Nafamostat (mesylate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I 0.133469
EIF1 eukaryotic translation initiation factor 1 0.0986303
HLA-A major histocompatibility complex, class I, A 0.0824064
RPL4 ribosomal protein L4 0.0808146
EZR ezrin 0.0789682
PTMA prothymosin, alpha 0.0770745
LAMB3 laminin, beta 3 0.0739648
LOC102724023 ES1 protein homolog, mitochondrial 0.0704315
RPS3 ribosomal protein S3 0.0679014
EFNA5 ephrin-A5 0.0665477
MUC4 mucin 4, cell surface associated 0.0658865
C3 complement component 3 0.0632156
PRRC2C proline-rich coiled-coil 2C 0.0600419
RBM39 RNA binding motif protein 39 0.0524536
EGR1 early growth response 1 0.0518166
PLAT plasminogen activator, tissue 0.0469645
RPS12 ribosomal protein S12 0.0461487
RPS2 ribosomal protein S2 0.0447054
MT2A metallothionein 2A 0.0442735
RPL37A ribosomal protein L37a 0.0430499
ERRFI1 ERBB receptor feedback inhibitor 1 0.0410753
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0407243
SOX4 SRY (sex determining region Y)-box 4 0.0405343
AKAP12 A kinase (PRKA) anchor protein 12 0.0388674
TMSB4X thymosin beta 4, X-linked 0.0387219
HLA-B major histocompatibility complex, class I, B 0.0381905
RBM25 RNA binding motif protein 25 0.0375826
KRT19 keratin 19, type I 0.0375448
RPS6 ribosomal protein S6 0.0371931
RPS18 ribosomal protein S18 0.036231
RPL18 ribosomal protein L18 0.0351716
OSMR oncostatin M receptor 0.0350002
RPL37 ribosomal protein L37 0.0342917
SET SET nuclear proto-oncogene 0.0338494
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0331801
RPS8 ribosomal protein S8 0.0331422
RACK1 receptor for activated C kinase 1 0.0328238
WWC1 WW and C2 domain containing 1 0.0323458
RPL26 ribosomal protein L26 0.0322563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320273
WFDC2 WAP four-disulfide core domain 2 0.0318785
GOLGA4 golgin A4 0.0310846
B2M beta-2-microglobulin 0.0309936
IL1RAP interleukin 1 receptor accessory protein 0.0298776
EIF4H eukaryotic translation initiation factor 4H 0.0292914
MKI67 marker of proliferation Ki-67 0.0292638
RPS27A ribosomal protein S27a 0.0289518
RPL12 ribosomal protein L12 0.0289295
NECTIN2 nectin cell adhesion molecule 2 0.0287922
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0287776
DSPP dentin sialophosphoprotein 0.0277406
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0274297
C6ORF132 chromosome 6 open reading frame 132 0.0274273
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0274015
BCL2L1 BCL2-like 1 0.0272696
IFITM1 interferon induced transmembrane protein 1 0.0267993
SACK1A scaffolding CK1 anchoring protein A 0.026462
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0264241
SPIDR scaffolding protein involved in DNA repair 0.0263084
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0262224
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0259421
AREG amphiregulin 0.0257998
PLAUR plasminogen activator, urokinase receptor 0.0256339
RB1CC1 RB1-inducible coiled-coil 1 0.0254073
TMF1 TATA element modulatory factor 1 0.0253984
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0251505
PNN pinin, desmosome associated protein 0.025101
RPL35A ribosomal protein L35a 0.0249095
LATS2 large tumor suppressor kinase 2 0.024745
RPL5 ribosomal protein L5 0.0247213
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0244487
RPL13A ribosomal protein L13a 0.0241853
RPS14 ribosomal protein S14 0.0239871
AKAP9 A kinase (PRKA) anchor protein 9 0.0236655
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0236292
SENP5 SUMO1/sentrin specific peptidase 5 0.0235644
RIMKLB ribosomal modification protein rimK-like family member B 0.0235252
SRSF11 serine/arginine-rich splicing factor 11 0.0230973
TGM2 transglutaminase 2 0.0229793
YBX3 Y box binding protein 3 0.0225429
TMSB10 thymosin beta 10 0.022488
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224728
ATF4 activating transcription factor 4 0.0224058
NACA nascent polypeptide-associated complex alpha subunit 0.0223631
EIF5B eukaryotic translation initiation factor 5B 0.0223279
MYO1E myosin IE 0.0219945
KIF13B kinesin family member 13B 0.0219124
PRRC2B proline-rich coiled-coil 2B 0.0218049
TPR translocated promoter region, nuclear basket protein 0.0217894
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0217316
CTNND1 catenin (cadherin-associated protein), delta 1 0.0215399
NAP1L1 nucleosome assembly protein 1-like 1 0.021473
RPS17 ribosomal protein S17 0.021212
RPL9 ribosomal protein L9 0.0210911
EEF2 eukaryotic translation elongation factor 2 0.0209341
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0209152
STC2 stanniocalcin 2 0.020867
KLF5 Kruppel-like factor 5 (intestinal) 0.0205975
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0204756
RPL34 ribosomal protein L34 0.0204319

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.418803
HMGA1 high mobility group AT-hook 1 -0.134168
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.12195
NDRG1 N-myc downstream regulated 1 -0.106934
POTEF POTE ankyrin domain family, member F -0.0885109
FNDC3B fibronectin type III domain containing 3B -0.081953
CD44 CD44 molecule (Indian blood group) -0.075365
ANXA2 annexin A2 -0.0742145
FN1 fibronectin 1 -0.0732204
UBE2H ubiquitin-conjugating enzyme E2H -0.0712391
LDHA lactate dehydrogenase A -0.0693813
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0642789
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0639883
CANX calnexin -0.06335
AHNAK AHNAK nucleoprotein -0.0629088
TSC22D2 TSC22 domain family, member 2 -0.0605933
RICTOR RPTOR independent companion of MTOR, complex 2 -0.054381
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0542572
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0532808
EMP1 epithelial membrane protein 1 -0.0516388
INTS6 integrator complex subunit 6 -0.0509766
PDE8A phosphodiesterase 8A -0.0498548
NAV2 neuron navigator 2 -0.0497247
CD47 CD47 molecule -0.0493049
DSG2 desmoglein 2 -0.049263
CDCP1 CUB domain containing protein 1 -0.0483724
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0460721
TXNIP thioredoxin interacting protein -0.0460164
TAOK1 TAO kinase 1 -0.045771
FAM3C family with sequence similarity 3, member C -0.0457554
PDIA3 protein disulfide isomerase family A, member 3 -0.0452308
FOSL1 FOS-like antigen 1 -0.0448705
PLAU plasminogen activator, urokinase -0.0445368
MBNL1 muscleblind-like splicing regulator 1 -0.0436945
MAML2 mastermind-like 2 (Drosophila) -0.0433314
F3 coagulation factor III (thromboplastin, tissue factor) -0.0416369
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0410081
RLF rearranged L-myc fusion -0.0402968
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0394234
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0393714
TMEM123 transmembrane protein 123 -0.0389324
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0387988
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0375633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0375395
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0364413
LPP LIM domain containing preferred translocation partner in lipoma -0.0362084
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0359862
ATP11B ATPase, class VI, type 11B -0.0354125
TRIO trio Rho guanine nucleotide exchange factor -0.0350795
PCBP2 poly(rC) binding protein 2 -0.0348438
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0347486
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0338872
ANKRD10 ankyrin repeat domain 10 -0.0335633
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0334917
LAMC2 laminin, gamma 2 -0.0334143
SYT14 synaptotagmin XIV -0.0326362
PICALM phosphatidylinositol binding clathrin assembly protein -0.0326146
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0325111
TM4SF1 transmembrane 4 L six family member 1 -0.0323983
RYBP RING1 and YY1 binding protein -0.0323794
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0319797
TAPBP TAP binding protein (tapasin) -0.0318874
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0315319
PARD3 par-3 family cell polarity regulator -0.0314071
ZBTB20 zinc finger and BTB domain containing 20 -0.0313833
SVIL supervillin -0.0312534
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0311209
SLMAP sarcolemma associated protein -0.0310358
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0309538
SRSF3 serine/arginine-rich splicing factor 3 -0.0309501
ECT2 epithelial cell transforming 2 -0.0309444
RPS15 ribosomal protein S15 -0.0302986
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0301263
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0299651
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0299612
RUNX1 runt-related transcription factor 1 -0.0295247
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0289824
ITGA6 integrin, alpha 6 -0.0287654
SETD5 SET domain containing 5 -0.0287621
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0286481
CLIC4 chloride intracellular channel 4 -0.0285199
ASPH aspartate beta-hydroxylase -0.0283734
BBX bobby sox homolog (Drosophila) -0.0282034
ITCH itchy E3 ubiquitin protein ligase -0.0279016
TPM4 tropomyosin 4 -0.0275217
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0274899
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0274502
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0272834
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0269658
RPL21 ribosomal protein L21 -0.0269463
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0267678
MBNL2 muscleblind-like splicing regulator 2 -0.0265979
YAP1 Yes-associated protein 1 -0.0264518
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0264471
TFG TRK-fused gene -0.0262004
KMT2E lysine (K)-specific methyltransferase 2E -0.0261563
ARHGAP5 Rho GTPase activating protein 5 -0.0261262
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.026091
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0260783
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0259916