Nephrocalcinosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

342 genes co-occuring with the disease Nephrocalcinosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CLDN16 claudin 16 3.618
CLCN5 chloride channel, voltage-sensitive 5 3.498
AGXT alanine-glyoxylate aminotransferase 3.479
PTH parathyroid hormone 3.426
CLDN19 claudin 19 3.403
GRHPR glyoxylate reductase/hydroxypyruvate reductase 3.223
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 3.136
CASR calcium-sensing receptor 3.131
OCRL oculocerebrorenal syndrome of Lowe 3.121
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.103
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 3.081
FGF23 fibroblast growth factor 23 3.076
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.065
CLCNKB chloride channel, voltage-sensitive Kb 3.031
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 3.002
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.992
PHEX phosphate regulating endopeptidase homolog, X-linked 2.982
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.952
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.94
FAM20A family with sequence similarity 20, member A 2.935
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.888
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.839
CLDN14 claudin 14 2.774
EMP1 epithelial membrane protein 1 2.714
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.593
WDR72 WD repeat domain 72 2.513
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.473
FAM20C family with sequence similarity 20, member C 2.469
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.468
CLDN10 claudin 10 2.466
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.461
CLCNKA chloride channel, voltage-sensitive Ka 2.439
ALPL alkaline phosphatase, liver/bone/kidney 2.422
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.42
OSGEP O-sialoglycoprotein endopeptidase 2.359
PHC3 polyhomeotic homolog 3 (Drosophila) 2.337
REN renin 2.33
ALB albumin 2.319
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.272
FOXI1 forkhead box I1 2.27
DNAH8 dynein, axonemal, heavy chain 8 2.253
MAGED2 melanoma antigen family D2 2.247
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.21
KL klotho 2.192
AQP2 aquaporin 2 (collecting duct) 2.191
LRP2 low density lipoprotein receptor-related protein 2 2.187
SPP1 secreted phosphoprotein 1 2.153
CDC73 cell division cycle 73 2.151
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.137
PTHLH parathyroid hormone-like hormone 2.121
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.093
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.093
UMOD uromodulin 2.08
CA2 carbonic anhydrase II 2.076
FAM20B family with sequence similarity 20, member B 2.076
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.054
GCM2 glial cells missing homolog 2 (Drosophila) 2.036
GC group-specific component (vitamin D binding protein) 2.032
MEN1 multiple endocrine neoplasia I 2.029
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.028
AMBP alpha-1-microglobulin/bikunin precursor 2.02
OAT ornithine aminotransferase 2.016
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.015
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.012
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.009
ACE angiotensin I converting enzyme 2.007
B2M beta-2-microglobulin 2.001
PTH1R parathyroid hormone 1 receptor 1.993
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.984
FXYD2 FXYD domain containing ion transport regulator 2 1.982
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.975
ENAM enamelin 1.971
CLDN2 claudin 2 1.969
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 1.968
MEPE matrix extracellular phosphoglycoprotein 1.955
DMP1 dentin matrix acidic phosphoprotein 1 1.942
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.939
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.936
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.934
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 1.911
WNK4 WNK lysine deficient protein kinase 4 1.91
CTNS cystinosin, lysosomal cystine transporter 1.903
PRODH2 proline dehydrogenase (oxidase) 2 1.901
AMBN ameloblastin (enamel matrix protein) 1.866
ARSJ arylsulfatase family, member J 1.843
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.84
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 1.839
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 1.832
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.827
CLDN3 claudin 3 1.825
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.814
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.813
BGLAP bone gamma-carboxyglutamate (gla) protein 1.813
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.802
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.783
CLDN8 claudin 8 1.776
ROGDI rogdi homolog (Drosophila) 1.772
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.751
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.75
APRT adenine phosphoribosyltransferase 1.73
CLDN15 claudin 15 1.729
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.711
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.709
SLC26A7 solute carrier family 26 (anion exchanger), member 7 1.697
COQ8B coenzyme Q8B 1.694
CLDN4 claudin 4 1.692
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.685
MMP20 matrix metallopeptidase 20 1.681
CLDN1 claudin 1 1.669
AVP arginine vasopressin 1.648
WNK1 WNK lysine deficient protein kinase 1 1.647
INS insulin 1.647
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.642
KLK4 kallikrein-related peptidase 4 1.642
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.642
KLHL3 kelch-like family member 3 1.627
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 1.617
CLCN7 chloride channel, voltage-sensitive 7 1.608
FAM111A family with sequence similarity 111, member A 1.6
ODAPH odontogenesis associated phosphoprotein 1.6
GNAS GNAS complex locus 1.594
MGP matrix Gla protein 1.592
DLX3 distal-less homeobox 3 1.591
HNF1B HNF1 homeobox B 1.583
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.581
COL4A5 collagen, type IV, alpha 5 1.581
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1.58
AMTN amelotin 1.575
OGA O-GlcNAcase 1.557
HAVCR1 hepatitis A virus cellular receptor 1 1.555
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 1.553
AIRE autoimmune regulator 1.551
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.549
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.546
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.544
CLCN4 chloride channel, voltage-sensitive 4 1.544
SACK1H scaffolding CK1 anchoring protein H 1.537
CLDN12 claudin 12 1.536
POMC proopiomelanocortin 1.524
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.523
S100G S100 calcium binding protein G 1.522
CST3 cystatin C 1.52
CLDN7 claudin 7 1.512
IGF1 insulin-like growth factor 1 (somatomedin C) 1.505
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 1.502
FGFR1 fibroblast growth factor receptor 1 1.485
CLDN11 claudin 11 1.48
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.475
CLDN6 claudin 6 1.466
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 1.464
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.463
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.463
AHSG alpha-2-HS-glycoprotein 1.462
LDHA lactate dehydrogenase A 1.457
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.457
RRAGD Ras-related GTP binding D 1.451
RUNX2 runt-related transcription factor 2 1.443
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.443
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 1.441
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.436
AMELX amelogenin, X-linked 1.428
GDNF glial cell derived neurotrophic factor 1.427
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 1.422
TJP1 tight junction protein 1 1.421
NLRP3 NLR family, pyrin domain containing 3 1.418
MMP25 matrix metallopeptidase 25 1.417
SOST sclerostin 1.413
IL1B interleukin 1, beta 1.411
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.398
PHOSPHO1 phosphatase, orphan 1 1.397
ESPN espin 1.396
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.391
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.391
EPO erythropoietin 1.383
RET ret proto-oncogene 1.383
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.383
ACP4 acid phosphatase 4 1.38
RHBG Rh family, B glycoprotein (gene/pseudogene) 1.379
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 1.377
SCNN1B sodium channel, non voltage gated 1 beta subunit 1.375
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.374
CLDN9 claudin 9 1.374
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.369
SMAD9 SMAD family member 9 1.369
AVPR2 arginine vasopressin receptor 2 1.367
CLCN3 chloride channel, voltage-sensitive 3 1.364
CALB1 calbindin 1, 28kDa 1.364
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.357
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.351
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.347
INSR insulin receptor 1.346
FGF7 fibroblast growth factor 7 1.338
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.336
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.335
ANXA2 annexin A2 1.331
MARVELD2 MARVEL domain containing 2 1.331
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 1.329
STX16 syntaxin 16 1.327
AMN amnion associated transmembrane protein 1.319
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.319
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.317
RHCG Rh family, C glycoprotein 1.31
COL4A4 collagen, type IV, alpha 4 1.305
SFRP4 secreted frizzled-related protein 4 1.302
NPHP1 nephronophthisis 1 (juvenile) 1.301
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 1.296
IL6 interleukin 6 1.296
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 1.294
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.294
CKMT1B creatine kinase, mitochondrial 1B 1.293
NXT2 nuclear transport factor 2-like export factor 2 1.292
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.291
CKB creatine kinase, brain 1.29
CKM creatine kinase, muscle 1.289
CLDN5 claudin 5 1.288
ACP5 acid phosphatase 5, tartrate resistant 1.283
AQP1 aquaporin 1 (Colton blood group) 1.28
TNF tumor necrosis factor 1.277
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.276
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.269
PLPPR4 phospholipid phosphatase related 4 1.264
OSTM1 osteopetrosis associated transmembrane protein 1 1.261
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.26
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.258
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.256
TGFB1 transforming growth factor, beta 1 1.252
CRP C-reactive protein, pentraxin-related 1.249
EVC Ellis van Creveld protein 1.234
NLRP5 NLR family, pyrin domain containing 5 1.226
ATP13A4 ATPase type 13A4 1.224
PDZK1 PDZ domain containing 1 1.219
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.217
EMC10 ER membrane protein complex subunit 10 1.216
PRL prolactin 1.216
MPDZ multiple PDZ domain protein 1.215
TBCE tubulin folding cofactor E 1.211
OCLN occludin 1.206
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.203
COQ6 coenzyme Q6 monooxygenase 1.203
CCDC158 coiled-coil domain containing 158 1.201
INPP5K inositol polyphosphate-5-phosphatase K 1.199
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.198
HPD 4-hydroxyphenylpyruvate dioxygenase 1.197
APOL1 apolipoprotein L, 1 1.194
ALG3 ALG3, alpha-1,3- mannosyltransferase 1.19
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.189
EVC2 Ellis van Creveld syndrome 2 1.186
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.182
SLC26A8 solute carrier family 26 (anion exchanger), member 8 1.175
RTL9 retrotransposon Gag like 9 1.171
DSPP dentin sialophosphoprotein 1.166
PEX6 peroxisomal biogenesis factor 6 1.166
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.163
FGF10 fibroblast growth factor 10 1.16
LCN2 lipocalin 2 1.16
FN1 fibronectin 1 1.16
FGF9 fibroblast growth factor 9 1.158
CHSY3 chondroitin sulfate synthase 3 1.157
ANKH ANKH inorganic pyrophosphate transport regulator 1.155
FGF8 fibroblast growth factor 8 (androgen-induced) 1.153
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.151
C4BPB complement component 4 binding protein, beta 1.14
CLCN1 chloride channel, voltage-sensitive 1 1.14
PAX2 paired box 2 1.139
FGF16 fibroblast growth factor 16 1.138
FGF3 fibroblast growth factor 3 1.138
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.136
TMEM164 transmembrane protein 164 1.131
FGF18 fibroblast growth factor 18 1.13
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 1.129
TLR4 toll-like receptor 4 1.129
GATA3 GATA binding protein 3 1.127
F2 coagulation factor II (thrombin) 1.127
FGF22 fibroblast growth factor 22 1.127
FGF6 fibroblast growth factor 6 1.125
CLCN2 chloride channel, voltage-sensitive 2 1.123
FGF20 fibroblast growth factor 20 1.122
PTH2R parathyroid hormone 2 receptor 1.121
FGF17 fibroblast growth factor 17 1.12
FGF5 fibroblast growth factor 5 1.117
GPR68 G protein-coupled receptor 68 1.117
FGF4 fibroblast growth factor 4 1.115
ELN elastin 1.112
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.107
INF2 inverted formin, FH2 and WH2 domain containing 1.106
ADCY10 adenylate cyclase 10 (soluble) 1.104
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 1.103
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.1
PLPPR3 phospholipid phosphatase related 3 1.098
CBS cystathionine-beta-synthase 1.097
GYPA glycophorin A (MNS blood group) 1.094
APOM apolipoprotein M 1.093
EGF epidermal growth factor 1.091
COL1A1 collagen, type I, alpha 1 1.09
TRPC3 transient receptor potential cation channel, subfamily C, member 3 1.089
TPO thyroid peroxidase 1.087
TBX1 T-box 1 1.087
PXDNL peroxidasin-like 1.08
CA14 carbonic anhydrase XIV 1.079
GCG glucagon 1.079
PXDN peroxidasin 1.079
STK39 serine threonine kinase 39 1.073
MSX2 msh homeobox 2 1.072
XDH xanthine dehydrogenase 1.07
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.069
MARVELD3 MARVEL domain containing 3 1.068
IL18 interleukin 18 1.065
DGKE diacylglycerol kinase, epsilon 64kDa 1.064
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.062
FGFR3 fibroblast growth factor receptor 3 1.061
SDF4 stromal cell derived factor 4 1.06
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.059
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.058
PKNOX1 PBX/knotted 1 homeobox 1 1.056
VPS33B vacuolar protein sorting 33 homolog B (yeast) 1.056
NADSYN1 NAD synthetase 1 1.055
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.055
ARHGAP1 Rho GTPase activating protein 1 1.054
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.05
WNK3 WNK lysine deficient protein kinase 3 1.047
CA6 carbonic anhydrase VI 1.047
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.046
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.046
SP7 Sp7 transcription factor 1.045
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.045
CSH2 chorionic somatomammotropin hormone 2 1.045
CLDN18 claudin 18 1.042
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.041
TG thyroglobulin 1.036
LAMA2 laminin, alpha 2 1.035
STIM1 stromal interaction molecule 1 1.034
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.032
TRIM21 tripartite motif containing 21 1.032
CD4 CD4 molecule 1.029
ITGB6 integrin, beta 6 1.023
HNF4A hepatocyte nuclear factor 4, alpha 1.015
MPV17 MpV17 mitochondrial inner membrane protein 1.013
COL1A2 collagen, type I, alpha 2 1.012
FGFR4 fibroblast growth factor receptor 4 1.008
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.008
IRF1 interferon regulatory factor 1 1.008
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.002