Nafamostat (mesylate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.156575
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.102023
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100569
ENO1 enolase 1, (alpha) 0.0993418
RPL4 ribosomal protein L4 0.0913852
RPS3 ribosomal protein S3 0.0659461
MT2A metallothionein 2A 0.0645117
EGR1 early growth response 1 0.060236
TOP2A topoisomerase (DNA) II alpha 170kDa 0.058058
RPS6 ribosomal protein S6 0.0526527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0507171
SET SET nuclear proto-oncogene 0.0503552
KTN1 kinectin 1 (kinesin receptor) 0.0502912
RPL37A ribosomal protein L37a 0.0480028
FTL ferritin, light polypeptide 0.0449236
RPL26 ribosomal protein L26 0.044289
RPS2 ribosomal protein S2 0.0428017
TMSB10 thymosin beta 10 0.0418404
SRRM2 serine/arginine repetitive matrix 2 0.0412169
RPS8 ribosomal protein S8 0.0401249
RPS19 ribosomal protein S19 0.0394717
RPL23 ribosomal protein L23 0.0394293
RPS12 ribosomal protein S12 0.0393266
RPL5 ribosomal protein L5 0.0388445
RPL18 ribosomal protein L18 0.0342801
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0337589
TPM3 tropomyosin 3 0.0333003
EIF1 eukaryotic translation initiation factor 1 0.0329324
YBX1 Y box binding protein 1 0.0326519
RBM25 RNA binding motif protein 25 0.032533
RPL31 ribosomal protein L31 0.0319721
RACK1 receptor for activated C kinase 1 0.0314418
INHBA inhibin, beta A 0.0310613
EZR ezrin 0.0307059
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0305309
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0303166
B2M beta-2-microglobulin 0.0302014
HMGB2 high mobility group box 2 0.0297249
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0289328
RPS27 ribosomal protein S27 0.0289002
MXI1 MAX interactor 1, dimerization protein 0.0287313
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0285643
PRRC2C proline-rich coiled-coil 2C 0.0284485
RPS17 ribosomal protein S17 0.0283697
PKM pyruvate kinase, muscle 0.0279186
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.027668
RPL12 ribosomal protein L12 0.0275963
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0275456
FTH1 ferritin, heavy polypeptide 1 0.0274041
CALR calreticulin 0.0272094
PABPN1 poly(A) binding protein, nuclear 1 0.0268569
RPL36 ribosomal protein L36 0.0261739
RPS27A ribosomal protein S27a 0.025954
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0255643
RSRC2 arginine/serine-rich coiled-coil 2 0.0254374
BHLHE40 basic helix-loop-helix family, member e40 0.0252568
HMGN2 high mobility group nucleosomal binding domain 2 0.0251878
MATR3 matrin 3 0.025015
ZNF292 zinc finger protein 292 0.024889
HLA-A major histocompatibility complex, class I, A 0.0246348
RPS5 ribosomal protein S5 0.024611
RANBP1 RAN binding protein 1 0.0241685
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0240919
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0240771
TMSB4X thymosin beta 4, X-linked 0.0239678
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238793
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0238428
HDGF hepatoma-derived growth factor 0.0237662
KMT2E lysine (K)-specific methyltransferase 2E 0.0236253
JUN jun proto-oncogene 0.0235194
KIF5B kinesin family member 5B 0.0228335
RPL13A ribosomal protein L13a 0.0223524
CENPF centromere protein F, 350/400kDa 0.0222153
RPLP1 ribosomal protein, large, P1 0.0222103
PNN pinin, desmosome associated protein 0.0219728
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0219701
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0219121
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0213851
HMGB3 high mobility group box 3 0.0212051
S100A9 S100 calcium binding protein A9 0.0211158
RPS18 ribosomal protein S18 0.0210672
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0207303
RPL30 ribosomal protein L30 0.020628
AKAP9 A kinase (PRKA) anchor protein 9 0.0204914
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0202632
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0202119
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0201546
EIF5B eukaryotic translation initiation factor 5B 0.019991
PRRC2A proline-rich coiled-coil 2A 0.0197963
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0197846
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0196256
KPNB1 karyopherin (importin) beta 1 0.0196137
OGA O-GlcNAcase 0.0194733
RBM39 RNA binding motif protein 39 0.0193778
SMC1A structural maintenance of chromosomes 1A 0.0192477
RPL7 ribosomal protein L7 0.0191997
PRC1 protein regulator of cytokinesis 1 0.0191533
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0188941
RIOK3 RIO kinase 3 0.0187873
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0187707

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.217607
NALF1 NALCN channel auxiliary factor 1 -0.174009
GPC6 glypican 6 -0.164108
NRG1 neuregulin 1 -0.113937
TENM1 teneurin transmembrane protein 1 -0.104339
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0984734
RIMS2 regulating synaptic membrane exocytosis 2 -0.0942531
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.072946
SNTG1 syntrophin, gamma 1 -0.071695
PDE4B phosphodiesterase 4B, cAMP-specific -0.0688496
SMYD3 SET and MYND domain containing 3 -0.0667913
NCKAP5 NCK-associated protein 5 -0.0648469
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0630467
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0586964
CNTNAP2 contactin associated protein-like 2 -0.0575366
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0574023
FGF14 fibroblast growth factor 14 -0.0568766
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0554857
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0527987
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.050507
PTCHD4 patched domain containing 4 -0.0497489
GMDS GDP-mannose 4,6-dehydratase -0.0488178
RORA RAR-related orphan receptor A -0.047543
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0467968
KIF26B kinesin family member 26B -0.0458627
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0457987
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0457184
ARB2A ARB2 cotranscriptional regulator A -0.0450724
TSHZ2 teashirt zinc finger homeobox 2 -0.0429267
RIT2 Ras-like without CAAX 2 -0.0420046
ZNF804A zinc finger protein 804A -0.0414581
GPC5 glypican 5 -0.0412631
AUTS2 autism susceptibility candidate 2 -0.0411224
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0403194
EXT1 exostosin glycosyltransferase 1 -0.0398611
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0391991
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0391833
RERE arginine-glutamic acid dipeptide (RE) repeats -0.039007
NOVA1 neuro-oncological ventral antigen 1 -0.0389934
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.038681
SYT1 synaptotagmin I -0.038224
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0376174
PCBP3 poly(rC) binding protein 3 -0.0371598
NBEA neurobeachin -0.0366039
TXNRD1 thioredoxin reductase 1 -0.036486
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.035669
ST18 suppression of tumorigenicity 18, zinc finger -0.0354772
CNKSR3 CNKSR family member 3 -0.0353052
TOX thymocyte selection-associated high mobility group box -0.0345216
WWOX WW domain containing oxidoreductase -0.0340118
MCTP1 multiple C2 domains, transmembrane 1 -0.0337274
LSAMP limbic system-associated membrane protein -0.0336237
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.033606
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0328306
IGF1R insulin-like growth factor 1 receptor -0.0326033
ANKRD17 ankyrin repeat domain 17 -0.032536
CADM1 cell adhesion molecule 1 -0.032438
ADGRL3 adhesion G protein-coupled receptor L3 -0.0323266
EPHA6 EPH receptor A6 -0.0318654
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0317477
ZBTB20 zinc finger and BTB domain containing 20 -0.0313047
EFNA5 ephrin-A5 -0.0308404
PDE4D phosphodiesterase 4D, cAMP-specific -0.030822
RGS7 regulator of G-protein signaling 7 -0.0303259
RABGAP1L RAB GTPase activating protein 1-like -0.0302441
STXBP5L syntaxin binding protein 5-like -0.0302425
RPH3AL rabphilin 3A-like (without C2 domains) -0.0300696
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0300037
NRXN1 neurexin 1 -0.0297807
PSD3 pleckstrin and Sec7 domain containing 3 -0.0296755
ASPH aspartate beta-hydroxylase -0.0294864
PCDH9 protocadherin 9 -0.0294352
PEX5L peroxisomal biogenesis factor 5-like -0.0290589
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0290152
SCFD2 sec1 family domain containing 2 -0.0283649
TCF12 transcription factor 12 -0.0283319
DTNA dystrobrevin, alpha -0.0279853
TENT5A terminal nucleotidyltransferase 5A -0.0279309
KLHL29 kelch-like family member 29 -0.0277655
ESRRG estrogen-related receptor gamma -0.0276358
TUSC3 tumor suppressor candidate 3 -0.0275828
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0271328
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0270843
SYT4 synaptotagmin IV -0.0270537
GDAP1 ganglioside induced differentiation associated protein 1 -0.0268102
NAV2 neuron navigator 2 -0.0268002
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0266424
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0266153
NDRG1 N-myc downstream regulated 1 -0.0266001
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0262968
ADGRL2 adhesion G protein-coupled receptor L2 -0.026181
TRAPPC9 trafficking protein particle complex 9 -0.0258673
FAF1 Fas (TNFRSF6) associated factor 1 -0.0256915
NPAS3 neuronal PAS domain protein 3 -0.0256528
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0255525
CDK13 cyclin-dependent kinase 13 -0.0254961
ASIC2 acid sensing (proton gated) ion channel 2 -0.0250473
GLCCI1 glucocorticoid induced 1 -0.0249842
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0249743
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -0.0247407