Naproxen_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Naproxen perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Naproxen_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.194929
ENO1 enolase 1, (alpha) 0.148575
FLNB filamin B, beta 0.127377
NDRG1 N-myc downstream regulated 1 0.124288
KRT17 keratin 17, type I 0.119498
UBC ubiquitin C 0.105103
PTMA prothymosin, alpha 0.104092
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0997789
TMSB10 thymosin beta 10 0.0980516
CLU clusterin 0.0900671
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0814599
GOLGA4 golgin A4 0.0709446
EEF2 eukaryotic translation elongation factor 2 0.0692535
MYH9 myosin, heavy chain 9, non-muscle 0.0663839
PKM pyruvate kinase, muscle 0.0658759
EZR ezrin 0.0633996
LDHA lactate dehydrogenase A 0.0620856
TRIO trio Rho guanine nucleotide exchange factor 0.0592655
ESYT2 extended synaptotagmin-like protein 2 0.0580727
TPM3 tropomyosin 3 0.0560042
NCOR2 nuclear receptor corepressor 2 0.0555949
STC1 stanniocalcin 1 0.0535894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0532289
EMP1 epithelial membrane protein 1 0.0524694
RPS6 ribosomal protein S6 0.0520926
APLP2 amyloid beta (A4) precursor-like protein 2 0.0520334
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0515658
MT2A metallothionein 2A 0.0510431
MEF2A myocyte enhancer factor 2A 0.0505758
FLNA filamin A, alpha 0.049413
RPS27A ribosomal protein S27a 0.0493925
KTN1 kinectin 1 (kinesin receptor) 0.0488882
MSN moesin 0.0478694
NAMPT nicotinamide phosphoribosyltransferase 0.0459079
PCBP2 poly(rC) binding protein 2 0.0455467
CALU calumenin 0.0454595
YBX1 Y box binding protein 1 0.045406
KRT14 keratin 14, type I 0.045302
PGK1 phosphoglycerate kinase 1 0.0447601
OGA O-GlcNAcase 0.0446658
LOC112694756 uncharaterized LOC112694756 0.0445179
RPS3 ribosomal protein S3 0.0438052
CALR calreticulin 0.0437988
RPL23 ribosomal protein L23 0.0427663
TNIP1 TNFAIP3 interacting protein 1 0.0421658
CD99 CD99 molecule 0.0417985
ANLN anillin, actin binding protein 0.0404737
ANXA1 annexin A1 0.0400039
SRRM2 serine/arginine repetitive matrix 2 0.0395228
MYOF myoferlin 0.0390857
RICTOR RPTOR independent companion of MTOR, complex 2 0.038741
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0375787
TGM2 transglutaminase 2 0.0374848
ITGA6 integrin, alpha 6 0.037209
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0363225
ARRDC3 arrestin domain containing 3 0.0359104
KRT6A keratin 6A, type II 0.0356437
DSTN destrin (actin depolymerizing factor) 0.0354683
POTEF POTE ankyrin domain family, member F 0.0354645
SET SET nuclear proto-oncogene 0.0348962
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0347652
KMT2E lysine (K)-specific methyltransferase 2E 0.0343906
ITCH itchy E3 ubiquitin protein ligase 0.0341943
PDIA3 protein disulfide isomerase family A, member 3 0.034097
SUCO SUN domain containing ossification factor 0.0336707
HDGF hepatoma-derived growth factor 0.0335054
EIF4A1 eukaryotic translation initiation factor 4A1 0.0333517
B2M beta-2-microglobulin 0.0332454
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326081
ACBD3 acyl-CoA binding domain containing 3 0.0323437
RPL8 ribosomal protein L8 0.0321155
RPL5 ribosomal protein L5 0.0318777
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0313201
PRRC2C proline-rich coiled-coil 2C 0.0308868
PCDH1 protocadherin 1 0.0307298
DLG1 discs, large homolog 1 (Drosophila) 0.0305795
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0304321
FTH1 ferritin, heavy polypeptide 1 0.0303176
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0302832
FNDC3B fibronectin type III domain containing 3B 0.0298504
RPLP2 ribosomal protein, large, P2 0.0298296
SQLE squalene epoxidase 0.0292465
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0291686
RPL3 ribosomal protein L3 0.0289937
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0289289
SRRM1 serine/arginine repetitive matrix 1 0.0289272
PLEC plectin 0.0287524
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0284471
LMNA lamin A/C 0.0284065
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0282505
RPS8 ribosomal protein S8 0.0281812
CTNND1 catenin (cadherin-associated protein), delta 1 0.0279791
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0274346
HOOK2 hook microtubule-tethering protein 2 0.027329
LAMA5 laminin, alpha 5 0.0271674
APP amyloid beta (A4) precursor protein 0.0271182
H1-0 H1.0 linker histone 0.0271135
TLN1 talin 1 0.0266608
NPEPPS aminopeptidase puromycin sensitive 0.0266507
AHNAK AHNAK nucleoprotein 0.0266507

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.342108
TIMP3 TIMP metallopeptidase inhibitor 3 -0.13677
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.12005
PDLIM5 PDZ and LIM domain 5 -0.0785058
DPYD dihydropyrimidine dehydrogenase -0.0778788
PDE4D phosphodiesterase 4D, cAMP-specific -0.0658963
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0520987
ALCAM activated leukocyte cell adhesion molecule -0.050941
TPT1 tumor protein, translationally-controlled 1 -0.0503997
OSMR oncostatin M receptor -0.04694
MECOM MDS1 and EVI1 complex locus -0.0443895
RIGI RNA sensor RIG-I -0.0441899
PALLD palladin, cytoskeletal associated protein -0.042771
HMGA2 high mobility group AT-hook 2 -0.039059
LMO7 LIM domain 7 -0.0388637
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0385314
SAMD9 sterile alpha motif domain containing 9 -0.0344781
TMSB4X thymosin beta 4, X-linked -0.0325689
AOPEP aminopeptidase O (putative) -0.0322512
BCAR3 breast cancer anti-estrogen resistance 3 -0.0314061
SLC35F3 solute carrier family 35, member F3 -0.0311624
RABGAP1L RAB GTPase activating protein 1-like -0.0310076
EXT1 exostosin glycosyltransferase 1 -0.0304453
FOXO1 forkhead box O1 -0.0304198
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0301167
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0298928
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0298883
EFNA5 ephrin-A5 -0.0291518
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0285695
RASAL2 RAS protein activator like 2 -0.0278804
MTAP methylthioadenosine phosphorylase -0.0272191
INTS6 integrator complex subunit 6 -0.0268576
ZEB1 zinc finger E-box binding homeobox 1 -0.0267194
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0265933
FOXP1 forkhead box P1 -0.0263974
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0253394
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0250567
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0245684
MACF1 microtubule-actin crosslinking factor 1 -0.0243431
PRELID2 PRELI domain containing 2 -0.0240586
CNTNAP3 contactin associated protein-like 3 -0.0239332
CDK6 cyclin-dependent kinase 6 -0.0238845
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0234301
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0233652
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0231246
RPS24 ribosomal protein S24 -0.0230433
RIN2 Ras and Rab interactor 2 -0.0229006
SOX5 SRY (sex determining region Y)-box 5 -0.0227682
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0227518
RPL35A ribosomal protein L35a -0.0226394
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0224412
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0219997
C4BPB complement component 4 binding protein, beta -0.0218791
LAMC2 laminin, gamma 2 -0.0217204
MEIS2 Meis homeobox 2 -0.0215497
FRMD4B FERM domain containing 4B -0.0209238
AMOTL1 angiomotin like 1 -0.020336
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0199136
PSD3 pleckstrin and Sec7 domain containing 3 -0.0198089
IFI16 interferon, gamma-inducible protein 16 -0.0197838
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0197659
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0194997
CSMD2 CUB and Sushi multiple domains 2 -0.0194891
THSD4 thrombospondin, type I, domain containing 4 -0.0194879
PLXNA2 plexin A2 -0.0193047
THBD thrombomodulin -0.01923
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0189939
PRSS23 protease, serine, 23 -0.0189249
ARHGAP29 Rho GTPase activating protein 29 -0.0186965
ARF1 ADP-ribosylation factor 1 -0.0186389
KLF5 Kruppel-like factor 5 (intestinal) -0.018553
VCL vinculin -0.0183451
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0183065
UTRN utrophin -0.0181948
KIAA1671 KIAA1671 -0.0181302
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0177847
AGO2 argonaute RISC catalytic component 2 -0.0176736
CORO2A coronin, actin binding protein, 2A -0.0172264
FAF1 Fas (TNFRSF6) associated factor 1 -0.017096
BMAL2 basic helix-loop-helix ARNT like 2 -0.0170671
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0167424
NRCAM neuronal cell adhesion molecule -0.0166706
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0161967
RAD51B RAD51 paralog B -0.0161646
EXOC4 exocyst complex component 4 -0.0159589
CDK13 cyclin-dependent kinase 13 -0.0159202
SP100 SP100 nuclear antigen -0.0159189
BLCAP bladder cancer associated protein -0.0155839
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0155611
MTSS1 metastasis suppressor 1 -0.0155218
CFLAR CASP8 and FADD-like apoptosis regulator -0.0153938
MAML2 mastermind-like 2 (Drosophila) -0.0153922
RNF217 ring finger protein 217 -0.0153502
NEK7 NIMA-related kinase 7 -0.0153497
DGKH diacylglycerol kinase, eta -0.0153481
RHOJ ras homolog family member J -0.0153304
TRAPPC9 trafficking protein particle complex 9 -0.015167
RTN3 reticulon 3 -0.0150416
ATG7 autophagy related 7 -0.0150352
KLF12 Kruppel-like factor 12 -0.0149381