Naproxen_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Naproxen perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Naproxen_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.180334
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.142668
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.139364
C3 complement component 3 0.122187
FNDC3B fibronectin type III domain containing 3B 0.0781583
ENO1 enolase 1, (alpha) 0.0776699
UBC ubiquitin C 0.0725996
PCBP2 poly(rC) binding protein 2 0.0724084
EEF2 eukaryotic translation elongation factor 2 0.0669314
PABPC1 poly(A) binding protein, cytoplasmic 1 0.053799
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0499036
RPS27A ribosomal protein S27a 0.0498943
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0468397
EML4 echinoderm microtubule associated protein like 4 0.0460008
GOLGA4 golgin A4 0.0458576
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0451647
RPS6 ribosomal protein S6 0.0445335
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0429131
A2M alpha-2-macroglobulin 0.0409124
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0401201
DSPP dentin sialophosphoprotein 0.040049
MYH9 myosin, heavy chain 9, non-muscle 0.039867
SRRM1 serine/arginine repetitive matrix 1 0.0396812
RPL3 ribosomal protein L3 0.0388297
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0360653
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0360414
AFDN afadin, adherens junction formation factor 0.0354309
SESTD1 SEC14 and spectrin domains 1 0.0351144
VEGFA vascular endothelial growth factor A 0.0345239
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0340826
APOB apolipoprotein B 0.0330059
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0319898
APLP2 amyloid beta (A4) precursor-like protein 2 0.0319079
LRRC1 leucine rich repeat containing 1 0.0318901
BRD4 bromodomain containing 4 0.0318295
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0315098
APOA2 apolipoprotein A-II 0.0314937
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0312284
PRRC2C proline-rich coiled-coil 2C 0.0287458
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0277478
TRIM26 tripartite motif containing 26 0.0277434
SET SET nuclear proto-oncogene 0.0277225
KTN1 kinectin 1 (kinesin receptor) 0.0275851
TOP1 topoisomerase (DNA) I 0.0274294
TNS1 tensin 1 0.0273131
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0265816
ELL2 elongation factor, RNA polymerase II, 2 0.026553
PAPOLA poly(A) polymerase alpha 0.0258975
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0258952
TPM3 tropomyosin 3 0.0258829
YAP1 Yes-associated protein 1 0.0255339
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0253722
PTBP3 polypyrimidine tract binding protein 3 0.0250568
NCOR2 nuclear receptor corepressor 2 0.024989
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0249689
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0247636
CCNL1 cyclin L1 0.024607
APOE apolipoprotein E 0.0245965
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0244987
DDIT4 DNA-damage-inducible transcript 4 0.0244085
HDGF hepatoma-derived growth factor 0.0241586
CFB complement factor B 0.0240553
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0240243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0240166
RPL4 ribosomal protein L4 0.0240006
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0239287
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0234315
ANKRD17 ankyrin repeat domain 17 0.0234181
KDM7A lysine (K)-specific demethylase 7A 0.023028
XPO1 exportin 1 0.0230167
VIM vimentin 0.0227022
AKAP9 A kinase (PRKA) anchor protein 9 0.022692
TNIP1 TNFAIP3 interacting protein 1 0.0225311
WDFY2 WD repeat and FYVE domain containing 2 0.0224932
PTMA prothymosin, alpha 0.0224308
ADAM17 ADAM metallopeptidase domain 17 0.0222896
PDE4D phosphodiesterase 4D, cAMP-specific 0.0221078
ADAM9 ADAM metallopeptidase domain 9 0.0219418
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0218991
MBNL1 muscleblind-like splicing regulator 1 0.0218477
SCAF11 SR-related CTD-associated factor 11 0.0217415
RAB6A RAB6A, member RAS oncogene family 0.0216245
PKM pyruvate kinase, muscle 0.0214258
RPS2 ribosomal protein S2 0.0211976
UBA6 ubiquitin-like modifier activating enzyme 6 0.0209362
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0208942
THOC2 THO complex 2 0.0208336
MKI67 marker of proliferation Ki-67 0.0203816
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0203366
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0199399
GIGYF2 GRB10 interacting GYF protein 2 0.0198809
TM4SF1 transmembrane 4 L six family member 1 0.0197867
PGAM4 phosphoglycerate mutase family member 4 0.0197818
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0196949
SRSF4 serine/arginine-rich splicing factor 4 0.0196436
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0195787
MBNL2 muscleblind-like splicing regulator 2 0.0193744
POTEF POTE ankyrin domain family, member F 0.0193595
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0193548
PDIA6 protein disulfide isomerase family A, member 6 0.019348

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.20423
IGF2 insulin-like growth factor 2 -0.19815
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.148634
TPT1 tumor protein, translationally-controlled 1 -0.137729
IGFBP1 insulin-like growth factor binding protein 1 -0.126461
RPS24 ribosomal protein S24 -0.11057
GPC3 glypican 3 -0.106265
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.105891
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0964916
RPLP1 ribosomal protein, large, P1 -0.0936412
RPL11 ribosomal protein L11 -0.0888308
FN1 fibronectin 1 -0.0887295
RPL35A ribosomal protein L35a -0.0879799
GPC6 glypican 6 -0.0728108
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0714309
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0701825
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0569253
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0566255
ATXN1 ataxin 1 -0.0564448
EHBP1 EH domain binding protein 1 -0.0560574
EXT1 exostosin glycosyltransferase 1 -0.054187
SVIL supervillin -0.0504333
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0502319
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0482361
RPL38 ribosomal protein L38 -0.0479796
RPLP0 ribosomal protein, large, P0 -0.0473556
ZBTB20 zinc finger and BTB domain containing 20 -0.0454201
PEG3 paternally expressed 3 -0.0451329
INTS6 integrator complex subunit 6 -0.0442731
FTL ferritin, light polypeptide -0.0438232
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0400006
MAML2 mastermind-like 2 (Drosophila) -0.0398948
FAM107B family with sequence similarity 107, member B -0.0397504
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0388037
NPAS2 neuronal PAS domain protein 2 -0.0386976
RPS8 ribosomal protein S8 -0.0384554
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0382951
RPS21 ribosomal protein S21 -0.0380115
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0375098
TFRC transferrin receptor -0.037255
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0363352
FOXP1 forkhead box P1 -0.0361734
RPL26 ribosomal protein L26 -0.0357006
CANX calnexin -0.034818
ACTG1 actin gamma 1 -0.0347954
RPL31 ribosomal protein L31 -0.0345932
PHF3 PHD finger protein 3 -0.0336242
RPL37 ribosomal protein L37 -0.0329052
CTSB cathepsin B -0.0323766
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0319544
KLF6 Kruppel-like factor 6 -0.0317816
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0313996
AGO2 argonaute RISC catalytic component 2 -0.0309291
LOC112694756 uncharaterized LOC112694756 -0.0308765
IER3 immediate early response 3 -0.0306797
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0303452
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0300376
RPS20 ribosomal protein S20 -0.0298884
EIF1 eukaryotic translation initiation factor 1 -0.029792
KIF21A kinesin family member 21A -0.0294368
RPS13 ribosomal protein S13 -0.0293646
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0291588
RPLP2 ribosomal protein, large, P2 -0.029084
RPS10 ribosomal protein S10 -0.0288757
PTPRK protein tyrosine phosphatase, receptor type, K -0.0287281
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0287225
RPL32 ribosomal protein L32 -0.0280567
RPL34 ribosomal protein L34 -0.0279027
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0277789
RPL19 ribosomal protein L19 -0.0275887
ASPH aspartate beta-hydroxylase -0.0274112
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0273498
LPP LIM domain containing preferred translocation partner in lipoma -0.0272567
LCN2 lipocalin 2 -0.0258877
CP ceruloplasmin (ferroxidase) -0.0253439
LRMDA leucine rich melanocyte differentiation associated -0.0248746
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0246715
RAD51B RAD51 paralog B -0.024393
RPL37A ribosomal protein L37a -0.0240915
GK glycerol kinase -0.0239702
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0238699
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0237398
RPS23 ribosomal protein S23 -0.0236765
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0236215
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0235834
HPCAL1 hippocalcin-like 1 -0.0232589
GNAS GNAS complex locus -0.0231473
SMAD3 SMAD family member 3 -0.0231355
RPS14 ribosomal protein S14 -0.0229269
MYO1D myosin ID -0.0226397
ZHX2 zinc fingers and homeoboxes 2 -0.0223449
CCL20 chemokine (C-C motif) ligand 20 -0.021934
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0219336
TAS2R14 taste receptor, type 2, member 14 -0.0217231
PLXDC2 plexin domain containing 2 -0.0217042
RPS19 ribosomal protein S19 -0.0216766
IGF1R insulin-like growth factor 1 receptor -0.0216568
PDLIM5 PDZ and LIM domain 5 -0.0212889
RPL27 ribosomal protein L27 -0.0212758
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0212082