Nafamostat (mesylate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nafamostat (mesylate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nafamostat (mesylate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRRC2C proline-rich coiled-coil 2C 0.0909868
RBM39 RNA binding motif protein 39 0.0680876
PTMA prothymosin, alpha 0.0621716
NAMPT nicotinamide phosphoribosyltransferase 0.0612064
RPL4 ribosomal protein L4 0.0573056
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0537365
OGA O-GlcNAcase 0.0517079
EIF1 eukaryotic translation initiation factor 1 0.0514673
RPS12 ribosomal protein S12 0.0507657
RPL26 ribosomal protein L26 0.048825
RBM25 RNA binding motif protein 25 0.0472482
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0471951
TPR translocated promoter region, nuclear basket protein 0.0466538
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.043954
RPL37A ribosomal protein L37a 0.0419936
RPL12 ribosomal protein L12 0.0401599
RPS2 ribosomal protein S2 0.0379935
RPS6 ribosomal protein S6 0.0364344
NAP1L1 nucleosome assembly protein 1-like 1 0.0352635
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.032157
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0317066
RPS3 ribosomal protein S3 0.0298043
OSMR oncostatin M receptor 0.0287483
RRBP1 ribosome binding protein 1 0.0286264
RPL5 ribosomal protein L5 0.0274855
GOLGA4 golgin A4 0.0274307
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0273127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0261483
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0258943
FBXO32 F-box protein 32 0.0257557
STC2 stanniocalcin 2 0.0248058
KDM3A lysine (K)-specific demethylase 3A 0.0240468
SRSF11 serine/arginine-rich splicing factor 11 0.024039
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0237207
RPL9 ribosomal protein L9 0.0231422
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0230489
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0224477
AKAP9 A kinase (PRKA) anchor protein 9 0.0223885
RPL36 ribosomal protein L36 0.0223701
RPL23 ribosomal protein L23 0.0221442
FTL ferritin, light polypeptide 0.0221336
TOP1 topoisomerase (DNA) I 0.0220943
RPL18 ribosomal protein L18 0.0219722
RSRC2 arginine/serine-rich coiled-coil 2 0.021603
RPL37 ribosomal protein L37 0.0216023
GIGYF2 GRB10 interacting GYF protein 2 0.0215958
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0213637
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0211038
KIF5B kinesin family member 5B 0.02107
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0210236
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0208314
RPS18 ribosomal protein S18 0.020796
RPL35A ribosomal protein L35a 0.0207468
MKI67 marker of proliferation Ki-67 0.0206218
PCM1 pericentriolar material 1 0.0206071
CALR calreticulin 0.0204969
SET SET nuclear proto-oncogene 0.0197549
TFG TRK-fused gene 0.019556
BASP1 brain abundant, membrane attached signal protein 1 0.0195234
RPL14 ribosomal protein L14 0.0194964
ATF4 activating transcription factor 4 0.0193679
ANGPTL4 angiopoietin-like 4 0.0189816
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0188297
PNN pinin, desmosome associated protein 0.0186485
RPL13A ribosomal protein L13a 0.0185822
SQSTM1 sequestosome 1 0.0185599
RB1CC1 RB1-inducible coiled-coil 1 0.0185101
PRELID2 PRELI domain containing 2 0.0183736
EFNA5 ephrin-A5 0.0183549
BHLHE40 basic helix-loop-helix family, member e40 0.0182287
VMP1 vacuole membrane protein 1 0.0181852
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0181401
AKAP12 A kinase (PRKA) anchor protein 12 0.0180416
RPS17 ribosomal protein S17 0.0180408
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.018034
CEP350 centrosomal protein 350kDa 0.0179895
DHFR dihydrofolate reductase 0.0179784
SRRM1 serine/arginine repetitive matrix 1 0.0179146
NACA nascent polypeptide-associated complex alpha subunit 0.0179138
WSB1 WD repeat and SOCS box containing 1 0.0179064
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0178302
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0177566
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0177013
GPBP1 GC-rich promoter binding protein 1 0.0173488
NRIP1 nuclear receptor interacting protein 1 0.0172843
TBC1D15 TBC1 domain family, member 15 0.0170256
KPNB1 karyopherin (importin) beta 1 0.0168814
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0168654
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0167842
PNISR PNN-interacting serine/arginine-rich protein 0.0167747
ACBD3 acyl-CoA binding domain containing 3 0.0167398
MT2A metallothionein 2A 0.0167284
CREBRF CREB3 regulatory factor 0.0166277
IWS1 IWS1 homolog (S. cerevisiae) 0.0166075
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0165105
NCOR1 nuclear receptor corepressor 1 0.0165043
CEP95 centrosomal protein 95kDa 0.0164838
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0163628
THOC2 THO complex 2 0.0163558
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0163155

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.634116
FN1 fibronectin 1 -0.238854
CXCL8 chemokine (C-X-C motif) ligand 8 -0.14571
NDRG1 N-myc downstream regulated 1 -0.137075
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.101461
NRG1 neuregulin 1 -0.0945226
HMGA2 high mobility group AT-hook 2 -0.0922637
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0780948
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0770994
TXNIP thioredoxin interacting protein -0.0630828
POTEF POTE ankyrin domain family, member F -0.0572163
HMGA1 high mobility group AT-hook 1 -0.0500569
PDIA3 protein disulfide isomerase family A, member 3 -0.0483809
MAP1B microtubule-associated protein 1B -0.0481771
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0465568
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.045534
HILPDA hypoxia inducible lipid droplet-associated -0.0435655
SFTPA2 surfactant protein A2 -0.0433823
S100A10 S100 calcium binding protein A10 -0.0430708
SOD2 superoxide dismutase 2, mitochondrial -0.0426514
MRPS6 mitochondrial ribosomal protein S6 -0.0425129
ITGA1 integrin, alpha 1 -0.0405011
CANX calnexin -0.0401636
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0398621
FNDC3B fibronectin type III domain containing 3B -0.0385119
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0374156
UBC ubiquitin C -0.0367174
GRB10 growth factor receptor-bound protein 10 -0.0360302
MBNL1 muscleblind-like splicing regulator 1 -0.0358709
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0334839
PKM pyruvate kinase, muscle -0.0321028
ASPH aspartate beta-hydroxylase -0.0319404
CD109 CD109 molecule -0.0317612
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0316285
TFPI2 tissue factor pathway inhibitor 2 -0.0314976
RAI14 retinoic acid induced 14 -0.0311579
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0305349
FOSL1 FOS-like antigen 1 -0.0301487
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0299222
SYT1 synaptotagmin I -0.0295132
CADM1 cell adhesion molecule 1 -0.0290974
LIMCH1 LIM and calponin homology domains 1 -0.0289249
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0284083
GLIS3 GLIS family zinc finger 3 -0.0280887
VEGFA vascular endothelial growth factor A -0.0275172
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.027281
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0271205
LOXL2 lysyl oxidase-like 2 -0.0270488
FAT1 FAT atypical cadherin 1 -0.0269539
TRIO trio Rho guanine nucleotide exchange factor -0.0269434
SPDYA speedy/RINGO cell cycle regulator family member A -0.026577
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0263572
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0256058
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0251309
CALU calumenin -0.025092
S100A6 S100 calcium binding protein A6 -0.0249078
EXT1 exostosin glycosyltransferase 1 -0.0248959
RHEB Ras homolog enriched in brain -0.0247153
IFI27 interferon, alpha-inducible protein 27 -0.0246363
ADAM9 ADAM metallopeptidase domain 9 -0.02406
TAGLN2 transgelin 2 -0.0239764
LYST lysosomal trafficking regulator -0.0230535
PGK1 phosphoglycerate kinase 1 -0.0229498
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0225791
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0224776
NRP1 neuropilin 1 -0.0223164
RAB1A RAB1A, member RAS oncogene family -0.0222364
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0220255
PRKCA protein kinase C, alpha -0.0220149
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0218888
AHNAK AHNAK nucleoprotein -0.0217758
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0216403
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0216086
FAM13A family with sequence similarity 13, member A -0.0215875
MCL1 myeloid cell leukemia 1 -0.0214357
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0213924
RICTOR RPTOR independent companion of MTOR, complex 2 -0.021382
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0213793
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0213739
INTS6 integrator complex subunit 6 -0.0213552
BSG basigin (Ok blood group) -0.0207515
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0205493
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0204828
SFRP1 secreted frizzled-related protein 1 -0.0204249
DSG2 desmoglein 2 -0.0203916
CD44 CD44 molecule (Indian blood group) -0.0199843
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.019772
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0196714
WASF2 WAS protein family, member 2 -0.0196472
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0196273
CTSD cathepsin D -0.019377
TMEM165 transmembrane protein 165 -0.0191071
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0190661
DSTN destrin (actin depolymerizing factor) -0.0189047
TRAM1 translocation associated membrane protein 1 -0.0186262
RASAL2 RAS protein activator like 2 -0.0186255
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0185857
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.018568
CDCP1 CUB domain containing protein 1 -0.0185151
LY6E lymphocyte antigen 6 complex, locus E -0.0182758