Nafamostat (mesylate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129824
PTMA prothymosin, alpha 0.103537
VIM vimentin 0.102261
RPS12 ribosomal protein S12 0.0836868
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0806659
RPL4 ribosomal protein L4 0.078614
CADM2 cell adhesion molecule 2 0.077339
RPS6 ribosomal protein S6 0.0740944
COL11A1 collagen, type XI, alpha 1 0.0687875
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0683593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0674953
COL5A2 collagen, type V, alpha 2 0.0638734
RPS2 ribosomal protein S2 0.0595524
ADGRV1 adhesion G protein-coupled receptor V1 0.0581794
COL3A1 collagen, type III, alpha 1 0.0579681
CALR calreticulin 0.0550209
PCDH9 protocadherin 9 0.054756
MACF1 microtubule-actin crosslinking factor 1 0.0524108
RAD51B RAD51 paralog B 0.0520075
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0507405
PDE4D phosphodiesterase 4D, cAMP-specific 0.0492603
TMSB10 thymosin beta 10 0.0474823
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0472488
MKI67 marker of proliferation Ki-67 0.0468211
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.045136
FUS FUS RNA binding protein 0.0445265
DPYD dihydropyrimidine dehydrogenase 0.0443551
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0443137
FOXP2 forkhead box P2 0.0418716
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0399156
RPL11 ribosomal protein L11 0.0397237
NPAS3 neuronal PAS domain protein 3 0.0392305
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0391446
SET SET nuclear proto-oncogene 0.0390972
EIF1 eukaryotic translation initiation factor 1 0.0390768
PDGFC platelet derived growth factor C 0.0387765
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0387067
SRRM2 serine/arginine repetitive matrix 2 0.0380403
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376838
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0359143
ATP5F1E ATP synthase F1 subunit epsilon 0.0357656
SIK2 salt-inducible kinase 2 0.0356894
MPG N-methylpurine-DNA glycosylase 0.0349317
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0344972
RBM39 RNA binding motif protein 39 0.0344417
PCLO piccolo presynaptic cytomatrix protein 0.034329
ARHGAP15 Rho GTPase activating protein 15 0.0339114
RPS4X ribosomal protein S4, X-linked 0.0338078
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0329824
GPC3 glypican 3 0.0327324
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0324915
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0320948
EIF5B eukaryotic translation initiation factor 5B 0.0314585
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.030595
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0300748
SOX5 SRY (sex determining region Y)-box 5 0.0299833
COL1A2 collagen, type I, alpha 2 0.0299223
ZFP36L1 ZFP36 ring finger protein-like 1 0.0298955
RACK1 receptor for activated C kinase 1 0.0298409
SHROOM3 shroom family member 3 0.0297189
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0294181
RPLP2 ribosomal protein, large, P2 0.0292062
TPT1 tumor protein, translationally-controlled 1 0.0291263
PDCD5 programmed cell death 5 0.0289346
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0289246
TENM2 teneurin transmembrane protein 2 0.0288098
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0287094
MEF2A myocyte enhancer factor 2A 0.0286685
FTL ferritin, light polypeptide 0.0285217
MATR3 matrin 3 0.0283874
PROS1 protein S (alpha) 0.0281689
CANX calnexin 0.0281641
RPL37 ribosomal protein L37 0.0281455
HMGB1 high mobility group box 1 0.0278686
NALF1 NALCN channel auxiliary factor 1 0.0276739
HMGN2 high mobility group nucleosomal binding domain 2 0.0275974
GOLGB1 golgin B1 0.0275428
TMSB4X thymosin beta 4, X-linked 0.0273915
RPLP1 ribosomal protein, large, P1 0.0271875
TUBA1B tubulin, alpha 1b 0.0271529
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0268331
EFNA5 ephrin-A5 0.0267211
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0266646
CHD4 chromodomain helicase DNA binding protein 4 0.0265766
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0265319
NAP1L1 nucleosome assembly protein 1-like 1 0.0264738
RPL12 ribosomal protein L12 0.0263923
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263356
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0260876
B2M beta-2-microglobulin 0.0259839
KPNB1 karyopherin (importin) beta 1 0.0259668
TUT4 terminal uridylyl transferase 4 0.0259066
RPS3 ribosomal protein S3 0.0257269
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0256959
PKM pyruvate kinase, muscle 0.0256812
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0255155
SLC38A2 solute carrier family 38, member 2 0.0254924
ELP4 elongator acetyltransferase complex subunit 4 0.0253688
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0252128
BABAM2 BRISC and BRCA1 A complex member 2 0.0250861

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.0976957
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0781515
PEG10 paternally expressed 10 -0.0776868
FNDC3B fibronectin type III domain containing 3B -0.0702666
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0652182
UTRN utrophin -0.0646169
PHIP pleckstrin homology domain interacting protein -0.0636601
PUM2 pumilio RNA-binding family member 2 -0.0630959
POTEF POTE ankyrin domain family, member F -0.0619657
MAP4 microtubule-associated protein 4 -0.0598936
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0558673
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0531598
JMJD1C jumonji domain containing 1C -0.0512067
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0501803
PARD3 par-3 family cell polarity regulator -0.049679
ATXN2 ataxin 2 -0.0489994
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0480952
RLF rearranged L-myc fusion -0.0457364
MED13L mediator complex subunit 13-like -0.0454494
PGAP1 post-GPI attachment to proteins 1 -0.0441014
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0421226
STRN3 striatin, calmodulin binding protein 3 -0.0418852
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0416892
ECT2 epithelial cell transforming 2 -0.0415779
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0412398
KCTD16 potassium channel tetramerization domain containing 16 -0.0408728
IARS1 isoleucyl-tRNA synthetase 1 -0.0408394
OSBPL10 oxysterol binding protein-like 10 -0.0403539
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0397623
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0392132
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.039123
FBXO11 F-box protein 11 -0.0382275
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0373769
SRP54 signal recognition particle 54kDa -0.0373664
ZEB2 zinc finger E-box binding homeobox 2 -0.0372375
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0369488
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0368806
RHOA ras homolog family member A -0.0368342
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0366303
SAMD4A sterile alpha motif domain containing 4A -0.0364062
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0363431
UBE2K ubiquitin-conjugating enzyme E2K -0.0353938
RC3H1 ring finger and CCCH-type domains 1 -0.0351913
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.035083
FAM171B family with sequence similarity 171, member B -0.0347922
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0347143
CKAP2 cytoskeleton associated protein 2 -0.0345867
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0343995
URI1 URI1, prefoldin-like chaperone -0.0339843
SUCO SUN domain containing ossification factor -0.0339513
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0338802
PFN1 profilin 1 -0.0335852
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0332883
TBC1D12 TBC1 domain family, member 12 -0.0329774
NCKAP1 NCK-associated protein 1 -0.0328911
SEC31A SEC31 homolog A (S. cerevisiae) -0.0328741
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0326735
TJP1 tight junction protein 1 -0.0325386
SP3 Sp3 transcription factor -0.0321058
NHSL1 NHS-like 1 -0.0317885
TRIO trio Rho guanine nucleotide exchange factor -0.0317093
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0315456
ADNP activity-dependent neuroprotector homeobox -0.0314095
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0311599
HMCN1 hemicentin 1 -0.0310598
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) -0.0309019
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0303786
MTF2 metal response element binding transcription factor 2 -0.0298352
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0296864
HDAC9 histone deacetylase 9 -0.0296702
PRKD1 protein kinase D1 -0.0292701
FNDC3A fibronectin type III domain containing 3A -0.0290038
UBXN7 UBX domain protein 7 -0.0289089
RYBP RING1 and YY1 binding protein -0.0288649
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0287599
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.028728
PICALM phosphatidylinositol binding clathrin assembly protein -0.0284261
BRMS1L breast cancer metastasis-suppressor 1-like -0.0283767
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0283293
RFX7 regulatory factor X, 7 -0.0280307
ENAH enabled homolog (Drosophila) -0.0280116
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0279607
USP3 ubiquitin specific peptidase 3 -0.0278666
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0278258
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0278186
ARL13B ADP-ribosylation factor-like 13B -0.0277529
WNK1 WNK lysine deficient protein kinase 1 -0.027746
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0276168
ZFR zinc finger RNA binding protein -0.0275764
MARCHF6 membrane associated ring-CH-type finger 6 -0.0275235
OLA1 Obg-like ATPase 1 -0.0273852
BMPR1A bone morphogenetic protein receptor, type IA -0.0273369
CAMTA1 calmodulin binding transcription activator 1 -0.0273221
KCMF1 potassium channel modulatory factor 1 -0.0271098
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0270411
TAOK1 TAO kinase 1 -0.0269091
PRTG protogenin -0.0264327
NEK7 NIMA-related kinase 7 -0.0264213
PTK2 protein tyrosine kinase 2 -0.0264119
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0263343