| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Naproxen_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.115024 |
| RPS12 | ribosomal protein S12 | 0.110606 |
| RPS2 | ribosomal protein S2 | 0.100624 |
| RPL4 | ribosomal protein L4 | 0.0990887 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0957154 |
| TPM3 | tropomyosin 3 | 0.0858268 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0805478 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0754584 |
| WDR43 | WD repeat domain 43 | 0.0710516 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0681329 |
| RNF145 | ring finger protein 145 | 0.0677922 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0675098 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0670756 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0669968 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0643076 |
| INHBA | inhibin, beta A | 0.0602363 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0593958 |
| PCBP2 | poly(rC) binding protein 2 | 0.0588869 |
| RPL37A | ribosomal protein L37a | 0.0586493 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0584487 |
| RBM39 | RNA binding motif protein 39 | 0.0581985 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0581519 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0574314 |
| RTN4 | reticulon 4 | 0.0554197 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0548924 |
| HDGF | hepatoma-derived growth factor | 0.0537312 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0530743 |
| EGFR | epidermal growth factor receptor | 0.0527367 |
| HSPA8 | heat shock 70kDa protein 8 | 0.050783 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0499935 |
| RPS17 | ribosomal protein S17 | 0.0484254 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0482282 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0471898 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0464416 |
| FLNA | filamin A, alpha | 0.0459891 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0446559 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0436695 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0429002 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.042142 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0417994 |
| RACK1 | receptor for activated C kinase 1 | 0.0415086 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0395326 |
| TMSB10 | thymosin beta 10 | 0.0389455 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0385854 |
| LMNA | lamin A/C | 0.0383419 |
| RPS27A | ribosomal protein S27a | 0.0383336 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0377912 |
| CCNL1 | cyclin L1 | 0.0377814 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0377787 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0377052 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370983 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0366889 |
| RPS3 | ribosomal protein S3 | 0.0363404 |
| CMIP | c-Maf inducing protein | 0.0361182 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0358607 |
| FLNB | filamin B, beta | 0.0355233 |
| UTRN | utrophin | 0.0354746 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0352303 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0347879 |
| PNN | pinin, desmosome associated protein | 0.0346505 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0343721 |
| IL6 | interleukin 6 | 0.0333703 |
| KIF5B | kinesin family member 5B | 0.033216 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0328541 |
| PAPOLA | poly(A) polymerase alpha | 0.0327564 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0325579 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0324342 |
| RPS6 | ribosomal protein S6 | 0.03177 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0313255 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0311215 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0309105 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0308916 |
| SRGN | serglycin | 0.0300369 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0295779 |
| RPL5 | ribosomal protein L5 | 0.0293033 |
| RPL3 | ribosomal protein L3 | 0.0292298 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.02917 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.029048 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0286064 |
| TUBA1B | tubulin, alpha 1b | 0.0285243 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.028449 |
| RPL37 | ribosomal protein L37 | 0.0281854 |
| THBS1 | thrombospondin 1 | 0.027802 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0274435 |
| NOP58 | NOP58 ribonucleoprotein | 0.0274425 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0273605 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0270879 |
| TPD52 | tumor protein D52 | 0.0270865 |
| RPL18 | ribosomal protein L18 | 0.0270297 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0268478 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0268022 |
| RPL26 | ribosomal protein L26 | 0.0267315 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0264957 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0263572 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0263316 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0260581 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0260463 |
| H1-4 | H1.4 linker histone, cluster member | 0.0260333 |
| TPI1 | triosephosphate isomerase 1 | 0.0259689 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0259651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.225685 |
| FTL | ferritin, light polypeptide | -0.167283 |
| GRAMD1B | GRAM domain containing 1B | -0.125919 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.120914 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0882649 |
| TXNRD1 | thioredoxin reductase 1 | -0.0797536 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0687384 |
| MT2A | metallothionein 2A | -0.0644425 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0588809 |
| RPL23 | ribosomal protein L23 | -0.0577475 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0552107 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0531312 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0523694 |
| RPLP1 | ribosomal protein, large, P1 | -0.051908 |
| RPL35A | ribosomal protein L35a | -0.0506023 |
| S100A10 | S100 calcium binding protein A10 | -0.0485557 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0480193 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0479836 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0456333 |
| DOCK4 | dedicator of cytokinesis 4 | -0.04553 |
| RPS24 | ribosomal protein S24 | -0.0451079 |
| IER3 | immediate early response 3 | -0.0440269 |
| RPL19 | ribosomal protein L19 | -0.0436641 |
| PARD3 | par-3 family cell polarity regulator | -0.0430044 |
| RPLP0 | ribosomal protein, large, P0 | -0.0424722 |
| FGB | fibrinogen beta chain | -0.0381131 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0372992 |
| NTN4 | netrin 4 | -0.0372518 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0359576 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0341658 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0339228 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0337874 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0328848 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0313592 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0308536 |
| CANX | calnexin | -0.0307208 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0303415 |
| MYOF | myoferlin | -0.0295174 |
| IGF2 | insulin-like growth factor 2 | -0.0293746 |
| MCL1 | myeloid cell leukemia 1 | -0.0290806 |
| RHEB | Ras homolog enriched in brain | -0.0284778 |
| RPL38 | ribosomal protein L38 | -0.0283868 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0283357 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0282544 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0282348 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0281952 |
| OSMR | oncostatin M receptor | -0.0277063 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.027652 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0275492 |
| FGG | fibrinogen gamma chain | -0.0264165 |
| WWOX | WW domain containing oxidoreductase | -0.0261734 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0255552 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0251396 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0247189 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.024668 |
| ECT2 | epithelial cell transforming 2 | -0.0245728 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0243762 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0243274 |
| TNPO1 | transportin 1 | -0.0237054 |
| RPS11 | ribosomal protein S11 | -0.0237037 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0235132 |
| HBP1 | HMG-box transcription factor 1 | -0.0234236 |
| BPTF | bromodomain PHD finger transcription factor | -0.0230375 |
| MT1X | metallothionein 1X | -0.0228113 |
| FAM107B | family with sequence similarity 107, member B | -0.0227824 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0227144 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0226782 |
| H1-0 | H1.0 linker histone | -0.0226667 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0225262 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0224554 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0221462 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0219517 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0216152 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0214374 |
| ANXA2 | annexin A2 | -0.0213485 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0213465 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0213271 |
| RTN3 | reticulon 3 | -0.0211211 |
| KLF6 | Kruppel-like factor 6 | -0.0211141 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0209417 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -0.0208689 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0208452 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0208159 |
| RPS20 | ribosomal protein S20 | -0.0208019 |
| TMEM170A | transmembrane protein 170A | -0.0206763 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.020583 |
| ANXA5 | annexin A5 | -0.0205395 |
| GLG1 | golgi glycoprotein 1 | -0.0205047 |
| ANKRD13C | ankyrin repeat domain 13C | -0.0203808 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0203237 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0203131 |
| EFNA5 | ephrin-A5 | -0.0202716 |
| CDC27 | cell division cycle 27 | -0.0201272 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0200968 |
| NPR2 | natriuretic peptide receptor 2 | -0.0200959 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.020005 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0197125 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0196493 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0192344 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0188098 |
