| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Naproxen perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Naproxen_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.131012 |
| PCBP2 | poly(rC) binding protein 2 | 0.0918327 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0863546 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0717394 |
| UBC | ubiquitin C | 0.0712644 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0651714 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0630412 |
| VIM | vimentin | 0.0540271 |
| TUBA1B | tubulin, alpha 1b | 0.0537631 |
| AHNAK | AHNAK nucleoprotein | 0.0531566 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0526286 |
| ENO1 | enolase 1, (alpha) | 0.0514985 |
| UTRN | utrophin | 0.0489429 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0488473 |
| CFL2 | cofilin 2 (muscle) | 0.0479165 |
| SET | SET nuclear proto-oncogene | 0.0464344 |
| FBXO11 | F-box protein 11 | 0.0461567 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0442778 |
| RHOA | ras homolog family member A | 0.0436414 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0417147 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0399479 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0391677 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0386292 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.038453 |
| COL5A2 | collagen, type V, alpha 2 | 0.0371598 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0368315 |
| LRRC4C | leucine rich repeat containing 4C | 0.0365914 |
| MB21D2 | Mab-21 domain containing 2 | 0.0361607 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0361024 |
| USP12 | ubiquitin specific peptidase 12 | 0.0360043 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.035811 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0356968 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0353726 |
| GSE1 | Gse1 coiled-coil protein | 0.0353571 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0349531 |
| DYNC1LI1 | dynein, cytoplasmic 1, light intermediate chain 1 | 0.0347071 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0346656 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0344623 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0341096 |
| NRDC | nardilysin convertase | 0.0332222 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0331921 |
| ATF7IP | activating transcription factor 7 interacting protein | 0.0325312 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0323471 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0318492 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0316324 |
| MAP1B | microtubule-associated protein 1B | 0.0315188 |
| FAM168A | family with sequence similarity 168, member A | 0.0314657 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0313003 |
| RASAL2 | RAS protein activator like 2 | 0.0312737 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.031009 |
| PLS3 | plastin 3 | 0.0309607 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.0308554 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.029348 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0292531 |
| SPAG9 | sperm associated antigen 9 | 0.0291629 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0291165 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0291024 |
| KIF1B | kinesin family member 1B | 0.0290991 |
| DST | dystonin | 0.0290624 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0289351 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0286681 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0286123 |
| EZR | ezrin | 0.0281049 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0280363 |
| TENM3 | teneurin transmembrane protein 3 | 0.0279335 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0276818 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0275329 |
| TLK2 | tousled-like kinase 2 | 0.0274094 |
| LDHA | lactate dehydrogenase A | 0.027251 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0271549 |
| EMC1 | ER membrane protein complex subunit 1 | 0.0270447 |
| CORO1C | coronin, actin binding protein, 1C | 0.0269304 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0267491 |
| RPL3 | ribosomal protein L3 | 0.0266303 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0262334 |
| USP34 | ubiquitin specific peptidase 34 | 0.0260713 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0258628 |
| SNX14 | sorting nexin 14 | 0.0258135 |
| TENM2 | teneurin transmembrane protein 2 | 0.0258101 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0256052 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0254749 |
| POU2F1 | POU class 2 homeobox 1 | 0.0254738 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0253057 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0252057 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0250014 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0249362 |
| TUBA1A | tubulin, alpha 1a | 0.0248501 |
| VCP | valosin containing protein | 0.02476 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0247392 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0246244 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0243495 |
| SNX3 | sorting nexin 3 | 0.0243345 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0242368 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0242043 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0240711 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0238381 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0237914 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0236144 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0235506 |
| RAB30 | RAB30, member RAS oncogene family | 0.0235114 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139081 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.114649 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0920511 |
| TMSB4X | thymosin beta 4, X-linked | -0.089341 |
| NTM | neurotrimin | -0.0786103 |
| ACTG1 | actin gamma 1 | -0.0768134 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0745446 |
| RPS16 | ribosomal protein S16 | -0.0744977 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0703196 |
| RPLP1 | ribosomal protein, large, P1 | -0.066804 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0644462 |
| CADM2 | cell adhesion molecule 2 | -0.0584769 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0583942 |
| SMYD3 | SET and MYND domain containing 3 | -0.056509 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0564084 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0553788 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0544109 |
| TFRC | transferrin receptor | -0.0534141 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0530521 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0525143 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0517662 |
| RPS6 | ribosomal protein S6 | -0.0514935 |
| RPL19 | ribosomal protein L19 | -0.0506845 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.050434 |
| GPC3 | glypican 3 | -0.0500754 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0491393 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0482049 |
| CLTC | clathrin, heavy chain (Hc) | -0.0474271 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0464664 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0461225 |
| PRKD1 | protein kinase D1 | -0.0456403 |
| HDAC9 | histone deacetylase 9 | -0.045506 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0454822 |
| TXNRD1 | thioredoxin reductase 1 | -0.0454381 |
| RPL12 | ribosomal protein L12 | -0.0442889 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0442273 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0433196 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0430666 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0426926 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0424274 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0421298 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0419449 |
| PARD3 | par-3 family cell polarity regulator | -0.0417556 |
| UPP1 | uridine phosphorylase 1 | -0.0417192 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0413782 |
| ZFR | zinc finger RNA binding protein | -0.0410537 |
| RPS8 | ribosomal protein S8 | -0.0410438 |
| TMSB10 | thymosin beta 10 | -0.0402247 |
| JMJD1C | jumonji domain containing 1C | -0.0398408 |
| POTEF | POTE ankyrin domain family, member F | -0.0397759 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0395112 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.039364 |
| HMGA1 | high mobility group AT-hook 1 | -0.0393272 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0390611 |
| RPL38 | ribosomal protein L38 | -0.038923 |
| RPS13 | ribosomal protein S13 | -0.0388486 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0386468 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0383651 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0379423 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0377602 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0374648 |
| POU3F2 | POU class 3 homeobox 2 | -0.0373892 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0373023 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0371731 |
| USP53 | ubiquitin specific peptidase 53 | -0.0367568 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0366319 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0365148 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0364793 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0364326 |
| RPL36A | ribosomal protein L36a | -0.0361807 |
| COG5 | component of oligomeric golgi complex 5 | -0.035989 |
| RPL34 | ribosomal protein L34 | -0.0357666 |
| RPL35A | ribosomal protein L35a | -0.0352259 |
| RPS10 | ribosomal protein S10 | -0.0347608 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0345872 |
| RPL37A | ribosomal protein L37a | -0.0344718 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0338319 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0336911 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0335461 |
| SRP54 | signal recognition particle 54kDa | -0.0334641 |
| OGA | O-GlcNAcase | -0.0333483 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0331659 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0325329 |
| RPL7 | ribosomal protein L7 | -0.0324904 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0324137 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0321382 |
| NPR2 | natriuretic peptide receptor 2 | -0.0321117 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0318883 |
| RPS19 | ribosomal protein S19 | -0.0313794 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0311668 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0310795 |
| CDC27 | cell division cycle 27 | -0.0304504 |
| CCDC88A | coiled-coil domain containing 88A | -0.0301758 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0300331 |
| HDAC2 | histone deacetylase 2 | -0.02975 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0296101 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0295914 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0294546 |
| ZNF292 | zinc finger protein 292 | -0.0294202 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0293186 |
