Naproxen_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Naproxen perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Naproxen_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBC ubiquitin C 0.112728
PTMA prothymosin, alpha 0.10903
CXCL8 chemokine (C-X-C motif) ligand 8 0.0914547
TPM3 tropomyosin 3 0.0894242
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0745828
PCBP2 poly(rC) binding protein 2 0.0724693
PABPC1 poly(A) binding protein, cytoplasmic 1 0.067329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0654329
EEF2 eukaryotic translation elongation factor 2 0.0638363
CALR calreticulin 0.0594173
PDIA6 protein disulfide isomerase family A, member 6 0.0593632
PTK2 protein tyrosine kinase 2 0.0589307
FLNB filamin B, beta 0.0587113
PDIA4 protein disulfide isomerase family A, member 4 0.0554833
ERRFI1 ERBB receptor feedback inhibitor 1 0.0551949
PICALM phosphatidylinositol binding clathrin assembly protein 0.0540972
ANKRD11 ankyrin repeat domain 11 0.0534107
RNF145 ring finger protein 145 0.0515874
NDRG1 N-myc downstream regulated 1 0.050738
PRKCA protein kinase C, alpha 0.0503313
NAMPT nicotinamide phosphoribosyltransferase 0.0498431
FXR1 fragile X mental retardation, autosomal homolog 1 0.0490293
PRRC2C proline-rich coiled-coil 2C 0.0480588
BHLHE40 basic helix-loop-helix family, member e40 0.0472062
NAP1L1 nucleosome assembly protein 1-like 1 0.0463944
DSCAM Down syndrome cell adhesion molecule 0.0457743
CDH13 cadherin 13 0.0457512
KTN1 kinectin 1 (kinesin receptor) 0.0454616
TGFBI transforming growth factor, beta-induced, 68kDa 0.0440137
IL6 interleukin 6 0.0433319
TRIO trio Rho guanine nucleotide exchange factor 0.041888
RO60 Ro60, Y RNA binding protein 0.0412602
THOC2 THO complex 2 0.0408998
BBX bobby sox homolog (Drosophila) 0.0403407
TMSB10 thymosin beta 10 0.0394443
SETD5 SET domain containing 5 0.038657
SLMAP sarcolemma associated protein 0.0381688
ADNP activity-dependent neuroprotector homeobox 0.0380229
SMAD3 SMAD family member 3 0.0376567
N4BP2L2 NEDD4 binding protein 2-like 2 0.0373484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.03715
TIMP3 TIMP metallopeptidase inhibitor 3 0.0370273
KMT2C lysine (K)-specific methyltransferase 2C 0.0367463
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0365828
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0365327
RAB1A RAB1A, member RAS oncogene family 0.0364322
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0363602
KPNB1 karyopherin (importin) beta 1 0.0359124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0358957
VMP1 vacuole membrane protein 1 0.0357454
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0357362
JMJD1C jumonji domain containing 1C 0.0354573
WDR43 WD repeat domain 43 0.0348238
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0348018
RPL23 ribosomal protein L23 0.0347549
LOC102724023 ES1 protein homolog, mitochondrial 0.0347296
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0347088
FN1 fibronectin 1 0.0343232
PDIA3 protein disulfide isomerase family A, member 3 0.0340957
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0340624
NKD1 naked cuticle homolog 1 (Drosophila) 0.0333618
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0331866
CKAP5 cytoskeleton associated protein 5 0.0328074
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0326891
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.032573
CD109 CD109 molecule 0.0325011
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0322066
FAM3C family with sequence similarity 3, member C 0.0321446
VGF VGF nerve growth factor inducible 0.0316684
EGFR epidermal growth factor receptor 0.0316243
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0315156
RSF1 remodeling and spacing factor 1 0.0314832
ZZZ3 zinc finger, ZZ-type containing 3 0.031318
EXT1 exostosin glycosyltransferase 1 0.0312912
CTNND1 catenin (cadherin-associated protein), delta 1 0.0310405
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0308989
BTBD9 BTB (POZ) domain containing 9 0.0308497
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0307816
ANXA2 annexin A2 0.0307765
SET SET nuclear proto-oncogene 0.0306272
GOLGB1 golgin B1 0.0305787
FNDC3B fibronectin type III domain containing 3B 0.0305523
ENO1 enolase 1, (alpha) 0.0305346
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0303698
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0302559
SUN1 Sad1 and UNC84 domain containing 1 0.0301923
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0300879
FMNL2 formin-like 2 0.0300737
FTH1 ferritin, heavy polypeptide 1 0.0299343
CUL3 cullin 3 0.0298617
TPI1 triosephosphate isomerase 1 0.029836
YME1L1 YME1-like 1 ATPase 0.0297744
SFPQ splicing factor proline/glutamine-rich 0.0296475
KDM5C lysine (K)-specific demethylase 5C 0.0296285
PPME1 protein phosphatase methylesterase 1 0.0295117
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.029438
TNIP1 TNFAIP3 interacting protein 1 0.0293096
UBA6 ubiquitin-like modifier activating enzyme 6 0.029288
TJP1 tight junction protein 1 0.0291467
PTBP3 polypyrimidine tract binding protein 3 0.0291067

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.181843
IGFBP3 insulin-like growth factor binding protein 3 -0.145705
MT2A metallothionein 2A -0.104451
HLA-B major histocompatibility complex, class I, B -0.101157
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0967958
COL6A1 collagen, type VI, alpha 1 -0.0701662
VCL vinculin -0.0631481
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.062617
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0624275
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0623817
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0601119
CANX calnexin -0.0589811
HLA-C major histocompatibility complex, class I, C -0.0587701
CALD1 caldesmon 1 -0.0584039
PRSS23 protease, serine, 23 -0.0566206
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0541855
GLIS3 GLIS family zinc finger 3 -0.052749
CD44 CD44 molecule (Indian blood group) -0.0522421
SDC4 syndecan 4 -0.0508107
F3 coagulation factor III (thromboplastin, tissue factor) -0.047724
AUTS2 autism susceptibility candidate 2 -0.0470902
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0466548
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0461725
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0456219
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0454917
MT1X metallothionein 1X -0.0450024
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0444297
TPST1 tyrosylprotein sulfotransferase 1 -0.0424451
HLA-A major histocompatibility complex, class I, A -0.0421533
PRELID2 PRELI domain containing 2 -0.0418935
DPYD dihydropyrimidine dehydrogenase -0.0413378
TFPI2 tissue factor pathway inhibitor 2 -0.0413302
TPM4 tropomyosin 4 -0.0409535
CAV1 caveolin 1, caveolae protein, 22kDa -0.0409461
STC1 stanniocalcin 1 -0.0401871
UBE2H ubiquitin-conjugating enzyme E2H -0.0394736
MYOF myoferlin -0.0394177
FLOT1 flotillin 1 -0.0392774
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0389899
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0382962
SON SON DNA binding protein -0.0377616
COL1A2 collagen, type I, alpha 2 -0.0374191
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0373985
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0367906
SAR1A secretion associated, Ras related GTPase 1A -0.0367826
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0366411
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0361099
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0353947
ANO6 anoctamin 6 -0.0352263
KCTD9 potassium channel tetramerization domain containing 9 -0.035206
LMAN1 lectin, mannose-binding, 1 -0.0347333
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0346099
ELL2 elongation factor, RNA polymerase II, 2 -0.0343859
PIBF1 progesterone immunomodulatory binding factor 1 -0.0338801
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0334999
IGFBP7 insulin-like growth factor binding protein 7 -0.0334142
VIM vimentin -0.0332149
KLHDC10 kelch domain containing 10 -0.0329545
EIF1 eukaryotic translation initiation factor 1 -0.0324484
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0322387
CLINT1 clathrin interactor 1 -0.0321236
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0317488
ARF1 ADP-ribosylation factor 1 -0.0315358
IFRD1 interferon-related developmental regulator 1 -0.0314959
RPLP1 ribosomal protein, large, P1 -0.0313791
IGFBP6 insulin-like growth factor binding protein 6 -0.0312868
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0311951
COL6A2 collagen, type VI, alpha 2 -0.0306945
FBXL7 F-box and leucine-rich repeat protein 7 -0.0304841
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0303643
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0302558
PDE4D phosphodiesterase 4D, cAMP-specific -0.0301827
MAPK8 mitogen-activated protein kinase 8 -0.0300477
IARS1 isoleucyl-tRNA synthetase 1 -0.0300173
UBAP1 ubiquitin associated protein 1 -0.0299739
RASAL2 RAS protein activator like 2 -0.0299536
ANKRD28 ankyrin repeat domain 28 -0.0293214
ANKRD12 ankyrin repeat domain 12 -0.0289195
DNAH11 dynein, axonemal, heavy chain 11 -0.0287968
ZBTB20 zinc finger and BTB domain containing 20 -0.0287513
RPS12 ribosomal protein S12 -0.0287271
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0286234
CLIC4 chloride intracellular channel 4 -0.0284214
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0276099
PHKB phosphorylase kinase, beta -0.0275652
PALLD palladin, cytoskeletal associated protein -0.0275596
BMERB1 bMERB domain containing 1 -0.0275435
ZIM3 zinc finger, imprinted 3 -0.0273751
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0272863
PFKL phosphofructokinase, liver -0.027241
HIP1 huntingtin interacting protein 1 -0.0271803
ZEB2 zinc finger E-box binding homeobox 2 -0.0271062
PRRC1 proline-rich coiled-coil 1 -0.027096
GPR75-ASB3 GPR75-ASB3 readthrough -0.0269457
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0269349
SH3RF3 SH3 domain containing ring finger 3 -0.0265417
SKIC3 SKI3 subunit of superkiller complex -0.02651
RAB10 RAB10, member RAS oncogene family -0.0262913
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0262582
GSE1 Gse1 coiled-coil protein -0.0260143