| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nafamostat (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nafamostat (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0521536 |
| EGR1 | early growth response 1 | 0.051737 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0453448 |
| RPL4 | ribosomal protein L4 | 0.0434581 |
| HLA-A | major histocompatibility complex, class I, A | 0.0421711 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0409309 |
| B2M | beta-2-microglobulin | 0.040361 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0392597 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0391059 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0377452 |
| SP100 | SP100 nuclear antigen | 0.0361833 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0350007 |
| MMP2 | matrix metallopeptidase 2 | 0.034564 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0330063 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0326254 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0319637 |
| ANGPTL4 | angiopoietin-like 4 | 0.0280006 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.026963 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0267286 |
| JUN | jun proto-oncogene | 0.026089 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0257557 |
| TPM3 | tropomyosin 3 | 0.0256998 |
| RBM39 | RNA binding motif protein 39 | 0.025348 |
| TOP1 | topoisomerase (DNA) I | 0.0252483 |
| RPS2 | ribosomal protein S2 | 0.0245239 |
| COL5A1 | collagen, type V, alpha 1 | 0.0240433 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0239976 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0236732 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0235284 |
| VEGFA | vascular endothelial growth factor A | 0.0231668 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0231094 |
| RBM25 | RNA binding motif protein 25 | 0.0230937 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0223218 |
| BRD2 | bromodomain containing 2 | 0.0223098 |
| AEBP1 | AE binding protein 1 | 0.0222876 |
| INHBA | inhibin, beta A | 0.0221846 |
| TLN1 | talin 1 | 0.0218074 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0215042 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0215002 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0214663 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0212847 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0211522 |
| HLA-B | major histocompatibility complex, class I, B | 0.0211355 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0210233 |
| SET | SET nuclear proto-oncogene | 0.0205302 |
| IFI44L | interferon-induced protein 44-like | 0.0202422 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0199855 |
| HDAC9 | histone deacetylase 9 | 0.0199065 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0195435 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0193778 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0191415 |
| TMEM178B | transmembrane protein 178B | 0.0191377 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0186902 |
| RPS12 | ribosomal protein S12 | 0.018502 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0184118 |
| FBXO32 | F-box protein 32 | 0.018247 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0173019 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0171907 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0171711 |
| ZNF292 | zinc finger protein 292 | 0.0168826 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0166401 |
| ECE1 | endothelin converting enzyme 1 | 0.0166303 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0165497 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0164003 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0162587 |
| HPCAL1 | hippocalcin-like 1 | 0.016151 |
| ATF4 | activating transcription factor 4 | 0.0157112 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0156846 |
| RPS18 | ribosomal protein S18 | 0.015156 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0150613 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0149736 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0148848 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0148278 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0147051 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0145987 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0145677 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0144774 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0143882 |
| TJP1 | tight junction protein 1 | 0.0142976 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.01426 |
| YBX1 | Y box binding protein 1 | 0.0142527 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0141682 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0141538 |
| PER1 | period circadian clock 1 | 0.0140465 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0140213 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0139507 |
| MEF2A | myocyte enhancer factor 2A | 0.0139003 |
| PNN | pinin, desmosome associated protein | 0.0137804 |
| IER2 | immediate early response 2 | 0.013729 |
| CCNL1 | cyclin L1 | 0.0137201 |
| HMGA2 | high mobility group AT-hook 2 | 0.0136521 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.01357 |
| NAV2 | neuron navigator 2 | 0.013489 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0133596 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0133299 |
| CERT1 | ceramide transporter 1 | 0.0132549 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0131865 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0131298 |
| CADM1 | cell adhesion molecule 1 | 0.0131184 |
| SPAG9 | sperm associated antigen 9 | 0.013074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.558584 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.326499 |
| VIM | vimentin | -0.184795 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.146589 |
| NDRG1 | N-myc downstream regulated 1 | -0.143293 |
| MT2A | metallothionein 2A | -0.119374 |
| PGK1 | phosphoglycerate kinase 1 | -0.110439 |
| COL1A2 | collagen, type I, alpha 2 | -0.0699982 |
| STC1 | stanniocalcin 1 | -0.0665502 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0540371 |
| LDHA | lactate dehydrogenase A | -0.0520129 |
| CD44 | CD44 molecule (Indian blood group) | -0.0453794 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0452926 |
| TMSB10 | thymosin beta 10 | -0.0388076 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0380984 |
| SETD5 | SET domain containing 5 | -0.0364991 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0363778 |
| CENPF | centromere protein F, 350/400kDa | -0.0359794 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0352456 |
| AHNAK | AHNAK nucleoprotein | -0.0351017 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0344077 |
| RPLP1 | ribosomal protein, large, P1 | -0.0328353 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0327688 |
| RPS21 | ribosomal protein S21 | -0.0327224 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0326334 |
| UBC | ubiquitin C | -0.0323907 |
| CDCP1 | CUB domain containing protein 1 | -0.0320931 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0320343 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0315235 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0304272 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0294329 |
| TPM4 | tropomyosin 4 | -0.0287814 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.028654 |
| IER3 | immediate early response 3 | -0.0285617 |
| RPS13 | ribosomal protein S13 | -0.0281581 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0279452 |
| TMEM263 | transmembrane protein 263 | -0.0279264 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0278023 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0276563 |
| FTL | ferritin, light polypeptide | -0.027646 |
| FBN1 | fibrillin 1 | -0.0275148 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0268302 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0265341 |
| S100A10 | S100 calcium binding protein A10 | -0.0259729 |
| PKM | pyruvate kinase, muscle | -0.0259131 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0259034 |
| ASPH | aspartate beta-hydroxylase | -0.0250627 |
| RPL19 | ribosomal protein L19 | -0.0245709 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0243241 |
| CAVIN1 | caveolae associated protein 1 | -0.0240257 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0238123 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0236588 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0235262 |
| CANX | calnexin | -0.0235204 |
| POTEF | POTE ankyrin domain family, member F | -0.0232811 |
| AFAP1 | actin filament associated protein 1 | -0.0232413 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0231285 |
| EHD2 | EH-domain containing 2 | -0.0227398 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0225012 |
| RPS24 | ribosomal protein S24 | -0.0223354 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0222537 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0221677 |
| CTSB | cathepsin B | -0.0219285 |
| LMNA | lamin A/C | -0.0219074 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0217565 |
| TPM1 | tropomyosin 1 (alpha) | -0.0217481 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0216128 |
| RPL8 | ribosomal protein L8 | -0.021323 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0212136 |
| SERF2 | small EDRK-rich factor 2 | -0.0211267 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0208652 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0207358 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0205668 |
| RPL11 | ribosomal protein L11 | -0.0203149 |
| NBEAL1 | neurobeachin-like 1 | -0.0200968 |
| RPLP2 | ribosomal protein, large, P2 | -0.020094 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0200388 |
| DEK | DEK proto-oncogene | -0.0200339 |
| BBX | bobby sox homolog (Drosophila) | -0.0198838 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0198226 |
| RPS19 | ribosomal protein S19 | -0.0197666 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0197027 |
| ANXA2 | annexin A2 | -0.0196663 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0196556 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0196489 |
| ZNF609 | zinc finger protein 609 | -0.0195367 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0194667 |
| CALU | calumenin | -0.0191063 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.0190529 |
| WASF2 | WAS protein family, member 2 | -0.0190162 |
| NBAS | neuroblastoma amplified sequence | -0.0190089 |
| HM13 | histocompatibility (minor) 13 | -0.0189746 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0189094 |
| TPX2 | TPX2, microtubule-associated | -0.018795 |
| RPS29 | ribosomal protein S29 | -0.0187228 |
| THBS1 | thrombospondin 1 | -0.0186633 |
| GNAS | GNAS complex locus | -0.018636 |
| RPS23 | ribosomal protein S23 | -0.018563 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0184569 |
| GOLGA4 | golgin A4 | -0.0184444 |
