| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Naproxen_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.157246 |
| ENO1 | enolase 1, (alpha) | 0.148657 |
| VIM | vimentin | 0.148073 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.134317 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.130437 |
| UBC | ubiquitin C | 0.125263 |
| COL1A1 | collagen, type I, alpha 1 | 0.119895 |
| COL6A3 | collagen, type VI, alpha 3 | 0.10888 |
| ATP13A3 | ATPase type 13A3 | 0.103522 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.100053 |
| CALR | calreticulin | 0.0922393 |
| AHNAK | AHNAK nucleoprotein | 0.085647 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0833262 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0759801 |
| ASPH | aspartate beta-hydroxylase | 0.0747377 |
| CD44 | CD44 molecule (Indian blood group) | 0.0746548 |
| TMSB10 | thymosin beta 10 | 0.0656154 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0651671 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0651454 |
| CADM1 | cell adhesion molecule 1 | 0.0645776 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0600299 |
| GOLGA4 | golgin A4 | 0.0586816 |
| AXL | AXL receptor tyrosine kinase | 0.0578678 |
| NAV2 | neuron navigator 2 | 0.0568136 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0566443 |
| VMP1 | vacuole membrane protein 1 | 0.0557699 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0555855 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0545775 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0541319 |
| CALU | calumenin | 0.0533948 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0529566 |
| PCBP2 | poly(rC) binding protein 2 | 0.052054 |
| IL6 | interleukin 6 | 0.050557 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0494184 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0480486 |
| FLNA | filamin A, alpha | 0.0471298 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0457463 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0456525 |
| RPS27A | ribosomal protein S27a | 0.0453535 |
| TLN1 | talin 1 | 0.0440835 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0429953 |
| SMAD3 | SMAD family member 3 | 0.0428606 |
| INHBA | inhibin, beta A | 0.0426488 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0419973 |
| NAV1 | neuron navigator 1 | 0.041917 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0415059 |
| PTMA | prothymosin, alpha | 0.0411005 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0402087 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0393321 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0387996 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.037827 |
| JUN | jun proto-oncogene | 0.0374937 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0362473 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0357044 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0356818 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0354664 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0353902 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0352844 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0351024 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0346608 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0345307 |
| SMYD3 | SET and MYND domain containing 3 | 0.03442 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0342695 |
| CLIC4 | chloride intracellular channel 4 | 0.0341818 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0341322 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0338075 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0337832 |
| SBF2 | SET binding factor 2 | 0.033767 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0331076 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0328478 |
| FAT1 | FAT atypical cadherin 1 | 0.0324596 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0324073 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0323869 |
| FLNB | filamin B, beta | 0.031897 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0313078 |
| HMGA2 | high mobility group AT-hook 2 | 0.0309112 |
| PKM | pyruvate kinase, muscle | 0.0308986 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0304083 |
| CDH13 | cadherin 13 | 0.0303191 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0299166 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0298063 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0296517 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0294644 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0293712 |
| BBX | bobby sox homolog (Drosophila) | 0.0288156 |
| CCNL1 | cyclin L1 | 0.0287327 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0287213 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0285803 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0285644 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.028306 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0282436 |
| COL5A1 | collagen, type V, alpha 1 | 0.0278935 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0276714 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0275141 |
| IL6ST | interleukin 6 signal transducer | 0.0273636 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0272991 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.027284 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0267956 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0267408 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0266155 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.240559 |
| NDRG1 | N-myc downstream regulated 1 | -0.213752 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.186583 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.112086 |
| MT2A | metallothionein 2A | -0.0992547 |
| IER3 | immediate early response 3 | -0.0850342 |
| FN1 | fibronectin 1 | -0.0741692 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0670808 |
| RPL35A | ribosomal protein L35a | -0.0644853 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0581064 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.055944 |
| COL1A2 | collagen, type I, alpha 2 | -0.0558659 |
| POSTN | periostin, osteoblast specific factor | -0.0534018 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0525779 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0483308 |
| MT1X | metallothionein 1X | -0.047625 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0467755 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0456498 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0445316 |
| FTL | ferritin, light polypeptide | -0.0421313 |
| S100A9 | S100 calcium binding protein A9 | -0.0387157 |
| RLF | rearranged L-myc fusion | -0.0377854 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0351802 |
| CAVIN1 | caveolae associated protein 1 | -0.0344309 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0344149 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0339917 |
| RPLP1 | ribosomal protein, large, P1 | -0.0331164 |
| PXDN | peroxidasin | -0.0319684 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0315675 |
| BSG | basigin (Ok blood group) | -0.027509 |
| RPS20 | ribosomal protein S20 | -0.0274659 |
| ACTG1 | actin gamma 1 | -0.0271302 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0267902 |
| RPS24 | ribosomal protein S24 | -0.0260358 |
| RPL38 | ribosomal protein L38 | -0.0259528 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0257015 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.024846 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0245428 |
| ARF4 | ADP-ribosylation factor 4 | -0.0243844 |
| RPL28 | ribosomal protein L28 | -0.024297 |
| S100A10 | S100 calcium binding protein A10 | -0.0241264 |
| RPLP0 | ribosomal protein, large, P0 | -0.0232608 |
| RPL19 | ribosomal protein L19 | -0.0232439 |
| FBN1 | fibrillin 1 | -0.0230843 |
| RAB1A | RAB1A, member RAS oncogene family | -0.022714 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0221649 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0220321 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0218283 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0214926 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0208035 |
| RPL30 | ribosomal protein L30 | -0.0206424 |
| HLA-B | major histocompatibility complex, class I, B | -0.0204471 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0200089 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.019988 |
| SPAG9 | sperm associated antigen 9 | -0.019706 |
| ADM | adrenomedullin | -0.0196368 |
| CTSB | cathepsin B | -0.0196194 |
| RPL11 | ribosomal protein L11 | -0.0194959 |
| GLIS3 | GLIS family zinc finger 3 | -0.0193685 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0192918 |
| PDE10A | phosphodiesterase 10A | -0.0191498 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0191021 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0190963 |
| RPL8 | ribosomal protein L8 | -0.0190786 |
| CCND1 | cyclin D1 | -0.0190338 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0186308 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.018526 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0183158 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0182489 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0181968 |
| NEK10 | NIMA-related kinase 10 | -0.0181 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0179105 |
| CLMP | CXADR-like membrane protein | -0.0178471 |
| RTN3 | reticulon 3 | -0.0176851 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.017412 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0170103 |
| RPS8 | ribosomal protein S8 | -0.0169999 |
| TPM4 | tropomyosin 4 | -0.0169209 |
| GOLT1B | golgi transport 1B | -0.0168475 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0168298 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0166589 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0164059 |
| RPL32 | ribosomal protein L32 | -0.0160639 |
| RPL6 | ribosomal protein L6 | -0.0157717 |
| ASTN2 | astrotactin 2 | -0.0156998 |
| RPS11 | ribosomal protein S11 | -0.0154655 |
| TXNL1 | thioredoxin-like 1 | -0.0152714 |
| RAB2A | RAB2A, member RAS oncogene family | -0.015261 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0149222 |
| IMMT | inner membrane protein, mitochondrial | -0.0149037 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0148508 |
| RNF220 | ring finger protein 220 | -0.0147147 |
| PARK7 | parkinson protein 7 | -0.0146982 |
| RPS19 | ribosomal protein S19 | -0.014586 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0144385 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0143005 |
| FAM162A | family with sequence similarity 162, member A | -0.0142353 |
| UST | uronyl-2-sulfotransferase | -0.0142001 |
| RPL36 | ribosomal protein L36 | -0.0139635 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0139201 |
