinase, platelet -0.0267244
TMEM165 transmembrane protein 165 -0.0266218
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0265271
RPS15 ribosomal protein S15 -0.0264775
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0263009
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0262455
RAP1B RAP1B, member of RAS oncogene family -0.026073
BIRC2 baculoviral IAP repeat containing 2 -0.0260089
ATG7 autophagy related 7 -0.0259597
XPO1 exportin 1 -0.025943
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0258893
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0258871
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0258819
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0258771
SENP6 SUMO1/sentrin specific peptidase 6 -0.0258657