| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Naproxen_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.18447 |
| PCBP2 | poly(rC) binding protein 2 | 0.105079 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.100966 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0942361 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0869692 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0860244 |
| PTMA | prothymosin, alpha | 0.0813427 |
| VIM | vimentin | 0.076533 |
| PRRC2C | proline-rich coiled-coil 2C | 0.075261 |
| PDGFC | platelet derived growth factor C | 0.0731508 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0707154 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0685198 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0635076 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0612208 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0604254 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0602146 |
| TUBA1B | tubulin, alpha 1b | 0.058484 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0563431 |
| WDR43 | WD repeat domain 43 | 0.056133 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0524445 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0513896 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0503766 |
| RPL4 | ribosomal protein L4 | 0.05019 |
| RACK1 | receptor for activated C kinase 1 | 0.0483896 |
| YBX1 | Y box binding protein 1 | 0.04792 |
| HMGB2 | high mobility group box 2 | 0.0460606 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0456729 |
| ENO1 | enolase 1, (alpha) | 0.045506 |
| RTN4 | reticulon 4 | 0.0446314 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0441565 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0440193 |
| NHSL1 | NHS-like 1 | 0.0413438 |
| RPL37 | ribosomal protein L37 | 0.0398617 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0397403 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0396241 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0390878 |
| MTAP | methylthioadenosine phosphorylase | 0.0381122 |
| GNAS | GNAS complex locus | 0.0378677 |
| EZR | ezrin | 0.0377112 |
| MKI67 | marker of proliferation Ki-67 | 0.0373734 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0365041 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0361236 |
| FLNA | filamin A, alpha | 0.0360331 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0358921 |
| ATL2 | atlastin GTPase 2 | 0.0358463 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0353809 |
| TPX2 | TPX2, microtubule-associated | 0.0352042 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0348247 |
| CIP2A | cellular inhibitor of PP2A | 0.0345932 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0344234 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0343922 |
| RPS12 | ribosomal protein S12 | 0.0333529 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0333512 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0333076 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.033071 |
| TUBA1C | tubulin, alpha 1c | 0.0330645 |
| RPS7 | ribosomal protein S7 | 0.0317066 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0308128 |
| TOP1 | topoisomerase (DNA) I | 0.0303077 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0297643 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0296255 |
| BRD4 | bromodomain containing 4 | 0.0291374 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0288131 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0287249 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286487 |
| RPL14 | ribosomal protein L14 | 0.0283423 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0280607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0280548 |
| RBM25 | RNA binding motif protein 25 | 0.0280012 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0279768 |
| KIF18B | kinesin family member 18B | 0.0279534 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0279043 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0278087 |
| ATP13A3 | ATPase type 13A3 | 0.0276602 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0275875 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0275747 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0274203 |
| RPS6 | ribosomal protein S6 | 0.027241 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0271656 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0270304 |
| RPL34 | ribosomal protein L34 | 0.027009 |
| RPL30 | ribosomal protein L30 | 0.0268554 |
| AHNAK | AHNAK nucleoprotein | 0.0267955 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0266448 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0265784 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0261853 |
| RPS27A | ribosomal protein S27a | 0.0260072 |
| NEGR1 | neuronal growth regulator 1 | 0.0259682 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0259215 |
| CCDC47 | coiled-coil domain containing 47 | 0.0259148 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0258602 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.02581 |
| KIF5B | kinesin family member 5B | 0.0258012 |
| DST | dystonin | 0.0255662 |
| ECT2 | epithelial cell transforming 2 | 0.0254842 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0254758 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0254202 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0253636 |
| CENPF | centromere protein F, 350/400kDa | 0.0252314 |
| YBX3 | Y box binding protein 3 | 0.0250043 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.175252 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.172498 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.106708 |
| ANXA1 | annexin A1 | -0.0775312 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0767723 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0738876 |
| FTL | ferritin, light polypeptide | -0.0605465 |
| USP34 | ubiquitin specific peptidase 34 | -0.0604347 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0601687 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0583545 |
| TXNRD1 | thioredoxin reductase 1 | -0.0579741 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0574987 |
| CLTC | clathrin, heavy chain (Hc) | -0.0569698 |
| MMP12 | matrix metallopeptidase 12 | -0.0567 |
| HMGA1 | high mobility group AT-hook 1 | -0.0548454 |
| PCDH7 | protocadherin 7 | -0.0500234 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0492779 |
| BCHE | butyrylcholinesterase | -0.0491946 |
| GPHN | gephyrin | -0.0487915 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0487524 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0479375 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0475355 |
| SETD5 | SET domain containing 5 | -0.0469154 |
| ANKRD17 | ankyrin repeat domain 17 | -0.046019 |
| POTEF | POTE ankyrin domain family, member F | -0.0459043 |
| NABP1 | nucleic acid binding protein 1 | -0.0458145 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0456568 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.0434636 |
| RPL38 | ribosomal protein L38 | -0.043421 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0432163 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0423506 |
| RPL19 | ribosomal protein L19 | -0.0420957 |
| RASAL2 | RAS protein activator like 2 | -0.0415428 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0409697 |
| CPOX | coproporphyrinogen oxidase | -0.0408496 |
| GLG1 | golgi glycoprotein 1 | -0.0406475 |
| EHBP1 | EH domain binding protein 1 | -0.0406322 |
| RPS13 | ribosomal protein S13 | -0.0402409 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0397448 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0396872 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0396594 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0390385 |
| GCG | glucagon | -0.0389569 |
| RPLP0 | ribosomal protein, large, P0 | -0.0384802 |
| ZNF804A | zinc finger protein 804A | -0.0383588 |
| TMSB10 | thymosin beta 10 | -0.0378921 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0376018 |
| RPL8 | ribosomal protein L8 | -0.0375382 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0370781 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0368465 |
| EXOC6B | exocyst complex component 6B | -0.0368405 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0363281 |
| ZNF292 | zinc finger protein 292 | -0.0358059 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0354214 |
| NEBL | nebulette | -0.0350325 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0348753 |
| TMEM123 | transmembrane protein 123 | -0.0346974 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0343541 |
| MGAT4C | MGAT4 family, member C | -0.0342147 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0340675 |
| MAP1B | microtubule-associated protein 1B | -0.0340303 |
| PFN1 | profilin 1 | -0.0339983 |
| CCND1 | cyclin D1 | -0.0337451 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0335473 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0335319 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.033323 |
| TMEM47 | transmembrane protein 47 | -0.0332438 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0329522 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0328699 |
| RPS2 | ribosomal protein S2 | -0.0325759 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0322905 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0320775 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0320772 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0318693 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0316448 |
| RNF13 | ring finger protein 13 | -0.0315975 |
| NF1 | neurofibromin 1 | -0.0314414 |
| RAI14 | retinoic acid induced 14 | -0.0312731 |
| NKTR | natural killer cell triggering receptor | -0.0311933 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0310928 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0308604 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0308421 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0302749 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0301024 |
| IL6ST | interleukin 6 signal transducer | -0.0300185 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.029969 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0299272 |
| ASTN2 | astrotactin 2 | -0.0297152 |
| SPAG9 | sperm associated antigen 9 | -0.0294771 |
| RTN3 | reticulon 3 | -0.0290982 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | -0.0289485 |
| ZNF652 | zinc finger protein 652 | -0.0288726 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0285934 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0284139 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0282799 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.027738 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0277074 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0274343 |
| NLGN1 | neuroligin 1 | -0.0270739 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0269319 |
