Naproxen_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Naproxen perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Naproxen_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.370624
UBC ubiquitin C 0.115114
FAM13A family with sequence similarity 13, member A 0.0879481
NDRG1 N-myc downstream regulated 1 0.0763488
MKI67 marker of proliferation Ki-67 0.0668673
UBA6 ubiquitin-like modifier activating enzyme 6 0.0666811
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0653447
PRRC2C proline-rich coiled-coil 2C 0.0633857
RUNX1 runt-related transcription factor 1 0.0599669
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0578395
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0556964
MCL1 myeloid cell leukemia 1 0.0544405
PCBP2 poly(rC) binding protein 2 0.0534495
TSC22D2 TSC22 domain family, member 2 0.0520791
CCNL1 cyclin L1 0.0519049
ANKRD12 ankyrin repeat domain 12 0.0490353
GSK3B glycogen synthase kinase 3 beta 0.0489758
NGLY1 N-glycanase 1 0.0487516
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0481621
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0477957
FTH1 ferritin, heavy polypeptide 1 0.0476853
MYH9 myosin, heavy chain 9, non-muscle 0.0467945
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0463399
NAMPT nicotinamide phosphoribosyltransferase 0.0449145
FTL ferritin, light polypeptide 0.0431114
CES1 carboxylesterase 1 0.0423087
ATP13A3 ATPase type 13A3 0.0409032
OGA O-GlcNAcase 0.040722
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0401831
PDE8A phosphodiesterase 8A 0.0390688
KMT2E lysine (K)-specific methyltransferase 2E 0.0387545
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0378556
EEF2 eukaryotic translation elongation factor 2 0.0377089
SPAG9 sperm associated antigen 9 0.0368754
HELZ helicase with zinc finger 0.0365966
ADAM17 ADAM metallopeptidase domain 17 0.0361438
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0360731
KDM2A lysine (K)-specific demethylase 2A 0.0353813
ARRDC3 arrestin domain containing 3 0.0350892
KCMF1 potassium channel modulatory factor 1 0.0343654
MT2A metallothionein 2A 0.0342999
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0342439
EIF4A1 eukaryotic translation initiation factor 4A1 0.0337136
ELL2 elongation factor, RNA polymerase II, 2 0.0332637
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0329402
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0325807
FNDC3B fibronectin type III domain containing 3B 0.0322703
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0320351
RASA2 RAS p21 protein activator 2 0.0317582
BLZF1 basic leucine zipper nuclear factor 1 0.031342
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0310993
KDM6A lysine (K)-specific demethylase 6A 0.0309649
EGR1 early growth response 1 0.0308955
ERRFI1 ERBB receptor feedback inhibitor 1 0.0308762
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0306477
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0302439
ZNF292 zinc finger protein 292 0.0299793
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0297704
MSN moesin 0.0292637
CSNK1A1 casein kinase 1, alpha 1 0.0291201
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0289873
AKAP13 A kinase (PRKA) anchor protein 13 0.0287279
CSNK1E casein kinase 1, epsilon 0.0281627
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0280553
RPS6 ribosomal protein S6 0.0274862
CD99 CD99 molecule 0.0272333
TMEM165 transmembrane protein 165 0.0271233
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0270527
RTN4 reticulon 4 0.0270194
TPM3 tropomyosin 3 0.027007
WASF2 WAS protein family, member 2 0.0268521
RNF24 ring finger protein 24 0.0266121
EP300 E1A binding protein p300 0.0265568
PKM pyruvate kinase, muscle 0.0264391
JMJD1C jumonji domain containing 1C 0.0261413
RAB7A RAB7A, member RAS oncogene family 0.0260077
MXI1 MAX interactor 1, dimerization protein 0.025976
LAMB3 laminin, beta 3 0.025933
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0258494
RAB6A RAB6A, member RAS oncogene family 0.0257051
RAP1B RAP1B, member of RAS oncogene family 0.0256716
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0254084
MED13L mediator complex subunit 13-like 0.0253207
ARHGAP21 Rho GTPase activating protein 21 0.0252805
LAMC2 laminin, gamma 2 0.0251238
VMP1 vacuole membrane protein 1 0.0251106
BRD4 bromodomain containing 4 0.0247545
MACF1 microtubule-actin crosslinking factor 1 0.02473
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0245637
RCOR1 REST corepressor 1 0.0245566
TPD52 tumor protein D52 0.0245178
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0243996
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0243717
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0242016
MT1X metallothionein 1X 0.0241608
ZMYM2 zinc finger, MYM-type 2 0.0240797
OFD1 oral-facial-digital syndrome 1 0.0240313
FAM193A family with sequence similarity 193, member A 0.0240273
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0238275
ANO6 anoctamin 6 0.0237474

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.131145
TXNRD1 thioredoxin reductase 1 -0.111252
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.088625
CAV1 caveolin 1, caveolae protein, 22kDa -0.0832872
RPL35A ribosomal protein L35a -0.0611628
ANXA2 annexin A2 -0.0608194
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.058995
PDE4D phosphodiesterase 4D, cAMP-specific -0.0554492
CANX calnexin -0.053444
AHNAK AHNAK nucleoprotein -0.0500701
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0491673
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0486384
CCND1 cyclin D1 -0.0485066
GCLC glutamate-cysteine ligase, catalytic subunit -0.0468322
GRAMD1B GRAM domain containing 1B -0.0456693
ACTG1 actin gamma 1 -0.0455906
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0439251
BZW1 basic leucine zipper and W2 domains 1 -0.0436261
AGR2 anterior gradient 2 -0.0431518
LPP LIM domain containing preferred translocation partner in lipoma -0.0430337
RPLP1 ribosomal protein, large, P1 -0.0428921
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0421634
EFNA5 ephrin-A5 -0.0412541
INTS6 integrator complex subunit 6 -0.0406881
GM2A GM2 ganglioside activator -0.0406475
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0405603
RPS24 ribosomal protein S24 -0.0405381
RNF213 ring finger protein 213 -0.0404509
LRP1B low density lipoprotein receptor-related protein 1B -0.0386607
UGDH UDP-glucose 6-dehydrogenase -0.0381563
KRT7 keratin 7, type II -0.0379578
MYOF myoferlin -0.0377776
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0376003
KRT18 keratin 18, type I -0.0372005
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.036018
THSD4 thrombospondin, type I, domain containing 4 -0.0356021
ABLIM1 actin binding LIM protein 1 -0.0353821
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0336774
SMYD3 SET and MYND domain containing 3 -0.0332781
HLA-B major histocompatibility complex, class I, B -0.0328327
BIRC3 baculoviral IAP repeat containing 3 -0.0325158
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0323892
CCSER1 coiled-coil serine-rich protein 1 -0.0319764
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0315183
NCOA7 nuclear receptor coactivator 7 -0.031039
EHBP1 EH domain binding protein 1 -0.0302925
PM20D1 peptidase M20 domain containing 1 -0.0302354
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0294531
IGFBP5 insulin-like growth factor binding protein 5 -0.0291016
IGF1R insulin-like growth factor 1 receptor -0.0290553
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0283179
TPT1 tumor protein, translationally-controlled 1 -0.0283039
ANKRD10 ankyrin repeat domain 10 -0.0271184
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0265809
RPS25 ribosomal protein S25 -0.0264307
PGK1 phosphoglycerate kinase 1 -0.0261728
RIMS2 regulating synaptic membrane exocytosis 2 -0.0255999
RIGI RNA sensor RIG-I -0.0250633
HOMER1 homer scaffolding protein 1 -0.0250569
SMIM14 small integral membrane protein 14 -0.0250048
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0249003
LDHA lactate dehydrogenase A -0.0246913
RPL37A ribosomal protein L37a -0.0246646
PTPRM protein tyrosine phosphatase, receptor type, M -0.0241404
AKR1C1 aldo-keto reductase family 1, member C1 -0.0240322
IGFBP3 insulin-like growth factor binding protein 3 -0.0240001
PDIA3 protein disulfide isomerase family A, member 3 -0.023986
RPL37 ribosomal protein L37 -0.0239285
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0237051
SLC38A2 solute carrier family 38, member 2 -0.023679
LARP1B La ribonucleoprotein domain family, member 1B -0.0233417
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0231386
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0229795
RPL30 ribosomal protein L30 -0.0228563
EXT1 exostosin glycosyltransferase 1 -0.0226542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225604
MAP7 microtubule-associated protein 7 -0.0223994
HDLBP high density lipoprotein binding protein -0.0223906
MAML3 mastermind-like 3 (Drosophila) -0.0222779
ZBTB20 zinc finger and BTB domain containing 20 -0.0220522
MX1 MX dynamin-like GTPase 1 -0.0219626
SPIRE1 spire-type actin nucleation factor 1 -0.0217528
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0216591
GOLGB1 golgin B1 -0.021529
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0213981
SP100 SP100 nuclear antigen -0.0212607
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0212234
PATJ PATJ crumbs cell polarity complex component -0.0211445
RPL38 ribosomal protein L38 -0.0210907
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0209998
PRKCA protein kinase C, alpha -0.0208618
DENND5B DENN/MADD domain containing 5B -0.0206387
LRP12 low density lipoprotein receptor-related protein 12 -0.0203185
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0202753
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0201483
RPL39 ribosomal protein L39 -0.020044
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0199875
RPL31 ribosomal protein L31 -0.0199643
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0197978
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0197239