Naproxen_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Naproxen perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Naproxen_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.286776
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.176032
MT2A metallothionein 2A 0.104339
AKAP12 A kinase (PRKA) anchor protein 12 0.103065
PLAT plasminogen activator, tissue 0.0987249
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0849704
FLNB filamin B, beta 0.0832248
CD44 CD44 molecule (Indian blood group) 0.0642202
FTH1 ferritin, heavy polypeptide 1 0.0618739
RPS6 ribosomal protein S6 0.0610465
CD99 CD99 molecule 0.0584977
PODXL podocalyxin-like 0.0561255
ERRFI1 ERBB receptor feedback inhibitor 1 0.0560452
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.055678
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0517614
COL3A1 collagen, type III, alpha 1 0.0463796
TPM3 tropomyosin 3 0.0458318
RHOBTB3 Rho-related BTB domain containing 3 0.0425934
RPS2 ribosomal protein S2 0.0425395
NAV1 neuron navigator 1 0.0421312
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0397084
EFNA5 ephrin-A5 0.0395523
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0391997
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0385644
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0374072
WWTR1 WW domain containing transcription regulator 1 0.0373296
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0370066
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0368515
RTN4 reticulon 4 0.0360985
ELL2 elongation factor, RNA polymerase II, 2 0.0355757
SEPTIN9 septin 9 0.0355075
CAPN2 calpain 2, (m/II) large subunit 0.0352446
STC1 stanniocalcin 1 0.0352179
SMAD3 SMAD family member 3 0.0343781
SET SET nuclear proto-oncogene 0.0334586
NFE2L1 nuclear factor, erythroid 2-like 1 0.0333757
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.032781
DPYSL3 dihydropyrimidinase-like 3 0.0325884
AHNAK AHNAK nucleoprotein 0.0324802
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0321082
FNDC3B fibronectin type III domain containing 3B 0.0317248
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0314177
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.03118
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0304267
SRRM2 serine/arginine repetitive matrix 2 0.0299987
RUNX1 runt-related transcription factor 1 0.0294315
SP3 Sp3 transcription factor 0.0293146
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.029167
EIF1 eukaryotic translation initiation factor 1 0.0288949
RPL28 ribosomal protein L28 0.0288568
RPS3 ribosomal protein S3 0.0287812
MB21D2 Mab-21 domain containing 2 0.0283939
DSTN destrin (actin depolymerizing factor) 0.0283634
NAMPT nicotinamide phosphoribosyltransferase 0.0281831
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0278014
LAMB1 laminin, beta 1 0.0275492
NEK7 NIMA-related kinase 7 0.0272077
SBF2 SET binding factor 2 0.0265257
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0261938
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.026009
ASPH aspartate beta-hydroxylase 0.0259735
PRRC2C proline-rich coiled-coil 2C 0.0256239
PGAM4 phosphoglycerate mutase family member 4 0.0255619
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0255039
RPS8 ribosomal protein S8 0.0254617
MEF2A myocyte enhancer factor 2A 0.025416
ANO6 anoctamin 6 0.0253996
RPS12 ribosomal protein S12 0.0250751
APP amyloid beta (A4) precursor protein 0.024943
LHFPL6 LHFPL tetraspan subfamily member 6 0.0248572
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0245903
EPAS1 endothelial PAS domain protein 1 0.0241826
TNIP1 TNFAIP3 interacting protein 1 0.0241816
MSN moesin 0.024141
EIF4H eukaryotic translation initiation factor 4H 0.0240389
EEF2 eukaryotic translation elongation factor 2 0.024007
PTBP3 polypyrimidine tract binding protein 3 0.0239608
MCFD2 multiple coagulation factor deficiency 2 0.0239555
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0239375
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.023854
EZR ezrin 0.0238284
HSPA8 heat shock 70kDa protein 8 0.0235823
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0232789
TPM1 tropomyosin 1 (alpha) 0.0228635
MKI67 marker of proliferation Ki-67 0.0225185
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0224845
CDK6 cyclin-dependent kinase 6 0.0219762
RPL12 ribosomal protein L12 0.0219572
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0218674
PICALM phosphatidylinositol binding clathrin assembly protein 0.021818
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0217945
RPS23 ribosomal protein S23 0.0217662
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0216873
RPS16 ribosomal protein S16 0.0216749
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0216648
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0215232
CEP170 centrosomal protein 170kDa 0.0211824
RACK1 receptor for activated C kinase 1 0.0210984
RPL36 ribosomal protein L36 0.0210096
ITM2B integral membrane protein 2B 0.0210017

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.207607
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.166169
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.121483
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.1129
ABI3BP ABI family, member 3 (NESH) binding protein -0.108305
COL8A1 collagen, type VIII, alpha 1 -0.0989342
TMSB10 thymosin beta 10 -0.0900681
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0894198
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.089237
LOX lysyl oxidase -0.0883478
TRIO trio Rho guanine nucleotide exchange factor -0.085568
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0842887
COL5A1 collagen, type V, alpha 1 -0.0838941
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0832661
FN1 fibronectin 1 -0.0827559
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0821882
NDRG1 N-myc downstream regulated 1 -0.0817828
ZFP36L1 ZFP36 ring finger protein-like 1 -0.078834
COPA coatomer protein complex, subunit alpha -0.0702355
ZBTB20 zinc finger and BTB domain containing 20 -0.0687691
RIGI RNA sensor RIG-I -0.0668308
MRPS6 mitochondrial ribosomal protein S6 -0.065494
SPAG9 sperm associated antigen 9 -0.0631369
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0625425
IARS1 isoleucyl-tRNA synthetase 1 -0.0612763
MEIS2 Meis homeobox 2 -0.0595565
LMNA lamin A/C -0.0593179
SOD2 superoxide dismutase 2, mitochondrial -0.0564539
CCND1 cyclin D1 -0.0561834
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0555229
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.054213
CD109 CD109 molecule -0.053703
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0532995
IFI16 interferon, gamma-inducible protein 16 -0.0524846
FNDC3A fibronectin type III domain containing 3A -0.0512911
MSI2 musashi RNA-binding protein 2 -0.0512455
PRSS23 protease, serine, 23 -0.0509332
CSTB cystatin B (stefin B) -0.0505479
SAMD9 sterile alpha motif domain containing 9 -0.0503424
SLC38A1 solute carrier family 38, member 1 -0.0492098
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0488459
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0483552
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0472026
MAP1B microtubule-associated protein 1B -0.0450386
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0443333
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0442469
TAGLN2 transgelin 2 -0.0436194
CANX calnexin -0.0432315
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0431269
VIM vimentin -0.0418937
SLC39A11 solute carrier family 39, member 11 -0.0401759
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0399804
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0396059
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0389484
LDHA lactate dehydrogenase A -0.0387484
S100A4 S100 calcium binding protein A4 -0.0383482
DST dystonin -0.0381144
WARS1 tryptophanyl-tRNA synthetase 1 -0.0377228
HLA-B major histocompatibility complex, class I, B -0.0374784
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0370894
TTC3 tetratricopeptide repeat domain 3 -0.0369679
SH3KBP1 SH3-domain kinase binding protein 1 -0.0369541
CAVIN1 caveolae associated protein 1 -0.036523
IL7R interleukin 7 receptor -0.0364659
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0363917
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0357037
OASL 2'-5'-oligoadenylate synthetase-like -0.0356256
JAZF1 JAZF zinc finger 1 -0.0352792
RASAL2 RAS protein activator like 2 -0.0350432
SAR1A secretion associated, Ras related GTPase 1A -0.0348417
ACLY ATP citrate lyase -0.0338255
GARS1 glycyl-tRNA synthetase 1 -0.0336973
CALU calumenin -0.0328434
SORBS2 sorbin and SH3 domain containing 2 -0.0323809
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0314244
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0310644
BIRC6 baculoviral IAP repeat containing 6 -0.0310147
ENO2 enolase 2 (gamma, neuronal) -0.0308891
EGFR epidermal growth factor receptor -0.0303898
AFF4 AF4/FMR2 family, member 4 -0.0299569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0290816
KCTD9 potassium channel tetramerization domain containing 9 -0.0290686
RAB7A RAB7A, member RAS oncogene family -0.0289291
FBXL7 F-box and leucine-rich repeat protein 7 -0.0287073
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0283743
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0281873
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0281608
TPM4 tropomyosin 4 -0.0280627
LMAN1 lectin, mannose-binding, 1 -0.0279066
AUTS2 autism susceptibility candidate 2 -0.0278004
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0274024
ARL15 ADP-ribosylation factor-like 15 -0.0271438
HDLBP high density lipoprotein binding protein -0.0270443
CDH13 cadherin 13 -0.0269134
MYL12B myosin, light chain 12B, regulatory -0.0267661
LOXL2 lysyl oxidase-like 2 -0.0267571
SEC31A SEC31 homolog A (S. cerevisiae) -0.0262109
HLA-C major histocompatibility complex, class I, C -0.0261816
ARF4 ADP-ribosylation factor 4 -0.026119
CMIP c-Maf inducing protein -0.0261009