| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nafamostat (mesylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.163753 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.142855 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.128827 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.118136 |
| S100A6 | S100 calcium binding protein A6 | 0.114208 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.10599 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0850134 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0810314 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0734555 |
| HLA-A | major histocompatibility complex, class I, A | 0.073111 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0692024 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0660195 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0653496 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.065194 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.062368 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0620368 |
| RBM39 | RNA binding motif protein 39 | 0.0610178 |
| LAMB3 | laminin, beta 3 | 0.0607868 |
| CDCP1 | CUB domain containing protein 1 | 0.060204 |
| EFNA5 | ephrin-A5 | 0.0601609 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0594786 |
| SDC4 | syndecan 4 | 0.0577695 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0577237 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0563067 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0562942 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0562603 |
| ENO1 | enolase 1, (alpha) | 0.0560472 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0529158 |
| OGA | O-GlcNAcase | 0.0526455 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0524275 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0523701 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0520548 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0511009 |
| HOMER2 | homer scaffolding protein 2 | 0.0495111 |
| ACTG1 | actin gamma 1 | 0.0491767 |
| MT2A | metallothionein 2A | 0.0477988 |
| TOP1 | topoisomerase (DNA) I | 0.0472833 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.047102 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0468146 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0466771 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0466062 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0462783 |
| GOLGA4 | golgin A4 | 0.0460476 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0447775 |
| RBM25 | RNA binding motif protein 25 | 0.044592 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0445182 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0444344 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0441116 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0440185 |
| AREG | amphiregulin | 0.0439581 |
| OSMR | oncostatin M receptor | 0.0436448 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0435542 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0428211 |
| BCL2L1 | BCL2-like 1 | 0.0416142 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0411299 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0407337 |
| EZR | ezrin | 0.0402718 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0399677 |
| IL6ST | interleukin 6 signal transducer | 0.0399638 |
| DSPP | dentin sialophosphoprotein | 0.0398878 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0394238 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.038746 |
| DUSP6 | dual specificity phosphatase 6 | 0.0385877 |
| RPS2 | ribosomal protein S2 | 0.0385661 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0382629 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0377309 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0374877 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0363763 |
| ADAR | adenosine deaminase, RNA-specific | 0.0355761 |
| UBC | ubiquitin C | 0.0351763 |
| SBF2 | SET binding factor 2 | 0.0351361 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0347515 |
| RPL34 | ribosomal protein L34 | 0.0340892 |
| HLA-B | major histocompatibility complex, class I, B | 0.0334798 |
| CD9 | CD9 molecule | 0.0329615 |
| NEK7 | NIMA-related kinase 7 | 0.0324097 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0323439 |
| KLF6 | Kruppel-like factor 6 | 0.0323398 |
| RAB6A | RAB6A, member RAS oncogene family | 0.032186 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.031507 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0313125 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0312953 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.031184 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.0311045 |
| FCHO2 | FCH domain only 2 | 0.0309645 |
| RPL12 | ribosomal protein L12 | 0.0306133 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0305712 |
| VIM | vimentin | 0.0304853 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0299924 |
| TXNIP | thioredoxin interacting protein | 0.0299344 |
| EREG | epiregulin | 0.0298643 |
| RPL26 | ribosomal protein L26 | 0.0292686 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0286685 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0286613 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0282187 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0281616 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0281055 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.028024 |
| ANXA1 | annexin A1 | 0.0279176 |
| FAM3C | family with sequence similarity 3, member C | 0.0277344 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.179575 |
| POTEF | POTE ankyrin domain family, member F | -0.177076 |
| HMGA1 | high mobility group AT-hook 1 | -0.0996185 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.078947 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0770483 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0723016 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0603809 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0573007 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0567502 |
| PKM | pyruvate kinase, muscle | -0.0490354 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0488873 |
| FTL | ferritin, light polypeptide | -0.0484352 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0478984 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0446738 |
| PLAU | plasminogen activator, urokinase | -0.0426644 |
| MSI2 | musashi RNA-binding protein 2 | -0.0406172 |
| RNF213 | ring finger protein 213 | -0.0392501 |
| USP3 | ubiquitin specific peptidase 3 | -0.03805 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.037989 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0376591 |
| FOSL1 | FOS-like antigen 1 | -0.0356053 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0342162 |
| MXD1 | MAX dimerization protein 1 | -0.0337435 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.033583 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0328767 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.032331 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.032157 |
| CANX | calnexin | -0.0316639 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0315525 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0312041 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0309294 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0304611 |
| ZNF292 | zinc finger protein 292 | -0.0302265 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0302062 |
| CCND1 | cyclin D1 | -0.0296558 |
| RHEB | Ras homolog enriched in brain | -0.0287737 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0287684 |
| RHOA | ras homolog family member A | -0.0284132 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0281155 |
| DTNA | dystrobrevin, alpha | -0.0279892 |
| DUSP10 | dual specificity phosphatase 10 | -0.0279592 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0276891 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0274588 |
| SLMAP | sarcolemma associated protein | -0.0274491 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.027421 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0273404 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0272964 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.027218 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0270965 |
| SEPTIN11 | septin 11 | -0.0267198 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0266142 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0265309 |
| CD47 | CD47 molecule | -0.026056 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0249514 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0249327 |
| WASF2 | WAS protein family, member 2 | -0.024278 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0239795 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0239189 |
| ECT2 | epithelial cell transforming 2 | -0.0238644 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0233004 |
| POU2F1 | POU class 2 homeobox 1 | -0.0226286 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0225607 |
| NABP1 | nucleic acid binding protein 1 | -0.0223108 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0221852 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0219591 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0216065 |
| INTS6 | integrator complex subunit 6 | -0.0214573 |
| YBX1 | Y box binding protein 1 | -0.0210446 |
| PGBD5 | piggyBac transposable element derived 5 | -0.021028 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0208719 |
| MED13 | mediator complex subunit 13 | -0.0206192 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0205861 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0205189 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.020513 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0200458 |
| PAPOLA | poly(A) polymerase alpha | -0.0198044 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.019763 |
| MX2 | MX dynamin-like GTPase 2 | -0.0196452 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0195224 |
| PCBP2 | poly(rC) binding protein 2 | -0.0194683 |
| HBP1 | HMG-box transcription factor 1 | -0.0192197 |
| CTBP2 | C-terminal binding protein 2 | -0.0190694 |
| RIGI | RNA sensor RIG-I | -0.0188865 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0188799 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0188502 |
| IRF6 | interferon regulatory factor 6 | -0.0187798 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0186024 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0184381 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0183834 |
| VEGFA | vascular endothelial growth factor A | -0.0180899 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0180581 |
| ABHD3 | abhydrolase domain containing 3 | -0.0178743 |
| LYST | lysosomal trafficking regulator | -0.0178631 |
| MSN | moesin | -0.0177025 |
| HDAC9 | histone deacetylase 9 | -0.0176849 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.017662 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.017636 |
| FNIP1 | folliculin interacting protein 1 | -0.0175154 |
| RLF | rearranged L-myc fusion | -0.0173945 |
| TAOK1 | TAO kinase 1 | -0.0171261 |
