Nafamostat (mesylate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0887784
RPL4 ribosomal protein L4 0.083934
EZR ezrin 0.0817587
RBM39 RNA binding motif protein 39 0.0647236
PDE4D phosphodiesterase 4D, cAMP-specific 0.0626746
RPS2 ribosomal protein S2 0.0622896
GOLGA4 golgin A4 0.054505
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0495841
EIF1 eukaryotic translation initiation factor 1 0.0459999
PRELID2 PRELI domain containing 2 0.043671
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0434878
PRRC2C proline-rich coiled-coil 2C 0.0428205
ZNF292 zinc finger protein 292 0.0405428
DSCAM Down syndrome cell adhesion molecule 0.0400117
AKAP9 A kinase (PRKA) anchor protein 9 0.0386352
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0363402
RPS18 ribosomal protein S18 0.0361205
RTN4 reticulon 4 0.035824
NCEH1 neutral cholesterol ester hydrolase 1 0.0354882
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0350276
SRRM2 serine/arginine repetitive matrix 2 0.0346835
SLC38A2 solute carrier family 38, member 2 0.0338857
PDGFC platelet derived growth factor C 0.0329054
RBM25 RNA binding motif protein 25 0.0325001
ENO2 enolase 2 (gamma, neuronal) 0.0313659
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0309103
ANK2 ankyrin 2, neuronal 0.0308079
EGFR epidermal growth factor receptor 0.0298076
CSF1 colony stimulating factor 1 (macrophage) 0.0297912
PLXNA1 plexin A1 0.0281696
FLNB filamin B, beta 0.0278145
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0265346
SESN2 sestrin 2 0.0257786
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0251379
NUP58 nucleoporin 58 0.0251165
UBA6 ubiquitin-like modifier activating enzyme 6 0.0249708
ZNF608 zinc finger protein 608 0.0241595
BRD2 bromodomain containing 2 0.0237087
TXNRD1 thioredoxin reductase 1 0.0235113
GARS1 glycyl-tRNA synthetase 1 0.023304
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0231562
SQSTM1 sequestosome 1 0.0231283
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0229625
VMP1 vacuole membrane protein 1 0.0226873
PCBP2 poly(rC) binding protein 2 0.0225506
ATF4 activating transcription factor 4 0.0223266
ATP9B ATPase, class II, type 9B 0.0221844
EEF2 eukaryotic translation elongation factor 2 0.0214707
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0213588
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0211679
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0211311
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0208635
MT2A metallothionein 2A 0.0206991
RSRC2 arginine/serine-rich coiled-coil 2 0.0206888
PSAT1 phosphoserine aminotransferase 1 0.020343
NAMPT nicotinamide phosphoribosyltransferase 0.0202211
EFNA5 ephrin-A5 0.0201831
PFN1 profilin 1 0.0199189
TBC1D22A TBC1 domain family, member 22A 0.0198599
TFG TRK-fused gene 0.0194043
MEF2A myocyte enhancer factor 2A 0.0193764
IRS1 insulin receptor substrate 1 0.0193723
CAMTA1 calmodulin binding transcription activator 1 0.0193452
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0193216
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0192771
JMJD1C jumonji domain containing 1C 0.0192445
RPL18 ribosomal protein L18 0.0189614
SRSF11 serine/arginine-rich splicing factor 11 0.0184845
ASPH aspartate beta-hydroxylase 0.0181831
RPS12 ribosomal protein S12 0.0180673
GATA6 GATA binding protein 6 0.0176626
CCNL1 cyclin L1 0.0175831
RB1CC1 RB1-inducible coiled-coil 1 0.0175511
DHFR dihydrofolate reductase 0.0173522
PER1 period circadian clock 1 0.0170552
SET SET nuclear proto-oncogene 0.0169644
ZBTB20 zinc finger and BTB domain containing 20 0.016698
MBD5 methyl-CpG binding domain protein 5 0.0166685
EEF1G eukaryotic translation elongation factor 1 gamma 0.0166535
HDGF hepatoma-derived growth factor 0.0165334
TMF1 TATA element modulatory factor 1 0.0165042
GPR107 G protein-coupled receptor 107 0.0165029
PKM pyruvate kinase, muscle 0.0163645
PNISR PNN-interacting serine/arginine-rich protein 0.0163294
ARID1A AT rich interactive domain 1A (SWI-like) 0.0162948
LENG8 leukocyte receptor cluster (LRC) member 8 0.0162671
TMEM41B transmembrane protein 41B 0.0161399
EXT1 exostosin glycosyltransferase 1 0.0159836
DENR density-regulated protein 0.0159734
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0159352
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0159343
S100A6 S100 calcium binding protein A6 0.0158258
ADAM9 ADAM metallopeptidase domain 9 0.0157564
NFE2L1 nuclear factor, erythroid 2-like 1 0.0157483
RPS3 ribosomal protein S3 0.0156876
RPL12 ribosomal protein L12 0.0155416
KMT2D lysine (K)-specific methyltransferase 2D 0.0153305
KDM6B lysine (K)-specific demethylase 6B 0.0152893
BTBD9 BTB (POZ) domain containing 9 0.0151156
ELOVL5 ELOVL fatty acid elongase 5 0.0151088

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193071
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.162113
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.133854
CPED1 cadherin-like and PC-esterase domain containing 1 -0.122488
BMP10 bone morphogenetic protein 10 -0.115663
PDE4B phosphodiesterase 4B, cAMP-specific -0.0974581
FOXP1 forkhead box P1 -0.0951236
AHNAK AHNAK nucleoprotein -0.0936405
TPT1 tumor protein, translationally-controlled 1 -0.0814596
VCL vinculin -0.0777258
DLG1 discs, large homolog 1 (Drosophila) -0.0750842
SSBP2 single-stranded DNA binding protein 2 -0.070358
NBEA neurobeachin -0.0622743
ADAM10 ADAM metallopeptidase domain 10 -0.056905
MKI67 marker of proliferation Ki-67 -0.0538271
PGK1 phosphoglycerate kinase 1 -0.052362
BMP2K BMP2 inducible kinase -0.0501706
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0501331
PTMA prothymosin, alpha -0.0497111
MYO5C myosin VC -0.0457855
HDAC9 histone deacetylase 9 -0.0455631
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.044742
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0441523
NFIA nuclear factor I/A -0.0440005
ACTG1 actin gamma 1 -0.0421397
NAV2 neuron navigator 2 -0.041791
TMSB4X thymosin beta 4, X-linked -0.0415095
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0404948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402853
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0398088
ZNF438 zinc finger protein 438 -0.039577
CAMKMT calmodulin-lysine N-methyltransferase -0.0387254
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0380147
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036967
DIAPH3 diaphanous-related formin 3 -0.0362879
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0362012
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0359233
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0352731
RPLP0 ribosomal protein, large, P0 -0.0350843
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0341437
EML4 echinoderm microtubule associated protein like 4 -0.0331452
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0326461
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0323542
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0321941
BPTF bromodomain PHD finger transcription factor -0.0321509
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0321427
CUX1 cut-like homeobox 1 -0.0319479
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0318354
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0318116
EBNA1BP2 EBNA1 binding protein 2 -0.0316024
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0314513
DPYD dihydropyrimidine dehydrogenase -0.0307927
ARL4C ADP-ribosylation factor-like 4C -0.0307748
HSPB1 heat shock 27kDa protein 1 -0.0302417
DOCK1 dedicator of cytokinesis 1 -0.030186
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0298295
S100A4 S100 calcium binding protein A4 -0.0297068
GSE1 Gse1 coiled-coil protein -0.0294219
RPL19 ribosomal protein L19 -0.0290185
RPS23 ribosomal protein S23 -0.0289534
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0289425
ZMYND8 zinc finger, MYND-type containing 8 -0.0288985
SOX6 SRY (sex determining region Y)-box 6 -0.0287341
PRUNE2 prune homolog 2 (Drosophila) -0.0284497
RSL1D1 ribosomal L1 domain containing 1 -0.0271241
RPL35A ribosomal protein L35a -0.0271149
MYL12B myosin, light chain 12B, regulatory -0.0269632
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0269476
WSB1 WD repeat and SOCS box containing 1 -0.0268767
LARP1 La ribonucleoprotein domain family, member 1 -0.0265308
TPM4 tropomyosin 4 -0.0261252
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0260913
SMC4 structural maintenance of chromosomes 4 -0.0260387
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0259288
EXOC6B exocyst complex component 6B -0.0258276
DEK DEK proto-oncogene -0.0256758
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0254784
ACACA acetyl-CoA carboxylase alpha -0.0251647
PSIP1 PC4 and SFRS1 interacting protein 1 -0.025137
CD47 CD47 molecule -0.025086
KPNB1 karyopherin (importin) beta 1 -0.0250814
GPATCH8 G patch domain containing 8 -0.0250523
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0247775
FAF1 Fas (TNFRSF6) associated factor 1 -0.0246419
MBNL1 muscleblind-like splicing regulator 1 -0.0242828
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0241006
LPP LIM domain containing preferred translocation partner in lipoma -0.0237204
VDAC1 voltage-dependent anion channel 1 -0.0236218
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0234885
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.023366
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0232758
GPHN gephyrin -0.0231621
NSD2 nuclear receptor binding SET domain protein 2 -0.0228373
KIF5B kinesin family member 5B -0.0227234
DUSP6 dual specificity phosphatase 6 -0.0224865
PDIA3 protein disulfide isomerase family A, member 3 -0.0224048
SEPTIN11 septin 11 -0.0222153
PDE7B phosphodiesterase 7B -0.0221504
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0218632
APP amyloid beta (A4) precursor protein -0.0217479