Narcolepsy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work. (Human Disease Ontology, DOID_8986)
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Genes

335 genes co-occuring with the disease Narcolepsy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HCRT hypocretin (orexin) neuropeptide precursor 4.0
HCRTR2 hypocretin (orexin) receptor 2 3.627
HCRTR1 hypocretin (orexin) receptor 1 3.582
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 3.474
HRH3 histamine receptor H3 3.298
PMCH pro-melanin-concentrating hormone 3.123
ATXN3L ataxin 3-like 2.817
TRIB2 tribbles pseudokinase 2 2.762
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.729
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.71
ATXN3 ataxin 3 2.698
PPAN-P2RY11 PPAN-P2RY11 readthrough 2.638
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.602
PDYN prodynorphin 2.561
OXR1 oxidation resistance 1 2.546
HRH1 histamine receptor H1 2.49
HDC histidine decarboxylase 2.479
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.457
FOS FBJ murine osteosarcoma viral oncogene homolog 2.428
TOR1B torsin family 1, member B (torsin B) 2.401
HRH4 histamine receptor H4 2.321
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.297
GAL galanin/GMAP prepropeptide 2.28
PNMA2 paraneoplastic Ma antigen 2 2.262
MAOB monoamine oxidase B 2.242
CTSH cathepsin H 2.231
NPY neuropeptide Y 2.225
GHRL ghrelin/obestatin prepropeptide 2.225
MAOA monoamine oxidase A 2.203
LEP leptin 2.201
PER2 period circadian clock 2 2.161
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.152
IGLON5 IgLON family member 5 2.144
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.137
OR13H1 olfactory receptor, family 13, subfamily H, member 1 2.133
POMC proopiomelanocortin 2.13
CHAD chondroadherin 2.129
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.128
BTBD9 BTB (POZ) domain containing 9 2.126
HRH2 histamine receptor H2 2.118
CHKB choline kinase beta 2.117
CRH corticotropin releasing hormone 2.117
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.116
MOG myelin oligodendrocyte glycoprotein 2.08
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.059
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.05
MCHR1 melanin-concentrating hormone receptor 1 2.035
CLOCK clock circadian regulator 2.032
CD4 CD4 molecule 2.03
TH tyrosine hydroxylase 2.027
AGRP agouti related neuropeptide 2.027
PER3 period circadian clock 3 2.018
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.013
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.003
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 1.971
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.966
TAAR1 trace amine associated receptor 1 1.966
TRH thyrotropin-releasing hormone 1.958
NPS neuropeptide S 1.953
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.947
OXT oxytocin/neurophysin I prepropeptide 1.936
EIF3G eukaryotic translation initiation factor 3, subunit G 1.934
DRD2 dopamine receptor D2 1.932
HRCT1 histidine rich carboxyl terminus 1 1.932
CRY1 cryptochrome circadian clock 1 1.929
SKOR1 SKI family transcriptional corepressor 1 1.92
CD8A CD8a molecule 1.9
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.882
IL6 interleukin 6 1.881
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.874
HLA-A major histocompatibility complex, class I, A 1.873
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.867
NTS neurotensin 1.858
HLA-B major histocompatibility complex, class I, B 1.857
BDNF brain-derived neurotrophic factor 1.857
INS insulin 1.856
OPN4 opsin 4 1.842
TNF tumor necrosis factor 1.806
ACHE acetylcholinesterase (Yt blood group) 1.803
SCT secretin 1.799
COMT catechol-O-methyltransferase 1.797
QRFP pyroglutamylated RFamide peptide 1.795
CRY2 cryptochrome circadian clock 2 1.788
HNMT histamine N-methyltransferase 1.769
LHX9 LIM homeobox 9 1.757
CHAT choline O-acetyltransferase 1.736
CPT1C carnitine palmitoyltransferase 1C 1.735
LGI1 leucine-rich, glioma inactivated 1 1.73
BHLHE41 basic helix-loop-helix family, member e41 1.72
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.72
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.719
CARTPT CART prepropeptide 1.718
MCHR2 melanin-concentrating hormone receptor 2 1.713
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.713
NPAS2 neuronal PAS domain protein 2 1.708
UBXN2B UBX domain protein 2B 1.674
PVALB parvalbumin 1.672
PNOC prepronociceptin 1.666
IL1B interleukin 1, beta 1.664
DPYSL5 dihydropyrimidinase-like 5 1.655
TAC1 tachykinin, precursor 1 1.654
APP amyloid beta (A4) precursor protein 1.653
PRL prolactin 1.649
CSNK1D casein kinase 1, delta 1.645
ADORA2A adenosine A2a receptor 1.63
IFNG interferon, gamma 1.626
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.625
CNTNAP2 contactin associated protein-like 2 1.622
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.618
MEIS1 Meis homeobox 1 1.597
OPRM1 opioid receptor, mu 1 1.595
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.589
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.58
BCHE butyrylcholinesterase 1.571
NPVF neuropeptide VF precursor 1.558
VIP vasoactive intestinal peptide 1.545
DRD1 dopamine receptor D1 1.532
FBXL3 F-box and leucine-rich repeat protein 3 1.516
DRD4 dopamine receptor D4 1.513
ADORA1 adenosine A1 receptor 1.512
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.511
HLA-C major histocompatibility complex, class I, C 1.509
CREB1 cAMP responsive element binding protein 1 1.506
CCR3 chemokine (C-C motif) receptor 3 1.501
TOX3 TOX high mobility group box family member 3 1.499
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.498
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.498
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.497
GHRH growth hormone releasing hormone 1.494
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 1.483
IL10 interleukin 10 1.48
MBP myelin basic protein 1.477
APOE apolipoprotein E 1.474
ALB albumin 1.468
GRM5 glutamate receptor, metabotropic 5 1.462
TOR1A torsin family 1, member A (torsin A) 1.459
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.458
PTPRD protein tyrosine phosphatase, receptor type, D 1.457
GCG glucagon 1.452
NMS neuromedin S 1.451
MAP2K5 mitogen-activated protein kinase kinase 5 1.447
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.447
NPTX2 neuronal pentraxin II 1.445
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1.441
NPSR1 neuropeptide S receptor 1 1.44
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.434
GRM2 glutamate receptor, metabotropic 2 1.425
RHO rhodopsin 1.422
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.42
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 1.415
ARRB2 arrestin, beta 2 1.411
SST somatostatin 1.411
GHSR growth hormone secretagogue receptor 1.409
CRHR1 corticotropin releasing hormone receptor 1 1.407
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.407
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.406
RFX4 regulatory factor X, 4 (influences HLA class II expression) 1.402
NEFL neurofilament, light polypeptide 1.399
SIGMAR1 sigma non-opioid intracellular receptor 1 1.397
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.395
HOMER1 homer scaffolding protein 1 1.393
QRFPR pyroglutamylated RFamide peptide receptor 1.391
IL10RB interleukin 10 receptor, beta 1.389
RIC8B RIC8 guanine nucleotide exchange factor B 1.381
CRP C-reactive protein, pentraxin-related 1.378
IL4 interleukin 4 1.377
AVP arginine vasopressin 1.376
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.375
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.371
MC4R melanocortin 4 receptor 1.369
CSNK1E casein kinase 1, epsilon 1.366
KIAA0753 KIAA0753 1.363
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.361
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.358
GFAP glial fibrillary acidic protein 1.358
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.346
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.34
IL2 interleukin 2 1.336
ARRB1 arrestin, beta 1 1.332
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 1.331
AMPH amphiphysin 1.326
DRD3 dopamine receptor D3 1.322
CCR1 chemokine (C-C motif) receptor 1 1.317
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.315
ADRA1B adrenoceptor alpha 1B 1.307
DPP6 dipeptidyl-peptidase 6 1.302
ADRB2 adrenoceptor beta 2, surface 1.296
MAPT microtubule-associated protein tau 1.295
HLA-DMA major histocompatibility complex, class II, DM alpha 1.294
NPC1 Niemann-Pick disease, type C1 1.292
IGF1 insulin-like growth factor 1 (somatomedin C) 1.289
IL1A interleukin 1, alpha 1.282
DPP10 dipeptidyl-peptidase 10 (non-functional) 1.28
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.278
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.277
IL17A interleukin 17A 1.272
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.272
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.267
BIN1 bridging integrator 1 1.261
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.256
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.252
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 1.25
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.248
MAGEL2 melanoma antigen family L2 1.247
HLA-DOA major histocompatibility complex, class II, DO alpha 1.238
CNR1 cannabinoid receptor 1 (brain) 1.238
TLR4 toll-like receptor 4 1.234
ACE angiotensin I converting enzyme 1.232
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.231
IFNB1 interferon, beta 1, fibroblast 1.23
CCK cholecystokinin 1.23
TAAR5 trace amine associated receptor 5 1.23
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.226
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.226
HLA-DRA major histocompatibility complex, class II, DR alpha 1.223
ZBTB24 zinc finger and BTB domain containing 24 1.221
ADA adenosine deaminase 1.218
MECP2 methyl CpG binding protein 2 1.216
NUCB2 nucleobindin 2 1.214
TMEM247 transmembrane protein 247 1.212
CCKAR cholecystokinin A receptor 1.212
KLHL11 kelch-like family member 11 1.209
NPY1R neuropeptide Y receptor Y1 1.209
NKAIN3 Na+/K+ transporting ATPase interacting 3 1.206
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.204
RLN3 relaxin 3 1.201
CXCL8 chemokine (C-X-C motif) ligand 8 1.2
CCL2 chemokine (C-C motif) ligand 2 1.2
TMEM132B transmembrane protein 132B 1.199
PYY peptide YY 1.197
TAAR2 trace amine associated receptor 2 1.194
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 1.192
PXDN peroxidasin 1.19
PHOX2B paired-like homeobox 2b 1.189
PXDNL peroxidasin-like 1.186
NCKAP5 NCK-associated protein 5 1.171
TRIM32 tripartite motif containing 32 1.17
BMP8B bone morphogenetic protein 8b 1.165
OXTR oxytocin receptor 1.154
GDNF glial cell derived neurotrophic factor 1.153
METTL22 methyltransferase like 22 1.151
POMT1 protein-O-mannosyltransferase 1 1.15
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.15
NGF nerve growth factor (beta polypeptide) 1.143
C4A complement component 4A (Rodgers blood group) 1.143
GH1 growth hormone 1 1.14
TACR1 tachykinin receptor 1 1.139
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.136
EFHD1 EF-hand domain family, member D1 1.136
PRKN parkin RBR E3 ubiquitin protein ligase 1.136
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.136
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.132
NRXN1 neurexin 1 1.125
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.125
AIF1 allograft inflammatory factor 1 1.125
MTNR1B melatonin receptor 1B 1.123
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.121
KISS1 KiSS-1 metastasis-suppressor 1.121
AOC1 amine oxidase, copper containing 1 1.12
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 1.115
GH2 growth hormone 2 1.114
TAAR8 trace amine associated receptor 8 1.111
PRCD progressive rod-cone degeneration 1.106
NPFFR1 neuropeptide FF receptor 1 1.102
ADRB1 adrenoceptor beta 1 1.101
EBF2 early B-cell factor 2 1.099
ADNP activity-dependent neuroprotector homeobox 1.096
NPC2 Niemann-Pick disease, type C2 1.094
TBL1X transducin (beta)-like 1X-linked 1.094
LEPR leptin receptor 1.093
UHRF1 ubiquitin-like with PHD and ring finger domains 1 1.092
PENK proenkephalin 1.091
GRM1 glutamate receptor, metabotropic 1 1.09
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.088
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 1.088
ZNF446 zinc finger protein 446 1.087
PDE10A phosphodiesterase 10A 1.086
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.084
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.084
TPGS1 tubulin polyglutamylase complex subunit 1 1.084
LRRK2 leucine-rich repeat kinase 2 1.081
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 1.08
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 1.08
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.08
PPY pancreatic polypeptide 1.08
ADIPOQ adiponectin, C1Q and collagen domain containing 1.078
CRAT carnitine O-acetyltransferase 1.076
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.073
ADRA2A adrenoceptor alpha 2A 1.07
IGFBP3 insulin-like growth factor binding protein 3 1.07
DAGLA diacylglycerol lipase, alpha 1.069
CD19 CD19 molecule 1.067
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.065
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 1.064
CALB1 calbindin 1, 28kDa 1.064
ADRA1A adrenoceptor alpha 1A 1.062
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.061
DNASE2B deoxyribonuclease II beta 1.06
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.059
SIK3 SIK family kinase 3 1.051
GJD2 gap junction protein, delta 2, 36kDa 1.051
SIM1 single-minded family bHLH transcription factor 1 1.05
REN renin 1.05
PHGDH phosphoglycerate dehydrogenase 1.049
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.047
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.047
TEF thyrotrophic embryonic factor 1.047
NMU neuromedin U 1.045
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.045
TAAR9 trace amine associated receptor 9 (gene/pseudogene) 1.042
RGS16 regulator of G-protein signaling 16 1.041
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.04
DNER delta/notch-like EGF repeat containing 1.04
ACE2 angiotensin I converting enzyme 2 1.037
SYN1 synapsin I 1.034
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.032
FAM3D family with sequence similarity 3, member D 1.029
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.028
IFNA1 interferon, alpha 1 1.026
BACE1 beta-site APP-cleaving enzyme 1 1.02
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.02
BHLHE40 basic helix-loop-helix family, member e40 1.018
PSEN1 presenilin 1 1.018
MFSD3 major facilitator superfamily domain containing 3 1.018
NDN necdin, melanoma antigen (MAGE) family member 1.017
TPM3 tropomyosin 3 1.016
OR5AK2 olfactory receptor, family 5, subfamily AK, member 2 1.016
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.013
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.012
MC3R melanocortin 3 receptor 1.009
SNRPN small nuclear ribonucleoprotein polypeptide N 1.005
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.005
ZFAND2A zinc finger, AN1-type domain 2A 1.002
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.002
SYN2 synapsin II 1.002