| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Nafamostat (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Nafamostat (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.109059 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.101123 |
| RPL4 | ribosomal protein L4 | 0.06087 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0487055 |
| RPS3 | ribosomal protein S3 | 0.0486618 |
| RAD51B | RAD51 paralog B | 0.0435439 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0387988 |
| CDH13 | cadherin 13 | 0.0381797 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0380051 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0375854 |
| HLA-A | major histocompatibility complex, class I, A | 0.0366493 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0355523 |
| ANGPTL4 | angiopoietin-like 4 | 0.0324163 |
| RPS12 | ribosomal protein S12 | 0.032156 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0317389 |
| DHFR | dihydrofolate reductase | 0.0300652 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0288574 |
| RBM25 | RNA binding motif protein 25 | 0.0284881 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0277378 |
| CENPF | centromere protein F, 350/400kDa | 0.0271731 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.026862 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0267952 |
| SET | SET nuclear proto-oncogene | 0.0266747 |
| CBX3 | chromobox homolog 3 | 0.0259477 |
| RPS2 | ribosomal protein S2 | 0.0245031 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0235481 |
| HDAC9 | histone deacetylase 9 | 0.0232296 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0230246 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0230028 |
| USP53 | ubiquitin specific peptidase 53 | 0.0222875 |
| CADM1 | cell adhesion molecule 1 | 0.0219481 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0215857 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0213656 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0213292 |
| MACROD2 | MACRO domain containing 2 | 0.0210537 |
| PTMA | prothymosin, alpha | 0.020886 |
| ENO1 | enolase 1, (alpha) | 0.0206988 |
| ATF4 | activating transcription factor 4 | 0.0205088 |
| EFNA5 | ephrin-A5 | 0.0200968 |
| RPS18 | ribosomal protein S18 | 0.0199498 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0198507 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0193807 |
| RPS14 | ribosomal protein S14 | 0.0192544 |
| TPM3 | tropomyosin 3 | 0.0190995 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.019098 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0189207 |
| HDAC4 | histone deacetylase 4 | 0.018667 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0181303 |
| TLN1 | talin 1 | 0.0179333 |
| MYO9A | myosin IXA | 0.0178082 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0177702 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.017696 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0176309 |
| BRCA1 | breast cancer 1, early onset | 0.0175573 |
| RNF130 | ring finger protein 130 | 0.0174782 |
| RBM6 | RNA binding motif protein 6 | 0.0171318 |
| HMGB2 | high mobility group box 2 | 0.0169161 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0168225 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0162814 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0162529 |
| RPL5 | ribosomal protein L5 | 0.0161427 |
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.0160335 |
| HMG20B | high mobility group 20B | 0.0159482 |
| ANKZF1 | ankyrin repeat and zinc finger domain containing 1 | 0.0158811 |
| RPL26 | ribosomal protein L26 | 0.0158721 |
| RPL12 | ribosomal protein L12 | 0.0158438 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0158411 |
| MKI67 | marker of proliferation Ki-67 | 0.0158295 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0158193 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0157024 |
| ASPH | aspartate beta-hydroxylase | 0.0156046 |
| EZR | ezrin | 0.0155957 |
| CALD1 | caldesmon 1 | 0.015582 |
| SHISA5 | shisa family member 5 | 0.0154511 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0153577 |
| PHF14 | PHD finger protein 14 | 0.0152039 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0152005 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0151876 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0148712 |
| TGFA | transforming growth factor, alpha | 0.0147595 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0147362 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0146642 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0145323 |
| DICER1 | dicer 1, ribonuclease type III | 0.0141934 |
| EXOC4 | exocyst complex component 4 | 0.0141553 |
| CEP128 | centrosomal protein 128kDa | 0.0140518 |
| RPL36 | ribosomal protein L36 | 0.0140501 |
| STXBP1 | syntaxin binding protein 1 | 0.0138837 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0138653 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0136141 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0135734 |
| RPL27 | ribosomal protein L27 | 0.0135657 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0133639 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0133623 |
| RPS6 | ribosomal protein S6 | 0.0133321 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0133111 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0132483 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0132463 |
| RPL37A | ribosomal protein L37a | 0.0130936 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0130222 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.295933 |
| FN1 | fibronectin 1 | -0.200034 |
| FNDC3B | fibronectin type III domain containing 3B | -0.121797 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.121313 |
| SFTPA2 | surfactant protein A2 | -0.0926018 |
| VIM | vimentin | -0.0806733 |
| LDHA | lactate dehydrogenase A | -0.0735993 |
| PMEL | premelanosome protein | -0.0684785 |
| NRG3 | neuregulin 3 | -0.0682786 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0643089 |
| MSI2 | musashi RNA-binding protein 2 | -0.0619102 |
| NDRG1 | N-myc downstream regulated 1 | -0.0609175 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0602095 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0601029 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0578838 |
| CANX | calnexin | -0.0573389 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0571936 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.057134 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0564056 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0556061 |
| FMNL2 | formin-like 2 | -0.0544047 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0542521 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0538866 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0515659 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0511205 |
| UBC | ubiquitin C | -0.0497769 |
| SPAG9 | sperm associated antigen 9 | -0.0483138 |
| LSAMP | limbic system-associated membrane protein | -0.0480143 |
| PGK1 | phosphoglycerate kinase 1 | -0.0479418 |
| POTEF | POTE ankyrin domain family, member F | -0.0478767 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0466877 |
| FMN1 | formin 1 | -0.0461359 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0436745 |
| FRMD4A | FERM domain containing 4A | -0.0434152 |
| CD44 | CD44 molecule (Indian blood group) | -0.043037 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0427456 |
| MAP4 | microtubule-associated protein 4 | -0.041737 |
| RHOA | ras homolog family member A | -0.0414167 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0413732 |
| CLIC4 | chloride intracellular channel 4 | -0.0401566 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.0398322 |
| NOTCH2 | notch 2 | -0.0393664 |
| CLTC | clathrin, heavy chain (Hc) | -0.0387497 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.038058 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0378176 |
| BBX | bobby sox homolog (Drosophila) | -0.0374528 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0371252 |
| ANXA2 | annexin A2 | -0.0370933 |
| WDR45B | WD repeat domain 45B | -0.0364163 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0363079 |
| SMAD3 | SMAD family member 3 | -0.0355687 |
| TFRC | transferrin receptor | -0.0353766 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0352241 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0350845 |
| CLINT1 | clathrin interactor 1 | -0.0349709 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0347553 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0344758 |
| SETD5 | SET domain containing 5 | -0.0340824 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0336621 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0329693 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0327654 |
| MSN | moesin | -0.0325311 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0324789 |
| RLIM | ring finger protein, LIM domain interacting | -0.0319021 |
| TXNRD1 | thioredoxin reductase 1 | -0.0318062 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0317179 |
| ICAM1 | intercellular adhesion molecule 1 | -0.031287 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0308996 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0308902 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0308032 |
| MORF4L2 | mortality factor 4 like 2 | -0.0304232 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0300499 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0296534 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.029644 |
| RHEB | Ras homolog enriched in brain | -0.029621 |
| H3-3B | H3.3 histone B | -0.0296139 |
| HELZ | helicase with zinc finger | -0.02961 |
| TAOK1 | TAO kinase 1 | -0.0294898 |
| APOD | apolipoprotein D | -0.0290666 |
| TENM1 | teneurin transmembrane protein 1 | -0.028974 |
| TMEM263 | transmembrane protein 263 | -0.0289089 |
| FOXO3 | forkhead box O3 | -0.0288676 |
| WASF2 | WAS protein family, member 2 | -0.0288524 |
| AFF4 | AF4/FMR2 family, member 4 | -0.028781 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0286576 |
| OXSR1 | oxidative stress responsive 1 | -0.0284996 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0282674 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0282586 |
| CTTN | cortactin | -0.0282129 |
| RTN4 | reticulon 4 | -0.0280634 |
| FRMD5 | FERM domain containing 5 | -0.0277174 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -0.0275511 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0273136 |
| HMGA1 | high mobility group AT-hook 1 | -0.0273072 |
| RPS23 | ribosomal protein S23 | -0.0272648 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0271621 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0267863 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0267735 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.026761 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0267304 |
