Natural killer cell mediated cytotoxicity Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. (Gene Ontology, GO_0042267)
External Link https://www.kegg.jp/entry/hsa04650
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Genes

131 proteins participating in the Natural killer cell mediated cytotoxicity pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ARAF A-Raf proto-oncogene, serine/threonine kinase
BID BH3 interacting domain death agonist
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD244 CD244 molecule, natural killer cell receptor 2B4
CD247 CD247 molecule
CD48 CD48 molecule
CLSTN1 calsyntenin 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB2 growth factor receptor-bound protein 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCST hematopoietic cell signal transducer
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRC3 killer cell lectin-like receptor subfamily C, member 3
KLRC4-KLRK1 KLRC4-KLRK1 readthrough
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102725023 killer cell immunoglobulin-like receptor 2DS3 allele 0020101
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NCR2 natural cytotoxicity triggering receptor 2
NCR3 natural cytotoxicity triggering receptor 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAET1E retinoic acid early transcript 1E
RAET1G retinoic acid early transcript 1G
RAET1L retinoic acid early transcript 1L
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SH3BP2 SH3-domain binding protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPNS1 spinster homolog 1 (Drosophila)
SYK spleen tyrosine kinase
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYROBP TYRO protein tyrosine kinase binding protein
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
ULBP3 UL16 binding protein 3
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF395 zinc finger protein 395