| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Naproxen_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.187137 |
| UBC | ubiquitin C | 0.173332 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.152328 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.109139 |
| ENO1 | enolase 1, (alpha) | 0.094263 |
| PTMA | prothymosin, alpha | 0.0873335 |
| HMGB2 | high mobility group box 2 | 0.0858494 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0781261 |
| DSPP | dentin sialophosphoprotein | 0.076709 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0759763 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0757559 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0755337 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0741684 |
| FAM13A | family with sequence similarity 13, member A | 0.0731006 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0655992 |
| CALR | calreticulin | 0.0653576 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0652923 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0626243 |
| G0S2 | G0/G1 switch 2 | 0.0593279 |
| NDRG1 | N-myc downstream regulated 1 | 0.0592639 |
| PCBP2 | poly(rC) binding protein 2 | 0.0546893 |
| ASPH | aspartate beta-hydroxylase | 0.0534994 |
| TPM3 | tropomyosin 3 | 0.051634 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0494758 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0458305 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0457086 |
| TOP1 | topoisomerase (DNA) I | 0.0454833 |
| AHNAK | AHNAK nucleoprotein | 0.042961 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0422213 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0399666 |
| SET | SET nuclear proto-oncogene | 0.0391562 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.037496 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0370215 |
| RPL4 | ribosomal protein L4 | 0.0361742 |
| LDHA | lactate dehydrogenase A | 0.0359863 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0345062 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.034474 |
| RPL23 | ribosomal protein L23 | 0.0344378 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0339276 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0337527 |
| MSI2 | musashi RNA-binding protein 2 | 0.0333208 |
| CANX | calnexin | 0.0328133 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0326709 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0298707 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0297692 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0297535 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0296522 |
| PKM | pyruvate kinase, muscle | 0.029551 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0294108 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0292948 |
| RBM39 | RNA binding motif protein 39 | 0.0291471 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0290594 |
| VEGFA | vascular endothelial growth factor A | 0.0290476 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.028831 |
| CCNY | cyclin Y | 0.0283562 |
| FOSL1 | FOS-like antigen 1 | 0.0280449 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.0278106 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0271762 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0271654 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.026773 |
| MSN | moesin | 0.0263961 |
| MKI67 | marker of proliferation Ki-67 | 0.0260163 |
| HDGF | hepatoma-derived growth factor | 0.0252801 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0251548 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0246998 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0246571 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0246483 |
| EZR | ezrin | 0.02443 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0241516 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0241447 |
| IRF6 | interferon regulatory factor 6 | 0.0241275 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0240291 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0238812 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0238472 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0235572 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0233359 |
| CD109 | CD109 molecule | 0.0231205 |
| TPX2 | TPX2, microtubule-associated | 0.0230644 |
| PAPOLA | poly(A) polymerase alpha | 0.0230341 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0226957 |
| RPS3 | ribosomal protein S3 | 0.0225677 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0223733 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0223561 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.022234 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0220235 |
| RYBP | RING1 and YY1 binding protein | 0.0219551 |
| SUCO | SUN domain containing ossification factor | 0.0217226 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0216389 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.02158 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.0214988 |
| JUN | jun proto-oncogene | 0.0214123 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0212196 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0211475 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.02076 |
| ARRDC3 | arrestin domain containing 3 | 0.0203009 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0201824 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0200778 |
| VIM | vimentin | 0.0199009 |
| ANLN | anillin, actin binding protein | 0.0197247 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0197166 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.167549 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.16517 |
| ACTG1 | actin gamma 1 | -0.118987 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.107221 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.10633 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.102806 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.100125 |
| RPL35A | ribosomal protein L35a | -0.0983266 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0928631 |
| FN1 | fibronectin 1 | -0.0921427 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.091922 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0794575 |
| CCND1 | cyclin D1 | -0.0759551 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0734993 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0731533 |
| ERBIN | erbb2 interacting protein | -0.0672341 |
| TXNRD1 | thioredoxin reductase 1 | -0.066668 |
| EFNA5 | ephrin-A5 | -0.0653298 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0649324 |
| LMO7 | LIM domain 7 | -0.0636125 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0598092 |
| RPL34 | ribosomal protein L34 | -0.0583837 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0539094 |
| KRT7 | keratin 7, type II | -0.0538166 |
| RPLP1 | ribosomal protein, large, P1 | -0.0528771 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0520359 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0516576 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0504424 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0495051 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0487955 |
| NF1 | neurofibromin 1 | -0.0478355 |
| RPS24 | ribosomal protein S24 | -0.047426 |
| S100A10 | S100 calcium binding protein A10 | -0.0467429 |
| RASAL2 | RAS protein activator like 2 | -0.0465792 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0460191 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0458093 |
| HMGA1 | high mobility group AT-hook 1 | -0.0456794 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0455887 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0454114 |
| EGFR | epidermal growth factor receptor | -0.0451269 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0438651 |
| SVIL | supervillin | -0.043708 |
| TMSB4X | thymosin beta 4, X-linked | -0.0432223 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0431614 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0431434 |
| TMEM165 | transmembrane protein 165 | -0.0426142 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.042332 |
| CCNI | cyclin I | -0.0421101 |
| RPL11 | ribosomal protein L11 | -0.0418017 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0412931 |
| RPLP0 | ribosomal protein, large, P0 | -0.0408898 |
| TJP1 | tight junction protein 1 | -0.0407483 |
| VGLL3 | vestigial-like family member 3 | -0.0406819 |
| JMJD1C | jumonji domain containing 1C | -0.0396077 |
| PLSCR1 | phospholipid scramblase 1 | -0.0392615 |
| SMAD3 | SMAD family member 3 | -0.0389623 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0383396 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0374241 |
| ATXN1 | ataxin 1 | -0.0369032 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0364565 |
| OSMR | oncostatin M receptor | -0.0360535 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0359095 |
| RPL30 | ribosomal protein L30 | -0.0356978 |
| RPL8 | ribosomal protein L8 | -0.0355114 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0354365 |
| RPL19 | ribosomal protein L19 | -0.0352395 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0350831 |
| RPL28 | ribosomal protein L28 | -0.0347945 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0344973 |
| TXNIP | thioredoxin interacting protein | -0.0343654 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0338978 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0337469 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0336494 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0336374 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.033571 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.032811 |
| RPS21 | ribosomal protein S21 | -0.0327638 |
| RPS23 | ribosomal protein S23 | -0.0324985 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.032421 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0319739 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0319053 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0319052 |
| RBM47 | RNA binding motif protein 47 | -0.0319041 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0318354 |
| RPS13 | ribosomal protein S13 | -0.0317458 |
| TPM4 | tropomyosin 4 | -0.03163 |
| ARF1 | ADP-ribosylation factor 1 | -0.0316081 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0315222 |
| MYO1E | myosin IE | -0.0314358 |
| CDCP1 | CUB domain containing protein 1 | -0.0313545 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0312941 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0311441 |
| RUNX1 | runt-related transcription factor 1 | -0.0311298 |
| RAB7A | RAB7A, member RAS oncogene family | -0.030883 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0307227 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0306862 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0305796 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0304633 |
| MAP4 | microtubule-associated protein 4 | -0.0301895 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0300207 |
