| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Naproxen_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.119624 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0898372 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0852942 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0823181 |
| XPO1 | exportin 1 | 0.081702 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0783757 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0730449 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0717896 |
| GOLGA4 | golgin A4 | 0.0716947 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0686177 |
| ACTN4 | actinin, alpha 4 | 0.0664766 |
| DTNA | dystrobrevin, alpha | 0.0659935 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0637481 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0634134 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0627875 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0626457 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0621194 |
| RNF24 | ring finger protein 24 | 0.0617344 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0615945 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0615219 |
| SETD5 | SET domain containing 5 | 0.0612886 |
| CLTC | clathrin, heavy chain (Hc) | 0.0610393 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0595166 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0578898 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0574271 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0572979 |
| VMP1 | vacuole membrane protein 1 | 0.0569129 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0566159 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0563782 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0557451 |
| AFDN | afadin, adherens junction formation factor | 0.055473 |
| COG5 | component of oligomeric golgi complex 5 | 0.0543658 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0537508 |
| TMEM123 | transmembrane protein 123 | 0.053195 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0531043 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0521212 |
| CDC73 | cell division cycle 73 | 0.0518814 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0512896 |
| RORA | RAR-related orphan receptor A | 0.0510873 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0507949 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0506893 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0506014 |
| PHF21A | PHD finger protein 21A | 0.0497294 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0494514 |
| SRPK2 | SRSF protein kinase 2 | 0.0489192 |
| VIM | vimentin | 0.0484578 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0483773 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0464846 |
| PTK2 | protein tyrosine kinase 2 | 0.0450973 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0448627 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0441662 |
| GLG1 | golgi glycoprotein 1 | 0.0435012 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0434807 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0432126 |
| RBM39 | RNA binding motif protein 39 | 0.0429801 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0426827 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0420339 |
| PTMA | prothymosin, alpha | 0.0420208 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.041749 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0415818 |
| ZNF207 | zinc finger protein 207 | 0.0413209 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0409426 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0409146 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0408899 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0396008 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0391999 |
| CUL3 | cullin 3 | 0.0384729 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0384193 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0380596 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0376134 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.037517 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0375043 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.037472 |
| FUS | FUS RNA binding protein | 0.037276 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0371966 |
| PCBP2 | poly(rC) binding protein 2 | 0.0370672 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0368167 |
| STK24 | serine/threonine kinase 24 | 0.0367009 |
| LDHA | lactate dehydrogenase A | 0.0366113 |
| FN1 | fibronectin 1 | 0.0365452 |
| BBX | bobby sox homolog (Drosophila) | 0.0362778 |
| ZNF638 | zinc finger protein 638 | 0.0362328 |
| PGK1 | phosphoglycerate kinase 1 | 0.0360666 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0359262 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.035594 |
| TMEM41B | transmembrane protein 41B | 0.035348 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0351721 |
| FBXO11 | F-box protein 11 | 0.0350237 |
| ENO1 | enolase 1, (alpha) | 0.0347337 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0346444 |
| TPM3 | tropomyosin 3 | 0.0346243 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.034033 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0339853 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0337696 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.033633 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0334958 |
| RPL7A | ribosomal protein L7a | 0.0334272 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0334139 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0334103 |
| YAP1 | Yes-associated protein 1 | 0.0332449 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | -0.152262 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.134645 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.119919 |
| MUC16 | mucin 16, cell surface associated | -0.110275 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0999372 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0903861 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0852114 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0844092 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0792283 |
| LAMB3 | laminin, beta 3 | -0.0706319 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0695089 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0685991 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0674847 |
| TPM4 | tropomyosin 4 | -0.0661827 |
| RIGI | RNA sensor RIG-I | -0.0660785 |
| SPAG9 | sperm associated antigen 9 | -0.0659143 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0656901 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.065371 |
| ABHD17C | abhydrolase domain containing 17C | -0.0626029 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0612062 |
| STC1 | stanniocalcin 1 | -0.0610728 |
| HLA-B | major histocompatibility complex, class I, B | -0.0604101 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0594181 |
| RPS20 | ribosomal protein S20 | -0.0589479 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.05851 |
| RBM47 | RNA binding motif protein 47 | -0.0577452 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0576714 |
| PARD3 | par-3 family cell polarity regulator | -0.0554392 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0551201 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0534707 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0531103 |
| EGFR | epidermal growth factor receptor | -0.0525129 |
| SMYD3 | SET and MYND domain containing 3 | -0.0524292 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0523492 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0518131 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0514316 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0513853 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0513625 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0513164 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0506607 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0499161 |
| OSMR | oncostatin M receptor | -0.0497423 |
| ANXA1 | annexin A1 | -0.0494595 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0493645 |
| RPL35A | ribosomal protein L35a | -0.0490356 |
| MT2A | metallothionein 2A | -0.0488962 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0484387 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0481511 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0468821 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.046672 |
| LMO7 | LIM domain 7 | -0.046461 |
| CD44 | CD44 molecule (Indian blood group) | -0.0460654 |
| HLA-A | major histocompatibility complex, class I, A | -0.0460562 |
| ERBIN | erbb2 interacting protein | -0.0458257 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0458189 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0454929 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0450295 |
| PKM | pyruvate kinase, muscle | -0.0447166 |
| PAPOLA | poly(A) polymerase alpha | -0.044529 |
| TUFT1 | tuftelin 1 | -0.044496 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0440602 |
| EFNA5 | ephrin-A5 | -0.0438756 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0434779 |
| MAP1B | microtubule-associated protein 1B | -0.0432103 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0430916 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0425989 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0424 |
| TBC1D15 | TBC1 domain family, member 15 | -0.0420943 |
| ATOSA | atos homolog A | -0.041962 |
| RUNX1 | runt-related transcription factor 1 | -0.0416642 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0414159 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0410502 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0403138 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0401855 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | -0.0397717 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0395953 |
| SEPTIN9 | septin 9 | -0.0394432 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0389973 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0389568 |
| NABP1 | nucleic acid binding protein 1 | -0.0389229 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.038906 |
| HOMER1 | homer scaffolding protein 1 | -0.0387963 |
| SH3D19 | SH3 domain containing 19 | -0.0386846 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0386329 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0383585 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0377417 |
| SETX | senataxin | -0.0376517 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0376192 |
| FRMD5 | FERM domain containing 5 | -0.0374246 |
| CMIP | c-Maf inducing protein | -0.0372906 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0372325 |
| RPLP0 | ribosomal protein, large, P0 | -0.037185 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0370424 |
| RTN4 | reticulon 4 | -0.0369371 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0361657 |
| PLEC | plectin | -0.0360444 |
| POTEF | POTE ankyrin domain family, member F | -0.0360069 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0357757 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0357662 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0354837 |
